Abstract：
:The influence of dose rate on radiation cataractogenesis has yet to be extensively studied. One recent epidemiological investigation suggested that protracted radiation exposure increases radiation-induced cataract risk: cumulative doses of radiation mostly <100 mGy received by US radiologic technologists over 5 years were associated with an increased excess hazard ratio for cataract development. However, there are few mechanistic studies to support and explain such observations. Low-dose radiation-induced DNA damage in the epithelial cells of the eye lens (LECs) has been proposed as a possible contributor to cataract formation and thus visual impairment. Here, 53BP1 foci was used as a marker of DNA damage. Unexpectedly, the number of 53BP1 foci that persisted in the mouse lens samples after γ-radiation exposure increased with decreasing dose-rate at 4 and 24 h. The C57BL/6 mice were exposed to 0.5, 1 and 2 Gy ƴ-radiation at 0.063 and 0.3 Gy/min and also 0.5 Gy at 0.014 Gy/min. This contrasts the data we obtained for peripheral blood lymphocytes collected from the same animal groups, which showed the expected reduction of residual 53BP1 foci with reducing dose-rate. These findings highlight the likely importance of dose-rate in low-dose cataract formation and, furthermore, represent the first evidence that LECs process radiation damage differently to blood lymphocytes.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Barnard SGR,McCarron R,Moquet J,Quinlan R,Ainsbury Edoi
10.1038/s41598-019-46893-3subject
Has Abstractpub_date
2019-07-18 00:00:00pages
10418issue
1issn
2045-2322pii
10.1038/s41598-019-46893-3journal_volume
9pub_type
杂志文章abstract：:Suffering from giant size of objective lenses and infeasible manipulations of distant targets, telescopes could not seek helps from present super-resolution imaging, such as scanning near-field optical microscopy, perfect lens and stimulated emission depletion microscopy. In this paper, local light diffraction shrinka...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18485
更新日期：2015-12-18 00:00:00
abstract：:Cell fate decisions are controlled by the interplay of transcription factors and epigenetic modifiers, which together determine cellular identity. Here we elaborate on the role of miR302 in the regulation of cell plasticity. Overexpression of miR302 effected silencing of the TGFβ type II receptor and facilitated plast...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42407
更新日期：2017-02-14 00:00:00
abstract：:Drought is one of the major impediments in wheat productivity. Traditional breeding and marker assisted QTL introgression had limited success. Available wheat genomic and RNA-seq data can decipher novel drought tolerance mechanisms with putative candidate gene and marker discovery. Drought is first sensed by root tiss...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49915-2
更新日期：2019-09-26 00:00:00
abstract：:Increasing the thermostability of proteins is often crucial for their successful use as analytic, synthetic or therapeutic tools. Most rational thermostabilization strategies were developed on small two-state proteins and, unsurprisingly, they tend to fail when applied to the much more abundant, larger, non-fully coop...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09129
更新日期：2015-03-16 00:00:00
abstract：:Genome-scale metabolic network models can be used for various analyses including the prediction of metabolic responses to changes in the environment. Legumes are well known for their rhizobial symbiosis that introduces nitrogen into the global nutrient cycle. Here, we describe a fully compartmentalised, mass and charg...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30884-x
更新日期：2018-08-21 00:00:00
abstract：:A long-standing debate regarding the configuration of Pangea during the Late Paleozoic has been going on among the paleomagnetic community concerning the validity of one of two significantly different Pangea reconstructions (Pangea A vs Pangea B) since the proposal of Pangea B. Although, Pangea B avoids any continenta...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25873-z
更新日期：2018-05-31 00:00:00
abstract：:Traditional strengthening ways, such as strain, precipitation, and solid-solution, come into effect by pinning the motion of dislocation. Here, through first-principles calculations we report on an extra-electron induced covalent strengthening mechanism, which alters chemical bonding upon the introduction of extra-val...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00718
更新日期：2012-01-01 00:00:00
abstract：:Pseudoalteromonas haloplanktis TAC125 is among the most commonly studied bacteria adapted to cold environments. Aside from its ecological relevance, P. haloplanktis has a potential use for biotechnological applications. Due to its importance, we decided to take advantage of next generation sequencing (Illumina) and th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52832-z
更新日期：2019-11-11 00:00:00
abstract：:Metal sulfide (MS, nickel sulfide/copper sulfide) hollow spheres with hierarchical, ultrathin shell structures have been constructed by a facile method. The as-formed MS hollow structures are shown to be uniform in sizes with hierarchical ultrathin shells, which could facilitate the transport of electrolyte ions. Elec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18504-6
更新日期：2018-01-08 00:00:00
abstract：:Scaling up atmospheric pressure glow discharge to large volume is desirable for low-temperature plasma applications. In this paper, an approach to generate a glow discharge in a planar shape with a fairly large volume is proposed in atmospheric pressure air through utilizing a direct-current excited rod array electrod...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03007-1
更新日期：2017-06-01 00:00:00
abstract：:Oxytocin has a conserved role in regulating animal social behaviour including parental-offspring interactions. Recently an oxytocin-like neuropeptide, nematocin, and its cognate receptors have been identified in the nematode Caenorhabditis elegans. We provide evidence for a pheromone signal produced by C. elegans larv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09350-7
更新日期：2017-08-31 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-44657-7
更新日期：2019-06-05 00:00:00
abstract：:We have previously reported that the sodium potassium adenosine triphosphatase (Na/K-ATPase) can effect the amplification of reactive oxygen species. In this study, we examined whether attenuation of oxidant stress by antagonism of Na/K-ATPase oxidant amplification might ameliorate experimental uremic cardiomyopathy i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34592
更新日期：2016-10-04 00:00:00
abstract：:This study compared effects of five hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) inhibitors on PC12 cells and primary rat neurons following oxygen-glucose deprivation (OGD). At 100 µM, the PHD inhibitors did not cause cytotoxicity and apoptosis. MTT activity was only significantly reduced by FG4592 or Baye...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58482-w
更新日期：2020-01-31 00:00:00
abstract：:Hearing loss resulting from hair cell degeneration is a common disease that affects millions of people worldwide. Strategies to overcome the apparent irreversible hair cell loss in mammals become paramount for hearing protection. Here we reported that, by using a well-established gentamicin-induced hair cell loss mode...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08181
更新日期：2015-02-02 00:00:00
abstract：:Loss of anorectal resting pressure due to internal anal sphincter (IAS) dysfunctionality causes uncontrolled fecal soiling and leads to passive fecal incontinence (FI). The study is focused on immediate and long-term safety and potential efficacy of bioengineered IAS BioSphincters to treat passive FI in a clinically r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54440-3
更新日期：2019-12-02 00:00:00
abstract：:It is common to find in the literature different values for the working voltage window (WVW) range for aqueous-based supercapacitors. In many cases, even with the best intentions of the widening the operating voltage window, the measured current using the cyclic voltammetry (CV) technique includes a significant contri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75851-7
更新日期：2020-11-05 00:00:00
abstract：:The highly polymorphic human leukocyte antigen (HLA) plays a crucial role in adaptive immunity and is associated with various complex diseases. Accurate analysis of HLA genes using ancient DNA (aDNA) data is crucial for understanding their role in human adaptation to pathogens. Here, we describe the TARGT pipeline for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64312-w
更新日期：2020-04-30 00:00:00
abstract：:In a large German community sample of adults, we investigated the association of chronic anxiousness with cardiovascular disease and mortality. Self-reported anxiousness from 11,643 German adults between 40 and 80 years of age from the Gutenberg Health Study (GHS) was analyzed over 5 years. Multivariable regression mo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69427-8
更新日期：2020-07-24 00:00:00
abstract：:Acrolein, a highly toxic α, β-unsaturated aldehyde, has been a longstanding key biomarker associated with a range of disorders related to oxidative stresses. One of the most promising methods for detecting acrolein involves the use of antibodies that can recognize the acrolein-lysine conjugate, 3-formyl-3, 4-dehydropi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35872
更新日期：2016-10-26 00:00:00
abstract：:The proinflammatory cytokine Interleukin 17A (hereafter named IL-17A) or IL-17A producing cells are elevated in breast tumors environment and correlate with poor prognosis. Increased IL-17A is associated with ER(-) or triple negative tumors and reduced Disease Free Survival. However, the pathophysiological role of IL-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03456
更新日期：2013-12-09 00:00:00
abstract：:Metabolic syndrome, including obesity and insulin resistance, has been reported to lower lung function in elderly subjects with asthma or chronic obstructive lung disease. This study aimed to find the association between lung function and insulin resistance in Korean young adults. This study used data from the Korean ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11337-3
更新日期：2017-09-15 00:00:00
abstract：:Aiming to promote low-cost production of protein-rich forage rice and resource recycling from wastewater treatment plants, a pot experiment was conducted to assess the possibility to substitute mineral fertilizers with composted sewage sludge (CSS) with/without top-dressing with treated municipal wastewater (TWW). Res...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67233-w
更新日期：2020-06-23 00:00:00
abstract：:The ability to accurately forecast seizures could significantly improve the quality of life of patients with drug-refractory epilepsy. Prediction capabilities rely on the adequate identification of seizure activity precursors from electroencephalography recordings. Although a long list of features has been proposed, n...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33969-9
更新日期：2018-10-19 00:00:00
abstract：:Local communities are assembled from larger-scale species pools via dispersal, environmental filtering, biotic interactions, and local stochastic demographic processes. The relative importance, scaling and interplay of these assembly processes can be elucidated by comparing local communities to variously circumscribed...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09337
更新日期：2015-03-23 00:00:00
abstract：:This paper aims to eliminate the disharmony between simulation and experiment, and takes the mechanical properties of 6082-T6 Al alloy as an example. In order to obtain the equivalent distribution of material properties after considering the randomicity of materials, a new inversion method combining with stochastic fi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54046-9
更新日期：2019-11-28 00:00:00
abstract：:RNA virus-based episomal vector (REVec) is an emerging viral vector system that mediates long-term stable gene expression in variety of cell types in vitro. However, little is known about its tissue tropism and persistence of gene expression in vivo. Here, to evaluate the feasibility of REVec for in vivo gene delivery...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62630-7
更新日期：2020-04-03 00:00:00
abstract：:Immunotherapeutic strategies for glioblastoma, the most frequent malignant primary brain tumor, aim to improve its disastrous consequences. On top of the standard treatment, one strategy uses T cell activation by autologous dendritic cells (DC) ex vivo loaded with tumor lysate to attack remaining cancer cells. Wonderi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12584-0
更新日期：2017-10-24 00:00:00
abstract：:In theory, a few naturally occurring evolutionary changes in the genome of a model organism may have little or no observable impact on its wild type phenotype, and yet still substantially impact the phenotypes of mutant strains through epistasis. To see if this is happening in a model organism, we obtained nine differ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38001
更新日期：2016-12-01 00:00:00
abstract：:Precision medicine is continuously demanding for novel point of care systems, potentially exploitable also for in-vivo analysis. Biosensing probes based on Lab-On-Fiber Technology have been recently developed to meet these challenges. However, devices exploiting standard label-free approaches (based on ligand/target m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14852-5
更新日期：2017-10-31 00:00:00
