Abstract：
:Local mRNA translation occurs in growing axons enabling precise control of the proteome in response to signals. To measure quantitatively the spatiotemporal dynamics of protein synthesis in growth cones, we further developed a technique for single molecule translation imaging (SMTI). We report that Netrin-1 triggers a burst of β-actin synthesis at multiple non-repetitive sites, particularly in the periphery. The response is remarkably rapid starting within 20 seconds of cue application.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ströhl F,Lin JQ,Laine RF,Wong HH,Urbančič V,Cagnetta R,Holt CE,Kaminski CFdoi
10.1038/s41598-017-00695-7subject
Has Abstractpub_date
2017-04-06 00:00:00pages
709issue
1issn
2045-2322pii
10.1038/s41598-017-00695-7journal_volume
7pub_type
杂志文章abstract：:Tropical Pacific stalagmites are commonly affected by dating uncertainties because of their low U concentration and/or elevated initial 230Th content. This poses problems in establishing reliable trends and periodicities for droughts and pluvial episodes in a region vulnerable to climate change. Here we constrain the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81941-x
更新日期：2021-01-26 00:00:00
abstract：:Chinese sturgeon (Acipenser sinensis) has been listed as a critically endangered species on the IUCN Red List and is an endemic fish of China. Five sets of duplex polymerase chain reactions (PCR) assays were developed with 10 tetranucleotide microsatellites for Chinese sturgeon. The size of CS57, ZHX43, ZHX69, AS105, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60401-y
更新日期：2020-02-26 00:00:00
abstract：:We investigated the association between impulsivity related traits and BMI at the observational and genetic epidemiology level in a cross-sectional population of healthy young American-European adults. We studied 998 students and university staff of European ancestry recruited from Chicago (Illinois) and Athens (Georg...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53922-8
更新日期：2019-11-26 00:00:00
abstract：:The pristine lignin molecules contain multiple reactive hydroxyl [OH] groups, some of which undergo limited polymerization depending on their configuration (aromatic or aliphatic) or conformation. The key issue in lignin-polymerization is to quantify the number of hydroxyl groups in the pristine molecules for subseque...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43296-2
更新日期：2019-05-07 00:00:00
abstract：:Phaeocystis globosa, one of the most typical red tide-forming species, is usually mixed in the food composition of rotifers. To explore how rotifers respond by adjusting life history strategy when feeding on different quality foods, we exposed the rotifer Brachionus plicatilis to cultures with 100% Chlorella, a mixtur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15863-y
更新日期：2017-11-13 00:00:00
abstract：:Agricultural land is typically managed based on visible plant life at the expense of the belowground majority. However, microorganisms mediate processes sustaining plant life and the soil environment. To understand the role of microbes we first must understand what controls soil microbial community assembly. We assess...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45369
更新日期：2017-03-28 00:00:00
abstract：:Stem and progenitor cells are the critical units for tissue maintenance, regeneration, and repair. The activation of regenerative events in response to tissue injury has been correlated with mobilization of tissue-resident progenitor cells, which is functional to the wound healing process. However, until now there has...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16574
更新日期：2015-11-12 00:00:00
abstract：:Coffee contains caffeine and diterpenes that were associated with decreased breast cancer risk, but results remained inconsistent. The study purpose was to investigate the associations between coffee products and breast cancer risk among Hong Kong Chinese women. We conducted a hospital-based case-control study in thre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49205-x
更新日期：2019-09-03 00:00:00
abstract：:Broadband acoustic absorbers with thin thickness are highly desired in practical situations such as architectural acoustics, yet it is still challenging to achieve high absorption by using structure with limited thickness. Here we report the theoretical optimal design, numerical simulation and experimental demonstrati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67688-x
更新日期：2020-07-01 00:00:00
abstract：:Niemann-Pick type C1 (NPC1) disease is a rare autosomal recessive, neurodegenerative lysosomal storage disorder, which presents with a range of clinical phenotypes and hence diagnosis remains a challenge. In view of these difficulties, the search for a novel, NPC1-specific biomarker (or set of biomarkers) is a topic o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06264-2
更新日期：2017-07-24 00:00:00
abstract：:Sustainable canola production is essential to meet growing human demands for vegetable oil, biodiesel, and meal for stock feed markets. Blackleg, caused by the fungal pathogen, Leptosphaeria maculans is a devastating disease that can lead to significant yield loss in many canola production regions worldwide. Breakdown...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61211-y
更新日期：2020-03-10 00:00:00
abstract：:This study investigates the effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on persistent post-concussion syndrome (PCS). The study design was a randomized (coin toss), placebo controlled, and double-blind study. Thirty-seven participants with PCS were assessed for eligibility; 22 were randomised and 18 ...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-019-41923-6
更新日期：2019-04-02 00:00:00
abstract：:Cuprizone-induced demyelination in mice is a frequently used model in preclinical multiple sclerosis research. A recent quantitative clinically-targeted MRI method, fast macromolecular proton fraction (MPF) mapping demonstrated a promise as a myelin biomarker in human and animal studies with a particular advantage of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46686
更新日期：2017-04-24 00:00:00
abstract：:Insulin resistance is a major risk factor for metabolic diseases such as Type 2 diabetes. Although the underlying mechanisms of insulin resistance remain elusive, oxidative stress is a unifying driver by which numerous extrinsic signals and cellular stresses trigger insulin resistance. Consequently, we sought to under...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20104-x
更新日期：2018-01-29 00:00:00
abstract：:In unpredictable environments in which reliable cues for predicting environmental variation are lacking, a diversifying bet-hedging strategy for diapause exit is expected to evolve, whereby only a portion of diapausing forms will resume development at the first occurrence of suitable conditions. This study focused on ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77727-2
更新日期：2020-12-07 00:00:00
abstract：:Understanding how a pathogen can grow on different substrates and how this growth impacts its dispersal are critical to understanding the risks and control of emerging infectious diseases. Pseudogymnoascus destructans (Pd) causes white-nose syndrome (WNS) in many bat species and can persist in, and transmit from, the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80707-1
更新日期：2021-01-12 00:00:00
abstract：:A generalization of the Raman scattering (RS) spectrum, the Raman excitation map (REM) is a hyperspectral two-dimensional (2D) data set encoding vibrational spectra, electronic spectra and their coupling. Despite the great potential of REM for optical sensing and characterization with remarkable sensitivity and select...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65757-9
更新日期：2020-06-08 00:00:00
abstract：:Chronic venous disease (CVD) is a multifactorial condition representing one of the most common disorders among populations of Western countries. The heritability of about 17% suggests genetic risk factors in CVD etiology. However, so far the genetic causes are unknown. We undertook the hitherto first genome-wide assoc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45652
更新日期：2017-04-04 00:00:00
abstract：:The establishment of the infant gut microbiota is a highly dynamic process dependent on extrinsic and intrinsic factors. We characterized the faecal microbiota of 4 breastfed infants and 4 formula-fed infants at 17 consecutive time points during the first 12 weeks of life. Microbiota composition was analysed by a comb...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08268-4
更新日期：2017-08-21 00:00:00
abstract：:Understanding virulence is vital for the development of novel therapeutics to target infections with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), which cause an ongoing epidemic in the United States and are on a global rise. However, what defines virulence particularly of global CA-MRSA ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27899
更新日期：2016-06-14 00:00:00
abstract：:Generally confinement size is considered to determine the dimensionality of nanostructures. While the exciton Bohr radius is used as a criterion to define either weak or strong confinement in optical experiments, the binding energy of confined excitons is difficult to measure experimentally. One alternative is to use ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40026
更新日期：2017-01-05 00:00:00
abstract：:Protective antigen (PA) of Bacillus anthracis is being considered as a vaccine candidate against anthrax and its production has been explored in several heterologous host systems. Since the systems tested introduced adverse issues such as inclusion body formation and endotoxin contamination, the production from B. ant...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-10-31 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03307
更新日期：2013-11-22 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-40320-3
更新日期：2019-03-12 00:00:00
abstract：:Cancer immunotherapy, including immune checkpoint inhibitors, exerts beneficial effects in cancer patients. However, immune checkpoint inhibitors are only advantageous for a limited population of cancer patients. Therefore, companion diagnostics are needed in order to identify patients for whom these therapies are eff...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39345-5
更新日期：2019-02-22 00:00:00
abstract：:Understanding the complex architecture, connectivity, and pathology of the human brain is a major application of magnetic resonance imaging (MRI). However, the cellular basis of MR signal is still poorly understood. The advent of MR microscopy (MRM) enables imaging biological samples at cellular resolution, helping to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08920
更新日期：2015-03-10 00:00:00
abstract：:This work focuses on the optimization of heterogeneous Fenton-like removal of organic pollutant (dye) from water using newly developed fibrous catalysts based on a full factorial experimental design. This study aims to approximate the feasibility of heterogeneous Fenton-like removal process and optionally make predict...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72401-z
更新日期：2020-09-30 00:00:00
abstract：:Radiotherapy (RT) is one of the most frequently used methods for cancer treatment. Despite remarkable advancements in RT techniquesthe treatment of radioresistant tumours (i.e. high-grade gliomas) is not yet satisfactory. Finding novel approaches less damaging for normal tissues is of utmost importance. This would mak...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70371-w
更新日期：2020-08-11 00:00:00
abstract：:The aim of this study was to investigate left ventricular (LV) global myocardial strain and LV involvement characteristics in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) and to evaluate their predictive value of adverse cardiac events. Sixty consecutive ARVD/C patients with a defin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50535-z
更新日期：2019-10-02 00:00:00
abstract：:Ischemic neural damages cause several devastating diseases, including brain stroke and ischemic retinopathies, and endoplasmic reticulum (ER) stress has been proposed to be the underlying mechanism of the neuronal cell death of these conditions. We previously synthesized Kyoto University substances (KUSs) as modulator...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44873
更新日期：2017-03-20 00:00:00
