Novel 2-phenyloxypyrimidine derivative induces apoptosis and autophagy via inhibiting PI3K pathway and activating MAPK/ERK signaling in hepatocellular carcinoma cells.

abstract：:In neuroblastoma (NB), one of the most common paediatric solid tumours, activation of anaplastic lymphoma kinase (ALK) is often associated with poor outcomes. Although genetic studies have identified copy number alteration and nonsynonymous mutations of ALK, the regulatory mechanism of ALK signalling at protein levels...

journal_title：Scientific reports

authors： Satoh S,Takatori A,Ogura A,Kohashi K,Souzaki R,Kinoshita Y,Taguchi T,Hossain MS,Ohira M,Nakamura Y,Nakagawara A

更新日期：2016-09-08 00:00:00

abstract：:Models of biological processes are often subject to different sources of noise. Developing an understanding of the combined effects of different types of uncertainty is an open challenge. In this paper, we study a variant of the susceptible-infective-recovered model of epidemic spread, which combines both agent-to-age...

journal_title：Scientific reports

authors： Herrerías-Azcué F,Galla T

更新日期：2017-10-11 00:00:00

abstract：:Grapevine is an important and extensively grown fruit crop, which is severely hampered by drought worldwide. So, comprehending the impact of drought on grapevine genetic resources is necessary. In the present study, RNA-sequencing was executed using cDNA libraries constructed from both drought-stress and control plant...

journal_title：Scientific reports

authors： Haider MS,Zhang C,Kurjogi MM,Pervaiz T,Zheng T,Zhang C,Lide C,Shangguan L,Fang J

更新日期：2017-10-13 00:00:00

abstract：:The present study investigated the treatment and survival outcomes of patients with synchronous primary esophageal squamous cell carcinoma and gastric adenocarcinoma. The medical records of 10,783 patients with primary esophageal squamous cancer treated at our institution between 1995 and 2012 were retrospectively rev...

journal_title：Scientific reports

authors： Li X,Lin S,Zhang Y,Wang H

更新日期：2015-08-20 00:00:00

abstract：:Export of messenger ribonucleic acids (mRNAs) into the cytoplasm is a fundamental step in gene regulation processes, which is meticulously quality controlled by highly efficient mechanisms in eukaryotic cells. Yet, it remains unclear how the aberrant mRNAs are recognized and retained inside the nucleus. Using a new mo...

journal_title：Scientific reports

authors： Soheilypour M,Mofrad MR

更新日期：2016-11-02 00:00:00

abstract：:The Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) has been counted on for conserving threatened marine fish since it regulates the commercial international trade of these species. Implementation of the international treaty for Mantas included on CITES Appendix II is challengin...

journal_title：Scientific reports

authors： Zeng Y,Wu Z,Zhang C,Meng Z,Jiang Z,Zhang J

更新日期：2016-11-23 00:00:00

abstract：:All-inorganic visibly-transparent energy-harvesting clear laminated glass windows are the most practical solution to boosting building-integrated photovoltaics (BIPV) energy outputs significantly while reducing cooling- and heating-related energy consumption in buildings. By incorporating luminophore materials into la...

journal_title：Scientific reports

authors： Alghamedi R,Vasiliev M,Nur-E-Alam M,Alameh K

更新日期：2014-10-16 00:00:00

abstract：:Textile forms of solar cells possess special advantages over other types of solar cells, including their light weight, high flexibility, and mechanical robustness. Recent demand for wearable devices has promoted interest in the development of high-efficiency textile-based solar cells for energy suppliers. However, the...

journal_title：Scientific reports

authors： Yun MJ,Cha SI,Seo SH,Lee DY

更新日期：2014-06-24 00:00:00

abstract：:Infection after renal transplantation remains a major cause of morbidity and death, especially infection from the extensively drug-resistant bacteria, A. baumannii. A total of fourteen A. baumannii isolates were isolated from the donors' preserved fluid from DCD (donation after cardiac death) renal transplantation and...

journal_title：Scientific reports

authors： Jiang H,Cao L,Qu L,Qu T,Liu G,Wang R,Li B,Wang Y,Ying C,Chen M,Lu Y,Feng S,Xiao Y,Wang J,Wu J,Chen J

更新日期：2017-05-16 00:00:00

abstract：:Here we construct mechanically flexible and optically transparent thin film solid state supercapacitors by assembling nano-engineered carbon electrodes, prepared in porous templates, with morphology of interconnected arrays of complex shapes and porosity. The highly textured graphitic films act as electrode and curren...

journal_title：Scientific reports

authors： Jung HY,Karimi MB,Hahm MG,Ajayan PM,Jung YJ

更新日期：2012-01-01 00:00:00

abstract：:Stromal capillary sheath cells in human spleens strongly express CD271, the low affinity nerve growth factor receptor p75. Serial sections of a representative adult human spleen were double-stained for CD271 versus smooth muscle alpha actin (SMA) plus CD34 to visualise capillary sheaths, the arterial tree and endothel...

journal_title：Scientific reports

authors： Steiniger BS,Wilhelmi V,Berthold M,Guthe M,Lobachev O

更新日期：2018-10-24 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Altair T,de Avellar MGB,Rodrigues F,Galante D

更新日期：2020-07-30 00:00:00

abstract：:Phasins or PhaPs are a group of amphiphilic proteins that are found attached to the surface of microbial polyhydroxyalkanoate (PHA) granules. They have both structural and regulatory functions and can affect intracellular PHA accumulation and mediate protein folding. The molecular basis for the diverse functions of th...

journal_title：Scientific reports

authors： Zhao H,Wei H,Liu X,Yao Z,Xu M,Wei D,Wang J,Wang X,Chen GQ

更新日期：2016-12-23 00:00:00

abstract：:Intrahepatic cholangiocarcinoma (IHCC) is a highly aggressive malignancy with a poor prognosis. It is thought to originate from cholangiocytes, which are the component cells of intrahepatic bile ducts. However, as patients with viral hepatitis often develop IHCC, it has been suggested that transformed hepatocytes may ...

journal_title：Scientific reports

authors： Saito Y,Nakaoka T,Muramatsu T,Ojima H,Sukeda A,Sugiyama Y,Uchida R,Furukawa R,Kitahara A,Sato T,Kanai Y,Saito H

更新日期：2018-02-12 00:00:00

abstract：:Tunable metasurfaces have emerged as an efficient approach to manipulate the wave propagation. Different from previous work concentrating on electrically tunable mechanisms, here we demonstrate a magnetically tunable metasurface composed of ferrite rods and metallic foils. By tuning the thickness of ferrite rods, meta...

journal_title：Scientific reports

authors： Yang H,Yu T,Wang Q,Lei M

更新日期：2017-07-14 00:00:00

abstract：:Glypican-3 (GPC3) is a cell-surface heparan sulfate proteoglycan highly expressed in hepatocellular carcinoma (HCC). We have generated a group of high-affinity mouse monoclonal antibodies targeting GPC3. Here, we report the humanization and testing of these antibodies for clinical development. We compared the affinity...

journal_title：Scientific reports

authors： Zhang YF,Ho M

更新日期：2016-09-26 00:00:00

abstract：:Soybean seeds are an important source of vegetable oil and biomaterials. The content of individual triacylglycerol species (TAG) in soybean seeds is difficult to quantify in an accurate and rapid way. The present study establishes an approach to quantify TAG species in soybean seeds utilizing an electrospray ionizatio...

journal_title：Scientific reports

authors： Li M,Butka E,Wang X

更新日期：2014-10-10 00:00:00

abstract：:Belgian Malinois (BM), one of the excellent military dog breeds in South Korea, is usually castrated before sexual maturation. Therefore, the transfer of their genetic features to the next generation is difficult. To overcome this, testicular cells from 4-month-old BMs were frozen. Testicular cells were thawed after 3...

journal_title：Scientific reports

authors： Lee KH,Lee WY,Kim DH,Lee SH,Do JT,Park C,Kim JH,Choi YS,Song H

更新日期：2016-02-24 00:00:00

abstract：:Transplacental transmission (TPT) of wild-type Indian BTV-1 had never been experimentally proved. This study was first time investigated TPT of Indian BTV-1 (isolated from aborted and stillborn goat fetal spleens). The sequential pathology, virological and immune cell kinetics (CD4+, CD8+ T-lymphocytes and NK cells in...

journal_title：Scientific reports

authors： Saminathan M,Singh KP,Vineetha S,Maity M,Biswas SK,Manjunathareddy GB,Chauhan HC,Milton AAP,Ramakrishnan MA,Maan S,Maan NS,Hemadri D,Chandel BS,Gupta VK,Mertens PPC

更新日期：2020-02-07 00:00:00

abstract：:A bubble merged from two parent bubbles with different size tends to be placed closer to the larger parent. This phenomenon is known as the coalescence preference. Here we demonstrate that the coalescence preference can be blocked inside a densely packed cluster of bubbles. We utilized high-speed high-resolution X-ray...

journal_title：Scientific reports

authors： Kim Y,Lim SJ,Gim B,Weon BM

更新日期：2015-01-13 00:00:00

abstract：:Fatty acid oxidation and subsequent ketogenesis is one of the major mechanisms to maintain hepatic lipid homeostasis under fasting conditions. Fasting hormone glucagon has been shown to stimulate ketone body production through activation of PPARα; however, the signal pathway linking glucagon to PPARα is largely undisc...

journal_title：Scientific reports

authors： Zhang ZN,Gong L,Lv S,Li J,Tai X,Cao W,Peng B,Qu S,Li W,Zhang C,Luan B

更新日期：2016-03-17 00:00:00

abstract：:Today, despite decades of developments in medicine and the growing interest in precision healthcare, vast majority of diagnoses happen once patients begin to show noticeable signs of illness. Early indication and detection of diseases, however, can provide patients and carers with the chance of early intervention, bet...

journal_title：Scientific reports

authors： Li Y,Rao S,Solares JRA,Hassaine A,Ramakrishnan R,Canoy D,Zhu Y,Rahimi K,Salimi-Khorshidi G

更新日期：2020-04-28 00:00:00

abstract：:Two new indolizidine alkaloids crepidatumines A (1) and B (2) together with the stereoisomer of dendrocrepidine B (3) and known analog dendrocrepine (4) were isolated from D. crepidatum. Their structures were determined by HR-ESI-MS, NMR, and Electronic Circular Dichroism (ECD) experiments together with comparison of ...

journal_title：Scientific reports

authors： Xu X,Chen X,Yang R,Li Z,Zhou H,Bai Y,Yu M,Li B,Ding G

更新日期：2020-06-12 00:00:00

abstract：:The Morris Water Maze is a widely used task in studies of spatial learning with rodents. Classical performance measures of animals in the Morris Water Maze include the escape latency, and the cumulative distance to the platform. Other methods focus on classifying trajectory patterns to stereotypical classes representi...

journal_title：Scientific reports

authors： Gehring TV,Luksys G,Sandi C,Vasilaki E

更新日期：2015-10-01 00:00:00

abstract：:Resistance of cancer cells to radiotherapy is a major clinical problem in cancer treatment. Therefore, understanding the molecular basis of cellular resistance to radiotherapy and identification of novel targets are essential for improving treatment efficacy for cancer patients. Our previous studies have demonstrated ...

journal_title：Scientific reports

authors： Chen S,Zhang Y,Zhang D

更新日期：2015-09-30 00:00:00

abstract：:Human learners can generalize a new concept from a small number of samples. In contrast, conventional machine learning methods require large amounts of data to address the same types of problems. Humans have cognitive biases that promote fast learning. Here, we developed a method to reduce the gap between human beings...

journal_title：Scientific reports

authors： Taniguchi H,Sato H,Shirakawa T

更新日期：2018-05-09 00:00:00

abstract：:The ability of human embryonic stem cells (hESCs) to differentiate into skeletal muscle cells is an important criterion in using them as a cell source to ameliorate skeletal muscle impairments. However, differentiation of hESCs into skeletal muscle cells still remains a challenge, often requiring introduction of trans...

journal_title：Scientific reports

authors： Hwang Y,Suk S,Shih YR,Seo T,Du B,Xie Y,Li Z,Varghese S

更新日期：2014-08-01 00:00:00

abstract：:Tumor necrosis factor receptor 2 (TNFR2) is known to mediate immune suppression and tissue regeneration. Interestingly, the transmembrane form of tumor necrosis factor (tmTNF) is necessary to robustly activate TNFR2. To characterize the stoichiometry and composition of tmTNF during TNFR2 activation, we constructed dif...

journal_title：Scientific reports

authors： Fischer R,Marsal J,Guttà C,Eisler SA,Peters N,Bethea JR,Pfizenmaier K,Kontermann RE

更新日期：2017-07-26 00:00:00

abstract：:Choosing an option increases a person's preference for that option. This phenomenon, called choice-based learning (CBL), has been investigated separately in the contexts of internally guided decision-making (IDM, e.g., preference judgment), for which no objectively correct answer exists, and externally guided decision...

journal_title：Scientific reports

authors： Nakao T,Kanayama N,Katahira K,Odani M,Ito Y,Hirata Y,Nasuno R,Ozaki H,Hiramoto R,Miyatani M,Northoff G

更新日期：2016-08-31 00:00:00

abstract：:Down syndrome (DS), caused by trisomy of chromosome 21, is one of the most common genetic disorders. Patients with DS display growth retardation and inevitably develop characteristic Alzheimer's disease (AD) neuropathology, including neurofibrillary tangles and neuritic plaques. The expression of amyloid precursor pro...

journal_title：Scientific reports

authors： Wu Y,Zhang S,Xu Q,Zou H,Zhou W,Cai F,Li T,Song W

更新日期：2016-03-03 00:00:00