Abstract：
:Viruses use a strategy of high mutational rates to adapt to environmental and therapeutic pressures, circumventing the deleterious effects of random single-point mutations by coevolved compensatory mutations, which restore protein fold, function or interactions damaged by initial ones. This mechanism has been identified as contributing to drug resistance in the HIV-1 Gag polyprotein and especially its capsid proteolytic product, which forms the viral capsid core and plays multifaceted roles in the viral life cycle. Here, we determined the X-ray crystal structure of C-terminal domain of the feline immunodeficiency virus (FIV) capsid and through interspecies analysis elucidate the structural basis of co-evolutionarily and spatially correlated substitutions in capsid sequences, which when otherwise uncoupled and individually substituted into HIV-1 capsid impair virion assembly and infectivity. The ability to circumvent the deleterious effects of single amino acid substitutions by cooperative secondary substitutions allows mutational flexibility that may afford viruses an important survival advantage. The potential of such interspecies structural analysis for preempting viral resistance by identifying such alternative but functionally equivalent patterns is discussed.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Khwaja A,Galilee M,Marx A,Alian Adoi
10.1038/srep24957subject
Has Abstractpub_date
2016-04-22 00:00:00pages
24957issn
2045-2322pii
srep24957journal_volume
6pub_type
杂志文章abstract：:We have engineered the electronic structure at the interface between Cu2O and ZnO nanorods (NRs) array, through adjusting the carrier concentration of Cu2O. The electrodeposition of Cu2O at pH 11 acquired the highest carrier concentration, resulting in the largest interfacial electric field between Cu2O and ZnO, which...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07882
更新日期：2015-01-20 00:00:00
abstract：:Most Group I Clostridium botulinum strains harbor botulinum neurotoxin (bont) genes on their chromosome, while some carry these genes (including bont/a, bont/b, and bont/f) on large plasmids. Prior work in our laboratory demonstrated that Group I BoNT plasmids were mobilized to C. botulinum recipient strains containin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21342-9
更新日期：2018-02-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54360-2
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01622
更新日期：2013-01-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43508
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79960-1
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17623-4
更新日期：2017-12-12 00:00:00
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pub_type： 杂志文章
doi：10.1038/s41598-017-00990-3
更新日期：2017-04-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04014-y
更新日期：2017-06-23 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47495-9
更新日期：2019-07-30 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31765-z
更新日期：2018-09-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51657-0
更新日期：2019-10-28 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56301-5
更新日期：2019-12-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31564
更新日期：2016-08-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70614-w
更新日期：2020-08-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09342-7
更新日期：2017-08-21 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-82420-z
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45756-1
更新日期：2019-07-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64667-0
更新日期：2020-05-06 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41615
更新日期：2017-01-30 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07596-9
更新日期：2017-08-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05368
更新日期：2014-06-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56319-9
更新日期：2019-12-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17110
更新日期：2015-11-25 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06566-5
更新日期：2017-07-24 00:00:00
