Potassium depletion induces cellular conversion in the outer medullary collecting duct altering Notch signaling pathway.

abstract：:Recent advances in our ability to design DNA binding factors with specificity for desired sequences have resulted in a revolution in genetic engineering, enabling directed changes to the genome to be made relatively easily. Technologies that facilitate specific and precise genome editing, such as knock-in, are critica...

journal_title：Scientific reports

authors： Wu M,Wei C,Lian Z,Liu R,Zhu C,Wang H,Cao J,Shen Y,Zhao F,Zhang L,Mu Z,Wang Y,Wang X,Du L,Wang C

更新日期：2016-04-11 00:00:00

abstract：:From the 1950s, the Po delta, one of the largest anthropogenic world deltas, has been subjected to a fast degradation and shoreline retreat due a marked reduction of sediment supply, mainly controlled by human impacts/factors, including subsidence. Through the interpretation of satellite images, coupled with the analy...

journal_title：Scientific reports

authors： Ninfo A,Ciavola P,Billi P

更新日期：2018-02-22 00:00:00

abstract：:The implementation of HTS (high-throughput sequencing) approaches is rapidly changing our understanding of the lichen symbiosis, by uncovering high bacterial and fungal diversity, which is often host-specific. Recently, HTS methods revealed the presence of multiple photobionts inside a single thallus in several lichen...

journal_title：Scientific reports

authors： Paul F,Otte J,Schmitt I,Dal Grande F

更新日期：2018-06-05 00:00:00

abstract：:Tyrosine hydroxylase (TH), the initial enzyme in the melanin pathway, catalyzes tyrosine conversion into Dopa. Although expression and regulation of TH have been shown to affect cuticle pigmentation in insects, no direct functional studies to date have focused on the specific physiological processes involving the enzy...

journal_title：Scientific reports

authors： Qiao L,Du M,Liang X,Hao Y,He X,Si F,Mei T,Chen B

更新日期：2016-07-15 00:00:00

abstract：:Dysregulation in acetylation homeostasis has been implicated in the pathogenesis of the amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. It is known that the acetylation of transcriptional factors regulates their activity. The acetylation state of NF-kB RelA has been found to dictate the neurop...

journal_title：Scientific reports

authors： Schiaffino L,Bonafede R,Scambi I,Parrella E,Pizzi M,Mariotti R

更新日期：2018-08-27 00:00:00

abstract：:Surface colonization by microorganisms leads to the formation of biofilms, i.e. aggregates of bacteria embedded within a matrix of extracellular polymeric substance. This promotes adhesion to the surface and protects bacterial community, providing an antimicrobial-resistant environment. The inhibition of biofilm growt...

journal_title：Scientific reports

authors： Sportelli MC,Tütüncü E,Picca RA,Valentini M,Valentini A,Kranz C,Mizaikoff B,Barth H,Cioffi N

更新日期：2017-09-19 00:00:00

abstract：:The endoplasmic reticulum (ER) is a multi functional organelle and plays a crucial role in protein folding and lipid biosynthesis. The SEC59 gene encodes dolichol kinase, required for protein glycosylation in the ER. The mutation of sec59-1 caused a protein N-glycosylation defect mediated ER stress resulting in increa...

journal_title：Scientific reports

authors： William James A,Ravi C,Srinivasan M,Nachiappan V

更新日期：2019-10-09 00:00:00

abstract：:Individuals in the state of psychological suboptimal health keep increasing, only scales and questionnaires were used to diagnose in clinic under current conditions, and symptoms of high reliability and accuracy are destitute. Therefore, the noninvasive and precise laboratory diagnostic methods are needed. This study ...

journal_title：Scientific reports

authors： Tian JS,Xia XT,Wu YF,Zhao L,Xiang H,Du GH,Zhang X,Qin XM

更新日期：2016-09-21 00:00:00

abstract：:Pesticides are commonly used in food crop production systems to control crop pests and diseases and ensure maximum yield with high market value. However, the accumulation of these chemical inputs in crop fields increases risks to biodiversity and human health. In addition, people are increasingly seeking foods in whic...

journal_title：Scientific reports

authors： Ali MP,Bari MN,Haque SS,Kabir MMM,Afrin S,Nowrin F,Islam MS,Landis DA

更新日期：2019-07-15 00:00:00

abstract：:During germ cell development, epigenetic modifications undergo extensive remodeling. Abnormal epigenetic modifications usually result in germ cell loss and reproductive defect. Prmt5 (Protein arginine methyltransferase 5) encodes a protein arginine methyltransferase which has been demonstrated to play important roles ...

journal_title：Scientific reports

authors： Wang Y,Zhu T,Li Q,Liu C,Han F,Chen M,Zhang L,Cui X,Qin Y,Bao S,Gao F

更新日期：2015-06-15 00:00:00

abstract：:One of the main challenges in quantum technologies is the ability to control individual quantum systems. This task becomes increasingly difficult as the dimension of the system grows. Here we propose a general setup for cyclic permutations Xd in d dimensions, a major primitive for constructing arbitrary qudit gates. U...

journal_title：Scientific reports

authors： Isdrailă TA,Kusko C,Ionicioiu R

更新日期：2019-04-19 00:00:00

abstract：:Amplicon based metabarcoding promises rapid and cost-efficient analyses of species composition. However, it is disputed whether abundance estimates can be derived from metabarcoding due to taxon specific PCR amplification biases. PCR-free approaches have been suggested to mitigate this problem, but come with considera...

journal_title：Scientific reports

authors： Krehenwinkel H,Wolf M,Lim JY,Rominger AJ,Simison WB,Gillespie RG

更新日期：2017-12-15 00:00:00

abstract：:Environmental stimuli have the ability to generate specific representations of the rewards they predict and in so doing alter the selection and performance of reward-seeking actions. The basolateral amygdala participates in this process, but precisely how is unknown. To rectify this, we monitored, in near-real time, b...

journal_title：Scientific reports

authors： Malvaez M,Greenfield VY,Wang AS,Yorita AM,Feng L,Linker KE,Monbouquette HG,Wassum KM

更新日期：2015-07-27 00:00:00

abstract：:Tuberculosis, a severe infectious disease caused by the Mycobacterium tuberculosis, arouses huge concerns globally. In this study, a total of 331,594 TB cases in Zhejiang Province were notified during the period of 2009-2018 with the gender ratio of male to female 2.16:1. The notified TB incidences demonstrated a cont...

journal_title：Scientific reports

authors： Liu K,Li T,Vongpradith A,Wang F,Peng Y,Wang W,Chai C,Chen S,Zhang Y,Zhou L,Chen X,Bian Q,Chen B,Wang X,Jiang J

更新日期：2020-05-04 00:00:00

abstract：:It is essential to understand how the loss of biodiversity impacts both ecosystem function (EF) and multifunctionality (EMF). Previous studies have mostly focused on predicting how species richness (SR) impacts EMF, while the effect of functional diversity (FD) on EMF remains unclear. Specifically, we know little abou...

journal_title：Scientific reports

authors： Huang X,Su J,Li S,Liu W,Lang X

更新日期：2019-05-06 00:00:00

abstract：:A single bout of electroacupuncture results in muscle contractions and increased whole body glucose uptake in women with polycystic ovary syndrome (PCOS). Women with PCOS have transcriptional and epigenetic alterations in the adipose tissue and we hypothesized that electroacupuncture induces epigenetic and transcripti...

journal_title：Scientific reports

authors： Kokosar M,Benrick A,Perfilyev A,Nilsson E,Källman T,Ohlsson C,Ling C,Stener-Victorin E

更新日期：2018-01-30 00:00:00

abstract：:We report evidence of the transition from n- to p-type conduction of InN with increasing Mg dopant concentration by using photoconductivity (PC) measurement at room temperature. This transition is depicted as a conversion from negative to positive PC under above-bandgap optical excitation. The n- to p-type transition ...

journal_title：Scientific reports

authors： Guo L,Wang XQ,Zheng XT,Yang XL,Xu FJ,Tang N,Lu LW,Ge WK,Shen B,Dmowski LH,Suski T

更新日期：2014-03-13 00:00:00

abstract：:Habitat fragmentation is considered as major threat to biodiversity worldwide. Biodiversity can be described as taxonomic, functional and phylogenetic diversity. However, the effect of forest fragmentation on taxonomic, phylogenetic and functional diversity is barely understood. We compare the response of taxonomic (s...

journal_title：Scientific reports

authors： Bełcik M,Lenda M,Amano T,Skórka P

更新日期：2020-11-23 00:00:00

abstract：:Given that many fundamental questions in neuroscience are still open, it seems pertinent to explore whether the brain might use other physical modalities than the ones that have been discovered so far. In particular it is well established that neurons can emit photons, which prompts the question whether these biophoto...

journal_title：Scientific reports

authors： Kumar S,Boone K,Tuszyński J,Barclay P,Simon C

更新日期：2016-11-07 00:00:00

abstract：:We demonstrate the capability of a novel Electron Backscatter Diffraction (EBSD) dictionary indexing (DI) approach by means of orientation mapping of a highly deformed graded microstructure in a shot peened Aluminium 7075-T651 alloy. A low microscope accelerating voltage was used to extract, for the first time from a ...

journal_title：Scientific reports

authors： Singh S,Guo Y,Winiarski B,Burnett TL,Withers PJ,De Graef M

更新日期：2018-07-20 00:00:00

abstract：:Respiratory syncytial virus (RSV) is an important cause of serious lower respiratory tract disease in infants. Several studies have shown evidence pointing to the genome of the host as an important factor determining susceptibility to respiratory disease caused by RSV. We sequenced the complete exomes of 54 patients i...

journal_title：Scientific reports

authors： Salas A,Pardo-Seco J,Cebey-López M,Gómez-Carballa A,Obando-Pacheco P,Rivero-Calle I,Currás-Tuala MJ,Amigo J,Gómez-Rial J,Martinón-Torres F,GENDRES network.

更新日期：2017-11-21 00:00:00

abstract：:Portal vein ligation (PVL) induces atrophy/hypertrophy complex (AHC). We hypothesised that simultaneous bile duct and portal vein ligation (BPL) might induce proper bile acid (BA) retention to enhance AHC by activating BA-mediated FXR signalling in the intact liver and promoting apoptosis in the ligated liver. We esta...

journal_title：Scientific reports

authors： Ren W,Chen G,Wang X,Zhang A,Li C,Lv W,Pan K,Dong JH

更新日期：2015-02-13 00:00:00

abstract：:Hominin dietary specialization is crucial to understanding the evolutionary changes of craniofacial biomechanics and the interaction of food processing methods' effects on teeth. However, the diet-related dental wear processes of the earliest European hominins remain unknown because most of the academic attention has ...

journal_title：Scientific reports

authors： Pérez-Pérez A,Lozano M,Romero A,Martínez LM,Galbany J,Pinilla B,Estebaranz-Sánchez F,Bermúdez de Castro JM,Carbonell E,Arsuaga JL

更新日期：2017-02-27 00:00:00

abstract：:The human pathogen Legionella pneumophila delivers a large array of the effector proteins into host cells using the Dot/Icm type IVB secretion system. Among the proteins composing the Dot/Icm system, an inner membrane protein DotI is known to be crucial for the secretion function but its structure and role in type IV ...

journal_title：Scientific reports

authors： Kuroda T,Kubori T,Thanh Bui X,Hyakutake A,Uchida Y,Imada K,Nagai H

更新日期：2015-06-03 00:00:00

abstract：:This study aimed to investigate the dosimetric characteristics of an isocentrically shielded RapidArc (IS-RA) technique for treatment of locally recurrent nasopharyngeal cancer (lrNPC). In IS-RA, the isocenter was placed at the center of the pre-irradiated brainstem (BS)/spinal cord (SC) and the jaws were set to shiel...

journal_title：Scientific reports

authors： Lu JY,Huang BT,Xing L,Chang DT,Peng X,Xie LX,Lin ZX,Li M

更新日期：2016-05-13 00:00:00

abstract：:It is known that a developing avian embryo resorbs micronutrients (calcium and other chemical elements) from the inner layer of the eggshell, inducing thinning and overall changes in the shell's chemical composition. However, an aspect yet to be explored relates to the local changes in the multi-elemental composition ...

journal_title：Scientific reports

authors： Orłowski G,Niedzielski P,Merta D,Pokorny P,Proch J

更新日期：2020-12-17 00:00:00

abstract：:Enzymatic conversion of chitin, a β-1,4 linked polymer of N-acetylglucosamine, is of major interest in areas varying from the biorefining of chitin-rich waste streams to understanding how medically relevant fungi remodel their chitin-containing cell walls. Although numerous chitinolytic enzymes have been studied in de...

journal_title：Scientific reports

authors： Liu Z,Gay LM,Tuveng TR,Agger JW,Westereng B,Mathiesen G,Horn SJ,Vaaje-Kolstad G,van Aalten DMF,Eijsink VGH

更新日期：2017-05-11 00:00:00

abstract：:Nettles are commonly consumed in South Africa, Europe and Asia and are used in traditional medicine to treat a variety of ailments. In this study, the nutritional value of the leaves of nettles (Laportea alatipes and Obetia tenax) was evaluated and compared, when cooked and uncooked. The results showed a decrease in t...

journal_title：Scientific reports

authors： Mahlangeni NT,Moodley R,Jonnalagadda SB

更新日期：2020-06-17 00:00:00

abstract：:In ART programs in sub-Saharan Africa, a growing proportion of HIV-infected persons initiating first-line antiretroviral therapy (ART) have a history of prior antiretroviral drug use (PAU). We assessed the effect of PAU on the risk of pre-treatment drug resistance (PDR) and virological failure (VF) in a multicountry c...

journal_title：Scientific reports

authors： Inzaule SC,Kityo CM,Siwale M,Akanmu AS,Wellington M,de Jager M,Ive P,Mandaliya K,Stevens W,Boender TS,Ondoa P,Sigaloff KCE,Naniche D,Rinke de Wit TF,Hamers RL

更新日期：2018-10-25 00:00:00

abstract：:Although chronic kidney disease (CKD) is associated with functional decline, whether proteinuria alone is associated with functional statuses over the course of acute illnesses independent of CKD is unclear. During 2014, we prospectively enrolled non-dialysis patients aged ≥65 years, and all participants underwent spo...

journal_title：Scientific reports

authors： Chao CT,Tsai HB,Chiang CK,Huang JW,Hung KY

更新日期：2017-02-08 00:00:00