当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Ruthenium(II) complexes with 6-methyl-2-thiouracil selectively reduce cell proliferation, cause DNA double-strand break and trigger caspase-mediated apoptosis through JNK/p38 pathways in human acute promyelocytic leukemia cells.

Ruthenium(II) complexes with 6-methyl-2-thiouracil selectively reduce cell proliferation, cause DNA double-strand break and trigger caspase-mediated apoptosis through JNK/p38 pathways in human acute promyelocytic leukemia cells.

Abstract：

:Ruthenium(II) complexes with 6-methyl-2-thiouracil cis-[Ru(6m2tu)2(PPh3)2] (1) and [Ru(6m2tu)2(dppb)] (2) (where PPh3 = triphenylphosphine; dppb = 1,4-bis(diphenylphosphino)butane; and 6m2tu = 6-methyl-2-thiouracil) are potent cytotoxic agents and able to bind DNA. The aim of this study was to evaluate in vitro cellular underlying mechanism and in vivo effectiveness of these ruthenium(II) complexes in human acute promyelocytic leukemia HL-60 cells. Both complexes displayed potent and selective cytotoxicity in myeloid leukemia cell lines, and were detected into HL-60 cells. Reduction of the cell proliferation and augmented phosphatidylserine externalization, caspase-3, -8 and -9 activation and loss of mitochondrial transmembrane potential were observed in HL-60 cells treated with both complexes. Cotreatment with Z-VAD(OMe)-FMK, a pan-caspase inhibitor, reduced Ru(II) complexes-induced apoptosis. In addition, both metal complexes induced phosphorylation of histone H2AX (S139), JNK2 (T183/Y185) and p38α (T180/Y182), and cotreatment with JNK/SAPK and p38 MAPK inhibitors reduced complexes-induced apoptosis, indicating DNA double-strand break and activation of caspase-mediated apoptosis through JNK/p38 pathways. Complex 1 also reduced HL-60 cell growth in xenograft model. Overall, the outcome indicated the ruthenium(II) complexes with 6-methyl-2-thiouracil as a novel promising antileukemic drug candidates.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Bomfim LM,de Araujo FA,Dias RB,Sales CBS,Rocha CAG,Correa RS,Soares MBP,Batista AA,Bezerra DP

doi

10.1038/s41598-019-47914-x

subject

Has Abstract

pub_date

2019-08-07 00:00:00

pages

11483

issue

1

issn

2045-2322

pii

10.1038/s41598-019-47914-x

journal_volume

9

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Transfusion Challenges in Patients with Hematological Malignancies in Sub-Saharan Africa: A Prospective Observational Study from the Uganda Cancer Institute.

    abstract：:Blood transfusion is fundamental in managing hematologic malignancies. We sought to evaluate the need and availability of blood products for patients with hematological malignancies at Uganda Cancer Institute. We prospectively studied the demand and supply of blood for patients with thrombocytopenia (platelet count ≤5...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59773-y

    authors： Ddungu H,Krantz EM,Kajja I,Naluzze S,Nabbanja H,Nalubwama F,Phipps W,Orem J,Wald A,Kiwanuka N

    更新日期：2020-02-18 00:00:00

  • Magnetic neutron scattering by magnetic vortices in thin submicron-sized soft ferromagnetic cylinders.

    abstract：:Using analytical expressions for the magnetization textures of thin submicron-sized magnetic cylinders in vortex state, we derive closed-form algebraic expressions for the ensuing small-angle neutron scattering (SANS) cross sections. Specifically, for the perpendicular and parallel scattering geometries, we have compu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25055

    authors： Metlov KL,Michels A

    更新日期：2016-04-26 00:00:00

  • Cluster analysis: a new approach for identification of underlying risk factors for coronary artery disease in essential hypertensive patients.

    abstract：:Grading of essential hypertension according to blood pressure (BP) level may not adequately reflect clinical heterogeneity of hypertensive patients. This study was carried out to explore clinical phenotypes in essential hypertensive patients using cluster analysis. This study recruited 513 hypertensive patients and ev...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep43965

    authors： Guo Q,Lu X,Gao Y,Zhang J,Yan B,Su D,Song A,Zhao X,Wang G

    更新日期：2017-03-07 00:00:00

  • Optimization of Performance and Emission Characteristics of Catalytic Coated IC Engine with Biodiesel Using Grey-Taguchi Method.

    abstract：:The performance and emission affected by piston catalytic coating have been analyzed in this study. The main contributing factors for improving performance such as load, fuel and speed have been preferred to reduce the emission and improve the performance of an IC engine. These specific standard parameters have been m...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-57129-9

    authors： Yessian S,Varthanan PA

    更新日期：2020-02-07 00:00:00

  • Transcriptomic profile of adverse neurodevelopmental outcomes after neonatal encephalopathy.

    abstract：:A rapid and early diagnostic test to identify the encephalopathic babies at risk of adverse outcome may accelerate the development of neuroprotectants. We examined if a whole blood transcriptomic signature measured soon after birth, predicts adverse neurodevelopmental outcome eighteen months after neonatal encephalopa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-70131-w

    authors： Montaldo P,Cunnington A,Oliveira V,Swamy R,Bandya P,Pant S,Lally PJ,Ivain P,Mendoza J,Atreja G,Padmesh V,Baburaj M,Sebastian M,Yasashwi I,Kamalarathnam C,Chandramohan R,Mangalabharathi S,Kumaraswami K,Kumar S,Benaka

    更新日期：2020-08-04 00:00:00

  • The short isoform of extended synaptotagmin-2 controls Ca2+ dynamics in T cells via interaction with STIM1.

    abstract：:Ca2+ release-activated Ca2+ (CRAC) channels elevate cytoplasmic Ca2+ concentration, which is essential for T cell activation, differentiation and effector functions. T cell receptor stimulation induces depletion of the endoplasmic reticulum (ER) Ca2+ stores, which is sensed by stromal interaction molecule 1 (STIM1). S...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71489-7

    authors： Woo JS,Sun Z,Srikanth S,Gwack Y

    更新日期：2020-09-02 00:00:00

  • 3D tracking of single nanoparticles and quantum dots in living cells by out-of-focus imaging with diffraction pattern recognition.

    abstract：:Live cells are three-dimensional environments where biological molecules move to find their targets and accomplish their functions. However, up to now, most single molecule investigations have been limited to bi-dimensional studies owing to the complexity of 3d-tracking techniques. Here, we present a novel method for ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16088

    authors： Gardini L,Capitanio M,Pavone FS

    更新日期：2015-11-03 00:00:00

  • Two-dimensional hyper-branched gold nanoparticles synthesized on a two-dimensional oil/water interface.

    abstract：:Two-dimensional (2D) gold nanoparticles can possess novel physical and chemical properties, which will greatly expand the utility of gold nanoparticles in a wide variety of applications ranging from catalysis to biomedicine. However, colloidal synthesis of such particles generally requires sophisticated synthetic tech...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep06119

    authors： Shin Y,Lee C,Yang MS,Jeong S,Kim D,Kang T

    更新日期：2014-08-26 00:00:00

  • Biomarkers of inflammation and breast cancer risk: a case-control study nested in the EPIC-Varese cohort.

    abstract：:Breast cancer (BC) is the leading cause of cancer death in women. Adipokines, and other inflammation molecules linked to adiposity, are suspected to be involved in breast carcinogenesis, however prospective findings are inconclusive. In a prospective nested case-control study within the EPIC-Varese cohort, we used con...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-12703-x

    authors： Agnoli C,Grioni S,Pala V,Allione A,Matullo G,Gaetano CD,Tagliabue G,Sieri S,Krogh V

    更新日期：2017-10-05 00:00:00

  • Molecular evolution of human adenoviruses.

    abstract：:The recent emergence of highly virulent human adenoviruses (HAdVs) with new tissue tropisms underscores the need to determine their ontogeny. Here we report complete high quality genome sequences and analyses for all the previously unsequenced HAdV serotypes (n = 20) within HAdV species D. Analysis of nucleotide seque...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep01812

    authors： Robinson CM,Singh G,Lee JY,Dehghan S,Rajaiya J,Liu EB,Yousuf MA,Betensky RA,Jones MS,Dyer DW,Seto D,Chodosh J

    更新日期：2013-01-01 00:00:00

  • Matrix metalloproteinases (MMPs) mediate leukocyte recruitment during the inflammatory phase of zebrafish heart regeneration.

    abstract：:In zebrafish, the role of matrix metalloproteinases (MMPs) in the inflammatory phase of heart regeneration following cryoinjury remains poorly understood. Here, we demonstrated an increase in MMP enzymatic activity and elevated expression of mmp9 and mmp13 in the injured area (IA) of hearts from as early as 1 day post...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-25490-w

    authors： Xu S,Webb SE,Lau TCK,Cheng SH

    更新日期：2018-05-08 00:00:00

  • GSK3 inhibitors CHIR99021 and 6-bromoindirubin-3'-oxime inhibit microRNA maturation in mouse embryonic stem cells.

    abstract：:Wnt/β-catenin signalling plays a prominent role in maintaining self-renewal and pluripotency of mouse embryonic stem cells (mESCs). microRNAs (miRNAs) have critical roles in maintaining pluripotency and directing reprogramming. To investigate the effect of GSK3 inhibitors on miRNA expression, we analysed the miRNA exp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep08666

    authors： Wu Y,Liu F,Liu Y,Liu X,Ai Z,Guo Z,Zhang Y

    更新日期：2015-03-02 00:00:00

  • Triggering of major eruptions recorded by actively forming cumulates.

    abstract：:Major overturn within a magma chamber can bring together felsic and mafic magmas, prompting de-volatilisation and acting as the driver for Plinian eruptions. Until now identification of mixing has been limited to analysis of lavas or individual crystals ejected during eruptions. We have recovered partially developed c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00731

    authors： Stock MJ,Taylor RN,Gernon TM

    更新日期：2012-01-01 00:00:00

  • Endothelial cell-surface tissue transglutaminase inhibits neutrophil adhesion by binding and releasing nitric oxide.

    abstract：:Nitric oxide (NO) produced by endothelial cells in response to cytokines displays anti-inflammatory activity by preventing the adherence, migration and activation of neutrophils. The molecular mechanism by which NO operates at the blood-endothelium interface to exert anti-inflammatory properties is largely unknown. He...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-16342-0

    authors： Lai TS,Lindberg RA,Zhou HL,Haroon ZA,Dewhirst MW,Hausladen A,Juang YL,Stamler JS,Greenberg CS

    更新日期：2017-11-23 00:00:00

  • Achromatic light patterning and improved image reconstruction for parallelized RESOLFT nanoscopy.

    abstract：:Fluorescence microscopy is rapidly turning into nanoscopy. Among the various nanoscopy methods, the STED/RESOLFT super-resolution family has recently been expanded to image even large fields of view within a few seconds. This advance relies on using light patterns featuring substantial arrays of intensity minima for d...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep44619

    authors： Chmyrov A,Leutenegger M,Grotjohann T,Schönle A,Keller-Findeisen J,Kastrup L,Jakobs S,Donnert G,Sahl SJ,Hell SW

    更新日期：2017-03-20 00:00:00

  • Mode of renal replacement therapy determines endotoxemia and neutrophil dysfunction in chronic kidney disease.

    abstract：:Bacterial infection and sepsis are common complications of chronic kidney disease (CKD). A vicious cycle of increased gut permeability, endotoxemia, inadequate activation of the innate immune system and resulting innate immune dysfunction is hypothesized. We assessed endotoxemia, neutrophil function and its relation t...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/srep34534

    authors： Lemesch S,Ribitsch W,Schilcher G,Spindelböck W,Hafner-Gießauf H,Marsche G,Pasterk L,Payerl D,Schmerböck B,Tawdrous M,Rosenkranz AR,Stiegler P,Kager G,Hallström S,Oettl K,Eberhard K,Horvath A,Leber B,Stadlbauer V

    更新日期：2016-10-04 00:00:00

  • Broad-scale morpho-functional traits of the mandible suggest no hard food adaptation in the hominin lineage.

    abstract：:An on-going debate concerning the dietary adaptations of archaic hominins and early Homo has been fuelled by contradictory inferences obtained using different methodologies. This work presents an extensive comparative sample of 30 extant primate species that was assembled to perform a morpho-functional comparison of t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-63739-5

    authors： Marcé-Nogué J,Püschel TA,Daasch A,Kaiser TM

    更新日期：2020-04-22 00:00:00

  • Thermoelectric microscopy of magnetic skyrmions.

    abstract：:The magnetic skyrmion is a nanoscale topological object characterized by the winding of magnetic moments, appearing in magnetic materials with broken inversion symmetry. Because of its low current threshold for driving the skyrmion motion, they have been intensely studied toward novel storage applications by using ele...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54833-4

    authors： Iguchi R,Kasai S,Koshikawa K,Chinone N,Suzuki S,Uchida KI

    更新日期：2019-12-05 00:00:00

  • Isotopic ratios of uranium and caesium in spherical radioactive caesium-bearing microparticles derived from the Fukushima Dai-ichi Nuclear Power Plant.

    abstract：:Spherical radioactive caesium (Cs)-bearing microparticles (CsMPs) were emitted during the Fukushima Dai-ichi Nuclear Power Plant (FDNPP) accident in March, 2011. The emission source (timing) and formation process of these particles remain unclear. In this study, the isotopic ratios of uranium (235U and 238U) and caesi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59933-0

    authors： Kurihara Y,Takahata N,Yokoyama TD,Miura H,Kon Y,Takagi T,Higaki S,Yamaguchi N,Sano Y,Takahashi Y

    更新日期：2020-02-24 00:00:00

  • Tick receptor for outer surface protein A from Ixodes ricinus - the first intrinsically disordered protein involved in vector-microbe recognition.

    abstract：:The tick receptor for outer surface protein A (TROSPA) is the only identified factor involved in tick gut colonization by various Borrelia species. TROSPA is localized in the gut epithelium and can recognize and bind the outer surface bacterial protein OspA via an unknown mechanism. Based on earlier reports and our la...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25205

    authors： Urbanowicz A,Lewandowski D,Szpotkowski K,Figlerowicz M

    更新日期：2016-04-26 00:00:00

  • Ranking nodes in growing networks: When PageRank fails.

    abstract：:PageRank is arguably the most popular ranking algorithm which is being applied in real systems ranging from information to biological and infrastructure networks. Despite its outstanding popularity and broad use in different areas of science, the relation between the algorithm's efficacy and properties of the network ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16181

    authors： Mariani MS,Medo M,Zhang YC

    更新日期：2015-11-10 00:00:00

  • Determining correlates of the average number of cigarette smoking among college students using count regression models.

    abstract：:College students, as a large part of young adults, are a vulnerable group to several risky behaviors including smoking and drug abuse. This study aimed to utilize and to compare count regression models to identify correlates of cigarette smoking among college students. This was a cross-sectional study conducted on stu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65813-4

    authors： Sharareh P,Leili T,Abbas M,Jalal P,Ali G

    更新日期：2020-06-01 00:00:00

  • Photoresponsivity of an all-semimetal heterostructure based on graphene and WTe2.

    abstract：:Heterostructures based on two-dimensional (2D) materials have sparked wide interests in both fundamental physics and applied devices. Recently, Dirac/Weyl semimetals are emerging as capable functional materials for optoelectronic devices. However, thus far the interfacial coupling of an all-semimetal 2D heterostructur...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29717-8

    authors： Liu Y,Liu C,Wang X,He L,Wan X,Xu Y,Shi Y,Zhang R,Wang F

    更新日期：2018-08-27 00:00:00

  • Graphene surface plasmons at the near-infrared optical regime.

    abstract：:Graphene has been identified as an emerging horizon for a nanoscale photonic platform because the Fermi level of intrinsic graphene can be engineered to support surface plasmons (SPs). The current solid back electrical gating and chemical doping methods cannot facilitate the demonstration of graphene SPs at the near-i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep06559

    authors： Zhang Q,Li X,Hossain MM,Xue Y,Zhang J,Song J,Liu J,Turner MD,Fan S,Bao Q,Gu M

    更新日期：2014-10-09 00:00:00

  • Enhancing robustness of coupled networks under targeted recoveries.

    abstract：:Coupled networks are extremely fragile because a node failure of a network would trigger a cascade of failures on the entire system. Existing studies mainly focused on the cascading failures and the robustness of coupled networks when the networks suffer from attacks. In reality, it is necessary to recover the damaged...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep08439

    authors： Gong M,Ma L,Cai Q,Jiao L

    更新日期：2015-02-13 00:00:00

  • Human neural stem cell-induced endothelial morphogenesis requires autocrine/paracrine and juxtacrine signaling.

    abstract：:Transplanted neural stem cells (NSC) interact with the host brain microenvironment. A neovascularization is commonly observed in the vicinity of the cell deposit, which is correlated with behavioral improvements. To elucidate the signaling mechanisms between human NSCs and endothelial cells (ECs), these were coculture...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep29029

    authors： Chou CH,Modo M

    更新日期：2016-07-04 00:00:00

  • Adenoviral E4 34K protein interacts with virus packaging components and may serve as the putative portal.

    abstract：:Studies on dsDNA bacteriophages have revealed that a DNA packaging complex assembles at a special vertex called the 'portal vertex' and consists of a portal, a DNA packaging ATPase and other components. AdV protein IVa2 is presumed to function as a DNA packaging ATPase. However, a protein that functions as a portal is...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07997-w

    authors： Ahi YS,Hassan AO,Vemula SV,Li K,Jiang W,Zhang GJ,Mittal SK

    更新日期：2017-08-08 00:00:00

  • Corrigendum: Engineering the residual side chains of HAP phytases to improve their pepsin resistance and catalytic efficiency.

    abstract：:This corrects the article DOI: 10.1038/srep42133. ...

    journal_title：Scientific reports

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/srep46871

    authors： Niu C,Yang P,Luo H,Huang H,Wang Y,Yao B

    更新日期：2017-06-30 00:00:00

  • Transfer of a bla CTX-M-1-carrying plasmid between different Escherichia coli strains within the human gut explored by whole genome sequencing analyses.

    abstract：:Horizontal transfer of antibiotic resistance determinants contributes to dissemination of antibiotic resistance. Such transfer of resistance genes within the human gut has been documented in some in vivo studies. The present study investigated seven bla CTX-M-1-carrying Escherichia coli isolates from three consecutive...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-18659-2

    authors： Knudsen PK,Gammelsrud KW,Alfsnes K,Steinbakk M,Abrahamsen TG,Müller F,Bohlin J

    更新日期：2018-01-10 00:00:00

  • Diagnosis of atlanto-occipital dissociation: Standardised measurements of normal craniocervical relationship in finless porpoises (genus Neophocaena) using postmortem computed tomography.

    abstract：:Due to the different craniocervical structures in humans and cetaceans, a standardised method assessing the normal craniocervical relationship in cetaceans is lacking, causing difficulties in defining the presence of atlanto-occipital dissociation (AOD) in cetaceans. The present study aimed to 1) describe a novel stan...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26866-8

    authors： Kot BCW,Chan DKP,Yuen AHL,Tsui HCL

    更新日期：2018-05-31 00:00:00