Abstract：
:Living organisms dynamically and flexibly operate a great number of components. As one of such redundant control mechanisms, low-dimensional coordinative structures among multiple components have been investigated. However, structures extracted from the conventional statistical dimensionality reduction methods do not reflect dynamical properties in principle. Here we regard coordinative structures in biological periodic systems with unknown and redundant dynamics as a nonlinear limit-cycle oscillation, and apply a data-driven operator-theoretic spectral analysis, which obtains dynamical properties of coordinative structures such as frequency and phase from the estimated eigenvalues and eigenfunctions of a composition operator. Using segmental angle series during human walking as an example, we first extracted the coordinative structures based on dynamics; e.g. the speed-independent coordinative structures in the harmonics of gait frequency. Second, we discovered the speed-dependent time-evolving behaviours of the phase by estimating the eigenfunctions via our approach on the conventional low-dimensional structures. We also verified our approach using the double pendulum and walking model simulation data. Our results of locomotion analysis suggest that our approach can be useful to analyse biological periodic phenomena from the perspective of nonlinear dynamical systems.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Fujii K,Takeishi N,Kibushi B,Kouzaki M,Kawahara Ydoi
10.1038/s41598-019-53187-1subject
Has Abstractpub_date
2019-11-14 00:00:00pages
16755issue
1issn
2045-2322pii
10.1038/s41598-019-53187-1journal_volume
9pub_type
杂志文章abstract：:Early diagnosis of hepatocellular carcinoma (HCC) remains challenging to date. Characteristic metabolic deregulations of HCC may enable novel biomarkers discovery for early diagnosis. A capillary electrophoresis-time of flight mass spectrometry (CE-TOF/MS)-based metabolomics approach was performed to discover and vali...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16101
更新日期：2015-11-03 00:00:00
abstract：:Helicobacter pylori cagA-positive strain delivers the CagA oncoprotein into gastric epithelial cells and at the same time elicits stomach inflammation. To experimentally investigate the pathophysiological interplay between CagA and inflammation, transgenic mice systemically expressing the bacterial cagA gene were trea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10024
更新日期：2015-05-06 00:00:00
abstract：:Nontuberculous mycobacteria (NTM) are environmental bacteria increasingly associated to public health problems. In water systems, free-living amoebae (FLA) feed on bacteria by phagocytosis, but several bacteria, including many NTM, are resistant to this predation. Thus, FLA can be seen as a training ground for pathoge...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46270
更新日期：2017-04-10 00:00:00
abstract：:Which factors are related to false negative results of the interferon-γ release assay (IGRA) is unclear. This systematic review described the risk factors associated with false negative IGRA results. Two authors independently identified studies designed to evaluate risk factors for false negative IGRA results from Pub...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-020-58459-9
更新日期：2020-01-31 00:00:00
abstract：:The red coral Corallium rubrum is a habitat-forming species with a prominent and structural role in mesophotic habitats, which sustains biodiversity hotspots. This precious coral is threatened by both over-exploitation and temperature driven mass mortality events. We report here that biocalcification, growth rates and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01457
更新日期：2013-01-01 00:00:00
abstract：:Barley (Hordeum vulgare L.) produces five leucine-derived hydroxynitrile glucosides, potentially involved in alleviating pathogen and environmental stresses. These compounds include the cyanogenic glucoside epiheterodendrin. The biosynthetic genes are clustered. Total hydroxynitrile glucoside contents were previously ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41884-w
更新日期：2019-04-05 00:00:00
abstract：:We aimed to discover novel associations between leptin and circulating proteins which could link leptin to the development of cardiovascular disease in patients with type 2 diabetes (T2DM). In a discovery phase, we investigated associations between 88 plasma proteins, assessed with a proximity extension assay, and pla...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69473-2
更新日期：2020-08-04 00:00:00
abstract：:Accumulating evidence indicates the association between obesity and lung function. However, no previous study has examined whether obesity affects lung function in normal weight participants with high body fat. We hypothesized that subjects with normal weight obesity (NWO) were inversely associated with lung function ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38804-3
更新日期：2019-06-20 00:00:00
abstract：:To begin studies on reproduction in common bed bug, Cimex lectularius, we identified three genes coding for vitellogenin (Vg, a protein required for the reproductive success of insects) and studied their hormonal regulation. RNA interference studied showed that expression of Vg3 gene in the adult females is a prerequi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35546
更新日期：2016-10-20 00:00:00
abstract：:The development of human induced pluripotent stem cell (iPSC) technology has revolutionized the regenerative medicine field. This technology provides a powerful tool for disease modeling and drug screening approaches. To circumvent the risk of random integration into the host genome caused by retroviruses, non-integra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08081
更新日期：2015-01-28 00:00:00
abstract：:Norovirus is one of the most common causes of gastroenteritis. Following infection, anti-norovirus salivary immunoglobulin G (IgG) rises steeply within 2 weeks and remains elevated for several months; this immunoconversion can serve as an indicator of infection. We used a multiplex salivary immunoassay to study norovi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56040-7
更新日期：2019-12-20 00:00:00
abstract：:Climate change and human activity are dooming species at an unprecedented rate via a plethora of direct and indirect, often synergic, mechanisms. Among these, primary extinctions driven by environmental change could be just the tip of an enormous extinction iceberg. As our understanding of the importance of ecological...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35068-1
更新日期：2018-11-13 00:00:00
abstract：:Decrease in blood concentration of branched-chain amino acids, especially leucine, is known to promote liver carcinogenesis in patients with chronic liver disease, but the mechanism is unclear. We herein established hepatocellular carcinoma (HCC) cells knocked out for DEPDC5 by using the CRISPR/Cas9 system, and elucid...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18323-9
更新日期：2018-01-08 00:00:00
abstract：:This study is to investigate the frequencies of T-helper (Th)22, Th17 and Th1 cells and the levels of related cytokines in subchondral bone marrow in patients with rheumatoid arthritis (RA). Bone marrow and peripheral blood samples were collected from RA, osteoarthritis (OA) patients and healthy controls. The frequenc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05014-8
更新日期：2017-07-06 00:00:00
abstract：:We investigated retinal structure and function in eyes with optic nerve hypoplasia (ONH). Twenty-nine eyes of 18 patients with ONH and 21 eyes of 21 control patients were analyzed. Spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (FF-ERG), and focal macular ERG (FM-ERG) were perfor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42480
更新日期：2017-02-16 00:00:00
abstract：:Accurate evaluation of individual risk of intravenous immunoglobin (IVIG)-resistance is critical for adopting regimens for the first treatment and prevention of coronary artery lesions (CALs) in patients with Kawasaki disease (KD). METHODS:The KD patients hospitalized in Chongqing Children's Hospital, in west China, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39330-y
更新日期：2019-02-11 00:00:00
abstract：:We investigate collective modes in three dimensional (3D) gapless multi-Weyl semimetals with anisotropic energy band dispersions (i.e., with a positive integer J). For comparison, we also consider the gapless semimetals with the isotropic band dispersions (i.e. E ~ kJ). We calculate analytically long-wavelength plasma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34023
更新日期：2016-09-30 00:00:00
abstract：:Any processing delay between the two eyes can result in illusory 3D percepts for moving objects because of either changes in the pure disparities over time for disparity sensors or by changes to sensors that encode motion/disparity conjointly. This is demonstrated by viewing a fronto-parallel pendulum through a neutra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06151-w
更新日期：2017-07-17 00:00:00
abstract：:We report abnormal magnetic field effects on electrogenerated chemiluminescence (MFEECL) based on triplet emission from the Ru(bpy)3Cl2-TPrA electrochemical system: the appearance of MFEECL after magnetic field ceases. In early studies the normal MFEECL have been observed from electrochemical systems during the applic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09105
更新日期：2015-03-16 00:00:00
abstract：:Classical swine fever (CSF) is a notifiable, highly contagious viral disease of swine which results in severe welfare and economic consequences in affected countries. To improve preparedness, it is critical to have some understanding of how CSF would spread should it be introduced. Based on the data recorded during th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42992
更新日期：2017-02-22 00:00:00
abstract：:Although stenting of non-branched arterial segments has acceptable clinical outcomes, in-stent restenosis (ISR) and stent thrombosis remain clinically significant issues for vascular bifurcations (15-28% restenosis). Local fluid and solid stresses appear to play an important role in restenosis and thrombosis. The comb...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66777-1
更新日期：2020-06-15 00:00:00
abstract：:Despite advances in stem cell research, cell transplantation therapy for liver failure is impeded by a shortage of human primary hepatocytes (HPH), along with current differentiation protocol limitations. Several studies have examined the concept of co-culture of human induced pluripotent cells (hiPSCs) with various t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45514-3
更新日期：2019-06-20 00:00:00
abstract：:Many systems biology studies lack context-relevant data and as a consequence the predictive capabilities can be limited in developing targeted cancer therapeutics. Production of colon crypt in vitro is ideal for studying colon systems biology. This report presents the first production of, to our knowledge, physiologic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11036
更新日期：2015-06-18 00:00:00
abstract：:Two embedded sulfur atoms in a novel [2 + 2] Schiff-base macrocyclic dinuclear Zn(II) complex were found to be easily autoxidized to the sulfone units on air exposure, and the resultant sulfone-functionalized macrocyclic complex was obtained by the post-modification strategy exhibiting enhanced antimicrobial activitie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15898-1
更新日期：2017-11-21 00:00:00
abstract：:The Glycoside hydrolase (GH) family 70 originally was established for glucansucrases of lactic acid bacteria (LAB) converting sucrose into α-glucan polymers. In recent years we have identified 3 subfamilies of GH70 enzymes (designated GtfB, GtfC and GtfD) as 4,6-α-glucanotransferases, cleaving (α1 → 4)-linkages in mal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07190-z
更新日期：2017-08-30 00:00:00
abstract：:From the viewpoint of thermodynamics, the formation of DNA loops and the interaction between them, which are all non-equilibrium processes, result in the change of free energy, affecting gene expression and further cell-to-cell variability as observed experimentally. However, how these processes dissipate free energy ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12765-x
更新日期：2017-10-03 00:00:00
abstract：:Biochar (BC) and magnetite (Fe3O4) nanoparticles (MNP) have both received considerable recent attention in part due to their potential use in water treatment. While both are effective independently in the removal of a range of anionic metals from aqueous solution, the efficacy of these materials is reduced considerabl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75924-7
更新日期：2020-11-04 00:00:00
abstract：:Solar thermoelectric generators (STEGs), which are used for various applications, (particularly small size electronic devices), have optical concentration systems for high energy conversion efficiency. In this study, a refraction-assisted STEG (R-STEG) is designed based on phase-change materials. As the phase-change m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27913
更新日期：2016-06-10 00:00:00
abstract：:The coupling of the surface plasmon near-field into the sensing medium is key to the sensitivity of surface plasmon-based sensing devices. A low-index dielectric is necessary for the sensing medium to support a highly-penetrating surface plasmon evanescent field that extends well into the dielectric medium. The air-li...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38859-2
更新日期：2019-02-19 00:00:00
abstract：:Omega-3 fatty acids, and specifically docosahexaenoic acid (DHA), are important and essential nutrients for human health. Thraustochytrids are recognised as commercial strains for nutraceuticals production, they are group of marine oleaginous microorganisms capable of co-synthesis of DHA and other valuable carotenoids...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58728-7
更新日期：2020-02-06 00:00:00
