Abstract：
:Mesenchymal stem cells (MSCs) aid the regeneration of tissues damaged by treatment with cisplatin. However, the effects of this cytotoxic drug on the stem cells have been largely unknown. Here we demonstrate that human bone marrow-derived MSCs are relatively resistant to cisplatin treatment and show resistance levels comparable to these of differentiated fibroblasts. Cisplatin did not affect cellular morphology, adhesion or induction of apoptosis in MSCs. The potential for differentiation was preserved after exposure to cisplatin, and established MSC surface markers were observed to be stably expressed irrespective of cisplatin treatment. Cytoskeletal rearrangements and high expression levels of individual heat shock proteins were detected in MSCs and may be partly responsible for the observed cisplatin resistance. The cisplatin-resistant phenotype of human MSCs supports the concept of further investigating these stem cells as a potential treatment option for cisplatin-induced tissue damage.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Nicolay NH,Lopez Perez R,Rühle A,Trinh T,Sisombath S,Weber KJ,Ho AD,Debus J,Saffrich R,Huber PEdoi
10.1038/srep20035subject
Has Abstractpub_date
2016-01-25 00:00:00pages
20035issn
2045-2322pii
srep20035journal_volume
6pub_type
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