Publisher Correction: PP2A inhibition from LB100 therapy enhances daunorubicin cytotoxicity in secondary acute myeloid leukemia via miR-181b-1 upregulation.

abstract：:The TREX complex mediates the passage of bulk cellular mRNA export to the nuclear export factor TAP/NXF1 via the export adaptors ALYREF or UIF, which appear to act in a redundant manner. TREX complex recruitment to nascent RNA is coupled with 5' capping, splicing and polyadenylation. Therefore to facilitate expression...

journal_title：Scientific reports

authors： Tunnicliffe RB,Tian X,Storer J,Sandri-Goldin RM,Golovanov AP

更新日期：2018-10-09 00:00:00

abstract：:Glutamine metabolism and the mechanistic target of rapamycin (mTOR) pathway are activated cooperatively in the differentiation and activation of inflammatory immune cells. But the combined inhibition of both pathways was rarely investigated. This study investigated how inhibiting both glutamine metabolism with 6-diazo...

journal_title：Scientific reports

authors： Ueda Y,Saegusa J,Okano T,Sendo S,Yamada H,Nishimura K,Morinobu A

更新日期：2019-04-23 00:00:00

abstract：:The aim of this study was to investigate whether a novel physiologically relevant marker, InsuTAG (fasting insulin × fasting triglycerides) can predict insulin resistance (IR) and metabolic syndrome (MetS). Data of 618 participants from the Retirement Health and Lifestyle Study (RHLS) were evaluated for the current st...

journal_title：Scientific reports

authors： Thota RN,Abbott KA,Ferguson JJA,Veysey M,Lucock M,Niblett S,King K,Garg ML

更新日期：2017-11-09 00:00:00

abstract：:Gut microbiota dysbiosis features progressive HIV infection and is a potential target for intervention. Herein, we explored the microbiome of 16 elite controllers (EC), 32 antiretroviral therapy naive progressors and 16 HIV negative controls. We found that the number of observed genera and richness indices in fecal mi...

journal_title：Scientific reports

authors： Vesterbacka J,Rivera J,Noyan K,Parera M,Neogi U,Calle M,Paredes R,Sönnerborg A,Noguera-Julian M,Nowak P

更新日期：2017-07-24 00:00:00

abstract：:Free standing, atomically thin transition metal dichalcogenides are a new class of ultralightweight nanoelectromechanical systems with potentially game-changing electro- and opto-mechanical properties, however, the energy dissipation pathways that fundamentally limit the performance of these systems is still poorly un...

journal_title：Scientific reports

authors： Matis BR,Houston BH,Baldwin JW

更新日期：2017-07-18 00:00:00

abstract：:Transgenic rice producing insecticidal proteins from Bacillus thuringiensis (Bt) could help protect the plants from damage by lepidopteran pests. However, one concern is the potential of Bt rice to harm non-target natural enemies, which play a vital role in pest control. In the present study, the potential effects of ...

journal_title：Scientific reports

authors： Tian JC,Romeis J,Liu K,Zhang FC,Zheng XS,Xu HX,Chen GH,He XC,Lu ZX

更新日期：2017-08-10 00:00:00

abstract：:Alpha-adrenoceptor antagonists (alpha-blockers) are widely prescribed to treat lower urinary tract symptoms (LUTS) in men but fail to ameliorate LUTS sufficiently, especially the storage symptoms related to frequency, urgency and nocturia. We performed a meta-analysis of randomised controlled trials (RCTs) comparing a...

journal_title：Scientific reports

authors： Li J,Shi Q,Bai Y,Pu C,Tang Y,Yuan H,Wu Y,Wei Q,Han P

更新日期：2014-02-04 00:00:00

abstract：:For people with synaesthesia ordinary stimuli such as digits or letters induce concurrent experiences such as colours. Synaesthesia is associated with a memory advantage and the aim of this study was to investigate whether this advantage persists across time. We tested recognition memory of four different types of syn...

journal_title：Scientific reports

authors： Lunke K,Meier B

更新日期：2020-02-26 00:00:00

abstract：:Apolipoprotein E4 (E4) and type 2 diabetes are major risk factors for cognitive decline and late onset Alzheimer's disease (AD). E4-associated phenotypes and insulin resistance (IR) share several features and appear to interact in driving cognitive dysfunction. However, shared mechanisms that could explain their overl...

journal_title：Scientific reports

authors： Johnson LA,Torres ER,Impey S,Stevens JF,Raber J

更新日期：2017-03-08 00:00:00

abstract：:In this article we advance a cutting-edge methodology for the study of the dynamics of plant movements of nutation. Our approach, unlike customary kinematic analyses of shape, period, or amplitude, is based on three typical signatures of adaptively controlled processes and motions, as reported in the biological and be...

journal_title：Scientific reports

authors： Raja V,Silva PL,Holghoomi R,Calvo P

更新日期：2020-11-10 00:00:00

abstract：:To assess extraspinal findings (ESFs) prevalence in lumbar spine MRI, including clinically significant findings using a systematic approach, and to determine their reporting rate. Lumbar spine MRI scans were retrospectively reviewed over 18 months by two radiologists. Reading discrepancies were resolved by consensus. ...

journal_title：Scientific reports

authors： Khasawneh RA,Mohaidat Z,Khasawneh FA,Farah A,Gharaibeh M,El-Heis M

更新日期：2021-01-13 00:00:00

abstract：:Current research on the influence of environmental and physicochemical factors in shaping the soil bacterial structure has seldom been approached from a pedological perspective. We studied the bacterial communities of eight soils selected along a pedogenic gradient at the local scale in a Mediterranean calcareous moun...

journal_title：Scientific reports

authors： Sánchez-Marañón M,Miralles I,Aguirre-Garrido JF,Anguita-Maeso M,Millán V,Ortega R,García-Salcedo JA,Martínez-Abarca F,Soriano M

更新日期：2017-11-06 00:00:00

abstract：:We study complex scaling properties of RR and QT intervals of electrocardiograms (ECGs) with their equivalences at the cellular level, that is, inter-beat intervals (IBI) and field potential durations (FPD) of spontaneously beating human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) aggregates. Our de...

journal_title：Scientific reports

authors： Kim J,Shah D,Potapov I,Latukka J,Aalto-Setälä K,Räsänen E

更新日期：2019-03-06 00:00:00

abstract：:Integrative and conjugative elements (ICEs) are mobile genetic elements that contribute to horizontal gene transfer. The aim of this work was to study different types of ICEs in clinical isolates of the emergent pathogen Shewanella spp., to compare their transfer efficiency and their ability to integrate a new host. H...

journal_title：Scientific reports

authors： Parmeciano DI Noto G,Iriarte A,Ramírez MS,Centrón D,Quiroga C

更新日期：2019-05-29 00:00:00

abstract：:To examine patterns of human immunodeficiency virus (HIV) cause-specific deaths, risk factors, and the effect of interactions on mortality, we conducted a retrospective cohort study in Zhejiang, China, from 2006 to 2013. All data were downloaded from the acquired immune deficiency syndrome (AIDS) Prevention and Contro...

journal_title：Scientific reports

authors： Chen L,Pan X,Ma Q,Yang J,Xu Y,Zheng J,Wang H,Zhou X,Jiang T,Jiang J,He L,Jiang J

更新日期：2017-02-15 00:00:00

abstract：:Hearing loss is often due to the absence or the degeneration of hair cells in the cochlea. Understanding the mechanisms regulating the generation of hair cells may therefore lead to better treatments for hearing disorders. To elucidate the transcriptional control mechanisms specifying the progenitor cells (i.e. prosen...

journal_title：Scientific reports

authors： Wilkerson BA,Chitsazan AD,VandenBosch LS,Wilken MS,Reh TA,Bermingham-McDonogh O

更新日期：2019-06-21 00:00:00

abstract：:A novel and convenient copper (II) bromide and 1,8-diazabicyclo[5.4.1]undec-7-ene (DBU) or 1,10-phenanthroline catalysis protocol for the construction of α-alkyl-β-keto sulfones via C(sp(3))-H bond functionalization followed by C(sp(3))-S bond formation between aryl ketones and sodium sulfinates at room temperature ha...

journal_title：Scientific reports

authors： Lan XW,Wang NX,Bai CB,Zhang W,Xing Y,Wen JL,Wang YJ,Li YH

更新日期：2015-12-18 00:00:00

abstract：:The bald eagle (Haliaeetus leucocephalus) once experienced near-extinction but has since rebounded. For decades, bald eagles near the Wisconsin River, USA, have experienced a lethal syndrome with characteristic clinical and pathological features but unknown etiology. Here, we describe a novel hepacivirus-like virus (F...

journal_title：Scientific reports

authors： Goldberg TL,Sibley SD,Pinkerton ME,Dunn CD,Long LJ,White LC,Strom SM

更新日期：2019-10-18 00:00:00

abstract：:Accumulation of advanced glycation end products (AGEs) is linked with development or aggravation of many degenerative processes or disorders, including aging and atherosclerosis. AGEs production in skin cells is known to promote stiffness and loss of elasticity through their buildup in connective tissue. However, the ...

journal_title：Scientific reports

authors： Lee EJ,Kim JY,Oh SH

更新日期：2016-06-13 00:00:00

abstract：:We introduce a method to study the spatial profiles of standing spin waves in ferromagnetic microstructures. The method relies on Nuclear Resonant Scattering of 57Fe using a microfocused beam of synchrotron radiation, the transverse coherence length of which is smaller than the length scale of lateral variations in th...

journal_title：Scientific reports

authors： Gollwitzer J,Bocklage L,Schlage K,Herlitschke M,Wille HC,Leupold O,Adolff CF,Meier G,Röhlsberger R

更新日期：2018-07-26 00:00:00

abstract：:Burgeoning availability of genome-wide association study (GWAS) results and national biobank data has led to growing interest in performing multi-trait genetic analyses. Numerous multi-trait GWAS methods that exploit either summary statistics or individual-level data have been developed, but their relative performance...

journal_title：Scientific reports

authors： Porter HF,O'Reilly PF

更新日期：2017-03-13 00:00:00

abstract：:Conversion of lignocellulosic biomass to biofuels and biomaterials suffers from high production costs associated with biomass pretreatment and enzymatic hydrolysis. In-planta expression of lignocellulose-digesting enzymes is a promising approach to reduce these cost elements. However, this approach faces a number of c...

journal_title：Scientific reports

authors： Mir BA,Myburg AA,Mizrachi E,Cowan DA

更新日期：2017-09-13 00:00:00

abstract：:Ribosomal RNA internal transcribed spacer-1 (ITS1) metabarcoding was used to investigate the distribution patterns of fungal communities and the factors influencing these patterns in subtropical Chinese seas, including the southern and northern Yellow Sea and the Bohai Sea. These seas were found to harbor high levels ...

journal_title：Scientific reports

authors： Li W,Wang MM,Wang XG,Cheng XL,Guo JJ,Bian XM,Cai L

更新日期：2016-05-20 00:00:00

abstract：:We describe a technique for imaging single mRNAs in living cells based on fluorescent protein (FP) complementation. We employ the high affinity interaction between the bacterial phage MS2/PP7 coat proteins and their respective RNA binding motifs as an RNA scaffold to bring two halves of a split-FP together to image si...

journal_title：Scientific reports

authors： Wu B,Chen J,Singer RH

更新日期：2014-01-09 00:00:00

abstract：:This study aimed to investigate whether interleukin-34 (IL-34) mRNA expression is aberrant and modulated by tumor necrosis factor-alpha (TNF-α) in knee osteoarthritis (OA) fibroblast-like synoviocytes (FLS) and determine associations of IL-34 mRNA and protein in the systemic and local joint environments with severity ...

journal_title：Scientific reports

authors： Udomsinprasert W,Jinawath A,Teerawattanapong N,Honsawek S

更新日期：2020-05-14 00:00:00

abstract：:Multiple Sclerosis (MS) require medications controlling severity of the pathology and depression, affecting more than half of the patients. In this study, the effect of antidepressant drug fluvoxamine, a selective serotonin reuptake inhibitor, was investigated in vitro and in vivo. Nanomolar concentrations of fluvoxam...

journal_title：Scientific reports

authors： Ghareghani M,Zibara K,Sadeghi H,Dokoohaki S,Sadeghi H,Aryanpour R,Ghanbari A

更新日期：2017-07-07 00:00:00

abstract：:The development of selective visual attention is critical for effectively engaging with an ever-changing world. Its optimal deployment depends upon interactions between neural, motor, and sensory systems across multiple timescales and neurocognitive loci. Previous work illustrates the spatio-temporal dynamics of these...

journal_title：Scientific reports

authors： Stallworthy IC,Sifre R,Berry D,Lasch C,Smith TJ,Elison JT

更新日期：2020-10-14 00:00:00

abstract：:Significant aggregation between ZnO nanoparticles (ZnO NPs) dispersed in polar and nonpolar solvents hinders the formation of high quality thin film for the device application and impedes their excellent electron transporting ability. Herein a bifunctional coordination complex, titanium diisopropoxide bis(acetylaceton...

journal_title：Scientific reports

authors： Lee W,Yeop J,Heo J,Yoon YJ,Park SY,Jeong J,Shin YS,Kim JW,An NG,Kim DS,Park J,Kim JY

更新日期：2020-10-22 00:00:00

abstract：:Crystal and electronic structures of ~380 nm BiFeO3 film grown on LaAlO3 substrate are comprehensively studied using advanced transmission electron microscopy (TEM) technique combined with first-principles theory. Cross-sectional TEM images reveal the BiFeO3 film consists of two zones with different crystal structures...

journal_title：Scientific reports

authors： Bae IT,Kovács A,Zhao HJ,Íñiguez J,Yasui S,Ichinose T,Naganuma H

更新日期：2017-04-19 00:00:00

abstract：:One key ability of human brain is invariant object recognition, which refers to rapid and accurate recognition of objects in the presence of variations such as size, rotation and position. Despite decades of research into the topic, it remains unknown how the brain constructs invariant representations of objects. Prov...

journal_title：Scientific reports

authors： Karimi-Rouzbahani H,Bagheri N,Ebrahimpour R

更新日期：2017-10-31 00:00:00