Abstract:
:Hedgehog (Hh) signaling plays a broad role in the development of many organs including bone and teeth. It is noted that sustained Hh activity in osteoblasts negatively regulates postnatal development in mice. However, it remains unknown whether Hh signaling contributes to cementum formation. In this study, to define the roles of Hh signaling in cementum formation, we analyzed two kinds of transgenic mouse models for Hh signaling activation designed by the inactivation of Suppressor of Fused (Sufu), a negative regulator of Hh signaling, (SufuOC) and a forced endogenous activation of Smo (SmoM2OC) under the control of osteocalcin (OC) promoter-driven Cre recombinase. Interestingly, cellular cementum apposition was remarkably reduced in both mutants. Consistently, matrix formation and mineralization ability were down-regulated in OCCM-30, a cementoblast cell line, following treatment with a pharmaceutical Smo agonist. In addition, reductions in Osx expression and β-catenin activity, which are critical for cellular cementum formation, were also detected in vitro. Furthermore, the compound mutant mice designed for the stabilization of β-catenin with both Hh-Smo signaling activation in cementoblasts revealed a complete restoration of defective cellular cementum. In addition, Wnt antagonists such as Sostdc1 and Dkk1 were also induced by Smo activation and played a role in the reduction of Osx expression and β-catenin activity. Collectively, our data demonstrated that Hh signaling negatively regulates cementum apposition in a Wnt/β-catenin/Osx-dependent manner.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Choi H,Liu Y,Yang L,Cho ESdoi
10.1038/s41598-020-64188-wsubject
Has Abstractpub_date
2020-04-29 00:00:00pages
7285issue
1issn
2045-2322pii
10.1038/s41598-020-64188-wjournal_volume
10pub_type
杂志文章abstract::The development and maturation of cortical circuits relies on the coordinated actions of long and short range axonal guidance cues. In this regard, the class 3 semaphorins and their receptors have been seen to be involved in the development and maturation of the hippocampal connections. However, although the role of m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19794-0
更新日期:2018-01-22 00:00:00
abstract::Seabirds are known to concentrate on prey patches or at predators aggregations standing for potential feeding opportunities. They may search for prey using olfaction or by detecting visually feeding con-specifics and sub-surface predators, or even boats. Thus, they might form a foraging network. We hypothesized that c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07480-6
更新日期:2017-08-04 00:00:00
abstract::Mesoporous silica nanoscale microsphere (MSNM), with a special morphology, high porosity, large pore volume and specific surface area, was successfully prepared and used as the matrix material of lauric acid (LA) to prepare a favorable shape-stabilized phase change material (LA/MSNM). The porous network structure of M...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52553-3
更新日期:2019-11-05 00:00:00
abstract::The early Pliocene shoaling of the Central American Seaway (CAS), ~4.7-4.2 million years ago (mega annum-Ma), is thought to have strengthened Atlantic Meridional Overturning Circulation (AMOC). The associated increase in northward flux of heat and moisture may have significantly influenced the evolution of Pliocene cl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12252
更新日期:2015-07-20 00:00:00
abstract::Portal vein ligation (PVL) induces atrophy/hypertrophy complex (AHC). We hypothesised that simultaneous bile duct and portal vein ligation (BPL) might induce proper bile acid (BA) retention to enhance AHC by activating BA-mediated FXR signalling in the intact liver and promoting apoptosis in the ligated liver. We esta...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08455
更新日期:2015-02-13 00:00:00
abstract::Although the demand for high-speed telecommunications has increased in recent years, the performance of transistors fabricated with traditional semiconductors such as silicon, gallium arsenide, and gallium nitride have reached their physical performance limits. Therefore, new materials with high carrier velocities sho...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03951
更新日期:2014-02-04 00:00:00
abstract::Mesothelin is an emerging cell surface target in mesothelioma and other solid tumors. Most antibody drug candidates recognize highly immunogenic Region I (296-390) on mesothelin. Here, we report a group of high-affinity non-Region I rabbit monoclonal antibodies. These antibodies do not compete for mesothelin binding w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09928
更新日期:2015-05-21 00:00:00
abstract::Automated patch clamp (APC) instruments enable efficient evaluation of electrophysiologic effects of drugs on human cardiac currents in heterologous expression systems. Differences in experimental protocols, instruments, and dissimilar site procedures affect the variability of IC50 values characterizing drug block pot...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62344-w
更新日期:2020-03-27 00:00:00
abstract::Sphingopyxis granuli strain TFA is an α-proteobacterium that belongs to the sphingomonads, a group of bacteria well-known for its degradative capabilities and oligotrophic metabolism. Strain TFA is the only bacterium in which the mineralisation of the aromatic pollutant tetralin has been completely characterized at bi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65258-9
更新日期:2020-05-26 00:00:00
abstract::First discovered in rural areas of middle-eastern China in 2009, severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne zoonosis affecting hundreds of cases reported in China each year. Using the national surveillance data from 2010 to 2013, we conducted this retrospective epidemiological study a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09679
更新日期:2015-04-23 00:00:00
abstract::Recent studies have shown inconsistent results regarding the value of desmoteplase for treating acute ischemic stroke (AIS) when administered within an extended time window. We performed a meta-analysis to explore the value of desmoteplase in AIS treatment. The MEDLINE, EMBASE, and Cochrane Library databases were sear...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33989
更新日期:2016-09-27 00:00:00
abstract::To investigate changes in the size of the population of patients who are receiving long-term, active treatment for neovascular age-related macular degeneration (AMD). This retrospective, observational study included 18,165 patients who received anti-vascular endothelial growth factor injections (3,974 eyes). The injec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49749-y
更新日期:2019-09-13 00:00:00
abstract::Sense of body ownership and body representation are fundamental parts of human consciousness, but the contribution of the visual modality to their development remains unclear. We tested congenitally and late blind adults on a somatosensory version of the rubber hand illusion, and on the Aristotle illusion, in which si...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06622
更新日期:2014-10-23 00:00:00
abstract::Hyperspectral imaging technique was employed to determine spatial distributions of chlorophyll (Chl), and carotenoid (Car) contents in cucumber leaves in response to angular leaf spot (ALS). Altogether, 196 hyperspectral images of cucumber leaves with five infection severities of ALS were captured by a hyperspectral i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27790
更新日期:2016-06-10 00:00:00
abstract::The alveolar echinococcosis of human is a severe helminthic disease caused by the larva of Echinococcus multilocularis tapeworms. Novel compounds or therapy strategies for the treatment of alveolar echinococcosis are urgently needed due to the limitation of the widely used albendazole. Magnetic microspheres as drug ca...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69484-z
更新日期:2020-07-28 00:00:00
abstract::The incisive evaluation of psychological stress may be required to determine the exercise performance of stressed hosts. We investigated objective markers of psychological stress that reflect exercise performance, focusing on the neutrophil function. We used murine water-immersion restraint (WIR) stress for our assess...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41077-5
更新日期:2019-03-14 00:00:00
abstract::The transport properties of films assembled from metal nanoclusters can be significantly different from the metals in their bulk or thin film forms due to quantum confinement effects and several competing energy and length scales. For a film composed of metal nanoclusters as its building blocks, the cluster size and t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07685
更新日期:2015-01-08 00:00:00
abstract::Mesenchymal stem cells (MSCs) aid the regeneration of tissues damaged by treatment with cisplatin. However, the effects of this cytotoxic drug on the stem cells have been largely unknown. Here we demonstrate that human bone marrow-derived MSCs are relatively resistant to cisplatin treatment and show resistance levels ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20035
更新日期:2016-01-25 00:00:00
abstract::Core-shell refractory plasmonic nanoparticles are used as excellent nanoantennas to improve the efficiency of lead-free perovskite solar cells (PSCs). SiO2 is used as the shell coating due to its high refractive index and low extinction coefficient, enabling the control over the sunlight directivity. An optoelectronic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63745-7
更新日期:2020-04-21 00:00:00
abstract::To survive and replicate in macrophages Mycobacterium tuberculosis (Mtb) has developed strategies to subvert host defence mechanisms, including autophagy. Autophagy induction has the potential to clear Mtb, but little is known about its effect during controlled tuberculosis and HIV co-infection. Mammalian target of ra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28171
更新日期:2016-06-15 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-23597-8
更新日期:2018-04-11 00:00:00
abstract::At the moment it is unknown to what extent the impaired function of T lymphocytes in ESRD patients depends on uremia, and to what extent on hemodialysis (HD) procedure. Therefore, the purpose of the study was to evaluate percentages of T lymphocyte subpopulations ex vivo, plasma concentrations of IL12p70, TNF, IL-10, ...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-019-41619-x
更新日期:2019-03-25 00:00:00
abstract::Liver cirrhosis is a severe disease with major impact on the overall health of the patient including poor oral health. Lately, there has been increasing focus on oral diseases as cirrhosis-related complications due to the potential impact on systemic health and ultimately mortality. Periodontitis is one of the most co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28905-w
更新日期:2018-07-16 00:00:00
abstract::Evolution of resistance threatens sustainability of transgenic crops producing insecticidal proteins from the bacterium Bacillus thuringiensis (Bt). The fall armyworm (Spodoptera frugiperda) is a devastating pest of corn in the Western Hemisphere initially controlled by transgenic Bt corn producing the Cry1Fa insectic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09866-y
更新日期:2017-09-07 00:00:00
abstract::Sea buckthorn (Hippophae Rhamnoides L.) is an important source of bioactive compounds such as: antioxidants, vitamins, fatty acids, amino acids, and minerals. Sea buckthorn leaves extracts have been proved to have anti-microbial, antioxidant, anti-inflammatory, and anti-viral properties. In this paper, the extraction ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48610-6
更新日期:2019-08-19 00:00:00
abstract::Rapid facial mimicry (RFM) is an automatic response, in which individuals mimic others' expressions. RFM, only demonstrated in humans and apes, is grounded in the automatic perception-action coupling of sensorimotor information occurring in the mirror neuron system. In humans, RFM seems to reflect the capacity of indi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01527
更新日期:2013-01-01 00:00:00
abstract::Enhancement of endogenous neurogenesis after ischemic stroke may improve functional recovery. We previously demonstrated that medium B, which is a combination with epidermal growth factor (EGF) and fibronectin, can promote neural stem/progenitor cell (NSPC) proliferation and migration. Here, we showed that medium B pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63598-0
更新日期:2020-04-20 00:00:00
abstract::Conduction Electron Paramagnetic Resonance Imaging (CEPRI) is presented as a sensitive technique for mapping metallic lithium species. The method is demonstrated using different samples that are either thick or thin compared to the microwave skin depth. As a thin sample, microstructured metallic lithium deposits in a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32112-y
更新日期:2018-09-25 00:00:00
abstract::Caterpillars have long been used as models for studying animal defence. Their impressive armour, including flamboyant warning colours, poisonous spines, irritating sprays, and mimicry of plant parts, snakes and bird droppings, has been extensively documented. But research has mainly focused on visual and chemical disp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31469
更新日期:2016-08-11 00:00:00
abstract::This prospective multicenter randomized comparative cross-over trial aimed at evaluating the influence of hemodialysis vs post-dilution hemodiafiltration with high-flux dialyzers in solute clearance and biocompatibility profile. 32 patients were sequentially dialyzed with Leoceed-21HX, Polypure-22S+, Rexsys-27H and VI...
journal_title:Scientific reports
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/s41598-019-54404-7
更新日期:2019-12-04 00:00:00