Abstract:
:Enhancement of endogenous neurogenesis after ischemic stroke may improve functional recovery. We previously demonstrated that medium B, which is a combination with epidermal growth factor (EGF) and fibronectin, can promote neural stem/progenitor cell (NSPC) proliferation and migration. Here, we showed that medium B promoted proliferation and migration of cultured NSPCs onto various 3-dimentional structures. When rat cortical neurons with oxygen glucose deprivation (OGD) were co-cultured with NSPCs, medium B treatment increased neuronal viability and reduced cell apoptosis. In a rat model with transient middle cerebral artery occlusion (MCAO), post-insult intraventricular medium B treatment enhanced proliferation, migration, and neuronal differentiation of NSPCs and diminished cell apoptosis in the infarct brain. In cultured post-OGD neuronal cells and the infarct brain from MCAO rats, medium B treatment increased protein levels of Bcl-xL, Bcl-2, phospho-Akt, phospho-GSK-3β, and β-catenin and decreased the cleaved caspase-3 level, which may be associated with the effects of anti-apoptosis. Notably, intraventricular medium B treatment increased neuronal density, improved motor function and reduced infarct size in MCAO rats. In summary, medium B treatment results in less neuronal death and better functional outcome in both cellular and rodent models of ischemic stroke, probably via promotion of neurogenesis and reduction of apoptosis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Chen YA,Tsai YC,Chen YD,Liu DZ,Young TH,Tsai LKdoi
10.1038/s41598-020-63598-0subject
Has Abstractpub_date
2020-04-20 00:00:00pages
6596issue
1issn
2045-2322pii
10.1038/s41598-020-63598-0journal_volume
10pub_type
杂志文章abstract::Galvanic vestibular stimulation (GVS) can be applied to induce the feeling of directional virtual head motion by stimulating the vestibular organs electrically. Conventional studies used a two-pole GVS, in which electrodes are placed behind each ear, or a three-pole GVS, in which an additional electrode is placed on t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10168
更新日期:2015-05-11 00:00:00
abstract::Successful establishment of invasive species is often related to the existence of vacant niches. Competition occurs when invaders use the same limiting resources as members of the recipient community, which will be reflected in some overlap of their trophic niches. The concept of isotopic niche has been used to study ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09715
更新日期:2015-05-19 00:00:00
abstract::SLC7A10 (Asc-1) is a sodium-independent amino acid transporter known to facilitate transport of a number of amino acids including glycine, L-serine, L-alanine, and L-cysteine, as well as their D-enantiomers. It has been described as a neuronal transporter with a primary role related to modulation of excitatory glutama...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35592
更新日期:2016-10-19 00:00:00
abstract::The increase in antibiotic resistant bacteria has raised global concern regarding the future effectiveness of antibiotics. Human activities that influence microbial communities and environmental resistomes can generate additional risks to human health. In this work, we characterized aquatic microbial communities and t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48200-6
更新日期:2019-08-13 00:00:00
abstract::Psychiatric disorders have been widely reported to be associated with systemic inflammation upregulation and adiposity. However, there are no data that link adipose tissue inflammation to these mental disorders. The analysis of adipokines and inflammation-related markers in adipose tissue could help to elucidate the p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35759-9
更新日期:2018-11-30 00:00:00
abstract::Rotaviruses (RVs) are the most common cause of severe diarrheal disease. To date two rotavirus oral vaccines are licensed: Rotarix and Rotateq. Our aim was to contribute to the post-marketing evaluation of these vaccines safety profile. We collected all RV vaccines-related reports of Adverse Events Following Immunizat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70653-3
更新日期:2020-08-12 00:00:00
abstract::Past evidence of an early Processing Negativity in auditory Go/NoGo event-related potential (ERP) data suggests that young adults proactively process sensory information in two-choice tasks. This study aimed to clarify the occurrence of Go/NoGo Processing Negativity and investigate the ERP component series related to ...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-020-61060-9
更新日期:2020-03-04 00:00:00
abstract::Gallic acid is a trihydroxybenzoic acid found in tea leaves and some plants. Here, we report the effect of gallic acid on cardiac dysfunction and fibrosis in a mouse model of pressure overload-induced heart failure and in primary rat cardiac fibroblasts, and compare the effects of gallic acid with those of drugs used ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27599-4
更新日期:2018-06-18 00:00:00
abstract::This study aimed to explore the risk of dementia in a middle- and older-aged population with severe or profound hearing impairments. Data were collected for the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013. Participants aged 40 or older were selected. The 4,432 severely hearing-imp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33325-x
更新日期:2018-10-15 00:00:00
abstract::There is a demand for ultra low-loss metal films with high-quality single crystals and perfect surface for nanophotonics and quantum information processing. Many researches are devoted to alternative materials, but silver is by far theoretically the most preferred low-loss material at optical and near-IR frequencies. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48508-3
更新日期:2019-08-22 00:00:00
abstract::Freshwater mussels are ecosystem engineers and keystone species in aquatic environments. Unfortunately, due to dramatic declines this fauna is among the most threatened globally. Here, we clarify the taxonomy and biogeography of Russian Unionidae species based on the most comprehensive multi-locus dataset sampled to d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59867-7
更新日期:2020-02-20 00:00:00
abstract::The aim of the present study was to compare the clinical, radiological and histomorphometrical outcome of simultaneous implant placement following augmentation of atrophic maxillary sinuses using allograft (block or particles). Consecutive patients with maxillary residual alveolar ridge height ≤3 mm, scheduled for sin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65874-5
更新日期:2020-06-03 00:00:00
abstract::The temperate bamboos (tribe Arundinarieae, Poaceae) are strongly supported as monophyly in recent molecular studies, but taxonomic delineation and phylogenetic relationships within the tribe lack resolution. Here, we sampled 39 species (36 temperate bamboos and 3 outgroups) for restriction-site associated DNA sequenc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11367-x
更新日期:2017-09-14 00:00:00
abstract::Ultrasound imaging is affected by coherent noise or speckle, which reduces contrast and overall image quality and degrades the diagnostic precision of the collected images. Elevational angular compounding (EAC) is an attractive means of addressing this limitation, since it reduces speckle noise while operating in real...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75092-8
更新日期:2020-10-23 00:00:00
abstract::Endothelial cells respond to changes in subendothelial stiffness by altering their migration and mechanics, but whether those responses are due to transcriptional reprogramming remains largely unknown. We measured traction force generation and also performed gene expression profiling for two endothelial cell types gro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54336-2
更新日期:2019-12-03 00:00:00
abstract::Functional imaging has become an important tool in oncology because it not only provides information about the size and localization of the tumour, but also about the pathophysiological features of the tumoural cells. One of the characteristic features of some tumour types is that their fast growth leads to deficient ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43618-4
更新日期:2019-05-08 00:00:00
abstract::Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in hum...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08267-5
更新日期:2017-08-15 00:00:00
abstract::A number of studies have shown that visible and near infrared spectroscopy (VIS-NIRS) offers a rapid on-site measurement tool for the determination of total contaminant concentration of petroleum hydrocarbons compounds (PHC), heavy metals and metalloids (HM) in soil. However none of them have yet assessed the feasibil...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41161-w
更新日期:2019-03-14 00:00:00
abstract::To investigate the influence of various factors on the two outcome parameters "procedure - specific complication" (femoral head necrosis, infection, nonunion, femoral neck shortening, screw loosening, implant penetration) and "functional outcome" in patients with displaced and undisplaced femoral neck fracture treated...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57696-2
更新日期:2020-01-20 00:00:00
abstract::Epidemiology of acute kidney injury (AKI) in developing countries is under-studied. We evaluated the risk and prognosis of AKI in patients admitted to intensive care units (ICUs) in Egypt. We recruited consecutive adults admitted to ICUs in Alexandria Teaching Hospitals over six months. We used the KDIGO criteria for ...
journal_title:Scientific reports
pub_type: 杂志文章,多中心研究
doi:10.1038/s41598-017-17264-7
更新日期:2017-12-07 00:00:00
abstract::Results from epidemiological and prospective studies indicate a close association between periodontitis and diabetes. However the mechanisms by which periodontal pathogens influence the development of prediabetes/diabetes are not clear. We previously reported that oral administration of a periodontal pathogen, Porphyr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65828-x
更新日期:2020-06-19 00:00:00
abstract::It is rigorously proved that ideal memcapacitors and meminductors are not passive or cyclo-passive devices. Equivalently, this implies that there exist excitation profiles that allow to extract more energy from the device than it is supplied with; so that their energy conversion efficiency exceeds 100%. This means tha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73833-3
更新日期:2020-10-07 00:00:00
abstract::Lightweight, simple and flexible self-powered photodetectors are urgently required for the development and application of advanced optical systems for the future of wearable electronic technology. Here, using a low-temperature reduction process, we report a chemical approach for producing freestanding monolithic reduc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33525
更新日期:2016-09-16 00:00:00
abstract::Perpendicular magnetization and precise control over the magnetic easy axis in magnetic thin film is necessary for a variety of applications, particularly in magnetic recording media. A strong (111) orientation is successfully achieved in the CoFe2O4 (CFO) thin film at relatively low substrate temperature of 100 °C, w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30074
更新日期:2016-07-20 00:00:00
abstract::The transparency of animals is an important biological feature. Ascidian eggs have various degrees of transparency, but this characteristic has not yet been measured quantitatively and comprehensively. In this study, we established a method for evaluating the transparency of eggs to first characterize the transparency...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77585-y
更新日期:2020-11-30 00:00:00
abstract::Plants exude a diverse cocktail of metabolites into the soil as response to exogenous and endogenous factors. So far, root exudates have mainly been studied under artificial conditions due to methodological difficulties. In this study, each five perennial grass and forb species were investigated for polar and semi-pol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54309-5
更新日期:2020-07-01 00:00:00
abstract::Bi-phasic or diauxic growth is often observed when microbes are grown in a chemically defined medium containing two sugars (for example glucose and lactose). Typically, the two growth stages are separated by an often lengthy phase of arrested growth, the so-called lag-phase. Diauxic growth is usually interpreted as an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25191
更新日期:2016-04-29 00:00:00
abstract::Glioblastoma (GBM) is one of the deadliest human cancers. Because of the extremely unfavorable prognosis of GBM, it is important to develop more effective diagnostic and therapeutic strategies based on biologically and clinically relevant subclassification systems. Analyzing a collection of seventeen patient-derived g...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/srep21557
更新日期:2016-02-09 00:00:00
abstract::Cytochrome P450 (CYP) 3A accounts for nearly 30% of the total CYP enzymes in the human liver and participates in the metabolism of over 50% of clinical drugs. Moreover, CYP3A plays an important role in chemical metabolism, toxicity, and carcinogenicity. New animal models are needed to investigate CYP3A functions, espe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42922
更新日期:2017-02-20 00:00:00
abstract::In the modern era, diathermic oils have been gotten the great attention from researchers due to its notable and momentous applications in engineering, mechanics and in the industrial field. The aim of this paper is to model the problem to augment the heat transfer rate of diathermic oils, specifically, Engine-oil (EO)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33547-z
更新日期:2018-10-16 00:00:00