Establishment of a new OSCC cell line derived from OLK and identification of malignant transformation-related proteins by differential proteomics approach.

abstract：:Metabolic images from Positron Emission Tomography (PET) are used routinely for diagnosis, follow-up or treatment planning purposes of cancer patients. In this study we aimed at determining if radiomic features extracted from 18F-Fluoro Deoxy Glucose (FDG) PET images could mirror tumor transcriptomics. In this study w...

journal_title：Scientific reports

authors： Tixier F,Cheze-le-Rest C,Schick U,Simon B,Dufour X,Key S,Pradier O,Aubry M,Hatt M,Corcos L,Visvikis D

更新日期：2020-03-27 00:00:00

abstract：:The human pathogen Legionella pneumophila delivers a large array of the effector proteins into host cells using the Dot/Icm type IVB secretion system. Among the proteins composing the Dot/Icm system, an inner membrane protein DotI is known to be crucial for the secretion function but its structure and role in type IV ...

journal_title：Scientific reports

authors： Kuroda T,Kubori T,Thanh Bui X,Hyakutake A,Uchida Y,Imada K,Nagai H

更新日期：2015-06-03 00:00:00

abstract：:Recently, graphene nanomesh (GNM) has attracted great attentions due to its unique porous structure, abundant active sites, finite band gap and possesses potential applications in the fields of electronics, gas sensor/storage, catalysis, etc. Therefore, diverse GNMs with different physical and chemical properties are ...

journal_title：Scientific reports

authors： Zhang J,Song H,Zeng D,Wang H,Qin Z,Xu K,Pang A,Xie C

更新日期：2016-08-26 00:00:00

abstract：:Boolean networks are widely used to model gene regulatory networks and to design therapeutic intervention strategies to affect the long-term behavior of systems. In this paper, we investigate the less-studied one-bit perturbation, which falls under the category of structural intervention. Previous works focused on fin...

journal_title：Scientific reports

authors： Hu M,Shen L,Zan X,Shang X,Liu W

更新日期：2016-05-19 00:00:00

abstract：:The most consistent sex differences in cognition are found for spatial ability, in which males, on average, outperform females. Utilizing a twin design, two studies have shown that females with male co-twins perform better than females with female co-twins on a mental rotation task. According to the Twin Testosterone ...

journal_title：Scientific reports

authors： Toivainen T,Pannini G,Papageorgiou KA,Malanchini M,Rimfeld K,Shakeshaft N,Kovas Y

更新日期：2018-09-12 00:00:00

abstract：:During viral infections, some viruses subvert the host proteins to promote the translation or RNA replication with their protease-mediated cleavage. Poly (A)-binding protein (PABP) is a target for several RNA viruses; however, the impact of duck hepatitis A virus (DHAV) on PABP remains unknown. In this study, we demon...

journal_title：Scientific reports

authors： Sun D,Wang M,Wen X,Cheng A,Jia R,Sun K,Yang Q,Wu Y,Zhu D,Chen S,Liu M,Zhao X,Chen X

更新日期：2017-11-24 00:00:00

abstract：:We study the dynamical Casimir-Polder force on a two-level atom with different initial states in the one-dimensional dielectric cavity with output coupling, and obtain the analytical expression of the expectation value of dynamical Casimir-Polder force. Results show that the expectation values of dynamical Casimir-Pol...

journal_title：Scientific reports

authors： Long Y,Wang W,Zhang X,Yang H,Zheng T

更新日期：2020-07-20 00:00:00

abstract：:Rab small GTPases play key roles in intracellular membrane trafficking. Rab33a promotes axon outgrowth of cultured rat hippocampal neurons by mediating the anterograde axonal transport of Golgi-derived vesicles and the concomitant exocytosis of these vesicles at the growth cone. However, the functions of Rab33 in vivo...

journal_title：Scientific reports

authors： Huang L,Urasaki A,Inagaki N

更新日期：2019-02-12 00:00:00

abstract：:Traditional strengthening ways, such as strain, precipitation, and solid-solution, come into effect by pinning the motion of dislocation. Here, through first-principles calculations we report on an extra-electron induced covalent strengthening mechanism, which alters chemical bonding upon the introduction of extra-val...

journal_title：Scientific reports

authors： Niu H,Chen XQ,Liu P,Xing W,Cheng X,Li D,Li Y

更新日期：2012-01-01 00:00:00

abstract：:The intensity and frequency of precipitation events are predicted to change over the coming decades. For many areas, longer periods without rainfall are expected. We investigated the importance of irrigation frequency under water deficit conditions for growth, physiology and chemistry of wheat (Triticum aestivum). Dro...

journal_title：Scientific reports

authors： Stallmann J,Schweiger R,Pons CAA,Müller C

更新日期：2020-06-22 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality globally. Because most patients are diagnosed at advanced stages of the disease, multi-targeted tyrosine kinase inhibitor sorafenib is the only available drug to show limited effectiveness. Novel and effective therapies are unmet me...

journal_title：Scientific reports

authors： Wang J,Sun P,Chen Y,Yao H,Wang S

更新日期：2018-07-19 00:00:00

abstract：:Fast and nondestructive assessment of leaf nitrogen concentration (LNC) is critical for crop growth diagnosis and nitrogen management guidance. In the last decade, multispectral LiDAR (MSL) systems have promoted developments in the earth and ecological sciences with the additional spectral information. With more wavel...

journal_title：Scientific reports

authors： Sun J,Shi S,Gong W,Yang J,Du L,Song S,Chen B,Zhang Z

更新日期：2017-01-16 00:00:00

abstract：:In the epoch of the Anthropocene change, complexity, and uncertainty create a demand for new systems of water management and governance. One such management model that is rapidly gaining traction amongst both scholars and practitioners is the concept of water resilience. Although increasing attention has been paid to ...

journal_title：Scientific reports

authors： Baird J,Dale G,Farhad S

更新日期：2020-04-06 00:00:00

abstract：:Targeted antineoplastic agents show great promise in the treatment of cancer, having the ability to impart cytotoxicity only to specific tumor types. However, these therapies do not experience uniform uptake throughout tumors, leading to sub-lethal cell killing that can impart treatment resistance, and cause problemat...

journal_title：Scientific reports

authors： Klein OJ,Yuan H,Nowell NH,Kaittanis C,Josephson L,Evans CL

更新日期：2017-10-17 00:00:00

abstract：:With land privatization and fencing of thousands of hectares of communal grazing areas, East Africa is struggling with one of the most radical cultural and environmental changes in its history. The 668,500-hectare Greater Mara is of crucial importance for the great migrations of large mammals and for Maasai pastoralis...

journal_title：Scientific reports

authors： Løvschal M,Bøcher PK,Pilgaard J,Amoke I,Odingo A,Thuo A,Svenning JC

更新日期：2017-01-25 00:00:00

abstract：:All electronic, optoelectronic or photovoltaic applications of silicon depend on controlling majority charge carriers via doping with impurity atoms. Nanoscale silicon is omnipresent in fundamental research (quantum dots, nanowires) but also approached in future technology nodes of the microelectronics industry. In ge...

journal_title：Scientific reports

authors： König D,Hiller D,Gutsch S,Zacharias M,Smith S

更新日期：2017-04-20 00:00:00

abstract：:Networks are widely used as a tool for describing diverse real complex systems and have been successfully applied to many fields. The distance between networks is one of the most fundamental concepts for properly classifying real networks, detecting temporal changes in network structures, and effectively predicting th...

journal_title：Scientific reports

authors： Shimada Y,Hirata Y,Ikeguchi T,Aihara K

更新日期：2016-10-11 00:00:00

abstract：:Recent migrations and inter-ethnic mating of long isolated populations have resulted in genetically admixed populations. To understand the complex population admixture process, which is critical to both evolutionary and medical studies, here we used admixture induced linkage disequilibrium (LD) to infer continuous adm...

journal_title：Scientific reports

authors： Zhou Y,Qiu H,Xu S

更新日期：2017-02-23 00:00:00

abstract：:The synthesis of highly biocompatible polymers is important for modern biotechnologies and medicine. Here, we report a unique process based on a two-step high-pressure ramp (HPR) for the ultrafast and efficient bulk polymerization of 2-(hydroxyethyl)methacrylate (HEMA) at room temperature without photo- and thermal ac...

journal_title：Scientific reports

authors： Evlyukhin E,Museur L,Traore M,Perruchot C,Zerr A,Kanaev A

更新日期：2015-12-16 00:00:00

abstract：:Intracellular signal transduction involves a number of biochemical reactions, which largely consist of protein-protein interactions and protein conformational changes. Monitoring Förster resonance energy transfer (FRET) by fluorescence lifetime imaging microscopy (FLIM), called FLIM-FRET, is one of the best ways to vi...

journal_title：Scientific reports

authors： Nakahata Y,Nabekura J,Murakoshi H

更新日期：2016-12-22 00:00:00

abstract：:Fruit ripening is a complex and genetically programmed process. Brassinosteroids (BRs) play an essential role in plant growth and development, including fruit ripening. As a central component of BR signaling, the transcription factor BZR1 is involved in fruit development in tomato. However, the transcriptional network...

journal_title：Scientific reports

authors： Liu L,Liu H,Li S,Zhang X,Zhang M,Zhu N,Dufresne CP,Chen S,Wang Q

更新日期：2016-09-29 00:00:00

abstract：:Recent advances in fluorescent protein technology provide a wide variety of biological imaging applications; however current tools for bio-imaging in the Gram-positive bacterium Staphylococcus aureus has necessitated further developments for fluorescence intensity and for a multicolor palette of fluorescent proteins. ...

journal_title：Scientific reports

authors： Kato F,Nakamura M,Sugai M

更新日期：2017-06-06 00:00:00

abstract：:Ischemic neural damages cause several devastating diseases, including brain stroke and ischemic retinopathies, and endoplasmic reticulum (ER) stress has been proposed to be the underlying mechanism of the neuronal cell death of these conditions. We previously synthesized Kyoto University substances (KUSs) as modulator...

journal_title：Scientific reports

authors： Hata M,Ikeda HO,Kikkawa C,Iwai S,Muraoka Y,Hasegawa T,Kakizuka A,Yoshimura N

更新日期：2017-03-20 00:00:00

abstract：:Internet technologies have demonstrated their value for the early detection and prediction of epidemics. In diverse cases, electronic surveillance systems can be created by obtaining and analyzing on-line data, complementing other existing monitoring resources. This paper reports the feasibility of building such a sys...

journal_title：Scientific reports

authors： Samaras L,García-Barriocanal E,Sicilia MA

更新日期：2020-03-16 00:00:00

abstract：:The lack of vaccines and antiviral treatment, along with the increasing number of cases of Zika virus (ZIKV) and Chikungunya virus (CHIKV) infections, emphasize the need for searching for new therapeutic strategies. In this context, the marine brown seaweed Canistrocarpus cervicornis has been proved to hold great anti...

journal_title：Scientific reports

authors： Cirne-Santos CC,de Souza Barros C,de Oliveira MC,Rabelo VW,Azevedo RC,Teixeira VL,Ferreira DF,de Palmer Paixão ICN

更新日期：2020-05-19 00:00:00

abstract：:We established in vivo and in vitro models to investigate the role of αB-Crystallin (CryAB) and assess the ability of aspirin (ASA) to protect the myocardium during prolonged heat stress. Thirty-day-old chickens were divided into three groups (n = 90): heat stress (HS, 40±1 °C); ASA(-)HS(+), 1 mg/kg ASA orally 2 h bef...

journal_title：Scientific reports

authors： Tang S,Yin B,Song E,Chen H,Cheng Y,Zhang X,Bao E,Hartung J

更新日期：2016-11-18 00:00:00

abstract：:Transmembrane flux of Cs+ (a K+ congener) was measured in human red blood cells (RBCs; erythrocytes) on the 10-s time scale. This is the first report on dissolution dynamic nuclear polarization (dDNP) nuclear magnetic resonance (NMR) spectroscopy with this nuclide in mammalian cells. Four technical developments regula...

journal_title：Scientific reports

authors： Kuchel PW,Karlsson M,Lerche MH,Shishmarev D,Ardenkjaer-Larsen JH

更新日期：2019-12-23 00:00:00

abstract：:Impaired immune function contributes to the development of chronic obstructive pulmonary disease (COPD). Disease progression is further exacerbated by pathogen infections due to impaired immune responses. Elimination of infected cells is achieved by cytotoxic CD8(+)  T cells that are activated by MHC I-mediated presen...

journal_title：Scientific reports

authors： Keller IE,Vosyka O,Takenaka S,Kloß A,Dahlmann B,Willems LI,Verdoes M,Overkleeft HS,Marcos E,Adnot S,Hauck SM,Ruppert C,Günther A,Herold S,Ohno S,Adler H,Eickelberg O,Meiners S

更新日期：2015-05-19 00:00:00

abstract：:Direct assembly of multiple linear DNA fragments via homologous recombination, a phenomenon known as in vivo assembly or transformation associated recombination, is used in biotechnology to assemble DNA constructs ranging in size from a few kilobases to full synthetic microbial genomes. It has also enabled the complet...

journal_title：Scientific reports

authors： King BC,Vavitsas K,Ikram NK,Schrøder J,Scharff LB,Bassard JÉ,Hamberger B,Jensen PE,Simonsen HT

更新日期：2016-04-29 00:00:00

abstract：:A microwave domain characterization approach is proposed to determine the properties of high quality factor optical resonators. This approach features a very high precision in frequency and aims to acquire a full knowledge of the complex transfer function (amplitude and phase) characterizing an optical resonator using...

journal_title：Scientific reports

authors： Abdallah Z,Boucher YG,Fernandez A,Balac S,Llopis O

更新日期：2016-06-02 00:00:00