Abstract：
:There is emerging evidence that microRNAs (miRNAs) dysregulation is involved in the genesis and the progression of Prostate Cancer (PCa), thus potentially increasing their use in urological clinical practice. This is the first pilot study which utilizes Illumina Deep Sequencing to examine the entire miRNAs spectrum existent in urine exfoliated prostate cells (UEPCs) of PCa patients. A total of 11 male patients with histological diagnosis of PCa were enrolled in the present study. First-catch urine (30 mL) was collected following a prostate massage. Total RNA was extracted from urine and sequenced using an HiSeq2500 System (Illumina). QPCR assay was used to validate the highest NGS results in PCA patients and in age-matched, caucasian men. Remarkably, PCA let-7 family was down-regulated (P < 0.01), compared to the controls. The results of our study support the notion of a relatively high diagnostic value of miRNA family for PCa detection, especially in the let-7 family. The present research confirmed the potential use of miRNAs as non-invasive biomarkers in the diagnosis of PCa, potentially reducing the invasiveness of actual clinical strategy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Guelfi G,Cochetti G,Stefanetti V,Zampini D,Diverio S,Boni A,Mearini Edoi
10.1038/s41598-018-24236-ysubject
Has Abstractpub_date
2018-05-08 00:00:00pages
7111issue
1issn
2045-2322pii
10.1038/s41598-018-24236-yjournal_volume
8pub_type
杂志文章abstract：:We discuss a scheme to retrieve transient conformational molecular structure information using photoelectron angular distributions (PADs) that have averaged over partial alignments of isolated molecules. The photoelectron is pulled out from a localized inner-shell molecular orbital by an X-ray photon. We show that a t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23655
更新日期：2016-03-30 00:00:00
abstract：:Although cooperation is central to the organisation of many social systems, relatively little is known about cooperation in situations of collective emergency. When groups of people flee from a danger such as a burning building or a terrorist attack, the collective benefit of cooperation is important, but the cost of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33417
更新日期：2016-09-15 00:00:00
abstract：:In this work, TiN film deposited by plasma enhanced atomic layer deposition (PEALD) is adopted to modify the commercial anatase TiO2 powders. A series of analyses indicate that the surface modification of 20, 50 and 100 cycles of TiN by PEALD does not change the morphology, crystal size, lattice parameters, and surfac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30726-w
更新日期：2018-08-14 00:00:00
abstract：:Soil erosion due to underground leakage is a major factor causing land degradation in karst regions. Rhizosphere effects (REs) on soil anti-erodibility (SAE) can alleviate this type of soil erosion by improving soil physical processes such as aggregate stability. However, the magnitudes and causes of interspecific var...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58784-z
更新日期：2020-02-12 00:00:00
abstract：:Metal pollution in drinking water source has been under scrutiny as it seriously affects human health. This work examined 12 dissolved metals in the surface and overlying water of the Xiangjiang River, an important drinking water source in southern China, and characterized their distribution, identified their possible...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80403-0
更新日期：2021-01-08 00:00:00
abstract：:In this study, nanowires/nanowalls were generated on a silicon wafer through a chemical etching method. Octadecyltrichlorosilane (OTS) was deposited onto the nanowire/nanowall surfaces to alter their hydrophobicity. The hydrophobic characteristics of the surfaces were further modified via a 1.5-μm-thick layer of n-oct...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38678
更新日期：2016-12-09 00:00:00
abstract：:Surface incident solar radiation (Rs) of reanalysis products is widely used in ecological conservation, agricultural production, civil engineering and various solar energy applications. It is of great importance to have a good knowledge of the uncertainty of reanalysis Rs products. In this study, we evaluated the Rs e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60460-1
更新日期：2020-02-26 00:00:00
abstract：:The spread of multidrug-resistant Staphylococcus aureus strains, including methicillin-resistant S. aureus (MRSA), has shortened the useful life of anti-staphylococcal drugs enormously. Two approaches can be followed to address this problem: screening various sources for new leads for antibiotics or finding ways to di...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03716-7
更新日期：2017-06-19 00:00:00
abstract：:Predation plays a central role in the lives of most organisms. Predators must find and subdue prey to survive and reproduce, whereas prey must avoid predators to do the same. The resultant antagonistic coevolution often leads to extreme adaptations in both parties. Few examples capture the imagination like a rapid str...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40412
更新日期：2017-01-13 00:00:00
abstract：:Attraction to infants is a common feature of non-human primates. Frequent affiliative male-infant interactions have been observed in many multimale, multifemale groups of macaques, including a behaviour termed 'bridging' in which two male macaques simultaneously lift an infant. This behaviour has been suggested to ser...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34406-7
更新日期：2018-11-02 00:00:00
abstract：:Amplification and sequencing of 16S amplicons are widely used for profiling the structure of oral microbiota. However, it remains not clear whether and to what degree DNA extraction and targeted 16S rRNA hypervariable regions influence the analysis. Based on a mock community consisting of five oral bacterial species i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34294-x
更新日期：2018-11-05 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-34742-8
更新日期：2018-11-01 00:00:00
abstract：:Marine blue holes are precious geological heritages with high scientific research values. Their physical and chemical characteristics are unique because of the steep-walled structure and isolated water column which create isolated ecosystems in geographically restricted areas. The Sansha Yongle Blue Hole (SYBH) is the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67221-0
更新日期：2020-06-24 00:00:00
abstract：:Organic solar cells (OSCs) are promising alternatives to the conventional inorganic solar cells due to their low-cost processing and compatibility with flexible substrates. The development of low band-gap polymer, e.g., poly-[[4,8-bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl] [3-fluoro-2-[(2-ethylhexy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13648
更新日期：2015-09-01 00:00:00
abstract：:The rectifying properties of α,ω-dithiol terminated oligo(phenylene ethynylene) molecules sandwiched between heterometallic electrodes, including the molecular length and side group effects, are theoretically investigated using the fully self-consistent nonequilibrium Green's function method combined with density func...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06357
更新日期：2014-09-15 00:00:00
abstract：:Colaughter-simultaneous laughter between two or more individuals-allows listeners across different cultures and languages to quickly evaluate affiliation within a social group. We examined whether infants are sensitive to acoustic information in colaughter that indicates affiliation, specifically whether they can diff...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38954-4
更新日期：2019-03-11 00:00:00
abstract：:Obesity is characterized as the excessive accumulation of body fat and has a complex genetic foundation in humans including monogenic high-risk mutations and polygenic contributions. Domestic pigs represent a valuable model on an obesity-promoting high-caloric diet while constantly evaluated for body characteristics. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08961-4
更新日期：2017-08-22 00:00:00
abstract：:Levels of neutral poly-/perfluoroalkyl substances (nPFASs) in air and snow collected from Ny-Ålesund were measured and their air-snow exchange was determined to investigate whether they could re-volatilize into the atmosphere driven by means of air-snow exchange. The total concentration of 12 neutral PFASs ranged from...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08912
更新日期：2015-03-09 00:00:00
abstract：:The aims of this study were to explore whether DNA methylation at INSR and IGF2 mediated the association of prenatal exposure to the Chinese great famine with adulthood waist circumference (WC) and BMI. A total of 235 subjects were selected into the present study from severely affected province and a neighbor province...
journal_title：Scientific reports
pub_type： 历史文章,杂志文章
doi：10.1038/s41598-020-69120-w
更新日期：2020-07-22 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-23047-5
更新日期：2018-03-12 00:00:00
abstract：:Terminally misfolded proteins are selectively recognized and cleared by the endoplasmic reticulum-associated degradation (ERAD) pathway. SEL1L, a component of the ERAD machinery, plays an important role in selecting and transporting ERAD substrates for degradation. We have determined the crystal structure of the mouse...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20261
更新日期：2016-02-09 00:00:00
abstract：:The novel nuclear protein nBMP2 is synthesized from the BMP2 gene by translational initiation at an alternative start codon. We generated a targeted mutant mouse, nBmp2NLStm, in which the nuclear localization signal (NLS) was inactivated to prevent nuclear translocation of nBMP2 while still allowing the normal synthes...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46464
更新日期：2017-04-18 00:00:00
abstract：:For treatment individualisation of patients with locally advanced head and neck squamous cell carcinoma (HNSCC) treated with primary radiochemotherapy, we explored the capabilities of different deep learning approaches for predicting loco-regional tumour control (LRC) from treatment-planning computed tomography images...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70542-9
更新日期：2020-09-24 00:00:00
abstract：:Staphylococcus aureus is a medically important pathogen with an abundance of virulence factors that are necessary for survival within a host, including the production of cytolytic toxins. The regulation of toxin production is mediated by the Agr quorum sensing system, and a poorly defined post-exponential growth phase...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14110-8
更新日期：2017-10-23 00:00:00
abstract：:Ocular graft-versus-host disease (GVHD) is a common complication after hematopoietic stem cell transplantation (HSCT). Here we compared the diagnostic rates of ocular GVHD, including its severity, prognosis and the agreement, obtained using three grading scales: the National Institutes of Health (NIH) eye score, Japan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06680
更新日期：2014-10-22 00:00:00
abstract：:Drug discovery efforts against the pathogen Mycobacterium tuberculosis (Mtb) have been advanced through phenotypic screens of extensive compound libraries. Such a screen revealed sulfolane 1 and indoline-5-sulfonamides 2 and 3 as potent inhibitors of mycobacterial growth. Optimization in the sulfolane series led to co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09642-y
更新日期：2017-08-25 00:00:00
abstract：:Alternatives to antibiotics for improving productivity and maintaining the health of livestock health are urgently needed. The scope of this research was conducted to investigate the effects of two alternatives (Bacillus licheniformis and Saccharomyces cerevisiae) to monensin on growth performance, antioxidant capacit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35081-4
更新日期：2018-11-12 00:00:00
abstract：:The aim is to design a patient-specific instrument (PSI) for multilevel cervical pedicle screw placement from C2 to C7, as well as verifying reliability and reproducibility. Computed tomography (CT) scans were obtained from 7 cadaveric cervical spines. Using Mimics software, semiautomatic segmentation was performed fo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51936-w
更新日期：2019-10-30 00:00:00
abstract：:Duckweed species have a great potential to develop into fast-growing crops for water remediation and bioenergy production. Seed production and utilization of hybrid vigour are essential steps in this process. However, even in the extensively-studied duckweed species, Lemna gibba, flower primordia were often aborted pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03240-8
更新日期：2017-06-08 00:00:00
abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal lung disease. This disease is characterized by an excessive accumulation of extracellular matrix deposition that modify normal lung physiology. Up to date, there are not efficient therapeutic tools to fight IPF. Glucagon-like peptide-1 receptor (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74912-1
更新日期：2020-10-22 00:00:00
