Abstract:
:The exposure of aqueous solutions to atmospheric plasmas results in the generation of relatively long-lived secondary products such as hydrogen peroxide which are biologically active and have demonstrated anti-microbial and cytotoxic activity. The use of plasma-activated solutions in applications such as microbial decontamination or anti-cancer treatments requires not only adequate performance on target cells but also a safe operating window regarding the impact on surrounding tissues. Furthermore the generation of plasma-activated fluids needs to be considered as a by-stander effect of subjecting tissue to plasma discharges. Cytotoxicity and mutagenicity assays using mammalian cell lines were used to elucidate the effects of solutions treated with di-electric barrier discharge atmospheric cold plasma. Plasma-treated PBS inhibited cell growth in a treatment time-dependent manner showing a linear correlation to the solutions' peroxide concentration which remained stable over several weeks. Plasma-treated foetal bovine serum (FBS) acting as a model for complex bio-fluids showed not only cytotoxic effects but also exhibited increased mutagenic potential as determined using the mammalian HPRT assay. Further studies are warranted to determine the nature, causes and effects of the cyto- and genotoxic potential of solutions exposed to plasma discharges to ensure long-term safety of novel plasma applications in medicine and healthcare.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Boehm D,Heslin C,Cullen PJ,Bourke Pdoi
10.1038/srep21464subject
Has Abstractpub_date
2016-02-24 00:00:00pages
21464issn
2045-2322pii
srep21464journal_volume
6pub_type
杂志文章abstract::We propose a hybrid plasmonic device consisting of a planar dielectric waveguide covering a gold nanostripe array fabricated on a gold film and investigate its guiding properties at telecom wavelengths. The fundamental modes of a hybrid device and their dependence on the key geometric parameters are studied. A communi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45196
更新日期:2017-03-24 00:00:00
abstract::Marine bacterial strains are of great interest for their ability to produce secondary metabolites with anticancer potentials. Isolation, identification, characterization and anticancer activities of isolated bacteria from El-Hamra Lake, Wadi El-Natrun (Egypt) were the objectives of this study. The isolated bacteria we...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70945-8
更新日期:2020-08-21 00:00:00
abstract::Host-genetic control of influenza virus infection has been the object of little attention. In this study we determined that two inbred lines of chicken differing in their genetic background , Lines 0 and C-B12, were respectively relatively resistant and susceptible to infection with the low pathogenicity influenza vir...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26787
更新日期:2016-06-09 00:00:00
abstract::Parvalbumin-containing projection neurons of the medial-septum-diagonal band of Broca ([Formula: see text]) are essential for hippocampal rhythms and learning operations yet are poorly understood at cellular and synaptic levels. We combined electrophysiological, optogenetic, and modeling approaches to investigate [For...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80245-w
更新日期:2021-01-22 00:00:00
abstract::Tuned gene expression is crucial to the proper growth and response to the environmental changes of an organism. To enable tunable gene expression as designed is desirable in both scientific research and industrial application. Here, we introduce a novel promoter switching method based on the DDI2 promoter (PDDI2) that...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49000-8
更新日期:2019-08-29 00:00:00
abstract::This paper describes an origami-inspired self-folding method to form three-dimensional (3D) microstructures of co-cultured cells. After a confluent monolayer of fibroblasts (NIH/3T3 cells) with loaded hepatocytes (HepG2 cells) was cultured onto two-dimensional (2D) microplates, degradation of the alginate sacrificial ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22598-x
更新日期:2018-03-14 00:00:00
abstract::Kyoto probe 1 (KP-1) rapidly distinguishes between human ES/iPS (hES/iPS) cells and their differentiated cells. Recently, we generated induced tissue-specific stem cells from pancreas (iTS-P cells) using reprogramming factors and tissue-specific selection. The iTS-P cells have self-renewal potential, and subcutaneousl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75016-6
更新日期:2020-10-22 00:00:00
abstract::Accumulation of advanced glycation end products (AGEs) is linked with development or aggravation of many degenerative processes or disorders, including aging and atherosclerosis. AGEs production in skin cells is known to promote stiffness and loss of elasticity through their buildup in connective tissue. However, the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27848
更新日期:2016-06-13 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-54946-w
更新日期:2019-12-02 00:00:00
abstract::Truffles (Tuber spp.) are the fruiting bodies of symbiotic fungi, which are prized food delicacies. The marked aroma variability observed among truffles of the same species has been attributed to a series of factors that are still debated. This is because factors (i.e. genetics, maturation, geographical location and t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27620-w
更新日期:2018-06-18 00:00:00
abstract::The Langendorff-perfused heart technique has become the model of choice for multiparametric optical mapping of cardiac function and electrophysiology. However, photon scattering in tissues represents a significant drawback of the optical imaging approach, fundamentally limiting its mapping capacity to the heart surfac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32317-1
更新日期:2018-09-20 00:00:00
abstract::We investigated the metabolic outcome of different coping strategies in 129S6/SvEvTac (129Sv) and C57BL/6Ntac (Bl6) strains. Two different batches of male 129Sv and Bl6 mice were used. One batch was not subjected to any behavioral manipulations (home cage control; HCC), whereas the other batch was treated with saline ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21752-9
更新日期:2018-02-21 00:00:00
abstract::Polymersome nanoparticles (PMs) are attractive candidates for spatio-temporal controlled delivery of therapeutic agents. Although many studies have addressed cellular uptake of solid nanoparticles, there is very little data available on intracellular release of molecules encapsulated in membranous carriers, such as po...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29460
更新日期:2016-07-11 00:00:00
abstract::Exploration of macroscopic quantum entanglement is of great interest in both fundamental science and practical application. We investigate a hybrid quantum system that consists of two nitrogen-vacancy centers ensembles (NVE) coupled to a superconducting coplanar waveguide resonator (CPWR). The collective magnetic coup...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21775
更新日期:2016-02-23 00:00:00
abstract::Humans bargaining over money tend to reject unfair offers, whilst chimpanzees bargaining over primary rewards of food do not show this same motivation to reject. Whether such reciprocal fairness represents a predominantly human motivation has generated considerable recent interest. We induced either moderate or severe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00593
更新日期:2012-01-01 00:00:00
abstract::Glypican-3 (GPC3) is a cell-surface heparan sulfate proteoglycan highly expressed in hepatocellular carcinoma (HCC). We have generated a group of high-affinity mouse monoclonal antibodies targeting GPC3. Here, we report the humanization and testing of these antibodies for clinical development. We compared the affinity...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33878
更新日期:2016-09-26 00:00:00
abstract::Heme catabolism exerts physiological functions that impact health through depressing inflammation. Upon reactive pathway progression, as in Gilbert's Syndrome (GS; UGT1A1*28 polymorphism), aggravated health effects have been determined. Based on lower inflammation and improved metabolic health reported for GS, inter-g...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00933-y
更新日期:2017-04-07 00:00:00
abstract::To unravel the molecular mechanism of defense against blister blight (BB) disease caused by an obligate biotrophic fungus, Exobasidium vexans, transcriptome of BB interaction with resistance and susceptible tea genotypes was analysed through RNA-seq using Illumina GAIIx at four different stages during ~20-day disease ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30412
更新日期:2016-07-28 00:00:00
abstract::The spectral properties of Fano resonance generated in multilayer dielectric gratings (MDGs) are reported and numerically investigated in this paper. We examine the MDG consisting of numerous identically alternative chalcogenide glass (As2S3) and silica (SiO2) multilayers with several grating widths inscribed through ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34787-9
更新日期:2018-11-06 00:00:00
abstract::Internal solitary waves (ISWs) in the NE South China Sea (SCS) are tidally generated at the Luzon Strait. Their propagation, evolution, and dissipation processes involve numerous issues still poorly understood. Here, a novel method of seismic oceanography capable of capturing oceanic finescale structures is used to st...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05374
更新日期:2014-06-20 00:00:00
abstract::The interactions of L-type calcium channels (LTCCs) and NMDA receptors (NMDARs) in memories are poorly understood. Here we investigated the specific roles of anterior piriform cortex (aPC) LTCCs and NMDARs in early odor preference memory in mice. Using calcium imaging in aPC slices, LTCC activation was shown to be dep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35256
更新日期:2016-10-14 00:00:00
abstract::Hydrothermal reduction is a promising approach for graphene oxide (GO) reduction since it is environmentally friendly, simple, and cost effective. We present a detailed study of structural changes occurring in graphene oxide during the reduction process. The correlations between the interlayer spacing, chemical states...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25194-1
更新日期:2018-05-01 00:00:00
abstract::Evidence suggest that overexpression of hypoxia-inducible factor-1α (HIF-1α) is linked to multidrug resistance of epilepsy. Here we explored whether aberrant expression of HIF-1α is regulated by miRNAs. Genome-wide microRNA expression profiling was performed on temporal cortex resected from mesial temporal lobe epilep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32091
更新日期:2016-08-24 00:00:00
abstract::Metallic glass (MG) generally fails in a brittle manner under uniaxial tension loading at room temperature. The lack of plastic strain of MG is due to the severe plastic instability via the easily formed one dominate shear band. There have been several approaches to improve the ductility in MG, but achieving uniform t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03319
更新日期:2013-11-25 00:00:00
abstract::In order to obtain a detailed understanding of the modulation of electronic properties in nanoporous Si (np-Si) nanowires with containing ordered, nanometer-sized cylindrical pores, we propose a theoretical method to clarify the band shift and associated with the dielectric modification determined by the geometrical p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14647-8
更新日期:2017-10-31 00:00:00
abstract::Receipt of broad-spectrum antibiotics enhances Candida albicans colonization of the GI tract, a risk factor for haematogenously-disseminated candidiasis. To understand how antibiotics influence C. albicans colonization, we treated mice orally with vancomycin or a combination of penicillin, streptomycin, and gentamicin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08131
更新日期:2015-02-03 00:00:00
abstract::The transforming growth factor beta (TGFβ) related signaling is one of the most important signaling pathways regulating early developmental events. Smad2 and Smad3 are structurally similar and it is mostly considered that they are equally important in mediating TGFβ signals. Here, we show that Smad3 is an insensitive ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21602
更新日期:2016-02-24 00:00:00
abstract::Clinical and experimental studies indicate that muscarinic acetylcholine receptors are potential pharmacological targets for the treatment of neurological diseases. Although these receptors have been described in human, bovine and rat cerebral microvascular tissue, a subtype functional characterization in mouse brain ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05384-z
更新日期:2017-07-11 00:00:00
abstract::The prognosis of pancreatic cancer remains dismal despite continuous and considerable efforts. Integrins (ITGs) are highly expressed in various malignant cancers. However, very few studies investigated the role of integrin α3 (ITGα3) in malignant cancers. Here, we determined the functional role of ITGα3 in pancreatic ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39628-x
更新日期:2019-02-26 00:00:00
abstract::Mortuary practices in human evolution record cognitive, social changes and technological innovations. The Neolithic Revolution in the Levant was a watershed in this domain that has long fascinated the archaeological community. Plaster modelled skulls are well known at Jericho and several other Neolithic sites, and in ...
journal_title:Scientific reports
pub_type: 历史文章,杂志文章
doi:10.1038/srep31053
更新日期:2016-08-09 00:00:00