Efficacy of alprostadil for preventing of contrast-induced nephropathy: A meta-analysis.

Abstract:

:Contrast-induced nephropathy (CIN) has become the third-leading cause of hospital-acquired acute renal injury. Although alprostadil has been proposed as an effective preventative measure, this conclusion remains inconsistent. Thus, we performed a meta-analysis of the published studies on this topic to evaluate the preventative effect of alprostadil on CIN. Databases, including PubMed, the Web of Science, Cochrane Library, Wanfang, the China Biological Medicine Database (SinoMed) and the China National Knowledge Infrastructure (CNKI) were systematically searched. Nineteen clinical trials involving 2267 individuals were identified. We utilized a random or a fixed effect model to calculate the pooled odd ratios (ORs) and the standardized mean differences (SMD), respectively. Compared to the control group, the CIN risk decreased significantly in the alprostadil group (P < 0.00001, OR = 0.29, 95% CI = 0.21-0.39). In the subgroup of coronary angiography patients, the use of alprostadil also decreased the risk of CIN (P < 0.00001, OR = 0.27, 95% CI: 0.19-0.39). In conclusion, Alprostadil might be associated with a significant reduction in postcontrast Scr, BUN and CysC level and decrease the incidence of CIN.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Zhang JZ,Kang XJ,Gao Y,Zheng YY,Wu TT,Li L,Liu F,Yang YN,Li XM,Ma YT,Xie X

doi

10.1038/s41598-017-01160-1

subject

Has Abstract

pub_date

2017-04-21 00:00:00

pages

1045

issue

1

issn

2045-2322

pii

10.1038/s41598-017-01160-1

journal_volume

7

pub_type

杂志文章,meta分析
  • Staphylococcal Superantigen-like protein 11 mediates neutrophil adhesion and motility arrest, a unique bacterial toxin action.

    abstract::Methicillin resistant Staphylococcus aureus (MRSA) is a major human pathogen, which causes superficial to lethal clinical infections. Neutrophils are the most abundant leukocytes in the blood and are the first defense mechanism against S. aureus infections. Here we show Staphylococcal Superantigen-Like protein 11 (SSL...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40817-x

    authors: Chen C,Yang C,Barbieri JT

    更新日期:2019-03-12 00:00:00

  • Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury.

    abstract::Although pneumococcal infection is a serious problem worldwide and has a high mortality rate, the molecular mechanisms underlying the lethality caused by pneumococcus remain elusive. Here, we show that BLT2, a G protein-coupled receptor for leukotriene B4 and 12(S)-hydroxyheptadecatrienoic acid (12-HHT), protects mice...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep34560

    authors: Shigematsu M,Koga T,Ishimori A,Saeki K,Ishii Y,Taketomi Y,Ohba M,Jo-Watanabe A,Okuno T,Harada N,Harayama T,Shindou H,Li JD,Murakami M,Hoka S,Yokomizo T

    更新日期:2016-10-05 00:00:00

  • 3D Polyaniline Architecture by Concurrent Inorganic and Organic Acid Doping for Superior and Robust High Rate Supercapacitor Performance.

    abstract::A good high rate supercapacitor performance requires a fine control of morphological (surface area and pore size distribution) and electrical properties of the electrode materials. Polyaniline (PANI) is an interesting material in supercapacitor context because it stores energy Faradaically. However in conventional ino...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep21002

    authors: Gawli Y,Banerjee A,Dhakras D,Deo M,Bulani D,Wadgaonkar P,Shelke M,Ogale S

    更新日期:2016-02-12 00:00:00

  • Overexpression of VIRE2-INTERACTING PROTEIN2 in Arabidopsis regulates genes involved in Agrobacterium-mediated plant transformation and abiotic stresses.

    abstract::Arabidopsis VIRE2-INTERACTING PROTEIN2 (VIP2) was previously described as a protein with a NOT domain, and Arabidopsis vip2 mutants are recalcitrant to Agrobacterium-mediated root transformation. Here we show that VIP2 is a transcription regulator and the C-terminal NOT2 domain of VIP2 interacts with VirE2. Interestin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-49590-3

    authors: Raman V,Anand A,Vasudevan B,Morsy MR,Pant BD,Lee HK,Tang Y,Mysore KS

    更新日期:2019-09-18 00:00:00

  • Andy's Algorithms: new automated digital image analysis pipelines for FIJI.

    abstract::Quantification of cellular antigens and their interactions via antibody-based detection methods are widely used in scientific research. Accurate high-throughput quantitation of these assays using general image analysis software can be time consuming and challenging, particularly when attempted by users with limited im...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-15885-6

    authors: Law AMK,Yin JXM,Castillo L,Young AIJ,Piggin C,Rogers S,Caldon CE,Burgess A,Millar EKA,O'Toole SA,Gallego-Ortega D,Ormandy CJ,Oakes SR

    更新日期:2017-11-16 00:00:00

  • Specificity Evaluation and Disease Monitoring in Arthritis Imaging with Complement Receptor of the Ig superfamily targeting Nanobodies.

    abstract::Single-photon emission computed tomography combined with micro-CT (SPECT/μCT) imaging using Nanobodies against complement receptor of the Ig superfamily (CRIg), found on tissue macrophages such as synovial macrophages, has promising potential to visualize joint inflammation in experimental arthritis. Here, we further ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep35966

    authors: Zheng F,Perlman H,Matthys P,Wen Y,Lahoutte T,Muyldermans S,Lu S,De Baetselier P,Schoonooghe S,Devoogdt N,Raes G

    更新日期:2016-10-25 00:00:00

  • Efficient and specific oligo-based depletion of rRNA.

    abstract::In most organisms, ribosomal RNA (rRNA) contributes to >85% of total RNA. Thus, to obtain useful information from RNA-sequencing (RNA-seq) analyses at reasonable sequencing depth, typically, mature polyadenylated transcripts are enriched or rRNA molecules are depleted. Targeted depletion of rRNA is particularly useful...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48692-2

    authors: Kraus AJ,Brink BG,Siegel TN

    更新日期:2019-08-22 00:00:00

  • Arbuscular mycorrhizal enhancement of phosphorus uptake and yields of maize under high planting density in the black soil region of China.

    abstract::Arbuscular mycorrhizal (AM) symbioses are an attractive means of improving the efficiency of soil phosphorus (P) that difficult to be used by plants and may provide a sustainable way of maintaining high yields while reducing P applications. However, quantifying the contribution of indigenous AM fungi on phosphorus upt...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-80074-x

    authors: Hou L,Zhang X,Feng G,Li Z,Zhang Y,Cao N

    更新日期:2021-01-13 00:00:00

  • The response of a boreal deep-sea sponge holobiont to acute thermal stress.

    abstract::Effects of elevated seawater temperatures on deep-water benthos has been poorly studied, despite reports of increased seawater temperature (up to 4 °C over 24 hrs) coinciding with mass mortality events of the sponge Geodia barretti at Tisler Reef, Norway. While the mechanisms driving these mortality events are unclear...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01091-x

    authors: Strand R,Whalan S,Webster NS,Kutti T,Fang JKH,Luter HM,Bannister RJ

    更新日期:2017-05-22 00:00:00

  • Dynamic through-silicon-via filling process using copper electrochemical deposition at different current densities.

    abstract::This work demonstrates the dynamic through-silicon-via (TSV) filling process through staged electrodeposition experiments at different current densities. Different morphologies corresponding to TSV filling results can be obtained by controlling the applied current density. Specifically, a low current density (4 mA/cm2...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep46639

    authors: Wang F,Zhao Z,Nie N,Wang F,Zhu W

    更新日期:2017-04-19 00:00:00

  • Synthesis and Characterization of PtTe2 Multi-Crystallite Nanoparticles using Organotellurium Nanocomposites.

    abstract::Herein, we report the synthesis of new PtTe2 multi-crystallite nanoparticles (NPs) in different sizes through an annealing process using new nanostructured Pt-Te organometallic NPs as a single source precursor. This precursor was obtained in a single reaction step using Ph2Te2 and H2PtCl6 and could be successfully siz...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10239-8

    authors: Fernández-Lodeiro J,Rodríguez-Gónzalez B,Novio F,Fernández-Lodeiro A,Ruiz-Molina D,Capelo JL,Santos AAD,Lodeiro C

    更新日期:2017-08-29 00:00:00

  • Parasitoid envenomation alters the Galleria mellonella midgut microbiota and immunity, thereby promoting fungal infection.

    abstract::Gut bacteria influence the development of different pathologies caused by bacteria, fungi and parasitoids in insects. Wax moth larvae became more susceptible to fungal infections after envenomation by the ectoparasitoid Habrobracon hebetor. In addition, spontaneous bacterioses occurred more often in envenomated larvae...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40301-6

    authors: Polenogova OV,Kabilov MR,Tyurin MV,Rotskaya UN,Krivopalov AV,Morozova VV,Mozhaitseva K,Kryukova NA,Alikina T,Kryukov VY,Glupov VV

    更新日期:2019-03-08 00:00:00

  • Microplastic contamination of table salts from Taiwan, including a global review.

    abstract::Plastic pollution is a rapidly worsening environmental problem, especially in oceanic habitats. Environmental pollution with microplastic particles is also causing food consumed by humans to be increasingly polluted, including table salts. Therefore, we present the first study which focuses only on table salt products...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-46417-z

    authors: Lee H,Kunz A,Shim WJ,Walther BA

    更新日期:2019-07-12 00:00:00

  • Evaluation of polypyrrole-modified bioelectrodes in a chemical absorption-bioelectrochemical reduction integrated system for NO removal.

    abstract::A Chemical absorption-bioelectrochemical reduction (CABER) system is based on Chemical absorption-biological reduction (CABR) system, which aims at NO removal and has been studied in many of our previous works. In this paper, we applied polypyrrole (PPy) on the electrode of bioelectrochemical reactor (BER) of CABER sy...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-49610-2

    authors: Guo T,Zhang C,Zhao J,Ma C,Li S,Li W

    更新日期:2019-09-10 00:00:00

  • miR-146a-mediated suppression of the inflammatory response in human adipocytes.

    abstract::The obesity-associated inflammation of white adipose tissue (WAT) is one of the factors leading to the development of related diseases such as insulin resistance and liver steatosis. Recently, microRNAs (miRNAs) were identified as important regulators of WAT functions. Herein, we cultured human Simpson-Golabi-Behmel s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep38339

    authors: Roos J,Enlund E,Funcke JB,Tews D,Holzmann K,Debatin KM,Wabitsch M,Fischer-Posovszky P

    更新日期:2016-12-06 00:00:00

  • Novel concept for neutron detection: proportional counter filled with 10B nanoparticle aerosol.

    abstract::The high neutron detection efficiency, good gamma-ray discrimination and non-toxicity of 3He made of proportional counters filled with this gas the obvious choice for neutron detection, particularly in radiation portal monitors (RPM), used to control the illicit transport of nuclear material, of which neutron detector...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep41699

    authors: Amaro FD,Monteiro CM,Dos Santos JM,Antognini A

    更新日期:2017-02-09 00:00:00

  • Therapeutic targeting of CBP/β-catenin signaling reduces cancer stem-like population and synergistically suppresses growth of EBV-positive nasopharyngeal carcinoma cells with cisplatin.

    abstract::Nasopharyngeal carcinoma (NPC) is an EBV-associated epithelial malignancy prevalent in southern China. Presence of treatment-resistant cancer stem cells (CSC) may associate with tumor relapse and metastasis in NPC. ICG-001 is a specific CBP/β-catenin antagonist that can block CBP/β-catenin-mediated transcription of st...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep09979

    authors: Chan KC,Chan LS,Ip JC,Lo C,Yip TT,Ngan RK,Wong RN,Lo KW,Ng WT,Lee AW,Tsao GS,Kahn M,Lung ML,Mak NK

    更新日期:2015-04-21 00:00:00

  • Estimation of chimpanzee age based on DNA methylation.

    abstract::In wild animal conservation, knowing the age of an individual animal is extremely beneficial. However, estimating the age is difficult for many species. Recently, epigenetics-based methods of estimating age have been reported. These studies were predominantly on humans with few reports on other animals, especially wil...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-28318-9

    authors: Ito H,Udono T,Hirata S,Inoue-Murayama M

    更新日期:2018-07-03 00:00:00

  • Thermoresponsive motor behavior is mediated by ring neuron circuits in the central complex of Drosophila.

    abstract::Insects are ectothermal animals that are constrained in their survival and reproduction by external temperature fluctuations which require either active avoidance of or movement towards a given heat source. In Drosophila, different thermoreceptors and neurons have been identified that mediate temperature sensation to ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-80103-9

    authors: Buhl E,Kottler B,Hodge JJL,Hirth F

    更新日期:2021-01-08 00:00:00

  • SNX27 links DGKζ to the control of transcriptional and metabolic programs in T lymphocytes.

    abstract::Sorting nexin 27 (SNX27) recycles PSD-95, Dlg1, ZO-1 (PDZ) domain-interacting membrane proteins and is essential to sustain adequate brain functions. Here we define a fundamental SNX27 function in T lymphocytes controlling antigen-induced transcriptional activation and metabolic reprogramming. SNX27 limits the activat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16370-w

    authors: Tello-Lafoz M,Rodríguez-Rodríguez C,Kinna G,Loo LS,Hong W,Collins BM,Teasdale RD,Mérida I

    更新日期:2017-11-27 00:00:00

  • Folate-Chitosan Nanoparticles Loaded with Ursolic Acid Confer Anti-Breast Cancer Activities in vitro and in vivo.

    abstract::Ursolic acid (UA) has proved to have broad-spectrum anti-tumor effects, but its poor water solubility and incompetent targeting property largely limit its clinical application and efficiency. Here, we synthesized a nanoparticle-based drug carrier composed of chitosan, UA and folate (FA-CS-UA-NPs) and demonstrated that...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30782

    authors: Jin H,Pi J,Yang F,Jiang J,Wang X,Bai H,Shao M,Huang L,Zhu H,Yang P,Li L,Li T,Cai J,Chen ZW

    更新日期:2016-07-29 00:00:00

  • The effect of sleep restriction on empathy for pain: An fMRI study in younger and older adults.

    abstract::Age and sleep both affect emotional functioning. Since sleep patterns change over the lifespan, we investigated the effects of short sleep and age on empathic responses. In a randomized cross-over experimental design, healthy young and older volunteers (n = 47 aged 20-30 years and n = 39 aged 65-75 years) underwent fu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12098-9

    authors: Tamm S,Nilsonne G,Schwarz J,Lamm C,Kecklund G,Petrovic P,Fischer H,Åkerstedt T,Lekander M

    更新日期:2017-09-25 00:00:00

  • Drought characteristics and its elevation dependence in the Qinghai-Tibet plateau during the last half-century.

    abstract::Associated with global warming, drought has destructive influences on agriculture and ecosystems, especially in the fragile Qinghai-Tibet Plateau (QTP). This study investigated spatial-temporal patterns of meteorological drought in the QTP and its surrounding areas and made an attempt to explore the relationship betwe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71295-1

    authors: Feng W,Lu H,Yao T,Yu Q

    更新日期:2020-08-31 00:00:00

  • The shallow structure of Solfatara Volcano, Italy, revealed by dense, wide-aperture seismic profiling.

    abstract::Two active-source, high-resolution seismic profiles were acquired in the Solfatara tuff cone in May and November 2014, with dense, wide-aperture arrays. Common Receiver Surface processing was crucial in improving signal-to-noise ratio and reflector continuity. These surveys provide, for the first time, high-resolution...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17589-3

    authors: Bruno PPG,Maraio S,Festa G

    更新日期:2017-12-12 00:00:00

  • Ontogeny of foraging behaviour in juvenile red-footed boobies (Sula sula).

    abstract::The early life stages represent a crucial period that can strongly influence population dynamics. We studied the development of foraging behaviour in the red-footed booby, a tropical seabird with an extensive post-fledging care period (3 to 6 months). Adults and juveniles were observed from shore and tracked at sea us...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-14478-7

    authors: Mendez L,Prudor A,Weimerskirch H

    更新日期:2017-10-24 00:00:00

  • Activation of p38 MAPK participates in the sulbactam-induced cerebral ischemic tolerance mediated by glial glutamate transporter-1 upregulation in rats.

    abstract::Our previous studies have shown that sulbactam can play a neuroprotection role in hippocampal neurons by upregulating the expression and function of glial glutamate transporter-1 (GLT-1) during ischemic insult. Here, using rat global cerebral ischemia model, we studied in vivo the role of p38 mitogen-activated protein...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-77583-0

    authors: Xian XH,Gao JX,Qi J,Fan SJ,Zhang M,Li WB

    更新日期:2020-11-26 00:00:00

  • Selection of suitable reference genes for quantitative real-time PCR gene expression analysis in Salix matsudana under different abiotic stresses.

    abstract::Salix matsudana is a deciduous, rapidly growing willow species commonly cultivated in China, which can tolerate drought, salt, and heavy metal stress conditions. Selection of suitable reference genes for quantitative real-time PCR is important for normalizing the expression of the key genes associated with various str...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40290

    authors: Zhang Y,Han X,Chen S,Zheng L,He X,Liu M,Qiao G,Wang Y,Zhuo R

    更新日期:2017-01-25 00:00:00

  • Capillary isoelectric focusing after sample enrichment with immunoaffinity chromatography in a single capillary.

    abstract::For accurate micro-scale quantification of a specific protein in biological fluids, immunoaffinity chromatography (IAC) and isoelectric focusing (IEF) were combined in a single fused-silica capillary. The inner wall of the capillary was coated with an anti-E-tag antibody at the inlet side to form an IAC column, and po...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep39221

    authors: Shimura K,Nagai T

    更新日期:2016-12-15 00:00:00

  • Plasmonically Enhanced Schottky Photovoltaic Devices.

    abstract::Solar-cells based on Schottky junctions between metals and semiconductors (without or with an intermediate insulator) are among the main possibilities towards economical photovoltaic conversion of the solar energy. This is mainly due to their structural simplicity and hence the ease of their realization. We propose he...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-14528-0

    authors: Farhat M,Kais S,Alharbi FH

    更新日期:2017-10-27 00:00:00

  • Identifiability of structural networks of nonlinear electronic oscillators.

    abstract::The interplay between structure and function is critical in the understanding of complex systems, their dynamics and their behavior. We investigated the interplay between structural and functional networks by means of the differential identifiability framework, which here quantifies the ability of identifying a partic...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71373-4

    authors: Vera-Ávila VP,Sevilla-Escoboza R,Goñi J,Rivera-Durón RR,Buldú JM

    更新日期:2020-09-04 00:00:00