Global miRNA expression profile reveals novel molecular players in aneurysmal subarachnoid haemorrhage.

abstract：:People with ataxia-telangiectasia (A-T) display phenotypic variability with regard to progression of immunodeficiency, sino-pulmonary disease, and neurologic decline. To determine the association between differential gene expression, epigenetic state, and phenotypic variation among people with A-T, we performed transc...

journal_title：Scientific reports

authors： McGrath-Morrow SA,Ndeh R,Helmin KA,Khuder B,Rothblum-Oviatt C,Collaco JM,Wright J,Reyfman PA,Lederman HM,Singer BD

更新日期：2020-05-04 00:00:00

abstract：:Quick inhibition of approach tendencies in response to signals of potential threats is thought to promote survival. However, little is known about the effect of viewing fearful expressions on the early dynamics of the human motor system. We used the high temporal resolution of single-pulse and paired-pulse transcrania...

journal_title：Scientific reports

authors： Borgomaneri S,Vitale F,Avenanti A

更新日期：2015-09-21 00:00:00

abstract：:The function of Forkhead box O 1 (FOXO1) and pSerine256-FOXO1 immunostaining in esophageal cancer is unclear. To clarify the prognostic role of nuclear FOXO1 and cytoplasmic pSerine256-FOXO1 immunostaining, a tissue microarray containing more than 600 esophageal cancers was analyzed. In non-neoplastic esophageal mucos...

journal_title：Scientific reports

authors： Grupp K,Uzunoglu FG,Melling N,Hofmann B,El Gammal AT,Grotelüschen R,Heumann A,Bellon E,Reeh M,Wolters-Eisfeld G,Ghabdan T,Nentwich M,Bachmann K,Bockhorn M,Bogoevski D,Izbicki JR,Kutup A

更新日期：2018-11-26 00:00:00

abstract：:The gliotransmitter glutamate released from astrocytes can modulate neuronal firing by activating neuronal N-methyl-D-aspartic acid (NMDA) receptors. This enables astrocytic glutamate(AG) to be involved in neuronal physiological and pathological functions. Based on empirical results and classical neuron-glial "tripart...

journal_title：Scientific reports

authors： Li J,Tang J,Ma J,Du M,Wang R,Wu Y

更新日期：2016-08-30 00:00:00

abstract：:To examine for a causal relationship between vitamin D and glioma risk we performed an analysis of genetic variants associated with serum 25-hydroxyvitamin D (25(OH)D) levels using Mendelian randomisation (MR), an approach unaffected by biases from confounding. Two-sample MR was undertaken using genome-wide associatio...

journal_title：Scientific reports

authors： Takahashi H,Cornish AJ,Sud A,Law PJ,Kinnersley B,Ostrom QT,Labreche K,Eckel-Passow JE,Armstrong GN,Claus EB,Il'yasova D,Schildkraut J,Barnholtz-Sloan JS,Olson SH,Bernstein JL,Lai RK,Schoemaker MJ,Simon M,Hoffmann P,

更新日期：2018-02-05 00:00:00

abstract：:Granule cells at the input layer of the cerebellum comprise over half the neurons in the human brain and are thought to be critical for learning. However, little is known about granule neuron signaling at the population scale during behavior. We used calcium imaging in awake zebrafish during optokinetic behavior to re...

journal_title：Scientific reports

authors： Sylvester SJG,Lee MM,Ramirez AD,Lim S,Goldman MS,Aksay ERF

更新日期：2017-11-24 00:00:00

abstract：:Comparison of kinetic and thermodynamic properties of IRP1 (iron regulatory protein1) binding to FRT (ferritin) and ACO2 (aconitase2) IRE-RNAs, with or without Mn2+, revealed differences specific to each IRE-RNA. Conserved among animal mRNAs, IRE-RNA structures are noncoding and bind Fe2+ to regulate biosynthesis rate...

journal_title：Scientific reports

authors： Khan MA,Walden WE,Theil EC,Goss DJ

更新日期：2017-08-17 00:00:00

abstract：:In this paper, we investigate the unified bound of quantum speed limit time in open systems based on the modified Bures angle. This bound is applied to the damped Jaynes-Cummings model and the dephasing model, and the analytical quantum speed limit time is obtained for both models. As an example, the maximum coherent ...

journal_title：Scientific reports

authors： Wu SX,Yu CS

更新日期：2020-03-26 00:00:00

abstract：:Bio-functionalized nanoparticles with semiconducting/metallic core encapsulated in a bio- or bio-derived materials are promising for applications in biology and especially in cancer diagnostic and healing. In this report, we report a facile, single-step, first-time synthesis and in-situ functionalization strategy for ...

journal_title：Scientific reports

authors： Liao W,Yu Z,Lin Z,Lei Z,Ning Z,Regenstein JM,Yang J,Ren J

更新日期：2015-12-21 00:00:00

abstract：:The Expanded Susceptibility to Smoking Index (ESSI) is based on the combination of susceptibility to smoking and curiosity about smoking. The ESSI can identify young people who are at risk of starting to smoke cigarettes and related products. The objective of this study was to analyse the ESSI results and to examine f...

journal_title：Scientific reports

authors： Santano-Mogena E,Franco-Antonio C,Chimento-Díaz S,Rico-Martín S,Cordovilla-Guardia S

更新日期：2021-01-21 00:00:00

abstract：:We performed an integrated analysis of the transcriptome and metabolome from purple (Pr) and normal cultivated varieties (CK) of Dendrobium officinale to gain insights into the regulatory networks associated with phenylpropanoid metabolism and to identify the key regulatory genes of pigmentation. Metabolite and transc...

journal_title：Scientific reports

authors： Zhan X,Qi J,Zhou B,Mao B

更新日期：2020-10-19 00:00:00

abstract：:Riemerella anatipestifer is a major pathogenic microorganism in poultry causing serositis with significant mortality. Serotype 1 and 2 were most pathogenic, prevalent, and liable over the world. In this study, the intracellular metabolites in R. anatipestifer strains RA-CH-1 (serotype 1) and RA-CH-2 (serotype 2) were ...

journal_title：Scientific reports

authors： Liu J,Cheng A,Wang M,Liu M,Zhu D,Yang Q,Wu Y,Jia R,Chen S,Zhao X,Zhang S,Huang J,Ou X,Mao S,Gao Q,Wen X,Zhang L,Liu Y,Yu Y,Tian B,Pan L,Ur Rehman M,Chen X

更新日期：2021-01-12 00:00:00

abstract：:In this work we study theoretically and experimentally the multi-particle structure of the so-called type-II quantum dots with spatially separated electrons and holes. Our calculations based on customarily developed full configuration interaction ap- proach reveal that exciton complexes containing holes interacting wi...

journal_title：Scientific reports

authors： Klenovský P,Steindl P,Geffroy D

更新日期：2017-03-30 00:00:00

abstract：:Enterococcus faecium is a commensal of the mammalian gastrointestinal tract, but is also found in non-enteric environments where it can grow between 10 °C and 45 °C. E. faecium has recently emerged as a multi-drug resistant nosocomial pathogen. We hypothesized that genes involved in the colonization and infection of m...

journal_title：Scientific reports

authors： Guzmán Prieto AM,Urbanus RT,Zhang X,Bierschenk D,Koekman CA,van Luit-Asbroek M,Ouwerkerk JP,Pape M,Paganelli FL,Wobser D,Huebner J,Hendrickx AP,Bonten MJ,Willems RJ,van Schaik W

更新日期：2015-12-17 00:00:00

abstract：:The mosquito, Aedes baisasi, which inhabits brackish mangrove swamps, is known to feed on fish. However, its host assemblage has not been investigated at the species level. We amplified and sequenced the cytochrome oxidase subunit I barcoding regions as well as some other regions from blood-fed females to identify hos...

journal_title：Scientific reports

authors： Miyake T,Aihara N,Maeda K,Shinzato C,Koyanagi R,Kobayashi H,Yamahira K

更新日期：2019-03-08 00:00:00

abstract：:Fungal laccases (EC 1.10.3.2) are multi-copper oxidases that oxidize a wide variety of substrates. Despite extensive studies, the molecular basis for their diverse activity is unclear. Notably, there is no current way to rationally predict the activity of a laccase toward a given substrate. Such knowledge would greatl...

journal_title：Scientific reports

authors： Mehra R,Muschiol J,Meyer AS,Kepp KP

更新日期：2018-11-23 00:00:00

abstract：:In this study we measured the degrees to which the Schottky barrier heights (SBHs) are lowered in ZnO nanowire (NW) devices under illumination with UV light. We measured the I-V characteristics of ZnO nanowire devices to confirm that ZnO is an n-type semiconductor and that the on/off ratio is approximately 10(4). From...

journal_title：Scientific reports

authors： Lu MY,Lu MP,You SJ,Chen CW,Wang YJ

更新日期：2015-10-12 00:00:00

abstract：:The ovules and egg cells are well developed to be fertilized at anthesis in many flowering plants. However, ovule development is triggered by pollination in most orchids. In this study, we characterized the function of a Bsister gene, named PeMADS28, isolated from Phalaenopsis equestris, the genome-sequenced orchid. S...

journal_title：Scientific reports

authors： Shen CY,Chen YY,Liu KW,Lu HC,Chang SB,Hsiao YY,Yang F,Zhu G,Zou SQ,Huang LQ,Liu ZJ,Tsai WC

更新日期：2021-01-13 00:00:00

abstract：:Soils - constituting the largest terrestrial carbon pool - are vulnerable to climatic warming. Currently existing uncertainties regarding carbon fluxes within terrestrial systems can be addressed by studies of past carbon cycle dynamics and related climate change recorded in sedimentary successions. Here we show an ex...

journal_title：Scientific reports

authors： Pieńkowski G,Hodbod M,Ullmann CV

更新日期：2016-08-24 00:00:00

abstract：:Although there are many reports on the effect of glucose metabolism on oocyte nuclear maturation, there are few studies on its effect on ooplasmic maturation. By manipulating glucose metabolism pathways using a maturation medium that could support oocyte nuclear maturation but only a limited blastocyst formation witho...

journal_title：Scientific reports

authors： Xie HL,Wang YB,Jiao GZ,Kong DL,Li Q,Li H,Zheng LL,Tan JH

更新日期：2016-02-09 00:00:00

abstract：:The presence of well-vascularised, endosteal bone in the medullary region of long bones of nonavian dinosaurs has been invoked as being homologous to medullary bone, a specialised bone tissue formed during ovulation in birds. However, similar bone tissues can result as a pathological response in modern birds and in no...

journal_title：Scientific reports

authors： Chinsamy A,Cerda I,Powell J

更新日期：2016-04-26 00:00:00

abstract：:There is a growing appreciation for the diverse regulatory consequences of the family of proteins that bind to the secondary channel of E. coli RNA polymerase (RNAP), such as GreA, GreB or DksA. Similar binding sites could suggest a competition between them. GreA is characterised to rescue stalled RNAP complexes due t...

journal_title：Scientific reports

authors： Fernández-Coll L,Potrykus K,Cashel M,Balsalobre C

更新日期：2020-09-30 00:00:00

abstract：:This work aimed to use artificial intelligence to predict subjective refraction from wavefront aberrometry data processed with a novel polynomial decomposition basis. Subjective refraction was converted to power vectors (M, J0, J45). Three gradient boosted trees (XGBoost) algorithms were trained to predict each power ...

journal_title：Scientific reports

authors： Rampat R,Debellemanière G,Malet J,Gatinel D

更新日期：2020-05-22 00:00:00

abstract：:Metabotropic glutamate receptor subtype 1 (mGluR1) is a crucial pharmacological target for several central nervous system disorders. In this study, we aimed to monitor in vivo regional changes of mGluR1 related to neuroinflammation in the brains of rats after pilocarpine-induced status epilepticus (PISE) using longitu...

journal_title：Scientific reports

authors： Yamasaki T,Fujinaga M,Mori W,Zhang Y,Wakizaka H,Nengaki N,Xie L,Hatori A,Zhang MR

更新日期：2017-11-02 00:00:00

abstract：:Pinus pinaster bark, an abundant by-product from the timber industry, has been studied as a potential low-cost adsorbent for the removal of Congo red (CR) dye from wastewaters. Surface morphological and physico-chemical characteristics of pine bark were analysed using Fourier transform infrared (FTIR) spectroscopy, sc...

journal_title：Scientific reports

authors： Litefti K,Freire MS,Stitou M,González-Álvarez J

更新日期：2019-11-11 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are immune cells that exert immunosuppression within the tumor, protecting cancer cells from the host's immune system and/or exogenous immunotherapies. While current research has been mostly focused in countering MDSC-driven immunosuppression, little is known about the mechanis...

journal_title：Scientific reports

authors： Duarte-Sanmiguel S,Shukla V,Benner B,Moore J,Lemmerman L,Lawrence W,Panic A,Wang S,Idzkowski N,Guio-Vega G,Higuita-Castro N,Ghadiali S,Carson WE,Gallego-Perez D

更新日期：2020-01-27 00:00:00

abstract：:Periodontitis is a local and systemic inflammatory condition and a risk factor of atherosclerosis, but no studies investigated the effect of a statin on atherogenesis affected by severe periodontitis. In this study, we investigated the effect of rosuvastatin (RSV) on atherogenesis in Apolipoprotein E-deficient mice re...

journal_title：Scientific reports

authors： Suh JS,Lee SH,Fouladian Z,Lee JY,Kim T,Kang MK,Lusis AJ,Boström KI,Kim RH,Park NH

更新日期：2020-04-14 00:00:00

abstract：:A larger amount of sequence data in private and public databases produced by next-generation sequencing put new challenges due to limitation associated with the alignment-based method for sequence comparison. So, there is a high need for faster sequence analysis algorithms. In this study, we developed an alignment-fre...

journal_title：Scientific reports

authors： Saw AK,Raj G,Das M,Talukdar NC,Tripathy BC,Nandi S

更新日期：2019-03-06 00:00:00

abstract：:Central visual field (CVF) loss has been linked to poorer vision-related quality of life in eyes with open-angle glaucoma (OAG) and can occur even in early-stage OAG eyes. The present study investigated whether the detection of choroidal microvasculature dropout (CMvD) during follow-up, which may be a sign of perfusio...

journal_title：Scientific reports

authors： Jo YH,Kwon J,Jeong D,Shon K,Kook MS

更新日期：2019-06-12 00:00:00

abstract：:Joint deterioration and associated chronic pain are common among people with haemophilia (PWH), having an impact on quality-of-life. Though non-pharmacological strategies are recommended, psychological interventions to promote pain control and quality-of-life have scarcely been tested in haemophilia. This randomised c...

journal_title：Scientific reports

authors： Paredes AC,Costa P,Fernandes S,Lopes M,Carvalho M,Almeida A,Pinto PR

更新日期：2019-09-16 00:00:00