Air-like plasmonics with ultralow-refractive-index silica aerogels.

abstract：:Accumulating evidence have shown the association of Parkinson's disease (PD) with osteoporosis. Bone loss in PD patients, considered to be multifactorial and a result of motor disfunction, is a hallmark symptom that causes immobility and decreased muscle strength, as well as malnutrition and medication. However, no kn...

journal_title：Scientific reports

authors： Handa K,Kiyohara S,Yamakawa T,Ishikawa K,Hosonuma M,Sakai N,Karakawa A,Chatani M,Tsuji M,Inagaki K,Kiuchi Y,Takami M,Negishi-Koga T

更新日期：2019-09-24 00:00:00

abstract：:Modern Computed Tomography (CT) scanners are capable of acquiring contrast dynamics of the whole brain, adding functional to anatomical information. Soft tissue segmentation is important for subsequent applications such as tissue dependent perfusion analysis and automated detection and quantification of cerebral patho...

journal_title：Scientific reports

authors： Manniesing R,Oei MTH,Oostveen LJ,Melendez J,Smit EJ,Platel B,Sánchez CI,Meijer FJA,Prokop M,van Ginneken B

更新日期：2017-03-09 00:00:00

abstract：:Cell fate decisions are controlled by the interplay of transcription factors and epigenetic modifiers, which together determine cellular identity. Here we elaborate on the role of miR302 in the regulation of cell plasticity. Overexpression of miR302 effected silencing of the TGFβ type II receptor and facilitated plast...

journal_title：Scientific reports

authors： De Chiara L,Andrews D,Watson A,Oliviero G,Cagney G,Crean J

更新日期：2017-02-14 00:00:00

abstract：:Tacrolimus has a narrow therapeutic window and considerable variability in clinical use. Our goal was to compare the performance of multiple linear regression (MLR) and eight machine learning techniques in pharmacogenetic algorithm-based prediction of tacrolimus stable dose (TSD) in a large Chinese cohort. A total of ...

journal_title：Scientific reports

authors： Tang J,Liu R,Zhang YL,Liu MZ,Hu YF,Shao MJ,Zhu LJ,Xin HW,Feng GW,Shang WJ,Meng XG,Zhang LR,Ming YZ,Zhang W

更新日期：2017-02-08 00:00:00

abstract：:Topological quantum computation has been extensively studied in the past decades due to its robustness against decoherence. One way to realize the topological quantum computation is by adiabatic evolutions-it requires relatively long time to complete a gate, so the speed of quantum computation slows down. In this work...

journal_title：Scientific reports

authors： Shi ZC,Wang W,Yi XX

更新日期：2016-02-25 00:00:00

abstract：:Available CFTR modulators provide no therapeutic benefit for cystic fibrosis (CF) caused by many loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel, including N1303K. We previously introduced the concept of 'co-potentiators' (combination-potentiators) to rescu...

journal_title：Scientific reports

authors： Phuan PW,Tan JA,Rivera AA,Zlock L,Nielson DW,Finkbeiner WE,Haggie PM,Verkman AS

更新日期：2019-11-27 00:00:00

abstract：:The lack of bone morphological markers associated with the human control of wild animals has prevented the documentation of incipient animal domestication in archaeology. Here, we assess whether direct environmental changes (i.e. mobility reduction) could immediately affect ontogenetic changes in long bone structure, ...

journal_title：Scientific reports

authors： Harbers H,Zanolli C,Cazenave M,Theil JC,Ortiz K,Blanc B,Locatelli Y,Schafberg R,Lecompte F,Baly I,Laurens F,Callou C,Herrel A,Puymerail L,Cucchi T

更新日期：2020-11-04 00:00:00

abstract：:Previous studies have evaluated gene expression in Alzheimer's disease (AD) brains to identify mechanistic processes, but have been limited by the size of the datasets studied. Here we have implemented a novel meta-analysis approach to identify differentially expressed genes (DEGs) in published datasets comprising 450...

journal_title：Scientific reports

authors： Li X,Long J,He T,Belshaw R,Scott J

更新日期：2015-07-23 00:00:00

abstract：:The repeated measurements of heart rate variability (HRV) is more relevant than a single HRV measurement in predicting patient prognosis but is less addressed previously. This prospective study aimed to investigate the association between repeated measurements of HRV and long-term mortality in chronic hemodialysis pat...

journal_title：Scientific reports

authors： Chang YM,Huang YT,Chen IL,Yang CL,Leu SC,Su HL,Kao JL,Tsai SC,Jhen RN,Shiao CC

更新日期：2020-01-21 00:00:00

abstract：:Wet-chemistry methods have crucial advantages for the synthesis of nanostructures, including simple, low-cost, large-area, and low-temperature deposition on almost arbitrary substrates. Nevertheless, the rational design of improved wet-chemistry procedures is extremely difficult because, in practice, only post-synthes...

journal_title：Scientific reports

authors： Orsini A,Falconi C

更新日期：2014-09-05 00:00:00

abstract：:Bruton tyrosine kinase (BTK) is a key enzyme in B-cell development whose improper regulation causes severe immunodeficiency diseases. Design of selective BTK therapeutics would benefit from improved, in-silico structural modeling of the kinase's solution ensemble. However, this remains challenging due to the immense c...

journal_title：Scientific reports

authors： Sultan MM,Denny RA,Unwalla R,Lovering F,Pande VS

更新日期：2017-11-15 00:00:00

abstract：:A novel polyphenolic natural product, galewone, with undescribed carbon skeleton, was isolated as a racemate from the culture of Daldinia eschscholzii IFB-TL01, a fungus obtained from the mantis (Tenodera aridifolia) gut. The galewone structure was elucidated by a combination of MS and NMR spectra, and substantiated b...

journal_title：Scientific reports

authors： Zhang AH,Jiang N,Wang XQ,Tan RX

更新日期：2019-10-04 00:00:00

abstract：:Glial fibrillary acidic protein expressing (GFAP+) glia modulate nociceptive neuronal activity in both the peripheral nervous system (PNS) and the central nervous system (CNS). Resident GFAP+ glia in dorsal root ganglia (DRG) known as satellite glial cells (SGCs) potentiate neuronal activity by releasing pro-inflammat...

journal_title：Scientific reports

authors： Xie AX,Madayag A,Minton SK,McCarthy KD,Malykhina AP

更新日期：2020-08-25 00:00:00

abstract：:CD134 (OX40) is a member of the tumour necrosis factor receptor superfamily (TNFRSF). It acts as a costimulatory receptor on T cells, but its role on NK cells is poorly understood. CD137, another TNFRSF member has been shown to enhance the anti-tumour activity of NK cells in various malignancies. Here, we examine the ...

journal_title：Scientific reports

authors： Turaj AH,Cox KL,Penfold CA,French RR,Mockridge CI,Willoughby JE,Tutt AL,Griffiths J,Johnson PWM,Glennie MJ,Levy R,Cragg MS,Lim SH

更新日期：2018-02-02 00:00:00

abstract：:We have observed that one in three patients admitted to the Neurological Rehabilitation Ward for Children and Adolescents due to a syndrome or disease associated with neurodysfunction is short of stature for their age. In order to identify the relationship between growth defects (short stature) and syndromes or diseas...

journal_title：Scientific reports

authors： Perenc L,Guzik A,Podgórska-Bednarz J,Drużbicki M

更新日期：2019-11-11 00:00:00

abstract：:The obesity-associated inflammation of white adipose tissue (WAT) is one of the factors leading to the development of related diseases such as insulin resistance and liver steatosis. Recently, microRNAs (miRNAs) were identified as important regulators of WAT functions. Herein, we cultured human Simpson-Golabi-Behmel s...

journal_title：Scientific reports

authors： Roos J,Enlund E,Funcke JB,Tews D,Holzmann K,Debatin KM,Wabitsch M,Fischer-Posovszky P

更新日期：2016-12-06 00:00:00

abstract：:Anthracnose, caused by the Colletotrichum species of fungi, is one of the most serious diseases affecting jute in China. The disease causes chlorotic regions with black brown sunken necrotic pits on the surfaces of stems. In late stages of disease, plants undergo defoliation, dieback and blight, which make anthracnose...

journal_title：Scientific reports

authors： Niu X,Gao H,Qi J,Chen M,Tao A,Xu J,Dai Z,Su J

更新日期：2016-04-28 00:00:00

abstract：:To improve the performance of solar photovoltaic devices one should mitigate three types of losses: optical, electrical and thermal. However, further reducing the optical and electrical losses in modern photovoltaic devices is becoming increasingly costly. Therefore, there is a rising interest in minimizing the therma...

journal_title：Scientific reports

authors： Vaillon R,Dupré O,Cal RB,Calaf M

更新日期：2018-09-03 00:00:00

abstract：:Excessive activation of inflammation and the accompanying lung vascular endothelial barrier disruption are primary pathogenic features of acute lung injury (ALI). Microtubule-associated protein 4 (MAP4), a tubulin assembly-promoting protein, is important for maintaining the microtubule (MT) cytoskeleton and cell-cell ...

journal_title：Scientific reports

authors： Li L,Hu J,He T,Zhang Q,Yang X,Lan X,Zhang D,Mei H,Chen B,Huang Y

更新日期：2015-03-09 00:00:00

abstract：:Quality assessment of protein models using no other information than the structure of the model itself has been shown to be useful for structure prediction. Here, we introduce two novel methods, ProQRosFA and ProQRosCen, inspired by the state-of-art method ProQ2, but using a completely different description of a prote...

journal_title：Scientific reports

authors： Uziela K,Shu N,Wallner B,Elofsson A

更新日期：2016-10-04 00:00:00

abstract：:The ultimate goal of epileptology is the complete abolishment of epileptic seizures. This might be achieved by a system that predicts seizure onset combined with a system that interferes with the process that leads to the onset of a seizure. Seizure prediction remains, as of yet, unresolved in absence-epilepsy, due to...

journal_title：Scientific reports

authors： Maksimenko VA,van Heukelum S,Makarov VV,Kelderhuis J,Lüttjohann A,Koronovskii AA,Hramov AE,van Luijtelaar G

更新日期：2017-05-29 00:00:00

abstract：:Tumor cell-derived exosomes (TEX) suppress functions of immune cells. Here, changes in the gene profiles of primary human T lymphocytes exposed in vitro to exosomes were evaluated. CD4(+) Tconv, CD8(+) T or CD4(+) CD39(+) Treg were isolated from normal donors' peripheral blood and co-incubated with TEX or exosomes iso...

journal_title：Scientific reports

authors： Muller L,Mitsuhashi M,Simms P,Gooding WE,Whiteside TL

更新日期：2016-02-04 00:00:00

abstract：:Irreversible electroporation (IRE) is a non-thermal ablation modality that has been shown to be safe and effective in its application to tumors that are close to risky areas. This study aims to assess the safety and efficacy of IRE for unresectable hilar cholangiocarcinoma. Nine patients from two medical centers in As...

journal_title：Scientific reports

authors： Hsiao CY,Yang PC,Li X,Huang KW

更新日期：2020-07-02 00:00:00

abstract：:Biomolecules for OMIC analysis of microbial communities are commonly extracted by bead-beating or ultra-sonication, but both showed varying yields. In addition to that, different disruption pressures are necessary to lyse bacteria and fungi. However, the disruption efficiency and yields comparing bead-beating and ultr...

journal_title：Scientific reports

authors： Starke R,Jehmlich N,Alfaro T,Dohnalkova A,Capek P,Bell SL,Hofmockel KS

更新日期：2019-04-04 00:00:00

abstract：:The increasing availability of electronic health care records has provided remarkable progress in the field of population health. In particular the identification of disease risk factors has flourished under the surge of available data. Researchers can now access patient data across a broad range of demographics and g...

journal_title：Scientific reports

authors： Feldman K,Stiglic G,Dasgupta D,Kricheff M,Obradovic Z,Chawla NV

更新日期：2016-07-27 00:00:00

abstract：:The root-knot nematodes of the genus Meloidogyne are highly adapted, obligate plant parasites, consisting of nearly one hundred valid species, and are considered the most economically important group of plant-parasitic nematodes. Six Meloidogyne species: M. arenaria, M. hapla, M. incognita, M. microtyla, M. naasi and ...

journal_title：Scientific reports

authors： Álvarez-Ortega S,Brito JA,Subbotin SA

更新日期：2019-08-13 00:00:00

abstract：:The gist of natural scenes can be extracted very rapidly and even without focal attention. However, it is unclear whether and to what extent the gist of natural scenes can break through the bottleneck of crowding, a phenomenon in which object recognition will be immensely impaired. In the first two experiments, a targ...

journal_title：Scientific reports

authors： Gong M,Xuan Y,Smart LJ,Olzak LA

更新日期：2018-09-19 00:00:00

abstract：:Soil microorganisms have important influences on plant growth and health. In this study, four black pepper fields consecutively monocultured for 12, 18, 28 and 38 years were selected for investigating the effect of planting age on rhizosphere and non-rhizosphere soil microbial communities and soil physicochemical prop...

journal_title：Scientific reports

authors： Li Z,Zu C,Wang C,Yang J,Yu H,Wu H

更新日期：2016-10-24 00:00:00

abstract：:Sertoli cells are essential for regulating normal spermatogenesis. However, the mechanisms underlying human Sertoli cell development remain largely elusive. Here we examined the function and signaling pathways of BMP6 in regulating human Sertoli cells. RT-PCR, immunocytochemistry and Western blots revealed that BMP6 a...

journal_title：Scientific reports

authors： Wang H,Yuan Q,Sun M,Niu M,Wen L,Fu H,Zhou F,Chen Z,Yao C,Hou J,Shen R,Lin Q,Liu W,Jia R,Li Z,He Z

更新日期：2017-04-07 00:00:00

abstract：:A range of chemistries were explored for the efficient covalent conjugation of DNA to poly(N-isopropylacrylamide) (poly(NIPAM)) in organic solvents. Amide coupling and thiol-ene Michael addition were found to be ineffective for the synthesis of the desired products. However, the inverse electron-demand Diels-Alder (DA...

journal_title：Scientific reports

authors： Wilks TR,O'Reilly RK

更新日期：2016-12-16 00:00:00