Abstract：
:The activity of the ubiquitin proteasome system (UPS) is downregulated in aggregation diseases such as Alzheimer's disease (AD). In this study, we investigated the therapeutic potential of the Agouti-related peptide (AgRP), which is secreted by human mesenchymal stem cells (MSCs), in terms of its effect on the regulation of proteasome activity in AD. When SH-SY5Y human neuroblastoma cells were co-cultured with MSCs isolated from human Wharton's Jelly (WJ-MSC), their proteasome activity was significantly upregulated. Further analysis of the conditioned media after co-culture allowed us to identify significant concentrations of a neuropeptide, called AgRP. The stereotactic delivery of either WJ-MSCs or AgRP into the hippocampi of C57BL6/J and 5XFAD mice induced a significant increase of proteasome activity and suppressed the accumulation of ubiquitin-conjugated proteins. Collectively, these findings suggest strong therapeutic potential for WJ-MSCs and AgRP to enhance proteasome activity, thereby potentially reducing abnormal protein aggregation and delaying the clinical progression of various neurodegenerative diseases.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lee NK,Park SE,Kwon SJ,Shim S,Byeon Y,Kim JH,Na DL,Chang JWdoi
10.1038/srep39340subject
Has Abstractpub_date
2017-01-04 00:00:00pages
39340issn
2045-2322pii
srep39340journal_volume
7pub_type
杂志文章abstract：:We report a novel method to fabricate high quality 2-inch freestanding GaN substrate grown on cross-stacked carbon nanotubes (CSCNTs) coated sapphire by hydride vapor phase epitaxy (HVPE). As nanoscale masks, these CSCNTs can help weaken the interface connection and release the compressive stress by forming voids duri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28620
更新日期：2016-06-24 00:00:00
abstract：:Understanding the genetic basis of phenotypic diversity is a challenge in contemporary biology. Domestication provides a model for unravelling aspects of the genetic basis of stress sensitivity. The ancestral Red Junglefowl (RJF) exhibits greater fear-related behaviour and a more pronounced HPA-axis reactivity than it...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-10-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34769
更新日期：2016-10-05 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-05-21 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2018-10-31 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-12-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-03-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57890-2
更新日期：2020-01-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22380-z
更新日期：2018-03-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42355-y
更新日期：2019-04-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27697
更新日期：2016-06-21 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06279-9
更新日期：2017-07-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33999-3
更新日期：2018-10-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12071
更新日期：2015-07-10 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03592-1
更新日期：2017-06-23 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44619
更新日期：2017-03-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35634
更新日期：2016-10-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,多中心研究
doi：10.1038/s41598-020-62278-3
更新日期：2020-03-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59561-8
更新日期：2020-02-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27080
更新日期：2016-06-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29626
更新日期：2016-07-15 00:00:00
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pub_type： 杂志文章
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更新日期：2017-05-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10073
更新日期：2015-05-18 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-07-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45804
更新日期：2017-04-05 00:00:00
abstract：:Maoto, a traditional Japanese Kampo medicine, has been used to treat various respiratory diseases, including respiratory infections and influenza. Ephedrine (EPD), the main ingredient in maoto, is also clinically used to treat respiratory diseases. However, the pharmacokinetics and distribution of EPD in the lungs aft...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44098
更新日期：2017-03-08 00:00:00
abstract：:Ga-68 Prostate-Specific Membrane Antigen PET/CT is a new tool for the assessment of prostate cancer. Standard imaging time is 60 minutes post injection of radiotracer. At 60 minutes, there is physiologic accumulation of radiotracer in the urinary bladder which may cause some lesions in its vicinity to be obscured. Our...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59296-6
更新日期：2020-02-17 00:00:00
abstract：:The aim of this study was to test the hypothesis that duplication/hybridization of functional domains of naturally occurring pellicle peptides amplified the inhibitory effect of hydroxyapatite crystal growth, which is related to enamel remineralization and dental calculus formation. Histatin 3, statherin, their functi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21854-4
更新日期：2018-02-28 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33601-w
更新日期：2018-10-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17042
更新日期：2015-11-26 00:00:00
