Abstract：
:To investigate the prognostic role of the estrogen receptor (ER) in gastric cancer (GC) patients, tumor tissues from 932 patients with advanced GC were assessed for ER expression using immunohistochemistry, and their clinicopathologic features were evaluated. Forty patients (4.3%) had ER expression and they were more frequently associated with diffuse type gastric cancer and shorter disease free survival. Furthermore, we carried out in vitro analysis to evaluate the effect of ER modulation on the proliferation of GC cell lines. Estradiol enhanced proliferation of ER positive GC cells while it did not show any effect on ER negative GC cells. When ER was inhibited by fulvestrant and ER siRNA, estradiol-induced proliferation of ER positive GC cell was suppressed. Paclitaxel showed synergistic anti-proliferative impacts with fulvestrant. Suppressing ER by fulvestrant, paclitaxel and ER siRNA showed increased expression of E-cadherin, which is a crucial factor in diffuse-type carcinogenesis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yi JH,Do IG,Jang J,Kim ST,Kim KM,Park SH,Park JO,Park YS,Lim HY,Kang WK,Lee Jdoi
10.1038/srep07592subject
Has Abstractpub_date
2014-12-23 00:00:00pages
7592issn
2045-2322pii
srep07592journal_volume
4pub_type
临床试验,杂志文章abstract：:Antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of action for many therapeutic antibodies. A therapeutic immunoglobulin (Ig) G1 monoclonal antibody lost more than half of its ADCC activity after heat stress at 40 °C for 4 months. Size-exclusion and ion-exchange chromatography were used t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-57184-2
更新日期：2020-01-15 00:00:00
abstract：:Ancestry informative single nucleotide polymorphisms (SNPs) can identify biogeographic ancestry (BGA); however, population substructure and relatively recent admixture can make differentiation difficult in heterogeneous Hispanic populations. Utilizing unrelated individuals from the Genomic Origins and Admixture in Lat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64245-4
更新日期：2020-05-08 00:00:00
abstract：:Human pancreatic islet amyloid polypeptide (hIAPP) and beta amyloid (Aβ) can accumulate in Type 2 diabetes (T2D) and Alzheimer's disease (AD) brains and evidence suggests that interaction between the two amyloidogenic proteins can lead to the formation of heterocomplex aggregates. However, the structure and consequenc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66602-9
更新日期：2020-06-25 00:00:00
abstract：:Cell-based assays are growing in importance for screening drugs and investigating their mechanisms of action. Most of the assays use so-called "normal" cell strain because it is difficult to produce cell lines in which the disease conditions are reproduced. In this study, we used a cell-resealing technique, which reve...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15443-0
更新日期：2017-11-09 00:00:00
abstract：:Modern flow cytometry instruments have become vital tools for high-throughput analysis of single cells. However, as issues with the cellular labeling techniques often used in flow cytometry have become more of a concern, the development of label-free modalities for cellular analysis is increasingly desired. Non-linear...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10751
更新日期：2015-05-29 00:00:00
abstract：:Microneedles, fabricated by nano-moulding technology show great promise in the field of drug delivery by enabling the painless self-administration of drugs in a patient-friendly manner. In this study, double-stranded salmon DNA (SDNA) was used as both a drug-delivery vehicle and structural material with a microneedle ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09904-9
更新日期：2017-08-29 00:00:00
abstract：:The nuclear pore complex (NPC) is one of the largest supramolecular structures in eukaryotic cells. Its octagonal ring-scaffold perforates the nuclear envelope and features a unique molecular machinery that regulates nucleocytoplasmic transport. NPCs are composed of ~30 different nucleoporins (Nups), averaged at 8, 16...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09372
更新日期：2015-03-23 00:00:00
abstract：:The activity of the ubiquitin proteasome system (UPS) is downregulated in aggregation diseases such as Alzheimer's disease (AD). In this study, we investigated the therapeutic potential of the Agouti-related peptide (AgRP), which is secreted by human mesenchymal stem cells (MSCs), in terms of its effect on the regulat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39340
更新日期：2017-01-04 00:00:00
abstract：:Multiexcitonic transitions and emission of several photons per excitation comprise a very attractive feature of semiconductor quantum dots for optoelectronics applications. However, these higher-order radiative processes are usually quenched in colloidal quantum dots by Auger and other nonradiative decay channels. To ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42307
更新日期：2017-02-14 00:00:00
abstract：:Microtubule-associated protein 1B (MAP1B) is expressed predominantly during the early stages of development of the nervous system, where it regulates processes such as axonal guidance and elongation. Nevertheless, MAP1B expression in the brain persists in adult stages, where it participates in the regulation of the st...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30069
更新日期：2016-07-18 00:00:00
abstract：:It is recently appreciated that many bacterial chemoreceptors have ligand-binding domains (LBD) of the dCACHE family, a structure with two PAS-like subdomains, one membrane-proximal and the other membrane-distal. Previous studies had implicated only the membrane-distal subdomain in ligand recognition. Here, we report ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14372-2
更新日期：2017-10-26 00:00:00
abstract：:Viral latency remains the most significant obstacle to HIV eradication. Clinical strategies aim to purge the latent CD4+ T cell reservoir by activating viral expression to induce death, but are undercut by the inability to target latently infected cells. Here we explored the acute signaling response of latent HIV-infe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15532-0
更新日期：2017-11-23 00:00:00
abstract：:Perpendicularly magnetized tunnel junctions (p-MTJs) that contain synthetic antiferromagnetic (SAF) frames show promise as reliable building blocks to meet the demands of perpendicular magnetic anisotropy (PMA)-based spintronic devices. In particular, Co/Pd multilayer-based SAFs have been widely employed due to their ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21324
更新日期：2016-02-18 00:00:00
abstract：:Alterations in the gut microbiome have been reported in liver cirrhosis, and probiotic interventions are considered a potential treatment strategy. This study aimed to evaluate the effects and mechanisms of Lactobacillus salivarius LI01, Pediococcus pentosaceus LI05, Lactobacillus rhamnosus GG, Clostridium butyricum M...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07091-1
更新日期：2017-07-31 00:00:00
abstract：:Human induced pluripotent stem cells (hiPSCs) represent an almost limitless source of cells for disease modelling and drug screening applications. Here we established an efficient and robust 3D platform for cardiomyocyte (CMs) production from hiPSCs, solely through small-molecule-based temporal modulation of the Wnt s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45047-9
更新日期：2019-06-25 00:00:00
abstract：:Adipocytes are the prevalent stromal cell type in adult bone marrow (BM), and leukemia cells continuously adapt to deficiency of nutrients acquiring chemoresistant profiles in the BM microenvironment. We have previously shown that fatty acid metabolism is a key energy pathway for survival of acute myeloid leukemia (AM...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35198-6
更新日期：2018-11-15 00:00:00
abstract：:Nano-scale investigations of bainitic structures formed at temperatures below 350 °C have shown that the bainitic ferrite lattice is super-saturated in carbon. A high density of intrinsic defects would be playing a part in the carbon-supersaturation levels detected. In this work, the role of C-vacancy complexes on car...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57469-x
更新日期：2020-01-16 00:00:00
abstract：:Separation of CO2 from other gasses offers environmental benefits since CO2 gas is the main contributor to global warming. Recently, graphene oxide (GO) based gas separation membranes are of interest due to their selective barrier properties. However, maintaining selectivity without sacrificing permeance is still chal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00433-z
更新日期：2017-03-28 00:00:00
abstract：:We summarized published data on the associations of apolipoprotein E (APOE) gene ε2/ε3/ε4 polymorphism with both cancer risk and circulating lipid profiles, aiming to examine the causal relevance between lipids and cancer risk. Article identification and data abstraction were conducted in duplicate and independently b...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep09495
更新日期：2015-03-30 00:00:00
abstract：:Uniaxial-stress experiments have been performed for the 3287- and 2445-cm-1 local vibrational modes assigned to the positive charge state of interstitial hydrogen [Formula: see text] and deuterium [Formula: see text], respectively, occurring in mono-crystalline rutile TiO2. The onset of the defect alignment under the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16660-3
更新日期：2017-12-06 00:00:00
abstract：:In the jejunum, PepT1 is particularly enriched in the well-differentiated absorptive epithelial cells in the villi. Studies of expression and function of PepT1 along the crypt-villus axis demonstrated that this protein is crucial to the process of di/tripeptide absorption. We recently exhibited that PepT1 plays an imp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27119
更新日期：2016-06-01 00:00:00
abstract：:Cells in vascular walls are exposed to blood pressure variability (BPV)-induced cycle-by-cycle fluctuations in mechanical forces which vary considerably with pathology. For example, BPV is elevated in hypertension but reduced under anesthesia. We hypothesized that the extent of mechanical fluctuations applied to vascu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-57301-1
更新日期：2020-01-15 00:00:00
abstract：:c-FLIP (cellular FLICE-inhibitory protein) is the pivotal regulator of TRAIL resistance in cancer cells, It is a short-lived protein degraded through the ubiquitin/proteasome pathway. The discovery of factors and mechanisms regulating its protein stability is important for the comprehension of TRAIL resistance by tumo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22999
更新日期：2016-03-14 00:00:00
abstract：:We investigated whether clinical factors including comorbidities, medications, and laboratory results predict inpatient fall risk in older adults. The participants in this case-control study included hospitalized older adults with acute conditions who had falls during their hospital stay (case group) and 410 hospitali...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81034-9
更新日期：2021-01-15 00:00:00
abstract：:Potassium depletion affects AQP2 expression and the cellular composition of the kidney collecting duct. This, in turn, contributes to the development of a secondary form of nephrogenic diabetes insipidus and hypokalemic nephropathy. Here we show that after 14 days of potassium depletion, the cellular fraction of A-typ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61882-7
更新日期：2020-03-31 00:00:00
abstract：:Ruthenium(II) complexes with 6-methyl-2-thiouracil cis-[Ru(6m2tu)2(PPh3)2] (1) and [Ru(6m2tu)2(dppb)] (2) (where PPh3 = triphenylphosphine; dppb = 1,4-bis(diphenylphosphino)butane; and 6m2tu = 6-methyl-2-thiouracil) are potent cytotoxic agents and able to bind DNA. The aim of this study was to evaluate in vitro cellul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47914-x
更新日期：2019-08-07 00:00:00
abstract：:Microcalcifications are vital mammographic indicators contributing to the early detection of up to 50% of non-palpable tumours and may also be valuable as prognostic markers. However, the precise mechanism by which they form remains incompletely understood. Following development of an in vitro model using human breast...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36496-9
更新日期：2019-01-24 00:00:00
abstract：:Single-photon emitters with stable and uniform photoluminescence properties are important for quantum technology. However, in many cases, colour centres in diamond exhibit spectral diffusion and photoluminescence intensity fluctuation. It is therefore essential to investigate the dynamics of colour centres at the sing...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12244
更新日期：2015-07-23 00:00:00
abstract：:The order Chlamydiales are biphasic intracellular bacterial pathogens infecting humans and domesticated animals. Wildlife infections have also been reported, with the most studied example being Chlamydia pecorum infections in the koala, an iconic Australian marsupial. In koalas, molecular evidence suggests that spill-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13164-y
更新日期：2017-10-09 00:00:00
abstract：:The purpose of this study was to determine the significance of deep structural lesions for impairment of consciousness following hemorrhagic stroke and recovery at ICU discharge. Our study focused on deep lesions that previously were implicated in studies of disorders of consciousness. We analyzed MRI measures obtaine...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41042-2
更新日期：2019-03-12 00:00:00
