Abstract：
:In-vitro studies have suggested that the antiarrhythmic drug digoxin might restrain the growth of cancer cells by inhibiting Na+/K+-ATPase. We evaluated the association between cancer mortality and digoxin, sotalol and general antiarrhythmic drug use in a retrospective cohort study. The study population consists of 78,615 men originally identified for the Finnish Randomized Study of Screening for Prostate Cancer. Information on antiarrhythmic drug purchases was collected from the national prescription database. We used the Cox regression method to analyze separately overall cancer mortality and mortality from the most common types of cancer. During the median follow-up of 17.0 years after the baseline 28,936 (36.8%) men died, of these 8,889 due to cancer. 9,023 men (11.5%) had used antiarrhythmic drugs. Overall cancer mortality was elevated among antiarrhythmic drug users compared to non-users (HR 1.43, 95% CI 1.34-1.53). Similar results were observed separately for digoxin and for sotalol. However, the risk associations disappeared in long-term use and were modified by background co-morbidities. All in all, cancer mortality was elevated among antiarrhythmic drug users. This association is probably non-causal as it was related to short-term use and disappeared in long-term use. Our results do not support the anticancer effects of digoxin or any other antiarrhythmic drug.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kaapu KJ,Rantaniemi L,Talala K,Taari K,Tammela TLJ,Auvinen A,Murtola TJdoi
10.1038/s41598-018-28541-4subject
Has Abstractpub_date
2018-07-09 00:00:00pages
10308issue
1issn
2045-2322pii
10.1038/s41598-018-28541-4journal_volume
8pub_type
杂志文章abstract：:We report on Y3Al5O12: Ce(3+) ceramic phosphor plate (CPP) using nano phosphor for high power laser diode (LD) application for white light in automotive lighting. The prepared CPP shows improved luminous properties as a function of Ce(3+) concentration. The luminous properties of the Y3Al5O12: Ce(3+) CPP nano phosphor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31206
更新日期：2016-08-09 00:00:00
abstract：:Cryo-electron tomography (cryo-ET) is one of the most advanced technologies for the in situ visualization of molecular machines by producing three-dimensional (3D) biological structures. However, cryo-ET imaging has two serious disadvantages-low dose and low image contrast-which result in high-resolution information b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20945-6
更新日期：2018-02-07 00:00:00
abstract：:Calcitriol, a metabolite of vitamin D, is often used in osteoporosis clinics. However, the material has other bioactivities; for example, it accelerates angiogenesis, has anti-inflammatory properties, and inhibits oxidative stress. We investigated the effects of calcitriol in a random skin flap rat model. "McFarlane f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18945
更新日期：2016-01-06 00:00:00
abstract：:Most of the artificial low-pressure plasmas contact with physical walls in laboratories; the plasma loss at the wall significantly affects the plasma device performance, e.g., an electric propulsion device. Near the surface of the wall, ions are spontaneously accelerated by a sheath and deliver their momentum and ener...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58022-6
更新日期：2020-01-23 00:00:00
abstract：:Diabetic nephropathy is characterised by the excessive amount of extracellular matrix in glomeruli and tubulointerstitial space. Lysyl oxidase-like 2 (LOXL2) is elevated in renal fibrosis and known to play key roles in ECM stabilisation by facilitating collagen cross-links, epithelial to mesenchymal transition and myo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27462-6
更新日期：2018-06-21 00:00:00
abstract：:Haemodynamic disorders are common clinical findings in hypertension and lead to adverse cardiovascular events. However, the haemodynamic conditions in hypertension models are poorly understood. This study aimed to observe the characteristics of haemodynamics in spontaneously hypertensive rats (SHRs) and antihypertensi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01906-x
更新日期：2017-05-17 00:00:00
abstract：:It has been reported that non-selective autophagy of infected hepatocytes could facilitate the development of malaria in the liver stage, but the fate of parasites following selective autophagy of infected hepatocytes is still not very clear. Here, we confirmed that sporozoite infection can induce a selective autophag...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38170
更新日期：2016-11-30 00:00:00
abstract：:Empowering an indirect band-gap material like Si with optical functionalities, firstly light emission, represents a huge advancement constantly pursued in the realization of any integrated photonic device. We report the demonstration of giant photoluminescence (PL) emission by a newly synthesized material consisting o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02674
更新日期：2013-01-01 00:00:00
abstract：:Radiation exposure severely damages the hematopoietic system. Although several radio-protectors have been proposed to prevent radiation-induced damage, most agents have limited efficacy. In the present study, we investigated whether mesenchymal stem cells (MSCs) could contribute to the expansion of hematopoietic cells...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27666-w
更新日期：2018-06-18 00:00:00
abstract：:As mammalian herbivores feed, they often encounter noxious insects on plants. It is unknown how they handle such insects. We experimentally examined the behavioural responses of goats to the noxious spring-webworm (Ocnogyna loewii), and manipulated their sensory perception to reveal the process of insect detection. Go...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14940-6
更新日期：2017-11-01 00:00:00
abstract：:Electromagnetic resonances in conducting structures give rise to the enhancement of local fields and extinction efficiencies. Conducting structures are conventionally fabricated with a fixed geometry that determines their resonant response. Here, we challenge this conventional approach by demonstrating the photo-gener...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03584
更新日期：2014-01-07 00:00:00
abstract：:Spatial tuning properties of retinal ganglion cells (RGCs) are sharpened by lateral inhibition originating at both the outer and inner plexiform layers. Lateral inhibition in the retina contributes to local contrast enhancement and sharpens edges. In this study, we used dynamic clamp recordings to examine the contribu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21966
更新日期：2016-02-24 00:00:00
abstract：:Staphylococcus aureus can cause different types of diseases from mild skin infections to life-threatening sepsis worldwide. Owing to the emergence and transmission of multidrug-resistant strains, developing an impactful immunotherapy especially vaccine control approach against S. aureus infections is increasingly enco...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22044-y
更新日期：2018-02-26 00:00:00
abstract：:To examine patterns of human immunodeficiency virus (HIV) cause-specific deaths, risk factors, and the effect of interactions on mortality, we conducted a retrospective cohort study in Zhejiang, China, from 2006 to 2013. All data were downloaded from the acquired immune deficiency syndrome (AIDS) Prevention and Contro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42366
更新日期：2017-02-15 00:00:00
abstract：:Sex-dependent effects of mismatched prenatal-postnatal maternal conditions are predicted by combining two evolutionary hypotheses: that foetal conditions provide a forecast of likely postnatal environments (Predictive Adaptive Response), and that the female foetus is better adapted than the male to maternal adversity ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39513-7
更新日期：2019-02-21 00:00:00
abstract：:In this study, we report a metallogel developed based on metal-phenolic coordination of natural low-cost polyphenolic molecule and metal ions. Gelation occurs by mixing tannic acid (TA) and group (IV) titanium ions (TiIV) to form TA-TiIV gel. The TA-TiIV gel exhibits good capability to incorporate diverse metal ions b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47978-9
更新日期：2019-08-09 00:00:00
abstract：:Allergic asthma and obesity are major public health problems in the world. Recent Meta-analysis studies implicated a positive relationship between serum leptin, which is elevated in obese individuals, and the risk of asthma. However, it is not well understood how obesity-associated elevation of leptin increases the ri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27278-4
更新日期：2018-06-11 00:00:00
abstract：:Copy number variation (CNV) is a newly discovered form of intra-species genetic polymorphism that is defined as deletions or duplications of genome segments ranging from 1 kbp to several Mbp. CNV accounts for the majority of the genetic variation observed in humans (CNV regions cover more than 10% of the human genome)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31340
更新日期：2016-08-11 00:00:00
abstract：:Olive (Olea europaea L.) is one of the most economically and historically important fruit crops worldwide. Genetic progress for valuable agronomic traits has been slow in olive despite its importance and benefits. Advances in next generation sequencing technologies provide inexpensive and highly reproducible genotypin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55338-w
更新日期：2019-12-10 00:00:00
abstract：:Regional differences in ion channel activity in the heart control the sequence of repolarization and may contribute to differences in contraction. Corticosteroids such as aldosterone or corticosterone increase the L-type Ca2+ current (ICaL) in the heart via the mineralocorticoid receptor (MR). Here, we investigate the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68308-4
更新日期：2020-07-14 00:00:00
abstract：:The alveolar echinococcosis of human is a severe helminthic disease caused by the larva of Echinococcus multilocularis tapeworms. Novel compounds or therapy strategies for the treatment of alveolar echinococcosis are urgently needed due to the limitation of the widely used albendazole. Magnetic microspheres as drug ca...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69484-z
更新日期：2020-07-28 00:00:00
abstract：:Programmed cell death 1 (PD-1) monoclonal antibodies have been approved by regulatory agencies for the treatment of various types of cancer, and the mechanism involves the restoration of T cell functions. We report herein the X-ray crystal structure of a fully human monoclonal antibody mAb059c fragment antigen-binding...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54231-w
更新日期：2019-11-28 00:00:00
abstract：:The pathological skin phenotype caused by hyperglycemia is an important indicator for the progress of diabetes mellitus. An early detection of diabetes assures an early intervention to regulate the carbohydrate metabolism. In this publication a non-invasive detection principle based on the measurement of complex scatt...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06034-0
更新日期：2017-07-19 00:00:00
abstract：:Tin doped indium oxide (ITO) thin films provide excellent transparency and conductivity for electrodes in displays and photovoltaic systems. Current advances in producing printable ITO inks are reducing the volume of wasted indium during thin film patterning. However, their applicability to flexible electronics is hin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38043-y
更新日期：2019-02-11 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-39022-7
更新日期：2019-05-03 00:00:00
abstract：:Visual acuity can be measured in many different ways, including with letters and Vernier offsets. Prior psychophysical work has suggested that the two acuities are strongly linked given that they both depend strongly on retinal eccentricity and both are similarly affected in amblyopia. Here we used high-density EEG re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72370-3
更新日期：2020-09-22 00:00:00
abstract：:In order to design a painless and mechanically durable micro syringe-needle system for biomedical applications, the study of insect stingers is of interest because of their elegant structures and functionalities. In the present work, the structure, mechanical properties and the mechanical behavior during insertion of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33386-y
更新日期：2018-10-08 00:00:00
abstract：:Many plant essential oils and their terpenoid constituents possess bioactivities including insecticidal activity, and they sometimes act synergistically when mixed. Although several hypotheses for this have been proposed, the underlying mechanism has not been fully elucidated thus far. In the present study, we report ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42432
更新日期：2017-02-09 00:00:00
abstract：:Magnesium battery is potentially a safe, cost-effective, and high energy density technology for large scale energy storage. However, the development of magnesium battery has been hindered by the limited performance and the lack of fundamental understandings of electrolytes. Here, we present a study in understanding co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03130
更新日期：2013-11-04 00:00:00
abstract：:Despite extensive efforts in studying radioactive aerosols, including the transmission of radionuclides in different chemical matrices throughout the body, the internal organ-specific radiation dose due to inhaled radioactive aerosols has largely relied on experimental deposition data and simplified human phantoms. Co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54040-1
更新日期：2019-11-25 00:00:00
