Molecular and structural analysis of Legionella DotI gives insights into an inner membrane complex essential for type IV secretion.

abstract：:Circulating levels of Brain Derived Neurotrophic Factor (BDNF) are lower in coronary heart disease (CHD) than in healthy subjects and are associated with coronary events and mortality. However, the mechanism(s) underling this association is not fully understood. We hypothesize that BDNF may influence fibrin fiber stru...

journal_title：Scientific reports

authors： Amadio P,Porro B,Sandrini L,Fiorelli S,Bonomi A,Cavalca V,Brambilla M,Camera M,Veglia F,Tremoli E,Barbieri SS

更新日期：2019-01-23 00:00:00

abstract：:Gelatin-methacryloyl (GelMA) is one of the most commonly used photopolymerizable biomaterials in bio-applications. However, GelMA synthesis remains suboptimal, as its reaction parameters have not been fully investigated. The goal of this study is to establish an optimal route for effective and controllable GelMA synth...

journal_title：Scientific reports

authors： Shirahama H,Lee BH,Tan LP,Cho NJ

更新日期：2016-08-09 00:00:00

abstract：:Multicolor microscopy tools necessary to localize and visualize the complexity of subcellular systems are limited by current fluorophore technology. While commercial fluorophores cover spectral space from the ultraviolet to the near infrared region and are optimized for conventional bandpass based fluorescence microsc...

journal_title：Scientific reports

authors： Bittel AM,Davis AM,Wang L,Nederlof MA,Escobedo JO,Strongin RM,Gibbs SL

更新日期：2018-03-15 00:00:00

abstract：:Low haemocompatibility of left ventricular assist devices (LVAD) surfaces necessitates anticoagulative therapy. Endothelial cell (EC) seeding can support haemocompatibility, however, the availability of autologous ECs is limited. In contrast, allogeneic ECs are readily available in sufficient quantity, but HLA dispari...

journal_title：Scientific reports

authors： Figueiredo C,Eicke D,Yuzefovych Y,Avsar M,Hanke JS,Pflaum M,Schmitto JD,Blasczyk R,Haverich A,Wiegmann B

更新日期：2019-08-05 00:00:00

abstract：:The demand for rapid, consistent and easy-to-use techniques for detecting and identifying pathogens in various areas, such as clinical diagnosis, the pharmaceutical industry, environmental science and food inspection, is very important. In this study, the reference strains of six food-borne pathogens, namely, Escheric...

journal_title：Scientific reports

authors： Khan MSI,Oh SW,Kim YJ

更新日期：2020-02-11 00:00:00

abstract：:During plaque progression, inflammatory cells progressively accumulate in the adventitia, paralleled by an increased presence of leaky vasa vasorum. We here show that next to vasa vasorum, also the adventitial lymphatic capillary bed is expanding during plaque development in humans and mouse models of atherosclerosis....

journal_title：Scientific reports

authors： Rademakers T,van der Vorst EP,Daissormont IT,Otten JJ,Theodorou K,Theelen TL,Gijbels M,Anisimov A,Nurmi H,Lindeman JH,Schober A,Heeneman S,Alitalo K,Biessen EA

更新日期：2017-03-28 00:00:00

abstract：:The development of selective visual attention is critical for effectively engaging with an ever-changing world. Its optimal deployment depends upon interactions between neural, motor, and sensory systems across multiple timescales and neurocognitive loci. Previous work illustrates the spatio-temporal dynamics of these...

journal_title：Scientific reports

authors： Stallworthy IC,Sifre R,Berry D,Lasch C,Smith TJ,Elison JT

更新日期：2020-10-14 00:00:00

abstract：:Calcified marine organisms typically experience increased oxidative stress and changes in mineralization in response to ocean acidification and warming conditions. These effects could hinder the potency of animal weapons, such as the mantis shrimp's raptorial appendage. The mechanical properties of this calcified weap...

journal_title：Scientific reports

authors： deVries MS,Webb SJ,Tu J,Cory E,Morgan V,Sah RL,Deheyn DD,Taylor JR

更新日期：2016-12-15 00:00:00

abstract：:Temporal baselines are needed for biodiversity, in order for the change in biodiversity to be measured over time, the targets for biodiversity conservation to be defined and conservation progress to be evaluated. Limited biodiversity information is widely recognized as a major barrier for identifying temporal baseline...

journal_title：Scientific reports

authors： Mihoub JB,Henle K,Titeux N,Brotons L,Brummitt NA,Schmeller DS

更新日期：2017-01-30 00:00:00

abstract：:Cancer cells accumulate somatic mutations as result of DNA damage, inaccurate repair and other mechanisms. Different genetic instability processes result in characteristic non-random patterns of DNA mutations, also known as mutational signatures. We developed mutSignatures, an integrated R-based computational framewor...

journal_title：Scientific reports

authors： Fantini D,Vidimar V,Yu Y,Condello S,Meeks JJ

更新日期：2020-10-26 00:00:00

abstract：:Adipocyte differentiation and function relies on a network of transcription factors, which is disrupted in obesity-associated low grade, chronic inflammation leading to adipose tissue dysfunction. In this context, there is a need for a thorough understanding of the transcriptional regulatory network involved in adipos...

journal_title：Scientific reports

authors： Firmin FF,Oger F,Gheeraert C,Dubois-Chevalier J,Vercoutter-Edouart AS,Alzaid F,Mazuy C,Dehondt H,Alexandre J,Derudas B,Dhalluin Q,Ploton M,Berthier A,Woitrain E,Lefebvre T,Venteclef N,Pattou F,Staels B,Eeckhoute J,L

更新日期：2017-10-26 00:00:00

abstract：:This study presents a modular-based implementation of augmented reality to provide an immersive experience in learning or teaching the planning phase, control system, and machining parameters of a fully automated work cell. The architecture of the system consists of three code modules that can operate independently or...

journal_title：Scientific reports

authors： Pai YS,Yap HJ,Md Dawal SZ,Ramesh S,Phoon SY

更新日期：2016-06-07 00:00:00

abstract：:Improving spatial accessibility to hospitals is a major task for health care systems which can be facilitated using recent methodological improvements of spatial accessibility measures. We used the integrated floating catchment area (iFCA) method to analyze spatial accessibility of general inpatient care (internal med...

journal_title：Scientific reports

authors： Bauer J,Klingelhöfer D,Maier W,Schwettmann L,Groneberg DA

更新日期：2020-11-05 00:00:00

abstract：:Pluripotent cells can be subdivided into two distinct states, the naïve and the primed state, the latter being further advanced on the path of differentiation. There are substantial differences in the regulation of pluripotency between human and mouse, and in humans only stem cells that resemble the primed state in mo...

journal_title：Scientific reports

authors： Ernst M,Abu Dawud R,Kurtz A,Schotta G,Taher L,Fuellen G

更新日期：2015-01-21 00:00:00

abstract：:Mitochondria are key cellular signaling platforms, affecting fundamental processes such as cell proliferation, differentiation and death. However, it remains unclear how mitochondrial signaling affects other organelles, particularly lysosomes. Here, we demonstrate that mitochondrial respiratory chain (RC) impairments ...

journal_title：Scientific reports

authors： Fernández-Mosquera L,Diogo CV,Yambire KF,Santos GL,Luna Sánchez M,Bénit P,Rustin P,Lopez LC,Milosevic I,Raimundo N

更新日期：2017-03-27 00:00:00

abstract：:The glycocalyx regulates the interaction of mammalian cells with extracellular molecules, such as cytokines. However, it is unknown to which extend the glycocalyx of distinct cancer cells control the binding and uptake of nanoparticles. In the present study, exome sequencing data of cancer patients and analysis of dis...

journal_title：Scientific reports

authors： von Palubitzki L,Wang Y,Hoffmann S,Vidal-Y-Sy S,Zobiak B,Failla AV,Schmage P,John A,Osorio-Madrazo A,Bauer AT,Schneider SW,Goycoolea FM,Gorzelanny C

更新日期：2020-12-31 00:00:00

abstract：:A variety of environmental factors contribute to progressive development of osteoarthritis (OA). Environmental factors that upset circadian rhythms have been linked to various diseases. Our recent work establishes chronic environmental circadian disruption - analogous to rotating shiftwork-associated disruption of cir...

journal_title：Scientific reports

authors： Kc R,Li X,Forsyth CB,Voigt RM,Summa KC,Vitaterna MH,Tryniszewska B,Keshavarzian A,Turek FW,Meng QJ,Im HJ

更新日期：2015-11-20 00:00:00

abstract：:Recent studies suggest that spatial training can maintain associative memory capacity in Tg2576 mice, but it is not known whether the beneficial effects can be inherited from the trained fathers to their offspring. Here, we exposed male wild-type and male 3XTg Alzheimer disease (AD) mice (3-m old) respectively to spat...

journal_title：Scientific reports

authors： Zhang S,Li X,Wang Z,Liu Y,Gao Y,Tan L,Liu E,Zhou Q,Xu C,Wang X,Liu G,Chen H,Wang JZ

更新日期：2017-05-08 00:00:00

abstract：:To what extent deep-time dispersal limitation shapes present-day biodiversity at broad spatial scales remains elusive. Here, we compiled a continental dataset on the distributions of African lizard species in the reptile subfamily Agaminae (a relatively young, Neogene radiation of agamid lizards which ancestors coloni...

journal_title：Scientific reports

authors： Kissling WD,Blach-Overgaard A,Zwaan RE,Wagner P

更新日期：2016-09-27 00:00:00

abstract：:Cover cropping is proposed to enhance soil microbial diversity and activity, with cover crop type affecting microbial groups in different ways. We compared fungal community compositions of bulk soils differing by cover crop treatment, season, and edaphic properties in the third year of an organic, conventionally tille...

journal_title：Scientific reports

authors： Cloutier ML,Murrell E,Barbercheck M,Kaye J,Finney D,García-González I,Bruns MA

更新日期：2020-04-10 00:00:00

abstract：:Selective attention plays a prominent role in prioritizing information in working memory (WM), improving performance for attended representations. However, it remains unclear whether unattended WM representations suffer from information loss. Here we tested the hypothesis that within WM, selectively attending to an it...

journal_title：Scientific reports

authors： Günseli E,Fahrenfort JJ,van Moorselaar D,Daoultzis KC,Meeter M,Olivers CNL

更新日期：2019-09-18 00:00:00

abstract：:In this work we study the entropy of the Gibbs state corresponding to a graph. The Gibbs state is obtained from the Laplacian, normalized Laplacian or adjacency matrices associated with a graph. We calculated the entropy of the Gibbs state for a few classes of graphs and studied their behavior with changing graph orde...

journal_title：Scientific reports

authors： Glos A,Krawiec A,Pawela Ł

更新日期：2021-01-11 00:00:00

abstract：:The experimental study deals with the investigation of the effect of diverse crystallinity of imidazolium ionic-liquid-based SPE on conductivity and current fluctuations. The experimental study was carried out on samples consisting of [EMIM][TFSI] as ionic liquid, PVDF as a polymer matrix and NMP as a solvent. After t...

journal_title：Scientific reports

authors： Sedlak P,Gajdos A,Macku R,Majzner J,Holcman V,Sedlakova V,Kubersky P

更新日期：2020-12-03 00:00:00

abstract：:Active immunotherapy targeting β-amyloid (Aβ) is the most promising strategy to prevent or treat Alzheimer's disease (AD). Based on pre-clinical studies and clinical trials, a safe and effective AD vaccine requires a delicate balance between providing therapeutically adequate anti-Aβ antibodies and eliminating or supp...

journal_title：Scientific reports

authors： Liu S,Shi D,Wang HC,Yu YZ,Xu Q,Sun ZW

更新日期：2015-01-14 00:00:00

abstract：:Elymus nutans is an herbaceous plant that can be used to restore degraded alpine and subalpine ecosystems. Here, we evaluated how sowing density affects soil reinforcement and slope stabilization properties of vegetation-concrete structures. To investigate the optimal sowing density of E. nutans in vegetation-concrete...

journal_title：Scientific reports

authors： Tan X,Huang Y,Xiong D,Lv K,Chen F

更新日期：2020-11-24 00:00:00

abstract：:Selective norepinephrine reuptake inhibitors (sNRIs) provide an effective class of approved antipsychotics, whose inhibitory mechanism could facilitate the discovery of privileged scaffolds with enhanced drug efficacy. However, the crystal structure of human norepinephrine transporter (hNET) has not been determined ye...

journal_title：Scientific reports

authors： Zheng G,Xue W,Wang P,Yang F,Li B,Li X,Li Y,Yao X,Zhu F

更新日期：2016-05-27 00:00:00

abstract：:Neuregulin 4 (NRG4), an epidermal growth factor-like signaling molecule, plays an important role in cell-to-cell communication during tissue development. Its function to regulate energy metabolism has recently been reported. This current study was designed to assess the preventive and therapeutic effects of NRG4 overe...

journal_title：Scientific reports

authors： Ma Y,Gao M,Liu D

更新日期：2016-05-17 00:00:00

abstract：:Hepatitis E Virus-like particles self-assemble in to noninfectious nanocapsids that are resistant to proteolytic/acidic mucosal delivery conditions. Previously, the nanocapsid was engineered to specifically bind and enter breast cancer cells, where successful tumor targeting was demonstrated in animal models. In the p...

journal_title：Scientific reports

authors： Stark MC,Baikoghli MA,Lahtinen T,Malola S,Xing L,Nguyen M,Nguyen M,Sikaroudi A,Marjomäki V,Häkkinen H,Cheng RH

更新日期：2017-12-06 00:00:00

abstract：:The trade of bumble bees started in the early nineties for pollinator-dependent greenhouse plants. Nowadays, its rearing and transport have received public attention, since managed bees can transfer pathogens to wild bee populations. Therefore, guaranteeing pathogen-free bumble bees is fundamental. The major protein s...

journal_title：Scientific reports

authors： Pereira KS,Meeus I,Smagghe G

更新日期：2019-03-12 00:00:00

abstract：:High tumor vascular endothelial growth factor (VEGF) levels are associated with poor treatment outcomes in prostate cancer (PCa), and immune deficiency in the PCa microenvironment, especially suppression of dendritic cell (DC) proliferation, has been confirmed. In this study, we (1) investigated whether VEGF participa...

journal_title：Scientific reports

authors： Zhang W,Shou WD,Xu YJ,Bai WK,Hu B

更新日期：2017-07-18 00:00:00