Abstract：
:Unusual protein-like, partially reversible associative behaviour has recently been observed in solutions of the water soluble carbohydrates known as 6-deoxy-6-(ω-aminoalkyl)aminocelluloses, which produce controllable self-assembling films for enzyme immobilisation and other biotechnological applications. Now, for the first time, we have found a fully reversible self-association (tetramerisation) within this family of polysaccharides. Remarkably these carbohydrate tetramers are then seen to associate further in a regular way into supra-molecular complexes. Fully reversible oligomerisation has been hitherto completely unknown for carbohydrates and instead resembles in some respects the assembly of polypeptides and proteins like haemoglobin and its sickle cell mutation. Our traditional perceptions as to what might be considered "protein-like" and what might be considered as "carbohydrate-like" behaviour may need to be rendered more flexible, at least as far as interaction phenomena are concerned.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Nikolajski M,Adams GG,Gillis RB,Besong DT,Rowe AJ,Heinze T,Harding SEdoi
10.1038/srep03861subject
Has Abstractpub_date
2014-01-24 00:00:00pages
3861issn
2045-2322pii
srep03861journal_volume
4pub_type
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