Abstract：
:The rainbow trout, a carnivorous fish, displays a 'glucose-intolerant' phenotype revealed by persistent hyperglycaemia when fed a high carbohydrate diet (HighCHO). Epigenetics refers to heritable changes in gene activity and is closely related to environmental changes and thus to metabolism adjustments governed by nutrition. In this study we first assessed in the trout liver whether and how nutritional status affects global epigenome modifications by targeting DNA methylation and histone marks previously reported to be affected in metabolic diseases. We then examined whether dietary carbohydrates could affect the epigenetic landscape of duplicated gluconeogenic genes previously reported to display changes in mRNA levels in trout fed a high carbohydrate diet. We specifically highlighted global hypomethylation of DNA and hypoacetylation of H3K9 in trout fed a HighCHO diet, a well-described phenotype in diabetes. g6pcb2 ohnologs were also hypomethylated at specific CpG sites in these animals according to their up-regulation. Our findings demonstrated that the hepatic epigenetic landscape can be affected by both nutritional status and dietary carbohydrates in trout. The mechanism underlying the setting up of these epigenetic modifications has now to be explored in order to improve understanding of its impact on the glucose intolerant phenotype in carnivorous teleosts.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Marandel L,Lepais O,Arbenoits E,Véron V,Dias K,Zion M,Panserat Sdoi
10.1038/srep32187subject
Has Abstractpub_date
2016-08-26 00:00:00pages
32187issn
2045-2322pii
srep32187journal_volume
6pub_type
杂志文章abstract：:Herein, water-oxidation reaction by cobalt(II) phthalocyanine, N,N'-bis (salicylidene) ethylenediamino cobalt(II), nickel(II) Schiff base (N,N'-bis (salicylidene)ethylenediamino nickel(II), nickel(II)) phthalocyanine-tetrasulfonate tetrasodium, manganese(II) phthalocyanine, 5,10,15,20-Tetraphenyl-21H,23H-porphine mang...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43953-6
更新日期：2019-05-16 00:00:00
abstract：:Buccal mucosa squamous cell carcinoma (BMSCC) is one of major subsites of oral cancer and is associated with a high rate of metastasis and poor prognosis. Heat shock proteins (HSPs) act as potential prognostic biomarkers in many cancer types. However, the role of HSPD1 in oral cancer, especially in BMSCC, is still unk...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45489-1
更新日期：2019-06-20 00:00:00
abstract：:Despite efforts during the past decades, loop modeling remains a difficult part of protein structure modeling. Several approaches have been developed in the framework of crystal structures. However, for homology models, the modeling of loops is still far from being solved. We propose DaReUS-Loop, a data-based approach...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32079-w
更新日期：2018-09-12 00:00:00
abstract：:Here we report exquisitely distinct material properties of primary vascular smooth muscle (VSM) cells isolated from the thoracic aorta of adult (8 months) vs. aged (30 months) F344XBN rats. Individual VSM cells derived from the aged animals showed a tense internal network of the actin cytoskeleton (CSK), exhibiting in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20763-w
更新日期：2018-02-08 00:00:00
abstract：:There are no clinical guidelines for the timing of cholecystectomy (CCY) after performing therapeutic endoscopic retrograde cholangiopancreatography (ERCP) for choledocholithiasis. We tried to analyze the clinical practice patterns, medical expenses, and subsequent outcomes between the early CCY, delayed CCY, and no C...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38428-z
更新日期：2019-02-18 00:00:00
abstract：:Genome-wide studies on high-altitude adaptation have received increased attention as a classical case of organismal evolution under extreme environment. However, the current genetic understanding of high-altitude adaptation emanated mainly from autosomal analyses. Only a few earlier genomic studies paid attention to t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35004
更新日期：2016-10-07 00:00:00
abstract：:The aim of this study is to develop an internal-external correlation model for internal motion estimation for lung cancer radiotherapy. Deformation vector fields that characterize the internal-external motion are obtained by respectively registering the internal organ meshes and external surface meshes from the 4DCT i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22023-3
更新日期：2018-02-27 00:00:00
abstract：:The potential energy profile of an ideal binary switch is a symmetric double well. Switching between the wells without energy dissipation requires time-modulating the height of the potential barrier separating the wells and tilting the profile towards the desired well at the precise juncture when the barrier disappear...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03204
更新日期：2013-11-13 00:00:00
abstract：:Ku-jin tea (KJT) is a health beverage prepared from the leaves of the plant Acer tataricum subsp. ginnala that has been consumed in some regions of China for thousands of years. KJT contains high levels of anti-inflammatory and antioxidative compounds such as ginnalins, but little is known about the chemopreventive ef...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16237-0
更新日期：2017-11-21 00:00:00
abstract：:Stem cell therapy has long been considered a promising mode of treatment for many incurable diseases. Human mesenchymal stem cells (hMSCs) have provided the most promising results to date for regenerative medicine. Nevertheless, due to several obstacles such as difficulty in sourcing and characterizing hMSCs, they rem...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42669-x
更新日期：2019-04-16 00:00:00
abstract：:Incompatible patterns viewed by each of the two eyes can provoke binocular rivalry, a competition of perception. Levelt's first law predicts that a highly visible stimulus will predominate over a less visible stimulus during binocular rivalry. In a behavioural study, we made a counterintuitive observation: high visibi...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-018-32703-9
更新日期：2018-09-26 00:00:00
abstract：:Pulmonary arterial hypertension is a progressive disease that causes the obstruction of precapillary pulmonary arteries and a sustained increase in pulmonary vascular resistance. The aim was to analyze functionally the variants found in the BMPR2 gene and to establish a genotype-phenotype correlation. mRNA expression ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02074-8
更新日期：2017-05-15 00:00:00
abstract：:Truffles (Tuber spp.) are the fruiting bodies of symbiotic fungi, which are prized food delicacies. The marked aroma variability observed among truffles of the same species has been attributed to a series of factors that are still debated. This is because factors (i.e. genetics, maturation, geographical location and t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27620-w
更新日期：2018-06-18 00:00:00
abstract：:β-Lactamases are a major threat to the clinical use of carbapenems, which are often antibiotics of last resort. Despite this, the reaction outcomes and mechanisms by which β-lactamases degrade carbapenems are still not fully understood. The carbapenem bicyclic core consists of a β-lactam ring fused to a pyrroline ring...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49264-0
更新日期：2019-09-20 00:00:00
abstract：:The precision prediction of peptide retention time (RT) plays an increasingly important role in liquid chromatography-tandem mass spectrometry (LC-MS/MS) based proteomics. Owing to the high reproducibility of liquid chromatography, RT prediction provides promising information for both identification and quantification...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43959
更新日期：2017-03-17 00:00:00
abstract：:Mesenchymal stem cells (MSCs) aid the regeneration of tissues damaged by treatment with cisplatin. However, the effects of this cytotoxic drug on the stem cells have been largely unknown. Here we demonstrate that human bone marrow-derived MSCs are relatively resistant to cisplatin treatment and show resistance levels ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20035
更新日期：2016-01-25 00:00:00
abstract：:Gastrointestinal (g.i.) large cell lymphoma is currently regarded as diffuse large B-cell lymphoma (DLBCL) despite a more favorable clinical outcome compared to other DLBCL. Cluster analyses on a transcriptome signature of NF-κB target genes of 30 g.i. marginal zone B-cell lymphomas (MZBL; 8 g.i. MZBL, 22 large cell M...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05116-3
更新日期：2017-07-20 00:00:00
abstract：:We study the local indistinguishability problem of quantum states. By introducing an easily calculated quantity, non-commutativity, we present an criterion which is both necessary and sufficient for the local indistinguishability of a complete set of pure orthogonal product states. A constructive distinguishing proced...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06336
更新日期：2014-09-11 00:00:00
abstract：:For a number of years nanomaterials have been continuously devised and comprehensively investigated because of the growing demand for them and their multifarious applications, especially in medicine. This paper reports on the properties of SrF2 nanoparticles (NPs) for applications in biomedicine, showing effective way...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45025-1
更新日期：2019-06-17 00:00:00
abstract：:The study of network topology provides insight into the function and behavior of physical, social, and biological systems. A natural step towards discovering the organizing principles of these complex topologies is to identify a reduced network representation using cohesive subgroups or communities. This procedure oft...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30401-0
更新日期：2018-08-09 00:00:00
abstract：:Here we report a photonic annealing process for yttria-stabilized zirconia films, which are one of the most well-known solid-state electrolytes for solid oxide fuel cells (SOFCs). Precursor films were coated using a wet-chemical method with a simple metal-organic precursor solution and directly annealed at standard pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12438-9
更新日期：2017-09-29 00:00:00
abstract：:Models on how perceptual and cognitive information on others' mental states are treated by the cognitive architecture are often framed as duplex models considering two independent systems. In the context of the neuroscience of empathy analogous systems have been described. Using event-related potentials (i.e., ERPs) t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07424
更新日期：2014-12-11 00:00:00
abstract：:Early-life social experiences cause lasting changes in behavior and health for a variety of animals including humans, but it is not well understood how social information ''gets under the skin'' resulting in these effects. Adult honey bees (Apis mellifera) exhibit socially coordinated collective nest defense, providin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15572
更新日期：2015-10-23 00:00:00
abstract：:Continuous and non-invasive monitoring of hemodynamic parameters through unobtrusive wearable sensors can potentially aid in early detection of cardiac abnormalities, and provides a viable solution for long-term follow-up of patients with chronic cardiovascular diseases without disrupting the daily life activities. El...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37524
更新日期：2016-11-22 00:00:00
abstract：:Studies on prevalence and significance of alternative polyadenylation (APA) in plants have been so far limited mostly to the model plants. Here, a genome-wide analysis of APA was carried out in different tissue types in the non-model forage legume red clover (Trifolium pratense L). A profile of poly(A) sites in differ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29699-7
更新日期：2018-07-27 00:00:00
abstract：:During bipedal walking, modern humans dorsiflex their forefoot at the metatarsophalangeal joints (MTPJs) prior to push off, which tightens the plantar soft tissues to convert the foot into a stiff propulsive lever. Particular features of metatarsal head morphology such as "dorsal doming" are thought to facilitate this...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30532
更新日期：2016-07-28 00:00:00
abstract：:Electrochemical biosensors have been studied intensively for several decades. Numerous sensing concepts and related interface architectures have been developed. However, all such architectures suffer a trade-off: simple architectures favour usability, whereas complex architectures favour better performance. To overcom...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04169
更新日期：2014-02-25 00:00:00
abstract：:It is known that ribosomal RNA (rRNA) synthesis is regulated by cellular energy and proliferation status. In this study, we investigated rRNA gene transcription in response to cytoskeletal stress. Our data revealed that the cell shape constrained by isotropic but not elongated micropatterns in HeLa cells led to a sign...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28685
更新日期：2016-06-28 00:00:00
abstract：:A new species of fossil conifer wood, Podocarpoxylon donghuaiense sp. nov., is described from the late Eocene of Nadu Formation in Baise Basin of the Guangxi Province, South China. This fossil wood is characterized by distinct growth rings, circular to oval tracheids in cross section, 1-2-seriate opposite pits on radi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32294
更新日期：2016-08-30 00:00:00
abstract：:Acute physical exercise improves memory functions by increasing neural plasticity in the hippocampus. In animals, a single session of physical exercise has been shown to boost anandamide (AEA), an endocannabinoid known to promote hippocampal plasticity. Hippocampal neuronal networks encode episodic memory representati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72108-1
更新日期：2020-09-18 00:00:00
