Abstract:
:Recent skin metagenomic studies have investigated the harbored viral diversity and its possible influence on healthy skin microbial populations, and tried to establish global patterns of skin-phage evolution. However, the detail associated with the phages that potentially play a role in skin health has not been investigated. While skin metagenome and -metavirome studies have indicated that the skin virome is highly site specific and shows marked interpersonal variation, they have not assessed the presence/absence of individual phages. Here, we took a semi-culture independent approach (metaviromic) to better understand the composition of phage communities on skin from South African study participants. Our data set adds over 130 new phage species of the skin to existing databases. We demonstrated that identical phages were present on different individuals and in different body sites, and we conducted a detailed analysis of the structural organization of these phages. We further found that a bacteriophage related to the Staphylococcus capitis phage Stb20 may be a common skin commensal virus potentially regulating its host and its activities on the skin.
journal_name
Sci Repjournal_title
Scientific reportsauthors
van Zyl LJ,Abrahams Y,Stander EA,Kirby-McCollough B,Jourdain R,Clavaud C,Breton L,Trindade Mdoi
10.1038/s41598-018-30705-1subject
Has Abstractpub_date
2018-08-16 00:00:00pages
12265issue
1issn
2045-2322pii
10.1038/s41598-018-30705-1journal_volume
8pub_type
杂志文章abstract::Oxytocin (OXT) is an important neuromodulator of social behaviors via activation of both oxytocin receptors (OXTR) and vasopressin (AVP) 1a receptors (AVPR1a). Marmosets are neotropical primates with a modified OXT ligand (Pro8-OXT), and this ligand shows significant coevolution with traits including social monogamy a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52024-9
更新日期:2019-10-29 00:00:00
abstract::Multiple parasitic arthropods of medical importance depend on symbiotic bacteria. While the link between scabies and secondary bacterial infections causing post infective complications of Group A streptococcal and staphylococcal pyoderma is increasingly recognized, very little is known about the microbiota of Sarcopte...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47892-0
更新日期:2019-08-13 00:00:00
abstract::MicroRNAs (miRNAs) are important effectors in mediating host-pathogen interaction. In this report, coelomocytes miRNA libraries of three Japanese sea cucumbers Apostichopus japonicus were built by Illumina(®) Hiseq2000 from different time points after lipopolysaccharide challenge (at time 0 h, 6 h and 12 h). The clean...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17763
更新日期:2015-12-04 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-64153-7
更新日期:2020-04-29 00:00:00
abstract::Currently, diagnostic testing for Lyme disease is done by determination of the serologic responses to Borrelia burgdorferi antigens, with the exception of the early localized phase of disease where diagnosis must be done clinically. Here, we describe the use of microfluidics technology to develop a multiplexed rapid l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35069
更新日期:2016-10-11 00:00:00
abstract::Microalgae and plankton can be a rich source of bioactivity. However, induction of secondary metabolite production in lab conditions can be difficult. One simple way of bypassing this issue is to collect biomass in the field and screen for bioactivity. Therefore, bulk net samples from three areas along the coast of no...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15980-8
更新日期:2017-11-20 00:00:00
abstract::Transistor biosensors are mass-fabrication-compatible devices of interest for point of care diagnosis as well as molecular interaction studies. While the actual transistor gates in processors reach the sub-10 nm range for optimum integration and power consumption, studies on design rules for the signal-to-noise ratio ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69493-y
更新日期:2020-07-29 00:00:00
abstract::Interferon regulatory factor 3 (IRF3) and IRF7 are closely related IRF members and the major factors for the induction of interferons, a key component in vertebrate innate immunity. However, there is limited knowledge regarding the evolution and adaptation of those IRFs to the environments. Two unique motifs in IRF3 a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61365-9
更新日期:2020-03-11 00:00:00
abstract::Toll-like receptors (TLRs), as innate immunity sensors, play critical roles in immune responses. Six SNPs of TLR3, TLR7, and TLR8 were genotyped to determine their associations with systemic lupus erythematosus (SLE) and clinical manifestations of SLE. TLR7 SNP rs3853839 was independently associated with SLE susceptib...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03792
更新日期:2014-01-21 00:00:00
abstract::The annotation of genomic ranges of interest represents a recurring task for bioinformatics analyses. These ranges can originate from various sources, including peaks called for transcription factor binding sites (TFBS) or histone modification ChIP-seq experiments, chromatin structure and accessibility experiments (su...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02464-y
更新日期:2017-06-01 00:00:00
abstract::To enhance the carbon dioxide (CO2) uptake of metal-organic frameworks (MOFs), amine functionalization of their pore surfaces has been studied extensively. In general, amine-functionalized MOFs have been synthesized via post-synthetic modifications. Herein, we introduce a one-step construction of a MOF ([(NiLethylamin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19337
更新日期:2016-01-13 00:00:00
abstract::Microscopic plastic (microplastic, 0.1 µm-5 mm) is a widespread pollutant impacting upon aquatic ecosystems across the globe. Environmental sampling has revealed synthetic fibers are prevalent in seawater, sediments and biota. However, microplastic fibers are rarely used in laboratory studies as they are unavailable f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34519
更新日期:2016-10-03 00:00:00
abstract::We isolated a novel bacterial strain from a prokaryotic consortium associated to the psychrophilic marine ciliate Euplotes focardii, endemic of the Antarctic coastal seawater. The 16S rDNA sequencing and the phylogenetic analysis revealed the close evolutionary relationship to the Antarctic marine bacterium Marinomona...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66878-x
更新日期:2020-06-23 00:00:00
abstract::Cell counts decrease with sediment depth. Typical explanations consider limiting factors such as water availability and chemistry, carbon source, nutrients, energy and temperature, and overlook the role of pore size. Our analyses consider sediment self-compaction, the evolution of pore size with depth, and the probabi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78714-3
更新日期:2020-12-10 00:00:00
abstract::After domestication in the Near East around 10,000 years ago several founder crops, flax included, spread to European latitudes. On reaching northerly latitudes the architecture of domesticated flax became more suitable to fiber production over oil, with longer stems, smaller seeds and fewer axillary branches. Latitud...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37086-5
更新日期:2019-01-30 00:00:00
abstract::Pseudooxynicotine amine oxidase (Pnao) is essential to the pyrrolidine pathway of nicotine degradation of Pseudomonas putida strain S16, which is significant for the detoxification of nicotine, through removing the CH3NH2 group. However, little is known about biochemical mechanism of this enzyme. Here, we characterize...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17770
更新日期:2015-12-04 00:00:00
abstract::Phages infecting Aeromonas salmonicida subsp. salmonicida, the causative agent of the fish disease furunculosis, have been isolated for decades but very few of them have been characterized. Here, the host range of 12 virulent phages, including three isolated in the present study, was evaluated against a panel of 65 A....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07401-7
更新日期:2017-08-01 00:00:00
abstract::Liquid pumping can occur along the outer surface of an electrode under a DC electric field. For biological applications, a better understanding of the ionic solution pumping mechanism is required. Here, we fabricated CNT wire electrodes (CWEs) and tungsten wire electrodes (TWEs) of various diameters to assess an ionic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11799
更新日期:2015-07-02 00:00:00
abstract::Maize streak virus disease (MSVD), caused by Maize streak virus (MSV; genus Mastrevirus), is one of the most severe and widespread viral diseases that adversely reduces maize yield and threatens food security in Africa. An effective control and management of MSVD requires robust and sensitive diagnostic tests capable ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76612-2
更新日期:2020-11-12 00:00:00
abstract::Tumor microenvironment favors tumor cells to promote their growth and metastasis such as migration, invasion, and angiogenesis. IL-1β, one of the inflammatory cytokines released from myeloid cells in tumor microenvironment, plays an important role in development and progress of tumor. The activation of inflammasome is...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48794-x
更新日期:2019-08-22 00:00:00
abstract::The ability of deep learning architectures to identify glaucomatous optic neuropathy (GON) in fundus photographs was evaluated. A large database of fundus photographs (n = 14,822) from a racially and ethnically diverse group of individuals (over 33% of African descent) was evaluated by expert reviewers and classified ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35044-9
更新日期:2018-11-12 00:00:00
abstract::Neuroinflammation and accompanying microglial dysfunction are now appreciated to be involved in Alzheimer's disease (AD) pathogenesis. Critical to the process of neuroinflammation are the type-I interferon (IFN) family of cytokines. Efforts to phenotypically characterize microglia within AD identify distinct populatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59917-0
更新日期:2020-02-21 00:00:00
abstract::Recent increases in family planning (FP) use have been reported among women of reproductive age in union (WRAU) in Senegal. However, trends have not been monitored among harder-to-reach groups (including adolescents, unmarried and rural poor women), key to understanding whether FP progress is equitable. We combined da...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41006
更新日期:2017-01-20 00:00:00
abstract::We sought to analyse plasma levels of peripheral blood microRNAs (miRs) as biomarkers of ST-segment-elevation myocardial infarction (STEMI) due to type-1 myocardial infarction as a model situation of vulnerable plaque (VP) rupture. Samples of 20 patients with STEMI were compared both with a group of patients without a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62835-w
更新日期:2020-04-03 00:00:00
abstract::Recombination is crucial for biological evolution, which provides many new combinations of genetic diversity. Accurate identification of recombination spots is useful for DNA function study. To improve the prediction accuracy, researchers have proposed several computational methods for recombination spot identificatio...
journal_title:Scientific reports
pub_type: 杂志文章,收录出版
doi:10.1038/srep23934
更新日期:2016-03-31 00:00:00
abstract::Bacterial communities in wastewater treatment plants (WWTPs) affect plant functionality through their role in the removal of pollutants from wastewater. Bacterial communities vary extensively based on plant operating conditions and influent characteristics. The capacity of WWTPs can also affect the bacterial community...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50952-0
更新日期:2019-10-15 00:00:00
abstract::Liver cancer stem cells (LCSCs) have attracted attention because they cause therapeutic resistance in hepatocellular carcinoma (HCC). Understanding the metabolism of LCSCs can be a key to developing therapeutic strategy, but metabolic characteristics have not yet been studied. Here, we systematically analyzed and comp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45557
更新日期:2017-04-03 00:00:00
abstract::Nucleoporins have been reported to regulate pluripotent biology, but how they do so remains partially characterized. This study examined the effects of nup155 gene disruption on mouse embryonic stem cells to gain insights into possible mechanisms by which nucleoporins regulate pluripotency in a pro-arrhythmogenic stem...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49147-4
更新日期:2019-09-03 00:00:00
abstract::Invasive infections caused by drug-resistant bacteria are frequently responsible for fatal sepsis, morbidity and mortality rates. In this work, we propose a new methodology based on nanosecond high frequency electric field bursts, which enables successful eradication of bacteria in vivo. High frequency (15 kHz) 15-25 ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32783-7
更新日期:2018-09-28 00:00:00
abstract::Coral reefs across the world's oceans are in the midst of the longest bleaching event on record (from 2014 to at least 2016). As many of the world's reefs are remote, there is limited information on how past thermal conditions have influenced reef composition and current stress responses. Using satellite temperature d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38402
更新日期:2016-12-06 00:00:00