Abstract:
:Portal vein ligation (PVL) induces atrophy/hypertrophy complex (AHC). We hypothesised that simultaneous bile duct and portal vein ligation (BPL) might induce proper bile acid (BA) retention to enhance AHC by activating BA-mediated FXR signalling in the intact liver and promoting apoptosis in the ligated liver. We established rat models of 90% BPL and 90% PVL and found that BPL was well-tolerated and significantly accelerated AHC. The enhanced BA retention in the intact liver promoted hepatocyte proliferation by promoting the activation of FXR signalling, while that in the ligated liver intensified caspase3-mediated apoptosis. Decreasing the BA pools in the rats that underwent BPL could compromise these effects, whereas increasing the bile acid pools of rats that underwent PVL could induce similar effects. Second-stage resection of posterior-caudate-lobe-spearing hepatectomy was performed 5 days after BPL (B-Hx), PVL (V-Hx) or sham (S-SHx), as well as whole-caudate-lobe-spearing hepatectomy 5 days after sham (S-Hx). The B-Hx group had the most favourable survival rate (93.3%, the S-SHx group 0%, the S-Hx group 26.7%, the V-Hx group 56.7%, P < 0.01) and the most sustained regeneration. We conclude that BPL is a safe and effective method, and the acceleration of AHC was bile acid-dependent.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ren W,Chen G,Wang X,Zhang A,Li C,Lv W,Pan K,Dong JHdoi
10.1038/srep08455subject
Has Abstractpub_date
2015-02-13 00:00:00pages
8455issn
2045-2322pii
srep08455journal_volume
5pub_type
杂志文章abstract::The Martian outflow channels comprise some of the largest known channels in the Solar System. Remote-sensing investigations indicate that cataclysmic floods likely excavated the channels ~3.4 Ga. Previous studies show that, in the southern circum-Chryse region, their flooding pathways include hundreds of kilometers of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39632-1
更新日期:2019-02-25 00:00:00
abstract::The molecular mechanisms behind aneurysmal subarachnoid haemorrhage (aSAH) are still poorly understood. Expression patterns of miRNAs may help elucidate the post-transcriptional gene expression in aSAH. Here, we evaluate the global miRNAs expression profile (miRnome) of patients with aSAH to identify potential biomark...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27078-w
更新日期:2018-06-08 00:00:00
abstract::In this work, photoacoustic eigen-spectrum analysis was proposed for noninvasively characterizing the mechanical properties of materials. We theoretically predicted the relationship between the photoacoustic eigen-spectra of cylindrical optical absorbers and their mechanical properties. Experimental measurements of ei...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26140-x
更新日期:2018-05-17 00:00:00
abstract::Many mathematical models have been published with the purpose of explaining aspects of T-cell development in the thymus. In this manuscript we adapted a four-compartment model of the thymus and used a range of mathematical approaches with the aim of explaining the dynamics of the four main thymocyte populations in the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36159
更新日期:2016-11-08 00:00:00
abstract::Light represents the principal signal driving circadian clock entrainment. However, how light influences the evolution of the clock remains poorly understood. The cavefish Phreatichthys andruzzii represents a fascinating model to explore how evolution under extreme aphotic conditions shapes the circadian clock, since ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27080-2
更新日期:2018-06-08 00:00:00
abstract::Recent studies suggest a functional involvement of Epithelial-Mesenchymal Transition (EMT) in tumor chemoresistance. Specifically, EMT is associated with chemoresistance and poor prognosis in triple-negative breast cancer. However, no effective therapy targeting EMT has been developed. Here, we report that periostin, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22340-7
更新日期:2018-03-05 00:00:00
abstract::The blood-based diagnosis has a potential to provide an alternative approach for easy diagnosis of Alzheimer's disease (AD) with less invasiveness and low-cost. However, present blood-based AD diagnosis mainly focuses on measuring the plasma Aβ level because no other biomarkers are found to possess evident transport m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15703
更新日期:2015-10-27 00:00:00
abstract::This paper investigates the possibility of saving a network that is predicted to have a cascading failure that will eventually lead to a total collapse. We model cascading failures using the recently proposed KQ model. Then predict an impending total collapse by monitoring critical slowing down indicators and subseque...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25591-6
更新日期:2018-05-10 00:00:00
abstract::Seed number per pod (SNPP) is one of the major yield components and breeding targets in rapeseed that shows great variation and is invaluable for genetic improvement. To elucidate the genetic architecture and uncover the mechanism of SNPP, we identified five quantitative trait loci (QTLs) using the BnaZNRIL population...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24124
更新日期:2016-04-12 00:00:00
abstract::A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41598-017-14858-z
更新日期:2017-11-07 00:00:00
abstract::In-vitro studies have suggested that the antiarrhythmic drug digoxin might restrain the growth of cancer cells by inhibiting Na+/K+-ATPase. We evaluated the association between cancer mortality and digoxin, sotalol and general antiarrhythmic drug use in a retrospective cohort study. The study population consists of 78...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28541-4
更新日期:2018-07-09 00:00:00
abstract::We demonstrate a label-free imaging approach to study cardiac remodeling of fibrotic and hypertrophic hearts, bridging scales from the whole organ down to the molecular level. To this end, we have used mice subjected to transverse aortic constriction and imaged adjacent cardiac tissue sections by microfocus X-ray diff...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76163-6
更新日期:2020-11-09 00:00:00
abstract::The most common surgical emergency is suspected acute appendicitis, the lifetime risk of acute appendicitis is estimated to be 8.6% for men and 6.7% for women, with a male to female ratio of 1.4:1; correct diagnosis can be made in 70-80% of patients after the operations about 32% of appendectomies revealed normal appe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58847-1
更新日期:2020-02-06 00:00:00
abstract::Phlebotomine sand flies are remarkable vectors of several etiologic agents (virus, bacterial, trypanosomatid Leishmania), posing a heavy health burden for human populations mainly located at developing countries. Their intestinal microbiota is involved in a wide range of biological and physiological processes, and cou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53769-z
更新日期:2019-11-28 00:00:00
abstract::In this study, an anatase/rutile mixed-phase titanium dioxide (TiO2) hierarchical network deposited with Au nanoparticles (Au/TiO2 ARHN) was synthesized using a facile hydrothermal method followed by a simple calcination step. Such a unique structure was designed for improving the light harvest, charge transportation/...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42524
更新日期:2017-02-10 00:00:00
abstract::We report the thermal annealing-induced formation of ring-like structure of Zn(II)-doped magnetite from iron alkoxide leaf-like nanoplate precusor. The phase, structure and morphology of magnetite nanorings were comprehensively characterized by powder X-ray diffraction, X-ray photoelectron spectroscopy, atomic force m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45480
更新日期:2017-04-03 00:00:00
abstract::Pro-inflammatory and amyloidogenic S100A9 protein is an important contributor to Alzheimer's disease (AD) pathology. Traumatic brain injury (TBI) is viewed as a precursor state for AD. Here we have shown that S100A9-driven amyloid-neuroinflammatory cascade was initiated in TBI and may serve as a mechanistic link betwe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31141-x
更新日期:2018-08-27 00:00:00
abstract::The life-like fidelity of organisms captured in amber is unique among all kinds of fossilization and represents an invaluable source for different fields of palaeontological and biological research. One of the most challenging aspects in amber research is the study of traits related to behaviour. Here, indirect eviden...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34352
更新日期:2016-10-04 00:00:00
abstract::The present study investigated the effect of acute stress on attentional bias to threat using behavioral and ERP methods. Sixty-two male participants were randomly assigned to a stress condition (Trier Social Stress Test) or a control condition. To examine the impact of stress-induced cortisol on attentional bias to t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14138-w
更新日期:2017-11-06 00:00:00
abstract::In dentistry, the wet-bonding approach relies on water to maintain demineralized collagen expanded for proper resin infiltration; nevertheless, hydrolytic instability of the resin-dentin interface is inevitable with current bonding techniques. Considering dimethyl sulfoxide's (DMSO) ability to "biomodify" collagen and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34726-8
更新日期:2018-11-15 00:00:00
abstract::In the Brown et al. study 'Increased food supply mitigates ocean acidification effects on calcification but exacerbates effects on growth' they show disagreement with the tested hypothesis and data analysis methodology used in our 2016 study. We acknowledge careful criticism and a constructive dialogue are necessary t...
journal_title:Scientific reports
pub_type: 评论,杂志文章
doi:10.1038/s41598-018-27670-0
更新日期:2018-06-28 00:00:00
abstract::The seven-helical bundle of rhodopsin and other G-protein coupled receptors undergoes structural rearrangements as the transmembrane receptor protein is activated. These structural changes are known to involve tilting and bending of various transmembrane helices. However, the cause and effect relationship among struct...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34129
更新日期:2016-09-23 00:00:00
abstract::Multiple approaches utilizing viral and DNA vectors have shown promise in the development of an effective vaccine against HIV. In this study, an alternative replication-defective flavivirus vector, RepliVax (RV), was evaluated for the delivery of HIV-1 immunogens. Recombinant RV-HIV viruses were engineered to stably e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56550-4
更新日期:2019-12-27 00:00:00
abstract::Glial cell-derived neurotrophic factor (GDNF) has shown beneficial effects in models of Parkinson's disease. The mild results observed in the double-blind clinical trial by intraputamenal infusion of recombinant GDNF proteins warrant a search for alternative delivery methods. In this study, we investigated the functio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02786
更新日期:2013-09-27 00:00:00
abstract::This study aims to examine the long-term effect of adjuvant treatment in Korean Medicine (KM) clinics in ischemic stroke patients, using a national sample cohort from the National Health Insurance Service in Korea between 2010 and 2013. The National Health Insurance Service - National Sample Cohort database from 2002 ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19841-w
更新日期:2018-01-26 00:00:00
abstract::Intracellular signal transduction involves a number of biochemical reactions, which largely consist of protein-protein interactions and protein conformational changes. Monitoring Förster resonance energy transfer (FRET) by fluorescence lifetime imaging microscopy (FLIM), called FLIM-FRET, is one of the best ways to vi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39564
更新日期:2016-12-22 00:00:00
abstract::A novel suite of instrumentation for the characterisation of materials held inside an air-tight tube furnace operated up to 250 °C has been developed. Real-time detection of released gases (volatile organic compounds (VOCs), CO2, NO, NO2, SO2, CO and O2) was achieved combining commercial off-the-shelf (COTS) gas senso...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65472-5
更新日期:2020-05-26 00:00:00
abstract::Tyrosine hydroxylase (TH) catalyzes the hydroxylation of L-tyrosine to L-DOPA. This is the rate-limiting step in the biosynthesis of the catecholamines - dopamine (DA), norepinephrine (NE), and epinephrine (EP). Catecholamines (CA) play a key role as neurotransmitters and hormones. Aberrant levels of CA are associated...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54461-y
更新日期:2019-12-09 00:00:00
abstract::Sixty norovirus outbreaks that occurred in Pudong District, Shanghai in 2017 and affected 959 people were summarised. Of the outbreaks, 29 (48.3%), 27 (45.0%), and 4 (6.7%) occurred in kindergartens, primary schools, and middle schools, respectively. Although the total number of outbreaks peaked in March (13/60, 21.7%...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33724-0
更新日期:2018-10-15 00:00:00
abstract::The addition of a small amount of dopant impurities to crystals is a common method to tune the properties of materials. Usually the doping grade is restricted by the low solubility of the dopants; increasing the doping concentration beyond this solubility limit leads to supersaturated solutions in which dopant cluster...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12730-8
更新日期:2017-10-03 00:00:00