Mice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo.

abstract：:This study aimed to evaluate the effects of ischemia-reperfusion injury (IRI) on the risk of hepatocellular carcinoma (HCC) recurrence after liver transplantation. Data of 195 patients were retrospectively analysed. Post-reperfusion aspartate (AST), alanine transaminase, and lactate dehydrogenase (LDH) levels were the...

journal_title：Scientific reports

authors： Grąt M,Krawczyk M,Wronka KM,Stypułkowski J,Lewandowski Z,Wasilewicz M,Krawczyk P,Grąt K,Patkowski W,Zieniewicz K

更新日期：2018-06-12 00:00:00

abstract：:Childhood obesity and early rapid growth increase the risk for type 2 diabetes. Such early overnutrition can be modeled in mice by reducing litter size. We investigated the effects of early overnutrition and increased dietary fat intake on β cell function in Swiss Webster mice. On a moderate-fat diet, early overnutrit...

journal_title：Scientific reports

authors： Glavas MM,Hui Q,Tudurí E,Erener S,Kasteel NL,Johnson JD,Kieffer TJ

更新日期：2019-03-06 00:00:00

abstract：:Recently, a new technique was developed for non-catalytically mixing microdroplets. In this method, an alternating-current (AC) electric field is used to promote the antigen-antibody reaction within the microdroplet. Previously, this technique has only been applied to histological examinations of flat structures, such...

journal_title：Scientific reports

authors： Shirasawa H,Kumagai J,Sato E,Kabashima K,Kumazawa Y,Sato W,Miura H,Nakamura R,Nanjo H,Minamiya Y,Akagami Y,Terada Y

更新日期：2015-10-19 00:00:00

abstract：:On an SiO2-patterned c-plane sapphire substrate, GaN domains were grown with their polarity controlled in accordance with the pattern. While N-polar GaN was grown on hexagonally arranged circular openings, Ga-polar GaN was laterally overgrown on mask regions due to polarity inversion occurring at the boundary of the c...

journal_title：Scientific reports

authors： Jang D,Jue M,Kim D,Kim HS,Lee H,Kim C

更新日期：2018-03-07 00:00:00

abstract：:Studies on dsDNA bacteriophages have revealed that a DNA packaging complex assembles at a special vertex called the 'portal vertex' and consists of a portal, a DNA packaging ATPase and other components. AdV protein IVa2 is presumed to function as a DNA packaging ATPase. However, a protein that functions as a portal is...

journal_title：Scientific reports

authors： Ahi YS,Hassan AO,Vemula SV,Li K,Jiang W,Zhang GJ,Mittal SK

更新日期：2017-08-08 00:00:00

abstract：:Flagellin is amongst the most abundant proteins in flagellated bacterial species and constitutes the major building block of the flagellar filament. The proteins FliW and FliS serve in the post-transcriptional control of flagellin and guide the protein to the flagellar type III secretion system (fT3SS), respectively. ...

journal_title：Scientific reports

authors： Altegoer F,Mukherjee S,Steinchen W,Bedrunka P,Linne U,Kearns DB,Bange G

更新日期：2018-08-01 00:00:00

abstract：:Local mRNA translation occurs in growing axons enabling precise control of the proteome in response to signals. To measure quantitatively the spatiotemporal dynamics of protein synthesis in growth cones, we further developed a technique for single molecule translation imaging (SMTI). We report that Netrin-1 triggers a...

journal_title：Scientific reports

authors： Ströhl F,Lin JQ,Laine RF,Wong HH,Urbančič V,Cagnetta R,Holt CE,Kaminski CF

更新日期：2017-04-06 00:00:00

abstract：:Tree leaves are commonly composed of thin mesophyll, carrying out photosynthesis under sunlight, and thick veins. Although the role of leaf veins in water transportation has been known for a long time, their role in providing structural support and guaranteeing large sunlighted area was rarely studied and remains elus...

journal_title：Scientific reports

authors： Sun Z,Cui T,Zhu Y,Zhang W,Shi S,Tang S,Du Z,Liu C,Cui R,Chen H,Guo X

更新日期：2018-09-14 00:00:00

abstract：:Mechanical forces are critical to modulate cell spreading, contractility, gene expression, and even stem cell differentiation. Yet, existing tools that can apply controllable subcellular forces to a large number of single cells simultaneously are still limited. Here we report a novel ultrasound tweezing cytometry util...

journal_title：Scientific reports

authors： Fan Z,Sun Y,Di Chen,Tay D,Chen W,Deng CX,Fu J

更新日期：2013-01-01 00:00:00

abstract：:Conservatives are more sensitive to threatening/anxious situations in perceptual and cognitive levels, experiencing emotional responses and stress, while liberals are more responsive to but tolerant of ambiguous and uncertain information. Interestingly, conservatives have greater psychological well-being and are more ...

journal_title：Scientific reports

authors： Kim T,Hur JW,Kwak S,Jang D,Lee SH,Kwon JS

更新日期：2020-09-28 00:00:00

abstract：:Some neural network can be trained by transfer learning, which uses a pre-trained neural network as the source task, for a small target task's dataset. The performance of the transfer learning depends on the knowledge (i.e., layers) selected from the pre-trained network. At present, this knowledge is usually chosen by...

journal_title：Scientific reports

authors： Imai S,Kawai S,Nobuhara H

更新日期：2020-05-18 00:00:00

abstract：:We present results from first-principles calculations on silane (SiH4) under pressure. We find that a three dimensional P-3 structure becomes the most stable phase above 241 GPa. A prominent structural feature, which separates the P-3 structure from previously observed/predicted SiH4 structures, is that a fraction of ...

journal_title：Scientific reports

authors： Cui W,Shi J,Liu H,Yao Y,Wang H,Iitaka T,Ma Y

更新日期：2015-08-12 00:00:00

abstract：:We report on chemical reactions triggered by core-level ionization of ammonium ([Formula: see text]) cation in aqueous solution. Based on a combination of photoemission experiments from a liquid microjet and high-level ab initio simulations, we identified simultaneous single and double proton transfer occurring on a v...

journal_title：Scientific reports

authors： Hollas D,Pohl MN,Seidel R,Aziz EF,Slavíček P,Winter B

更新日期：2017-04-07 00:00:00

abstract：:Molecular crystals demonstrate drastically different behavior in solid and liquid state, mainly due to their difference in structural frameworks. Therefore, designing of unique structured molecular compound which can work at both these interfaces has been a challenge. Here, we present remarkable 'molecular' property b...

journal_title：Scientific reports

authors： Mande HM,Ghalsasi PS

更新日期：2015-09-28 00:00:00

abstract：:Knowledge of brain correlates of postural control is limited by the technical difficulties in performing controlled experiments with currently available neuroimaging methods. Here we present a system that allows the measurement of anticipatory postural adjustment of human legs to be synchronized with the acquisition o...

journal_title：Scientific reports

authors： de Lima-Pardini AC,de Azevedo Neto RM,Coelho DB,Boffino CC,Shergill SS,de Oliveira Souza C,Brant R,Barbosa ER,Cardoso EF,Teixeira LA,Cohen RG,Horak FB,Amaro E Jr

更新日期：2017-02-23 00:00:00

abstract：:The influence of dose rate on radiation cataractogenesis has yet to be extensively studied. One recent epidemiological investigation suggested that protracted radiation exposure increases radiation-induced cataract risk: cumulative doses of radiation mostly <100 mGy received by US radiologic technologists over 5 years...

journal_title：Scientific reports

authors： Barnard SGR,McCarron R,Moquet J,Quinlan R,Ainsbury E

更新日期：2019-07-18 00:00:00

abstract：:Pt/K2CO3/MgAlOx-reduced graphene oxide (Pt/K/MgAlOx-rGO) hybrids were synthesized, characterized and tested as a promising NOx storage and reduction (NSR) catalyst. Mg-Al layered double hydroxides (LDHs) were grown on rGO via in situ hydrothermal crystallization. The structure and morphology of samples were thoroughly...

journal_title：Scientific reports

authors： Mei X,Yan Q,Lu P,Wang J,Cui Y,Nie Y,Umar A,Wang Q

更新日期：2017-02-16 00:00:00

abstract：:Knowledge of the structure-property-function relationship of humic substances (HSs) is key for understanding their role in soil. Despite progress, studies on this topic are still under discussion. We analyzed 37 humic fractions with respect to their isotopic composition, structural characteristics, and properties resp...

journal_title：Scientific reports

authors： García AC,de Souza LG,Pereira MG,Castro RN,García-Mina JM,Zonta E,Lisboa FJ,Berbara RL

更新日期：2016-02-10 00:00:00

abstract：:Histone methylation is thought to control the regulation of genetic program and the dysregulation of it has been found to be closely associated with cancer. JMJD3 has been identified as an H3K27 demethylase and its role in cancer development is context specific. The role of JMJD3 in gastric cancer (GC) has not been ex...

journal_title：Scientific reports

authors： Xu Z,Xia Y,Xiao Z,Jia Y,Li L,Jin Y,Zhao Q,Wan L,Yi T,Yu Y,Wen Q,Zhu Y,Qin B,Zhang F,Shen J

更新日期：2019-01-29 00:00:00

abstract：:The Gram-negative bacterium B. pertussis is the causative agent of whooping cough. This infection is re-emerging and new features related to Bordetella pathogenesis and microbiology could be relevant to defeat it. Therefore, we focused our attention on BP1253, a predicted exported protein from B. pertussis erroneously...

journal_title：Scientific reports

authors： Moramarco F,Pezzicoli A,Salvini L,Leuzzi R,Pansegrau W,Balducci E

更新日期：2019-11-19 00:00:00

abstract：:Viruses use a strategy of high mutational rates to adapt to environmental and therapeutic pressures, circumventing the deleterious effects of random single-point mutations by coevolved compensatory mutations, which restore protein fold, function or interactions damaged by initial ones. This mechanism has been identifi...

journal_title：Scientific reports

authors： Khwaja A,Galilee M,Marx A,Alian A

更新日期：2016-04-22 00:00:00

abstract：:Enhancement of endogenous neurogenesis after ischemic stroke may improve functional recovery. We previously demonstrated that medium B, which is a combination with epidermal growth factor (EGF) and fibronectin, can promote neural stem/progenitor cell (NSPC) proliferation and migration. Here, we showed that medium B pr...

journal_title：Scientific reports

authors： Chen YA,Tsai YC,Chen YD,Liu DZ,Young TH,Tsai LK

更新日期：2020-04-20 00:00:00

abstract：:Dating the start of intensive anthropogenic influence on ecosystems is important for identifying the conditions necessary for ecosystem recovery. However, few studies have focused on determining when anthropogenic influences on wetland began through sedimentary archives. To fill this critical gap in our knowledge, com...

journal_title：Scientific reports

authors： Cong J,Gao C,Zhang Y,Zhang S,He J,Wang G

更新日期：2016-02-24 00:00:00

abstract：:To appraise the content and pollution level of cadmium (Cd), arsenic (As), mercury (Hg), nickel (Ni) and lead (Pb) in bus stop dusts, representative samples (n = 53) were collected from the city of Qingyang in Gansu province, NW China. The Cd, As, Hg, Ni, and Pb contents and physicochemical properties (particle size, ...

journal_title：Scientific reports

authors： Wu Y,Lu X

更新日期：2018-08-22 00:00:00

abstract：:Transition metal oxides potentially present higher specific capacities than the current anodes based on carbon, providing an increasing energy density as compared to commercial Li-ion batteries. However, many parameters could influence the performance of the batteries, which depend on the processing of the electrode m...

journal_title：Scientific reports

authors： Prado FD,Andersen HF,Taeño M,Mæhlen JP,Ramírez-Castellanos J,Maestre D,Karazhanov S,Cremades A

更新日期：2020-03-26 00:00:00

abstract：:Quantum bits (qubits) are at the heart of quantum information processing schemes. Currently, solid-state qubits, and in particular the superconducting ones, seem to satisfy the requirements for being the building blocks of viable quantum computers, since they exhibit relatively long coherence times, extremely low diss...

journal_title：Scientific reports

authors： Ivić Z,Lazarides N,Tsironis GP

更新日期：2016-07-12 00:00:00

abstract：:From the viewpoint of thermodynamics, the formation of DNA loops and the interaction between them, which are all non-equilibrium processes, result in the change of free energy, affecting gene expression and further cell-to-cell variability as observed experimentally. However, how these processes dissipate free energy ...

journal_title：Scientific reports

authors： Huang L,Liu P,Yuan Z,Zhou T,Yu J

更新日期：2017-10-03 00:00:00

abstract：:GlgE, an enzyme of the pathway that converts trehalose to α-glucans, is essential for Mycobacterium tuberculosis. Inhibition of GlgE, which transfers maltose from a maltose-1-phosphate donor to α-glucan/maltooligosaccharide chain acceptor, leads to a toxic accumulation of maltose-1-phosphate that culminates in cellula...

journal_title：Scientific reports

authors： Mendes V,Blaszczyk M,Maranha A,Empadinhas N,Blundell TL

更新日期：2015-11-30 00:00:00

abstract：:Stem and progenitor cells of the submandibular salivary gland (SMG) give rise to, maintain, and regenerate the multiple lineages of mature epithelial cells including those belonging to the ductal, acinar, basal and myoepithelial subtypes. Here we have exploited single cell RNA-sequencing and in vivo genetic lineage tr...

journal_title：Scientific reports

authors： Song EC,Min S,Oyelakin A,Smalley K,Bard JE,Liao L,Xu J,Romano RA

更新日期：2018-09-19 00:00:00

abstract：:Next generation sequencing (NGS) data analysis is highly compute intensive. In-memory computing, vectorization, bulk data transfer, CPU frequency scaling are some of the hardware features in the modern computing architectures. To get the best execution time and utilize these hardware features, it is necessary to tune ...

journal_title：Scientific reports

authors： Kathiresan N,Temanni R,Almabrazi H,Syed N,Jithesh PV,Al-Ali R

更新日期：2017-08-22 00:00:00