Elucidating the putative link between prefrontal neurotransmission, functional connectivity, and affective symptoms in irritable bowel syndrome.

abstract：:Photodynamic therapy (PDT) is an efficacious treatment for some types of cancers. However, PDT-induced tumor hypoxia as a result of oxygen consumption and vascular damage can reduce the efficacy of this therapy. Measuring and monitoring intrinsic and PDT-induced tumor hypoxia in vivo during PDT is of high interest for...

journal_title：Scientific reports

authors： Tong X,Srivatsan A,Jacobson O,Wang Y,Wang Z,Yang X,Niu G,Kiesewetter DO,Zheng H,Chen X

更新日期：2016-08-22 00:00:00

abstract：:Protein aggregation is a process by which misfolded proteins polymerizes into aggregates and forms fibrous structures with a β-sheet conformation, known as amyloids. It is an undesired outcome, as it not only causes numerous neurodegenerative diseases, but is also a major deterrent in the development of protein biopha...

journal_title：Scientific reports

authors： Rajan R,Matsumura K

更新日期：2017-04-04 00:00:00

abstract：:We investigated molecular dissociation induced by 10-keV X-ray irradiation in dense ice at pressures up to 40 GPa at 300 K. The dissociation yield estimated from the oxygen K-edge X-ray Raman spectra, showed that the molecular dissociation was enhanced up to 14 GPa and gradually suppressed on further compression to 40...

journal_title：Scientific reports

authors： Fukui H,Hiraoka N,Hirao N,Aoki K,Akahama Y

更新日期：2016-05-25 00:00:00

abstract：:Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell structure and behaviour, affecting cell morphology, proliferation, survival and differentiation. Consequently, mutations in specific integrins, or their deregulated expression, are associated with a variety of diseases. In t...

journal_title：Scientific reports

authors： Kapp TG,Rechenmacher F,Neubauer S,Maltsev OV,Cavalcanti-Adam EA,Zarka R,Reuning U,Notni J,Wester HJ,Mas-Moruno C,Spatz J,Geiger B,Kessler H

更新日期：2017-01-11 00:00:00

abstract：:Competing endogenous RNA (ceRNA) have received wide attention because they are a novel way to regulate genes through sharing microRNAs (miRNAs) that are crucial for complex processes in many diseases. However, no systematic analysis of ceRNA mechanism in cardiovascular disease (CVD) is known. To gain insights into the...

journal_title：Scientific reports

authors： Song C,Zhang J,Qi H,Feng C,Chen Y,Cao Y,Ba L,Ai B,Wang Q,Huang W,Li C,Sun H

更新日期：2017-08-31 00:00:00

abstract：:Helicobacter pylori cagA-positive strain delivers the CagA oncoprotein into gastric epithelial cells and at the same time elicits stomach inflammation. To experimentally investigate the pathophysiological interplay between CagA and inflammation, transgenic mice systemically expressing the bacterial cagA gene were trea...

journal_title：Scientific reports

authors： Suzuki N,Murata-Kamiya N,Yanagiya K,Suda W,Hattori M,Kanda H,Bingo A,Fujii Y,Maeda S,Koike K,Hatakeyama M

更新日期：2015-05-06 00:00:00

abstract：:Histological chorioamnionitis (HCA) is an infection of fetal membranes and complicates 5.2% to 28.5% of all live births. HCA is associated with increased mortality and morbidity in both premature and term neonates. Exposure to HCA may have long-term consequences, including an increased risk for allergic disorders and ...

journal_title：Scientific reports

authors： Gayen Nee' Betal S,Murthy S,Favara M,Fong G,Chan JSY,Addya S,Shaffer TH,Greenspan J,Bhandari V,Rahman I,Aghai ZH

更新日期：2019-04-10 00:00:00

abstract：:Conflicting results of survival outcomes for primary and secondary muscle-invasive bladder cancer (MIBC) have been reported in previous studies. Primary MIBC is defined as presentation of muscle-invasive disease at initial diagnosis while secondary MIBC presumes that non-muscle invasive disease later progressed to MIB...

journal_title：Scientific reports

authors： Ge P,Wang L,Lu M,Mao L,Li W,Wen R,Lin J,Wang J,Chen J

更新日期：2018-05-15 00:00:00

abstract：:The high hydrophobicity of poly(vinylidene fluoride) (PVDF) membrane remains an obstacle to be applied in some purification processes of water or wastewater. Herein, a highly hydrophilic hybrid mesoporous titania membrane composed of mesoporous anatase titania (meso-TiO2) materials inside the three-dimensional (3D) ma...

journal_title：Scientific reports

authors： Wang M,Yang G,Jin P,Tang H,Wang H,Chen Y

更新日期：2016-01-12 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Kakar KU,Nawaz Z,Cui Z,Cao P,Jin J,Shu Q,Ren X

更新日期：2020-03-10 00:00:00

abstract：:CVB3 is a common human pathogen to be highly lethal to newborns and causes viral myocarditis and pancreatitis in adults. However, there is no vaccine available for clinical use. CVB3 capsid protein VP1 is an immunodominant structural protein, containing several B- and T-cell epitopes. However, immunization of mice wit...

journal_title：Scientific reports

authors： Qi X,Xiong S

更新日期：2017-02-02 00:00:00

abstract：:Mineral dust aerosols are responsible for some of the largest sources of uncertainties in our current understanding of climate change. Here we show that a severe drought is having a significant impact in one of largest sources of mineral dust aerosols of the U.S., the Owens Lake area in California's southwest. Measure...

journal_title：Scientific reports

authors： Borlina CS,Rennó NO

更新日期：2017-05-11 00:00:00

abstract：:Multi-principle element alloys have enormous potential, but their exploration suffers from the tremendously large range of configurations. In the last decade such alloys have been designed with a focus on random solid solutions. Here we apply an experimentally verified, combined thermodynamic and first-principles desi...

journal_title：Scientific reports

authors： Rogal L,Bobrowski P,Körmann F,Divinski S,Stein F,Grabowski B

更新日期：2017-05-19 00:00:00

abstract：:There is lack of consensus regarding the prognostic significance of primary tumor location of upper tract urothelial carcinoma(UTUC). We performed a meta-analysis to evaluate the impact of primary tumor location on prognosis in patients with UTUC who had undergone radical nephroureterectomy(RNU). We included eligible ...

journal_title：Scientific reports

authors： Wu Y,Dong Q,Liu L,Han P,Wei Q

更新日期：2014-09-15 00:00:00

abstract：:Genome editing tools have revolutionized the generation of genetically modified animals including livestock. In particular, the domestic pig is a proven model of human physiology and an agriculturally important species. In this study, we utilized the CRISPR/Cas9 system to edit the NANOS2 gene in pig embryos to generat...

journal_title：Scientific reports

authors： Park KE,Kaucher AV,Powell A,Waqas MS,Sandmaier SE,Oatley MJ,Park CH,Tibary A,Donovan DM,Blomberg LA,Lillico SG,Whitelaw CB,Mileham A,Telugu BP,Oatley JM

更新日期：2017-01-10 00:00:00

abstract：:The digit ratio has been used as a retrospective noninvasive biomarker to investigate the putative effects of prenatal exposure to androgens. In recent years, many scholars have paid attention to the association between 2D:4D (the second and fourth digits) and prostatic cancer. This study explored the prognostic signi...

journal_title：Scientific reports

authors： Li G,Sun K,Guo J,Li S,Li B,Cao J,Lu P,Yang J,Zhang Y,Yang X,Gao L,He Y,Cui T,Ma B

更新日期：2017-07-12 00:00:00

abstract：:The fabrication of Ru nanostructures by focused electron beam induced deposition (FEBID) requires suitable precursor molecules and processes to obtain the pure metal. So far this is problematic because established organometallic Ru precursors contain large organic ligands, such as cyclopentadienyl anions, that tend to...

journal_title：Scientific reports

authors： Rohdenburg M,Boeckers H,Brewer CR,McElwee-White L,Swiderek P

更新日期：2020-07-02 00:00:00

abstract：:Aphids are important agricultural pests causing major yield losses worldwide. Since aphids can rapidly develop resistance to chemical insecticides there is an urgent need to find alternative aphid pest management strategies. Despite the economic importance of bluegreen aphid (Acyrthosiphon kondoi), very few genetic re...

journal_title：Scientific reports

authors： Jacques S,Reidy-Crofts J,Sperschneider J,Kamphuis LG,Gao LL,Edwards OR,Singh KB

更新日期：2020-01-31 00:00:00

abstract：:The concept of novel responsive materials with a displacement conversion capability was further developed through the design of new machine-augmented composites (MACs). Embedded converter machines and MACs with improved geometry were designed and fabricated by multi-material 3D printing. This technique proved to be ve...

journal_title：Scientific reports

authors： Bafekrpour E,Molotnikov A,Weaver JC,Brechet Y,Estrin Y

更新日期：2014-01-21 00:00:00

abstract：:CD43 (leukosialin) is a large sialoglycoprotein abundantly expressed on the surface of most cells from the hematopoietic lineage. CD43 is directly involved in the contact between cells participating in a series of events such as signaling, adherence and host parasite interactions. In this study we examined the role of...

journal_title：Scientific reports

authors： Alisson-Silva F,Mantuano NR,Lopes AL,Vasconcelos-Dos-Santos A,Vale AM,Costa MM,Cannon JL,Oliveira AC,Todeschini AR

更新日期：2019-06-13 00:00:00

abstract：:Breast cancer (BC) is the leading cause of cancer death in women. Adipokines, and other inflammation molecules linked to adiposity, are suspected to be involved in breast carcinogenesis, however prospective findings are inconclusive. In a prospective nested case-control study within the EPIC-Varese cohort, we used con...

journal_title：Scientific reports

authors： Agnoli C,Grioni S,Pala V,Allione A,Matullo G,Gaetano CD,Tagliabue G,Sieri S,Krogh V

更新日期：2017-10-05 00:00:00

abstract：:Endocannabinoids are small signaling lipids, with 2-arachidonoylglycerol (2-AG) implicated in modulating axonal growth and synaptic plasticity. The concept of short-range extracellular signaling by endocannabinoids is supported by the lack of trans-synaptic 2-AG signaling in mice lacking sn-1-diacylglycerol lipases (D...

journal_title：Scientific reports

authors： Keimpema E,Alpár A,Howell F,Malenczyk K,Hobbs C,Hurd YL,Watanabe M,Sakimura K,Kano M,Doherty P,Harkany T

更新日期：2013-01-01 00:00:00

abstract：:Living organisms in drying environments build anisotropic structures and exhibit directionality through self-organization of biopolymers. However, the process of macro-scale assembly is still unknown. Here, we introduce a dissipative structure through a non-equilibrium process between hydration and deposition in the d...

journal_title：Scientific reports

authors： Okeyoshi K,Okajima MK,Kaneko T

更新日期：2017-07-21 00:00:00

abstract：:Particle shape plays a crucial role in determining packing characteristics. Real particles in nature usually have rounded corners. In this work, we systematically investigate the rounded corner effect on the dense packings of spherotetrahedral particles. The evolution of dense packing structure as the particle shape c...

journal_title：Scientific reports

authors： Jin W,Lu P,Li S

更新日期：2015-10-22 00:00:00

abstract：:Bisphosphonates have benefits in breast cancer and multiple myeloma patients and have been used with adoptive immunotherapy with γδ T cells expressing Vγ2 Vδ2 TCRs. Although treatment with γδ T cells is safe, it has shown limited efficacy. Present bisphosphonates stimulate γδ T cells but were designed to inhibit bone ...

journal_title：Scientific reports

authors： Tanaka Y,Iwasaki M,Murata-Hirai K,Matsumoto K,Hayashi K,Okamura H,Sugie T,Minato N,Morita CT,Toi M

更新日期：2017-07-20 00:00:00

abstract：:Outer hair cells in the cochlea have a unique motility in their cell body based on mechanoelectric coupling, with which voltage changes generated by stimuli at their hair bundles drive the cell body and, in turn, it has been assumed, amplifies the signal. In vitro experiments show that the movement of the charges of t...

journal_title：Scientific reports

authors： Iwasa KH

更新日期：2017-09-21 00:00:00

abstract：:Many scientists are seeking better therapies for treating fibromyalgia (FM) pain. We used a mouse model of FM to determine if ASIC3 and its relevant signaling pathway participated in FM pain. We demonstrated that FM-induced mechanical hyperalgesia was attenuated by electroacupuncture (EA). The decrease in fatigue-indu...

journal_title：Scientific reports

authors： Yen LT,Hsieh CL,Hsu HC,Lin YW

更新日期：2017-04-25 00:00:00

abstract：:Aluminum (Al) toxicity is a serious problem for rice crop productivity in acidic soils worldwide. The present work was conducted to look out for the alteration in ROS homeostasis; metabolic fingerprint; and morphology in two contrasting Indica rice cultivars of North East India (NE India) to Al toxicity. Al stress led...

journal_title：Scientific reports

authors： Awasthi JP,Saha B,Panigrahi J,Yanase E,Koyama H,Panda SK

更新日期：2019-06-18 00:00:00

abstract：:Light-sheet microscopy enables considerable speed and phototoxicity gains, while quantitative-phase imaging confers label-free recognition of cells and organelles, and quantifies their number-density that, thermodynamically, is more representative of metabolism than size. Here, we report the fusion of these two imagin...

journal_title：Scientific reports

authors： Subedi NR,Jung PS,Bredeweg EL,Nemati S,Baker SE,Christodoulides DN,Vasdekis AE

更新日期：2020-11-19 00:00:00

abstract：:Single epitaxially-grown semiconductor quantum dots have great potential as single photon sources for photonic quantum technologies, though in practice devices often exhibit nonideal behavior. Here, we demonstrate that amplitude modulation can improve the performance of quantum-dot-based sources. Starting with a brigh...

journal_title：Scientific reports

authors： Ates S,Agha I,Gulinatti A,Rech I,Badolato A,Srinivasan K

更新日期：2013-01-01 00:00:00