Southwest Greenland shelf glaciation during MIS 4 more extensive than during the Last Glacial Maximum.

abstract：:IHC4 and PAM50 assays have been shown to provide additional prognostic information for patients with early breast cancer. We evaluated whether incorporating TP53 mutation analysis can further enhance their prognostic accuracy. We examined TP53 mutation and the IHC4 score in tumors of 605 patients diagnosed with stage ...

journal_title：Scientific reports

authors： Lin CH,Chen IC,Huang CS,Hu FC,Kuo WH,Kuo KT,Wang CC,Wu PF,Chang DY,Wang MY,Chang CH,Chen WW,Lu YS,Cheng AL

更新日期：2015-12-16 00:00:00

abstract：:The abundance and diversity of bacteria in two types of ponds were investigated by quantitative PCR and Illumina MiSeq sequencing. The results revealed that the abundance of bacterial 16S rRNA genes in D ponds (with grass carp fed sudan grass) was significantly lower than that in E ponds (with grass carp fed commercia...

journal_title：Scientific reports

authors： Qin Y,Hou J,Deng M,Liu Q,Wu C,Ji Y,He X

更新日期：2016-10-19 00:00:00

abstract：:Nitrous-oxide emission and nitrate addition from agriculture to earth's environment are two main agriculture related anthropogenic causes of environmental degradation that needs greater attention. For addressing the aforesaid issue, new techniques/practices need to be developed and implemented. The present investigati...

journal_title：Scientific reports

authors： Sharma A,Kumar S,Khan SA,Kumar A,Mir JI,Sharma OC,Singh DB,Arora S

更新日期：2021-01-28 00:00:00

abstract：:Determining mechanisms that naturally protect species from developing cancer is critical in order to prevent and treat cancer. Here, we describe a novel cancer-suppressing mechanism, via the secretion of bioactive factors by mammary cells, that is present in domesticated mammals with a low mammary cancer incidence. Sp...

journal_title：Scientific reports

authors： Ledet MM,Harman RM,Fan JC,Schmitt-Matzen E,Diaz-Rubio ME,Zhang S,Van de Walle GR

更新日期：2020-11-25 00:00:00

abstract：:In spite of extensive efforts over decades an experimentally-derived structure of full-length eukaryotic pentameric ligand-gated ion channels (pLGICs) is still lacking. These pharmaceutically highly-relevant channels contain structurally well-conserved and characterized extracellular and transmembrane domains. The int...

journal_title：Scientific reports

authors： Pandhare A,Grozdanov PN,Jansen M

更新日期：2016-04-05 00:00:00

abstract：:Erwinia tracheiphila is a bacterial plant pathogen that causes a fatal wilt infection in some cucurbit crop plants. Wilt symptoms are thought to be caused by systemic bacterial colonization through xylem that impedes sap flow. However, the genetic determinants of within-plant movement are unknown for this pathogen spe...

journal_title：Scientific reports

authors： Rocha J,Shapiro LR,Kolter R

更新日期：2020-12-10 00:00:00

abstract：:As critical primary producers and recyclers of organic matter, the diversity of marine protists has been extensively explored by high-throughput barcode sequencing. However, classification of short metabarcoding sequences into traditional taxonomic units is not trivial, especially for lineages mainly known by their ge...

journal_title：Scientific reports

authors： Cai R,Kayal E,Alves-de-Souza C,Bigeard E,Corre E,Jeanthon C,Marie D,Porcel BM,Siano R,Szymczak J,Wolf M,Guillou L

更新日期：2020-02-13 00:00:00

abstract：:We report on the optical and structural characterization of rubrene polycrystalline films fabricated from vacuum deposition with various substrate temperatures (Tsub). Depending on Tsub, the role of twisted and planar rubrene conformational isomers on the properties of rubrene films is focused. The temperature (T)-dep...

journal_title：Scientific reports

authors： Lin KY,Wang YJ,Chen KL,Ho CY,Yang CC,Shen JL,Chiu KC

更新日期：2017-01-16 00:00:00

abstract：:Macro- and micro-environmental factors modulate parasite loads in fish, determining parasitic abundances, diversity, and interaction dynamics. In this study, seasonal variations in larval ectoparasites on fish larvae in the northern Humboldt Current System (HCS) were evaluated using a delta-gamma generalized linear mo...

journal_title：Scientific reports

authors： Paredes LD,Landaeta MF,Molinet C,González MT

更新日期：2021-01-12 00:00:00

abstract：:Morphological phylogenies stand in a major conflict with molecular hypotheses regarding the phylogeny of Cryptodira, the most diverse and widely distributed clade of extant turtles. However, molecular hypotheses are often considered a better estimate of phylogeny given that it is more consistent with the stratigraphic...

journal_title：Scientific reports

authors： Zhou CF,Rabi M

更新日期：2015-11-10 00:00:00

abstract：:Surface Temperature (ST) over India has increased by ~0.055 K/decade during 1860-2005 and follows the global warming trend. Here, the natural and external forcings (e.g., natural and anthropogenic) responsible for ST variability are studied from Coupled Model Inter-comparison phase 5 (CMIP5) models during the 20th cen...

journal_title：Scientific reports

authors： Basha G,Kishore P,Ratnam MV,Jayaraman A,Agha Kouchak A,Ouarda TBMJ,Velicogna I

更新日期：2017-06-07 00:00:00

abstract：:Identification of mutants with impairments in auxin biosynthesis and dynamics by forward genetic screening is hindered by the complexity, redundancy and necessity of the pathways involved. Furthermore, although a few auxin-deficient mutants have been recently identified by screening for altered responses to shade, eth...

journal_title：Scientific reports

authors： Wu L,Luo P,Di DW,Wang L,Wang M,Lu CK,Wei SD,Zhang L,Zhang TZ,Amakorová P,Strnad M,Novák O,Guo GQ

更新日期：2015-07-06 00:00:00

abstract：:Protein glycosylation has been described as the most abundant and complex post-translational modification occurring in nature. Recent studies have enhanced our view of how this modification occurs in bacteria highlighting the role of protein glycosylation in various processes such as biofilm formation, virulence and h...

journal_title：Scientific reports

authors： Avilés-Reyes A,Freires IA,Besingi R,Purushotham S,Deivanayagam C,Brady LJ,Abranches J,Lemos JA

更新日期：2018-03-16 00:00:00

abstract：:In day-to-day life, humans usually perceive the location of sound sources as outside their heads. This externalized auditory spatial perception can be reproduced through headphones by recreating the sound pressure generated by the source at the listener's eardrums. This requires the acoustical features of the recordin...

journal_title：Scientific reports

authors： Gil-Carvajal JC,Cubick J,Santurette S,Dau T

更新日期：2016-11-17 00:00:00

abstract：:The scale-eating cichlid Perissodus microlepis exhibits significant lateralised predation behaviour using an asymmetric mouth. But how the acquisition of the behavioural laterality depends, if at all, on experience during development remains obscure. Here, naïve juveniles were tested in a series of predation sessions....

journal_title：Scientific reports

authors： Takeuchi Y,Oda Y

更新日期：2017-08-21 00:00:00

abstract：:Cisplatin, a highly effective and widely used chemotherapeutic agent, has a major limitation for its nephrotoxicity. We recently identified a novel strategy for attenuating its nephrotoxicity in chemotherapy by an effective adjuvant via epigenetic modification through targeting HDAC2. Molecular docking and SPR assay f...

journal_title：Scientific reports

authors： Ma T,Huang C,Meng X,Li X,Zhang Y,Ji S,Li J,Ye M,Liang H

更新日期：2016-05-05 00:00:00

abstract：:The activation and regulation of coagulation Factor XIII (FXIII) protein has been the subject of active research for the past three decades. Although discrete evidence exists on various aspects of FXIII activation and regulation a combinatorial structure/functional view in this regard is lacking. In this study, we pre...

journal_title：Scientific reports

authors： Gupta S,Biswas A,Akhter MS,Krettler C,Reinhart C,Dodt J,Reuter A,Philippou H,Ivaskevicius V,Oldenburg J

更新日期：2016-07-25 00:00:00

abstract：:Animals are capable of using visual cues to find the correct route during navigation. These visual cues, which contain spatial information on the direction towards the goal point, are perceived either allocentrically or egocentrically. In this study, we examined how navigating with these two types of visual cues affec...

journal_title：Scientific reports

authors： Chun J,Kim Y,Choi JW,Kim D,Jo S

更新日期：2019-04-23 00:00:00

abstract：:Robot-assisted laparoscopic radical prostatectomy (RALRP) is a minimally invasive procedure; however, some amount of surgical trauma that can trigger systemic inflammation remains. Moreover, pneumoperitoneum during RALRP induces ischemia-reperfusion injury (IRI). Propofol, an anesthetic, is known to have anti-inflamma...

journal_title：Scientific reports

authors： Roh GU,Song Y,Park J,Ki YM,Han DW

更新日期：2019-03-27 00:00:00

abstract：:Hedgehog (Hh) signaling plays a broad role in the development of many organs including bone and teeth. It is noted that sustained Hh activity in osteoblasts negatively regulates postnatal development in mice. However, it remains unknown whether Hh signaling contributes to cementum formation. In this study, to define t...

journal_title：Scientific reports

authors： Choi H,Liu Y,Yang L,Cho ES

更新日期：2020-04-29 00:00:00

abstract：:Application of alginate-microencapsulated therapeutic cells is a promising approach for diseases that require a local and constant supply of therapeutic molecules. However most conventional alginate microencapsulation systems are associated with low mechanical stability and protrusion of cells which is associated with...

journal_title：Scientific reports

authors： Bhujbal SV,de Haan B,Niclou SP,de Vos P

更新日期：2014-10-31 00:00:00

abstract：:Cystic fibrosis (CF) patients experience heightened levels of anxiety and depression. Stress from dealing with chronic disease and rigorous treatment regimens certainly are primary contributors to these outcomes. We previously have demonstrated that microtubule alterations in CF are linked to a number of CF phenotypes...

journal_title：Scientific reports

authors： Corey DA,Rymut SM,Kelley TJ

更新日期：2020-10-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Abzhandadze T,Reinholdsson M,Sunnerhagen KS

更新日期：2020-02-27 00:00:00

abstract：:This study aimed to investigate changes in types of dental arch form during adolescence and explore adolescent changes in size and form of dental arch. Hong Kong Chinese were recruited and digital dental arch models were obtained at ages 12, 15, and 18 years. Geometric morphometrics was used to investigate adolescent ...

journal_title：Scientific reports

authors： Wen YF,Wong HM,Pei T,McGrath C

更新日期：2019-12-06 00:00:00

abstract：:The ability to obtain three-dimensional (3-D) information about morphologies of nanostructures elucidates many interesting properties of materials in both physical and biological sciences. Here we demonstrate a novel method in scanning transmission electron microscopy (STEM) that gives a fast and reliable assessment o...

journal_title：Scientific reports

authors： Oveisi E,Letouzey A,Alexander DTL,Jeangros Q,Schäublin R,Lucas G,Fua P,Hébert C

更新日期：2017-09-06 00:00:00

abstract：:The insect membrane-protein, Torso, is a member of the receptor-tyrosine-kinase family, and is activated by its ligand, prothoracicotropic hormone (PTTH). Although PTTH is one of the most important regulators of insect development, the mechanism of Torso activation by the hormone has remained elusive. In this study, u...

journal_title：Scientific reports

authors： Konogami T,Yang Y,Ogihara MH,Hikiba J,Kataoka H,Saito K

更新日期：2016-03-01 00:00:00

abstract：:The 28,000-year-old remains of a woolly mammoth, named 'Yuka', were found in Siberian permafrost. Here we recovered the less-damaged nucleus-like structures from the remains and visualised their dynamics in living mouse oocytes after nuclear transfer. Proteomic analyses demonstrated the presence of nuclear components ...

journal_title：Scientific reports

authors： Yamagata K,Nagai K,Miyamoto H,Anzai M,Kato H,Miyamoto K,Kurosaka S,Azuma R,Kolodeznikov II,Protopopov AV,Plotnikov VV,Kobayashi H,Kawahara-Miki R,Kono T,Uchida M,Shibata Y,Handa T,Kimura H,Hosoi Y,Mitani T,Matsumo

更新日期：2019-03-11 00:00:00

abstract：:The objective of this study was to examine the relationship between sleep duration and ischemic and hemorrhagic stroke in a community-based cohort. The current analysis included 95,023 Chinese participants who were free of stroke at the baseline survey (2006-2007). Cox proportional hazards models were used to calculat...

journal_title：Scientific reports

authors： Song Q,Liu X,Zhou W,Wang L,Zheng X,Wang X,Wu S

更新日期：2016-09-16 00:00:00

abstract：:Fibrin polymerization is a necessary part of hemostasis but clots can obstruct blood vessels and cause heart attacks and strokes. The polymerization reactions are specific and controlled, involving strong knob-into-hole interactions to convert soluble fibrinogen into insoluble fibrin. It has long been assumed that clo...

journal_title：Scientific reports

authors： Chernysh IN,Nagaswami C,Purohit PK,Weisel JW

更新日期：2012-01-01 00:00:00

abstract：:The exact roles of acid-sensing ion channels (ASICs) in synaptic plasticity remain elusive. Here, we address the contribution of ASIC1a to five forms of synaptic plasticity in the mouse hippocampus using an in vitro multi-electrode array recording system. We found that genetic deletion or pharmacological blockade of A...

journal_title：Scientific reports

authors： Liu MG,Li HS,Li WG,Wu YJ,Deng SN,Huang C,Maximyuk O,Sukach V,Krishtal O,Zhu MX,Xu TL

更新日期：2016-03-21 00:00:00