Systems analysis of latent HIV reversal reveals altered stress kinase signaling and increased cell death in infected T cells.

abstract：:Long-term supply of synthetic nitrogen (N) has the potential to affect the soil N processes. This study aimed to (i) establish N response curves to find the best balance between inputs and outputs of N over four ratoons; (ii) use 15N-labeled fertilizer to estimate the N recovery efficiency of fertilizer applied in the...

journal_title：Scientific reports

authors： Joris HAW,Vitti AC,Ferraz-Almeida R,Otto R,Cantarella H

更新日期：2020-11-02 00:00:00

abstract：:We demonstrate an ultrahigh-sensitivity gas pressure sensor based on the Fabry-Perot interferometer employing a fiber-tip diaphragm-sealed cavity. The cavity is comprised of a silica capillary and ultrathin silica diaphragm with a thickness of 170 nm, with represents the thinnest silica diaphragm fabricated thus far b...

journal_title：Scientific reports

authors： Liu S,Wang Y,Liao C,Wang Y,He J,Fu C,Yang K,Bai Z,Zhang F

更新日期：2017-04-11 00:00:00

abstract：:Macular edema due to neovascular age-related macular degeneration, diabetes or retinal vein occlusion can cause central vision loss. Intravitreal treatment with antibody-based biopharmaceutical compounds designed to neutralize vascular endothelial growth factor (VEGF) has proven to be an efficient strategy to ameliora...

journal_title：Scientific reports

authors： Sivertsen MS,Jørstad ØK,Grevys A,Foss S,Moe MC,Andersen JT

更新日期：2018-02-01 00:00:00

abstract：:The applications of machine learning/deep learning (ML/DL) methods in meteorology have developed considerably in recent years. Massive amounts of meteorological data are conducive to improving the training effect and model performance of ML/DL, but the establishment of training datasets is often time consuming, especi...

journal_title：Scientific reports

authors： Lu C,Kong Y,Guan Z

更新日期：2020-09-14 00:00:00

abstract：:Electroceutical wound dressings, especially those involving current flow with silver based electrodes, show promise for treating biofilm infections. However, their mechanism of action is poorly understood. We have developed an in vitro agar based model using a bioluminescent strain of Pseudomonas aeruginosa to measure...

journal_title：Scientific reports

authors： Dusane DH,Lochab V,Jones T,Peters CW,Sindeldecker D,Das A,Roy S,Sen CK,Subramaniam VV,Wozniak DJ,Prakash S,Stoodley P

更新日期：2019-02-14 00:00:00

abstract：:Calcitriol, a metabolite of vitamin D, is often used in osteoporosis clinics. However, the material has other bioactivities; for example, it accelerates angiogenesis, has anti-inflammatory properties, and inhibits oxidative stress. We investigated the effects of calcitriol in a random skin flap rat model. "McFarlane f...

journal_title：Scientific reports

authors： Zhou KL,Zhang YH,Lin DS,Tao XY,Xu HZ

更新日期：2016-01-06 00:00:00

abstract：:Here we show that electrical tuning of the sensitivity of chemitransistor sensors, namely field-effect-transistors (FETs) exploiting nano/mesostructured sensing materials, can be used to effectively address two chief problems of state-of-the-art gas sensors, specifically fabrication reliability and degradation by agin...

journal_title：Scientific reports

authors： Lazzerini GM,Strambini LM,Barillaro G

更新日期：2013-01-01 00:00:00

abstract：:Power semiconductor devices require low on-resistivity and high breakdown voltages simultaneously. Vertical-type metal-oxide-semiconductor field-effect transistors (MOSFETs) meet these requirements, but have been incompleteness in diamond. Here we show vertical-type p-channel diamond MOSFETs with trench structures and...

journal_title：Scientific reports

authors： Oi N,Inaba M,Okubo S,Tsuyuzaki I,Kageura T,Onoda S,Hiraiwa A,Kawarada H

更新日期：2018-07-13 00:00:00

abstract：:Understanding and control of heat dissipation is an important challenge in nanoelectronics wherein field-accelerated hot carriers in current-carrying ballistic systems release a large part of the kinetic energy into external bulk phonon baths. Here we report on a physical mechanism of this remote heat dissipation and ...

journal_title：Scientific reports

authors： Tsutsui M,Morikawa T,Yokota K,Taniguchi M

更新日期：2018-05-18 00:00:00

abstract：:The interplay between orbital, charge, spin, and lattice degrees of freedom is at the core of correlated oxides. This is extensively studied at the interface of heterostructures constituted of two-layer or multilayer oxide films. Here, we demonstrate the interactions between orbital reconstruction and charge transfer ...

journal_title：Scientific reports

authors： Cui B,Song C,Li F,Wang GY,Mao HJ,Peng JJ,Zeng F,Pan F

更新日期：2014-02-26 00:00:00

abstract：:NF-κB signaling pathway has important roles in the regulation of growth and development of nervous system. This pathway has also been shown to participate in the pathogenesis of schizophrenia. Meanwhile, activity of NF-κB signaling pathway is regulated by several factors including non-coding RNAs (lncRNAs). In the cur...

journal_title：Scientific reports

authors： Safa A,Badrlou E,Arsang-Jang S,Sayad A,Taheri M,Ghafouri-Fard S

更新日期：2020-10-22 00:00:00

abstract：:Persistent human papillomavirus (HPV) infection is the vital factor driving cervical carcinogenesis; however, other features of the local cervicovaginal microenvironment (CVM) may play a critical role in development of precancerous cervical dysplasia and progression to invasive cervical carcinoma (ICC). Here we invest...

journal_title：Scientific reports

authors： Łaniewski P,Cui H,Roe DJ,Barnes D,Goulder A,Monk BJ,Greenspan DL,Chase DM,Herbst-Kralovetz MM

更新日期：2019-05-14 00:00:00

abstract：:There has been much interest in understanding collective dynamics in networks of brain regions due to their role in behavior and cognitive function. Here we show that a simple, homogeneous system of densely connected oscillators, representing the aggregate activity of local brain regions, can exhibit a rich variety of...

journal_title：Scientific reports

authors： Singh R,Menon SN,Sinha S

更新日期：2016-02-26 00:00:00

abstract：:The volcanic eruption of Santorini in the Bronze Age left detectable debris across the Mediterranean, serving as an anchor in time for the region, synchronizing chronologies of different sites. However, dating the eruption has been elusive for decades, as radiocarbon indicates a date about a century earlier than archa...

journal_title：Scientific reports

authors： Ehrlich Y,Regev L,Boaretto E

更新日期：2021-01-12 00:00:00

abstract：:Clinicians often hesitate prescribing corticosteroids to treat corticosteroid-responsive conditions in sickle cell disease (SCD) patients because their use can be associated with complications (increased hospital readmission, rebound pain, strokes, avascular necrosis, acute chest syndrome). Consequently, SCD patients ...

journal_title：Scientific reports

authors： Almeida LEF,Damsker JM,Albani S,Afsar N,Kamimura S,Pratt D,Kleiner DE,Quezado M,Gordish-Dressman H,Quezado ZMN

更新日期：2018-04-17 00:00:00

abstract：:Endothelial mesenchymal transition (EndMT) plays a critical role in the pathogenesis and progression of interstitial and perivascular fibrosis after acute myocardial infarction (AMI). Pigment epithelium-derived factor (PEDF) is shown to be a new therapeutic target owing to its protective role in cardiovascular disease...

journal_title：Scientific reports

authors： Zhang H,Hui H,Li Z,Pan J,Jiang X,Wei T,Cui H,Li L,Yuan X,Sun T,Liu Z,Zhang Z,Dong H

更新日期：2017-02-07 00:00:00

abstract：:We investigated the surface reformation of poly(dimethylsiloxane) (PDMS) elastomers by means of ion beam bombardment for fabricating wrinkle structures. Oxidation on the PDMS surface formed a silica-like outer layer that interacted with the inner PDMS layer, leading to the formation of wrinkle structures that minimize...

journal_title：Scientific reports

authors： Park HG,Jeong HC,Jung YH,Seo DS

更新日期：2015-07-21 00:00:00

abstract：:A new and facile approach to selectively functionalize the internal and external surfaces of porous silicon (pSi) for drug delivery applications is reported. To provide a surface that is suitable for sustained drug release of the hydrophobic cancer chemotherapy drug camptothecin (CPT), the internal surfaces of pSi fil...

journal_title：Scientific reports

authors： Zhang DX,Yoshikawa C,Welch NG,Pasic P,Thissen H,Voelcker NH

更新日期：2019-02-04 00:00:00

abstract：:Iron is vital for nearly all living organisms, but during infection, not readily available to pathogens. Infectious bacteria therefore depend on specialized mechanisms to survive when iron is limited. These mechanisms make attractive targets for new drugs. Here, by genome-wide phenotypic profiling, we identify and cat...

journal_title：Scientific reports

authors： Dragset MS,Ioerger TR,Zhang YJ,Mærk M,Ginbot Z,Sacchettini JC,Flo TH,Rubin EJ,Steigedal M

更新日期：2019-08-06 00:00:00

abstract：:To manage a stressful stimulus animals react both behaviorally and physiologically to restore the homeostasis. In stable horses, a stressful stimulus can be represented by social separation, riding discomfort or the presence of novel objects in their environment. Although Heart Rate Variability is a common indicator o...

journal_title：Scientific reports

authors： Scopa C,Palagi E,Sighieri C,Baragli P

更新日期：2018-11-30 00:00:00

abstract：:The exposure of aqueous solutions to atmospheric plasmas results in the generation of relatively long-lived secondary products such as hydrogen peroxide which are biologically active and have demonstrated anti-microbial and cytotoxic activity. The use of plasma-activated solutions in applications such as microbial dec...

journal_title：Scientific reports

authors： Boehm D,Heslin C,Cullen PJ,Bourke P

更新日期：2016-02-24 00:00:00

abstract：:Attention can be directed at features and feature dimensions to facilitate perception. Here, we investigated whether feature-based-attention (FBA) can also dynamically weight feature-specific representations within multi-feature objects held in visual working memory (VWM). Across three experiments, participants retain...

journal_title：Scientific reports

authors： Niklaus M,Nobre AC,van Ede F

更新日期：2017-02-24 00:00:00

abstract：:Chronic sleep fragmentation (SF) commonly occurs in human populations, and although it does not involve circadian shifts or sleep deprivation, it markedly alters feeding behaviors ultimately promoting obesity and insulin resistance. These symptoms are known to be related to the host gut microbiota. Mice were exposed t...

journal_title：Scientific reports

authors： Poroyko VA,Carreras A,Khalyfa A,Khalyfa AA,Leone V,Peris E,Almendros I,Gileles-Hillel A,Qiao Z,Hubert N,Farré R,Chang EB,Gozal D

更新日期：2016-10-14 00:00:00

abstract：:The evolution of bone tissue quantity and quality in contact with the surface of orthopedic and dental implants is a strong determinant of the surgical outcome but remains difficult to be assessed quantitatively. The aim of this study was to investigate the performance of a quantitative ultrasound (QUS) method to meas...

journal_title：Scientific reports

authors： Fraulob M,Vayron R,Le Cann S,Lecuelle B,Hériveaux Y,Albini Lomami H,Flouzat Lachaniette CH,Haïat G

更新日期：2020-12-15 00:00:00

abstract：:The rapid increase in the number of genetically modified (GM) varieties has led to a demand for high-throughput methods to detect genetically modified organisms (GMOs). We describe a new dynamic array-based high throughput method to simultaneously detect 48 targets in 48 samples on a Fludigm system. The test targets i...

journal_title：Scientific reports

authors： Li X,Wu Y,Li J,Li Y,Long L,Li F,Wu G

更新日期：2015-01-05 00:00:00

abstract：:Herein, we examined the association between cytomegalovirus (CMV) coinfection and the progression of liver fibrosis in hepatitis C virus (HCV) infection, and investigated the effect of CMV coinfection on JAK-STAT pathway. CMV DNAemia was detected by PCR in DNA from controls (n = 120), and HCV patients with early (F0-F...

journal_title：Scientific reports

authors： Ibrahim MK,Khedr A,Bader El Din NG,Khairy A,El Awady MK

更新日期：2017-09-04 00:00:00

abstract：:N-myc downstream regulated gene 1 (NDRG1) is a responsible gene for a hereditary motor and sensory neuropathy-Lom (Charcot-Marie-Tooth disease type 4D). This is the first study aiming to assess the contribution of NDRG1 to differentiation of macrophage lineage cells, which has important implications for bone remodelin...

journal_title：Scientific reports

authors： Watari K,Shibata T,Nabeshima H,Shinoda A,Fukunaga Y,Kawahara A,Karasuyama K,Fukushi J,Iwamoto Y,Kuwano M,Ono M

更新日期：2016-01-18 00:00:00

abstract：:The visual magnocellular system is thought to play a crucial role in learning to read. Here therefore, we examined whether magnocellular based training could improve reading in children with visual reading problems. The participants were 24 male primary school students aged between 9-11 (Mean = 9.76, SD = 0.59) with s...

journal_title：Scientific reports

authors： Ebrahimi L,Pouretemad H,Khatibi A,Stein J

更新日期：2019-02-04 00:00:00

abstract：:The prevalence of chronic kidney disease (CKD), characterized by progressive renal dysfunction with tubulointerstitial fibrosis, is increasing because of societal aging. Uremic toxins, accumulated during renal dysfunction, cause kidney damage, leading to renal deterioration. A recent metabolomic analysis revealed that...

journal_title：Scientific reports

authors： Okada A,Nangaku M,Jao TM,Maekawa H,Ishimono Y,Kawakami T,Inagi R

更新日期：2017-09-11 00:00:00

abstract：:Interfacial charge transfer from photoexcited ruthenium-based N3 dye molecules into ZnO thin films received controversial interpretations. To identify the physical origin for the delayed electron transfer in ZnO compared to TiO2, we probe directly the electronic structure at both dye-semiconductor interfaces by applyi...

journal_title：Scientific reports

authors： Borgwardt M,Wilke M,Kampen T,Mähl S,Xiao M,Spiccia L,Lange KM,Kiyan IY,Aziz EF

更新日期：2016-04-13 00:00:00