Features of the cervicovaginal microenvironment drive cancer biomarker signatures in patients across cervical carcinogenesis.

abstract：:Natural Bacillus isolates generate limited amounts of surfactin (<10% of their biomass), which functions as an antibiotic or signalling molecule in inter-/intra-specific interactions. However, overproduction of surfactin in Bacillus amyloliquefaciens MT45 was observed at a titre of 2.93 g/l, which is equivalent to hal...

journal_title：Scientific reports

authors： Zhi Y,Wu Q,Xu Y

更新日期：2017-01-23 00:00:00

abstract：:In general, the poultry industry uses 0.5-1 ppm chlorine solution in the meat sanitization process. However, chlorine can react with organic material and produce halogenated organic compounds, notably chloroform, which causes bladder and rectal cancer in humans. For this reason, many industries try to avoid chlorine. ...

journal_title：Scientific reports

authors： Royintarat T,Choi EH,Boonyawan D,Seesuriyachan P,Wattanutchariya W

更新日期：2020-01-31 00:00:00

abstract：:Neurotransmitter release is mediated by the SNARE complex, but the role of its phosphorylation has scarcely been elucidated. Although PKC activators are known to facilitate synaptic transmission, there has been a heated debate on whether PKC mediates facilitation of neurotransmitter release through phosphorylation. On...

journal_title：Scientific reports

authors： Katayama N,Yamamori S,Fukaya M,Kobayashi S,Watanabe M,Takahashi M,Manabe T

更新日期：2017-08-11 00:00:00

abstract：:All-spin logic device (ASLD) has attracted increasing interests as one of the most promising post-CMOS device candidates, thanks to its low power, non-volatility and logic-in-memory structure. Here we investigate the key current-limiting factors and develop a physics-based model of ASLD through nano-magnet switching, ...

journal_title：Scientific reports

authors： Su L,Zhang Y,Klein JO,Zhang Y,Bournel A,Fert A,Zhao W

更新日期：2015-10-09 00:00:00

abstract：:We demonstrate theoretically that photon-photon attraction can be engineered in the continuum of scattering states for pairs of photons propagating in a hollow-core photonic crystal fiber filled with cold atoms. The atoms are regularly spaced in an optical lattice configuration and the photons are resonantly tuned to ...

journal_title：Scientific reports

authors： Litinskaya M,Tignone E,Pupillo G

更新日期：2016-05-12 00:00:00

abstract：:Unusual protein-like, partially reversible associative behaviour has recently been observed in solutions of the water soluble carbohydrates known as 6-deoxy-6-(ω-aminoalkyl)aminocelluloses, which produce controllable self-assembling films for enzyme immobilisation and other biotechnological applications. Now, for the ...

journal_title：Scientific reports

authors： Nikolajski M,Adams GG,Gillis RB,Besong DT,Rowe AJ,Heinze T,Harding SE

更新日期：2014-01-24 00:00:00

abstract：:In this study, we demonstrate that the lysine methyltransferase G9a inhibits sarcomere organization through regulation of the MEF2C-HDAC5 regulatory axis. Sarcomeres are essential for muscle contractile function. Presently, skeletal muscle disease and dysfunction at the sarcomere level has been associated with mutatio...

journal_title：Scientific reports

authors： Ow JR,Palanichamy Kala M,Rao VK,Choi MH,Bharathy N,Taneja R

更新日期：2016-09-26 00:00:00

abstract：:Oxidative stress and mitochondrial dysfunction have been associated with metabolic and age-related diseases. Thus, the prevention of mitochondrial oxidative damage is nowadays a recognized pharmacological strategy to delay disease progression. Epidemiological studies suggested an association between the consumption of...

journal_title：Scientific reports

authors： Teixeira J,Oliveira C,Amorim R,Cagide F,Garrido J,Ribeiro JA,Pereira CM,Silva AF,Andrade PB,Oliveira PJ,Borges F

更新日期：2017-07-28 00:00:00

abstract：:Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, yet current therapeutic treatments are inadequate due to a complex disease pathogenesis. The plant polyphenol apigenin has been shown to have anti-inflammatory and neuroprotective properties in a number of cell and animal models; however...

journal_title：Scientific reports

authors： Balez R,Steiner N,Engel M,Muñoz SS,Lum JS,Wu Y,Wang D,Vallotton P,Sachdev P,O'Connor M,Sidhu K,Münch G,Ooi L

更新日期：2016-08-12 00:00:00

abstract：:Omniphobic surfaces with reentrant microstructures have been investigated for a range of applications, but the evaporation of high- and low-surface-tension liquid droplets placed on such surfaces has not been rigorously studied. In this work, we develop a technique to fabricate omniphobic surfaces on copper substrates...

journal_title：Scientific reports

authors： Chen X,Weibel JA,Garimella SV

更新日期：2015-11-25 00:00:00

abstract：:Ultrathin transmission metasurface devices are designed on the basis of the Yang-Gu amplitude-phase retrieval algorithm for focusing the terahertz (THz) radiation into four or nine spots with focal spacing of 2 or 3 mm at a frequency of 0.8 THz. The focal properties are experimentally investigated in detail, and the r...

journal_title：Scientific reports

authors： He J,Ye J,Wang X,Kan Q,Zhang Y

更新日期：2016-06-27 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is usually preceded by the oral premalignant lesions, mainly oral leukoplakia (OLK) after repeated insults of carcinogens, tobacco. B(a)P and DMBA are key carcinogens in tobacco smoke. In the present study, for the first time we established the cancerous cell line OSCC-BD induced by...

journal_title：Scientific reports

authors： Dong Y,Zhao Q,Ma X,Ma G,Liu C,Chen Z,Yu L,Liu X,Zhang Y,Shao S,Xiao J,Li J,Zhang W,Fu M,Dong L,Yang X,Guo X,Xue L,Fang F,Zhan Q,Zhang L

更新日期：2015-08-03 00:00:00

abstract：:Carbonatites, usually occurring within intra-continental rift-related settings, have strong light rare earth element (LREE) enrichment; they rarely contain economic heavy REE (HREE). Here, we report the identification of Late Triassic HREE-Mo-rich carbonatites in the northernmost Qinling orogen. The rocks contain abun...

journal_title：Scientific reports

authors： Song W,Xu C,Smith MP,Kynicky J,Huang K,Wei C,Zhou L,Shu Q

更新日期：2016-11-18 00:00:00

abstract：:Living organisms dynamically and flexibly operate a great number of components. As one of such redundant control mechanisms, low-dimensional coordinative structures among multiple components have been investigated. However, structures extracted from the conventional statistical dimensionality reduction methods do not ...

journal_title：Scientific reports

authors： Fujii K,Takeishi N,Kibushi B,Kouzaki M,Kawahara Y

更新日期：2019-11-14 00:00:00

abstract：:This study proposed a novel method to heal microcrack within Mg alloy tubes using high density eddy current pulse treatment (ECPT). Through electromagnetic induction inside a copper coil connected with a high density pulse power source supply, the high density (greater than 5 × 109 A/m2) and short duration eddy curren...

journal_title：Scientific reports

authors： Xu W,Yang C,Yu H,Jin X,Guo B,Shan D

更新日期：2018-04-16 00:00:00

abstract：:Identifying how spatially distributed information becomes integrated in the brain is essential to understanding higher cognitive functions. Previous computational and empirical studies suggest a significant influence of brain network structure on brain network function. However, there have been few analytical approach...

journal_title：Scientific reports

authors： Moon JY,Kim J,Ko TW,Kim M,Iturria-Medina Y,Choi JH,Lee J,Mashour GA,Lee U

更新日期：2017-04-20 00:00:00

abstract：:This article shows that nanodiamonds can transmigrate through the insect cuticle easily, and the doses used were not hemocytotoxic and did not cause inhibition of cellular and humoral immune responses in larvae, pupae and adults of Tenebrio molitor. The examination of the nanodiamond biodistribution in insect cells de...

journal_title：Scientific reports

authors： Czarniewska E,Nowicki P,Kuczer M,Schroeder G

更新日期：2019-07-17 00:00:00

abstract：:Bats are an important reservoir for zoonotic viruses. To date, only three RVA strains have been reported in bats in Kenya and China. In the current study we investigated the genetic diversity of RVAs in fecal samples from 87 straw-colored fruit bats living in close contact with humans in Cameroon using viral metagenom...

journal_title：Scientific reports

authors： Yinda CK,Zeller M,Conceição-Neto N,Maes P,Deboutte W,Beller L,Heylen E,Ghogomu SM,Van Ranst M,Matthijnssens J

更新日期：2016-09-26 00:00:00

abstract：:In this study, 111 Cryptosporidium parvum IId isolates from several species of animals in China, Sweden, and Egypt were subtyped by multilocus sequence typing (MLST). One to eleven subtypes were detected at each of the 12 microsatellite, minisatellite, and single nucleotide polymorphism (SNP) loci, forming 25 MLST sub...

journal_title：Scientific reports

authors： Wang R,Zhang L,Axén C,Bjorkman C,Jian F,Amer S,Liu A,Feng Y,Li G,Lv C,Zhao Z,Qi M,Dong H,Wang H,Sun Y,Ning C,Xiao L

更新日期：2014-02-27 00:00:00

abstract：:Visual field (VF) testing has usually been performed with the central gaze as a fixed point. Recent publications indicated optic nerve head deformations induced by optic nerve traction force can promote the progression of optic neuropathies, including glaucoma. We generated a new static test protocol that adds 6° addu...

journal_title：Scientific reports

authors： Shoji T,Mine I,Kumagai T,Kosaka A,Yoshikawa Y,Shinoda K

更新日期：2020-12-03 00:00:00

abstract：:Histological molecular classification of hepatocellular carcinoma (HCC) is clinically important for predicting the prognosis. However, a reliable serum marker has not been established. The aim of this study was to evaluate the diagnostic value of serum Wisteria Floribunda agglutinin-positive sialylated mucin 1 (WFA-si...

journal_title：Scientific reports

authors： Tamaki N,Kuno A,Matsuda A,Tsujikawa H,Yamazaki K,Yasui Y,Tsuchiya K,Nakanishi H,Itakura J,Korenaga M,Mizokami M,Kurosaki M,Sakamoto M,Narimatsu H,Izumi N

更新日期：2017-03-21 00:00:00

abstract：:Mosquito surveillance is a fundamental component of planning and evaluating vector control programmes. However, logistical and cost barriers can hinder the implementation of surveillance, particularly in vector-borne disease-endemic areas and in outbreak scenarios in remote areas where the need is often most urgent. T...

journal_title：Scientific reports

authors： Hoshi T,Brugman VA,Sato S,Ant T,Tojo B,Masuda G,Kaneko S,Moji K,Medlock JM,Logan JG

更新日期：2019-08-06 00:00:00

abstract：:The clinical and mycobacterial features of tuberculous meningitis (TBM) cases in China are not well described; especially in western provinces with poor tuberculosis control. We prospectively enrolled patients in whom TBM was considered in Shaanxi Province, northwestern China, over a 2-year period (September 2010 to D...

journal_title：Scientific reports

authors： Wang T,Feng GD,Pang Y,Liu JY,Zhou Y,Yang YN,Dai W,Zhang L,Li Q,Gao Y,Chen P,Zhan LP,Marais BJ,Zhao YL,Zhao G

更新日期：2016-05-04 00:00:00

abstract：:Hydrogen has therapeutic and preventive effects against various diseases. Although animal and clinical studies have reported promising results, hydrogen distribution in organs after administration remains unclear. Herein, the sequential changes in hydrogen concentration in tissues over time were monitored using a high...

journal_title：Scientific reports

authors： Yamamoto R,Homma K,Suzuki S,Sano M,Sasaki J

更新日期：2019-02-04 00:00:00

abstract：:The effect of hypoglycemia on the progression of atherosclerosis in patients with type 2 diabetes mellitus (T2DM) remains largely unknown. This is a post hoc analysis of a randomized trial to investigate the relationship between hypoglycemic episodes and changes in carotid intima-media thickness (IMT). Among 274 study...

journal_title：Scientific reports

authors： Mita T,Katakami N,Shiraiwa T,Yoshii H,Kuribayashi N,Osonoi T,Kaneto H,Kosugi K,Umayahara Y,Gosho M,Shimomura I,Watada H

更新日期：2017-01-09 00:00:00

abstract：:Horizontal gene transfer (HGT) was attributed as a major driving force for the innovation and evolution of prokaryotic genomes. Previously, multiple research endeavors were undertaken to decipher HGT in different bacterial lineages. The genus Mycobacterium houses some of the most deadly human pathogens; however, the i...

journal_title：Scientific reports

authors： Panda A,Drancourt M,Tuller T,Pontarotti P

更新日期：2018-10-04 00:00:00

abstract：:Transgenic sheep can be used to achieve genetic improvements in breeds and as an important large-animal model for biomedical research. In this study, we generated a TALEN plasmid specific for ovine MSTN and transfected it into fetal fibroblast cells of STH sheep. MSTN biallelic-KO somatic cells were selected as nuclea...

journal_title：Scientific reports

authors： Li H,Wang G,Hao Z,Zhang G,Qing Y,Liu S,Qing L,Pan W,Chen L,Liu G,Zhao R,Jia B,Zeng L,Guo J,Zhao L,Zhao H,Lv C,Xu K,Cheng W,Li H,Zhao HY,Wang W,Wei HJ

更新日期：2016-09-22 00:00:00

abstract：:The competitive multi-armed bandit (CMAB) problem is related to social issues such as maximizing total social benefits while preserving equality among individuals by overcoming conflicts between individual decisions, which could seriously decrease social benefits. The study described herein provides experimental evide...

journal_title：Scientific reports

authors： Chauvet N,Jegouso D,Boulanger B,Saigo H,Okamura K,Hori H,Drezet A,Huant S,Bachelier G,Naruse M

更新日期：2019-08-22 00:00:00

abstract：:Nanoporous electrodes have received great attention because of their unique electrochemical properties. Here, the electrocatalytic oxygen evolution reaction (OER) activities at porous Pt layers with pore dimensions in the microporous range were examined. The OER activity of the porous Pt layers in acidic media increas...

journal_title：Scientific reports

authors： Lim T,Sung M,Kim J

更新日期：2017-11-13 00:00:00

abstract：:Acoustic structure quantification (ASQ) is a recently developed technique widely used for detecting liver fibrosis. Ultrasound Nakagami parametric imaging based on the Nakagami distribution has been widely used to model echo amplitude distribution for tissue characterization. We explored the feasibility of using ultra...

journal_title：Scientific reports

authors： Tsui PH,Ho MC,Tai DI,Lin YH,Wang CY,Ma HY

更新日期：2016-09-08 00:00:00