Abstract:
:Coffee contains caffeine and diterpenes that were associated with decreased breast cancer risk, but results remained inconsistent. The study purpose was to investigate the associations between coffee products and breast cancer risk among Hong Kong Chinese women. We conducted a hospital-based case-control study in three public hospitals. 2169 Chinese women aged 24-84 years old were interviewed using a standardized questionnaire with questions asking types, cups and duration on coffee drinking. We used unconditional multivariate logistic regression to calculate the adjusted odds ratio (AOR) and 95% confidence interval (95% CI) for breast cancer risk with different coffee products. 238 (20.6%) cases and 179 (17.7%) controls are habitual coffee drinkers. No association was found between overall coffee drinking and breast cancer risk. Compared to the non-habitual coffee drinkers, women who consumed instant coffee (AOR = 1.50, 95% CI = 1.10-2.03) were significantly associated with an increased breast cancer risk. Women who drank brewed coffee (AOR = 0.48, 95% CI = 0.28-0.82) were negatively associated with breast cancer risk. A positive association between instant coffee and breast cancer risk was observed, contradicted to the outcomes of drinking brewed coffee. Larger studies are warranted to ascertain the role of different types of coffee products in breast cancer risk.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lee PMY,Chan WC,Kwok CC,Wu C,Law SH,Tsang KH,Yu WC,Yeung YC,Chang LDJ,Wong CKM,Wang F,Tse LAdoi
10.1038/s41598-019-49205-xsubject
Has Abstractpub_date
2019-09-03 00:00:00pages
12684issue
1issn
2045-2322pii
10.1038/s41598-019-49205-xjournal_volume
9pub_type
杂志文章abstract::Non-syndromic cleft lip and/or palate (NSCLP) is a common congenital malformation with a multifactorial model of inheritance. Although several at-risk alleles have been identified, they do not completely explain the high heritability. We postulate that epigenetic factors as DNA methylation might contribute to this mis...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02721-0
更新日期:2017-05-26 00:00:00
abstract::The development of bulk, three-dimensional (3D), macroporous polymers with high permeability, large surface area and large volume is highly desirable for a range of applications in the biomedical, biotechnological and environmental areas. The experimental techniques currently used are limited to the production of smal...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21154
更新日期:2016-02-17 00:00:00
abstract::Body mass index (BMI) is associated with increased future risk of inflammatory bowel disease(IBD) particularly Crohn's disease(CD), where associations with high and low BMI have been observed. Most studies are based on adult women. We aimed to explore the impact of BMI in men entering adult life on their long-term ris...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42642-8
更新日期:2019-04-23 00:00:00
abstract::Mammals and birds can process ordinal numerical information which can be used, for instance, for recognising an object on the basis of its position in a sequence of similar objects. Recent studies have shown that teleost fish possess numerical abilities comparable to those of other vertebrates, but it is unknown if th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15497
更新日期:2015-10-26 00:00:00
abstract::A particular type of miniature ceramic vessel locally known as "veneneras" is occasionally found during archaeological excavations in the Maya Area. To date, only one study of a collection of such containers successfully identified organic residues through coupled chromatography-mass spectrometry methods. That study i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81158-y
更新日期:2021-01-15 00:00:00
abstract::We recently showed that spinal cord injury (SCI) leads to a decrease in mRNA editing of serotonin receptor 2C (5-HT2CR) contributing to post-SCI spasticity. Here we study post-SCI mRNA editing and global gene expression using massively parallel sequencing. Evidence is presented that the decrease in 5-HT2CR editing is ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12615
更新日期:2015-07-30 00:00:00
abstract::Habitat filtering models predict ecologically similar plant species to jointly colonize sites due to comparable environmental characteristics leading to an aggregated pattern of species spatial occurrence. Models focused on interspecific competition expect species with similar ecological requirements to be spatially s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00255-z
更新日期:2017-03-21 00:00:00
abstract::Mitochondria-targeted antioxidants are known to alleviate mitochondrial oxidative damage that is associated with a variety of diseases. Here, we showed that SkQ1, a decyltriphenyl phosphonium cation conjugated to a quinone moiety, exhibited strong antibacterial activity towards Gram-positive Bacillus subtilis, Mycobac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00802-8
更新日期:2017-05-03 00:00:00
abstract::The relationship between alcohol consumption and mortality generally exhibits a U-shaped curve. The longevity observed with moderate alcohol consumption may be explained by other confounding factors, and, if such a relationship is present, the mechanism is not well understood. Indeed, the optimal amount of alcohol con...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38904-0
更新日期:2019-02-05 00:00:00
abstract::Ovarian tissue cryopreservation is considered as a useful option to preserve fertility for cancer patients. This study purposed to evaluate the change of telomere length and senescence markers during human ovarian tissue cryopreservation. Ovarian tissues were obtained from women who underwent benign ovarian surgery in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81973-3
更新日期:2021-01-26 00:00:00
abstract::The micro-capillary condensation of a new high boiling point organic reagent (HBPO), is studied in a periodic mesoporous oxide (PMO) with ∼34 % porosity and k-value ∼2.3. At a partial pressure of 3 mT, the onset of micro-capillary condensation occurs around +20 °C and the low-k matrix is filled at -20 °C. The condense...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20099-5
更新日期:2018-01-30 00:00:00
abstract::Recently, some very tight constraints of annihilating dark matter have been obtained from gamma-ray data of the Milky Way and Milky Way dwarf spheroidal satellite galaxies. In this article, we report that there are two excellent galaxy clusters (A2877 and Fornax) which can provide interesting constraints for annihilat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14950-4
更新日期:2017-11-02 00:00:00
abstract::DNA double-strand break (DSB) repair is crucial to maintain genomic stability. The fidelity of the repair depends on the complexity of the lesion, with clustered DSBs being more difficult to repair than isolated breaks. Using live cell imaging of heavy ion tracks produced at a high-energy particle accelerator we visua...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58084-6
更新日期:2020-01-29 00:00:00
abstract::The secreted frizzled-related protein 5 gene (SFRP5) that antagonize the Wnt/β-catenin signaling is frequently inactivated by promoter methylation and oncogenic activation of the Wnt signaling pathway is common in many cancers. The curcumin-rich Curcuma longa has been reported to potent anti-cancer property involved i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53509-3
更新日期:2019-11-21 00:00:00
abstract::We quantitatively evaluated breast tumor movement and volume changes between magnetic resonance imaging (MRI) scans in prone and supine positions. Twenty-seven breast tumor patients who received neoadjuvant systemic therapy (NST) for breast-conserving surgery were studied. Before and after NST, MRI scans in prone and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61802-9
更新日期:2020-03-17 00:00:00
abstract::The cation diffusion facilitator (CDF) is a conserved family of divalent d-block metal cation transporters that extrude these cations selectively from the cytoplasm. CDF proteins are composed of two domains: the transmembrane domain, through which the cations are transported, and a regulatory cytoplasmic C-terminal do...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71036-4
更新日期:2020-08-20 00:00:00
abstract::The brown alga Fucus vesiculosus is a keystone marine species, which is subject to heavy surface colonisation. This study was designed to analyse the surface epibiome of F. vesiculosus in conjunction with the composition and spatial distribution of its surface metabolome. The amplicon sequencing, SEM and CARD-FISH ima...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37914-8
更新日期:2019-01-31 00:00:00
abstract::There is emerging evidence that microRNAs (miRNAs) dysregulation is involved in the genesis and the progression of Prostate Cancer (PCa), thus potentially increasing their use in urological clinical practice. This is the first pilot study which utilizes Illumina Deep Sequencing to examine the entire miRNAs spectrum ex...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24236-y
更新日期:2018-05-08 00:00:00
abstract::Today's electronic devices are fabricated using highly toxic materials and processes which limits their applications in environmental sensing applications and mandates complex encapsulation methods in biological and medical applications. This paper proposes a fully resorbable high density bio-compatible and environmen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15395-5
更新日期:2017-11-07 00:00:00
abstract::This study was to evaluate the prognostic value of pretreatment inflammatory indexes including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII) in colorectal cancer (CRC) patients receiving neoadjuvant chemoradiot...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21093-7
更新日期:2018-02-14 00:00:00
abstract::We constructed Antarctic ice velocity maps from Landsat 8 images for the years 2014 and 2015 at a high spatial resolution (100 m). These maps were assembled from 10,690 scenes of displacement vectors inferred from more than 10,000 optical images acquired from December 2013 through March 2016. We estimated the mass dis...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22765-0
更新日期:2018-03-14 00:00:00
abstract::Childhood and adolescent overweight and obesity are increasing in China, but limited information is available on its secular trends in Guangzhou. In this cross-sectional study, ten-wave successive data were obtained from the physical fitness surveillance for students in Guangzhou from 2003 to 2012. A total of 2,619,15...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-017-12094-z
更新日期:2017-09-21 00:00:00
abstract::Application of acute kidney injury (AKI) biomarkers with consideration of nonrenal conditions and systemic severity has not been sufficiently determined. Herein, urinary neutrophil gelatinase-associated lipocalin (NGAL), L-type fatty acid-binding protein (L-FABP) and nonrenal disorders, including inflammation, hypoper...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33077
更新日期:2016-09-08 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-58755-4
更新日期:2020-01-30 00:00:00
abstract::Leaf functional traits have attracted the attention of ecologists for several decades, but few studies have systematically assessed leaf morphological traits (termed "economic traits"), stomatal (termed "hydraulic"), and anatomical traits of entire forest communities, thus it is unclear whether their relationships are...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42335-2
更新日期:2019-04-09 00:00:00
abstract::PP2A is a master controller of multiple inflammatory signaling pathways. It is a target in asthma; however the molecular mechanisms by which PP2A controls inflammation warrant further investigation. In A549 lung epithelial cells in vitro we show that inhibition of basal PP2A activity by okadaic acid (OA) releases rest...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10063
更新日期:2015-05-18 00:00:00
abstract::Low phase noise mode-locked fiber laser finds important applications in telecommunication, ultrafast sciences, material science, and biology, etc. In this paper, two types of carbon nano-materials, i.e. single-wall carbon nanotube (SWNT) and graphene oxide (GO), are investigated as efficient saturable absorbers (SAs) ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25266
更新日期:2016-04-29 00:00:00
abstract::Previously, we reported that the hyperthermophilic archaeon Thermococcus onnurineus NA1 could grow on formate and produce H2. Formate conversion to hydrogen was mediated by a formate-hydrogen lyase complex and was indeed a part of chemiosmotic coupling to ATP generation. In this study, we employed an adaptation approa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05424-8
更新日期:2017-07-21 00:00:00
abstract::Medicinal plants are considered as one of the ideal sources for cancer therapy due to their bioactive contents and low toxicity to humans. Vernonia genus is one of the common medicinal plants, which has wide spread usage in food and medicine. However, there are limited studies to explore its anticancer properties. In ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23255
更新日期:2016-03-24 00:00:00
abstract::Sickle cell anaemia (SCA) is characterized by reduced red blood cell (RBC) deformability and nitric oxide (NO) bioavailability. The aim of the study was to investigate whether exercise might affect these parameters in SCA. SCA patients and healthy controls (AA) performed an acute submaximal exercise test until subject...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48364-1
更新日期:2019-08-14 00:00:00