A retrospective cohort study on the outcomes of ischemic stroke patients with adjuvant Korean Medicine treatment.

Abstract:

:This study aims to examine the long-term effect of adjuvant treatment in Korean Medicine (KM) clinics in ischemic stroke patients, using a national sample cohort from the National Health Insurance Service in Korea between 2010 and 2013. The National Health Insurance Service - National Sample Cohort database from 2002 to 2013 was used in this study. Ischemic stroke patients were defined and covariates were included to account for socioeconomic variables, comorbidities and disease severity. Propensity score matching was applied. Cox proportional hazards modeling and Kaplan-Meier analysis were applied to determine the differences between KM and non-KM treated groups. The results shows that KM-treated group had a higher probability of survival than non-KM group patients. No significant difference was observed between the risk of readmission between the treated and non-treated patients. Kaplan-Meier analysis showed a weak effect of KM treatments in the patients with 8 to 28 days of hospital stay for a lower risk of recurrence than in non-treated patients. In conclusion, KM treatment of mild to moderate ischemic stroke patients has a mild effect on the survival probability of stroke. Its effect for improving long-term recurrence need to be explored in the future studies.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Lee YS,Kwon S,Chae Y,Jang BH,Ko SG

doi

10.1038/s41598-018-19841-w

subject

Has Abstract

pub_date

2018-01-26 00:00:00

pages

1656

issue

1

issn

2045-2322

pii

10.1038/s41598-018-19841-w

journal_volume

8

pub_type

杂志文章
  • Relationship Between Homodimeric Glucocorticoid Receptor and Transcriptional Regulation Assessed via an In Vitro Fluorescence Correlation Spectroscopy-Microwell System.

    abstract::Glucocorticoid receptor (GR) is a hormone-activated transcription regulatory protein involved in metabolism as well as adrenocortical responses to psychosocial stress. Ligand-activated GR localizes to the nucleus, where GR homodimers regulate gene transcription via direct binding to glucocorticoid response elements (G...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-25393-w

    authors: Oasa S,Mikuni S,Yamamoto J,Kurosaki T,Yamashita D,Kinjo M

    更新日期:2018-05-10 00:00:00

  • Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma.

    abstract::We have performed a genome-wide association study (GWAS) including 473 Japanese HBV (hepatitis B virus)-positive HCC (hepatocellular carcinoma) patients and 516 HBV carriers including chronic hepatitis and asymptomatic carrier individuals to identify new host genetic factors associated with HBV-derived HCC in Japanese...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-26217-7

    authors: Sawai H,Nishida N,Khor SS,Honda M,Sugiyama M,Baba N,Yamada K,Sawada N,Tsugane S,Koike K,Kondo Y,Yatsuhashi H,Nagaoka S,Taketomi A,Fukai M,Kurosaki M,Izumi N,Kang JH,Murata K,Hino K,Nishina S,Matsumoto A,Tanaka

    更新日期:2018-05-21 00:00:00

  • More than redox, biological organic ligands control iron isotope fractionation in the riparian wetland.

    abstract::Although redox reactions are recognized to fractionate iron (Fe) isotopes, the dominant mechanisms controlling the Fe isotope fractionation and notably the role of organic matter (OM) are still debated. Here, we demonstrate how binding to organic ligands governs Fe isotope fractionation beyond that arising from redox ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-81494-z

    authors: Lotfi-Kalahroodi E,Pierson-Wickmann AC,Rouxel O,Marsac R,Bouhnik-Le Coz M,Hanna K,Davranche M

    更新日期:2021-01-21 00:00:00

  • Thymoquinone Alleviates the Experimental Diabetic Peripheral Neuropathy by Modulation of Inflammation.

    abstract::Thymoquinone has been reported to exhibit antioxidant and anti-inflammatory effects. Inflammation plays an important role in pathogenesis of diabetic peripheral neuropathy. This study investigated the effects of TQ on proliferation and apoptosis of Schwann cells exposed to high glucose conditions and electrophysiologi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep31656

    authors: Chen L,Li B,Chen B,Shao Y,Luo Q,Shi X,Chen Y

    更新日期:2016-08-22 00:00:00

  • Investigation of thermal energy transport interface of hybrid graphene-carbon nanotube/polyethylene nanocomposites.

    abstract::It is well known the thermal properties of three-dimensional (3-D) hybrid graphene (GR)-carbon nanotube (CNT) structures are not superior to that of the individual GR and CNT, however, the 3-D hybrid GR-CNT structures can effectively improve the thermal properties of polymer matrix. Therefore, understanding the therma...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-14710-4

    authors: Liu F,Liu X,Hu N,Ning H,Atobe S,Yan C,Mo F,Fu S,Zhang J,Wang Y,Mu X

    更新日期:2017-10-31 00:00:00

  • Matrix description of the complete topology of three-dimensional cells.

    abstract::A new, efficient method based on a series of matrices is introduced to completely describe the detailed topology of individual domains and their topology evolution in three-dimensional cellular structures. With this approach, we found a lot of new topological grain forms which are never reported before, i.e., there ar...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25877

    authors: Xue W,Wang H,Liu G,Meng L,Xiang S,Ma G,Li W

    更新日期:2016-05-10 00:00:00

  • Protective effect of epigallocatechin-3-gallate (EGCG) on toxic metalloproteinases-mediated skin damage induced by Scyphozoan jellyfish envenomation.

    abstract::Jellyfish stingings are currently raising serious public health concerns around the world. Hence, the search for an effective first aid reagent for the envenomation has been the goal of many investigators in the field. There have been a few previous reports of in vivo as well as in vivo studies suggesting the metallop...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-75269-1

    authors: Hwang DH,Lee H,Choudhary I,Kang C,Chae J,Kim E

    更新日期:2020-10-29 00:00:00

  • Comparative mode of action of the antimicrobial peptide melimine and its derivative Mel4 against Pseudomonas aeruginosa.

    abstract::Melimine and Mel4 are chimeric cationic peptides with broad-spectrum antimicrobial activity. They have been shown to be highly biocompatible in animal models and human clinical trials. The current study examined the mechanism of action of these two antimicrobial peptides against P. aeruginosa. The effect of the peptid...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42440-2

    authors: Yasir M,Dutta D,Willcox MDP

    更新日期:2019-05-08 00:00:00

  • Thiamine antagonists trigger p53-dependent apoptosis in differentiated SH-SY5Y cells.

    abstract::Accumulating evidences suggest that p53 is a key coordinator of cellular events triggered by oxidative stress often associated with the impairment in thiamine metabolism and its functions. However, there are limited data regarding the pursuant feedback between p53 transactivation and thiamine homeostasis. Impairment i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10878-x

    authors: Chornyy S,Parkhomenko Y,Chorna N

    更新日期:2017-09-06 00:00:00

  • Rassf Proteins as Modulators of Mst1 Kinase Activity.

    abstract::Rassf1A/5 tumor suppressors serve as adaptor proteins possessing a modular architecture with the C-terminal consisting of a coiled-coil SARAH (Salvador-Rassf-Hippo) domain and the central portion being composed of Ras associated (RA) domain. Here, we investigate the effect of Rassf effectors on Mst1 function by mappin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45020

    authors: Bitra A,Sistla S,Mariam J,Malvi H,Anand R

    更新日期:2017-03-22 00:00:00

  • A model of the entrance pupil of the human eye.

    abstract::The aperture stop of the iris is subject to refraction by the cornea, and thus an outside observer sees a virtual image: the "entrance pupil" of the eye. When viewed off-axis, the entrance pupil has an elliptical form. The precise appearance of the entrance pupil is a consequence of the anatomical and optical properti...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45827-3

    authors: Aguirre GK

    更新日期:2019-06-27 00:00:00

  • A 5'-BODIPY End-label for Monitoring DNA Duplex-Quadruplex Exchange.

    abstract::Fluorescent probes that can distinguish different DNA topologies through changes in optical readout are sought after for DNA-based diagnostics. In this work, the 4,4-difluoro-4-bora-3a, 4a-diaza-s-indacene (BODIPY) chromophore attached to cyanophenyl substituents (BODIPY-CN) has been tethered to the 5'-end of the 15-m...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35352-0

    authors: Deore PS,Soldatov DV,Manderville RA

    更新日期:2018-11-15 00:00:00

  • Characteristics of pulsed runoff-erosion events under typical rainstorms in a small watershed on the Loess Plateau of China.

    abstract::The pulsed events of rainstorm erosion on the Loess Plateau are well-known, but little information is available concerning the characteristics of superficial soil erosion processes caused by heavy rainstorms at the watershed scale. This study statistically evaluated characteristics of pulsed runoff-erosion events base...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-22045-x

    authors: Wu L,Jiang J,Li GX,Ma XY

    更新日期:2018-02-27 00:00:00

  • Multidisciplinary approach to COVID-19 risk communication: a framework and tool for individual and regional risk assessment.

    abstract::The COVID-19 pandemic has exceeded over sixty-five million cases globally. Different approaches are followed to mitigate its impact and reduce its spreading in different countries, but limiting mobility and exposure have been de-facto precautions to reduce transmission. However, a full lockdown cannot be sustained for...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-78779-0

    authors: Parajuli RR,Mishra B,Banstola A,Ghimire BR,Poudel S,Sharma K,Dixit SM,Sah SK,Simkhada P,van Teijlingen E

    更新日期:2020-12-10 00:00:00

  • Heterostructured electrode with concentration gradient shell for highly efficient oxygen reduction at low temperature.

    abstract::Heterostructures of oxides have been widely investigated in optical, catalytic and electrochemical applications, because the heterostructured interfaces exhibit pronouncedly different transport, charge, and reactivity characteristics compared to the bulk of the oxides. Here we fabricated a three-dimensional (3D) heter...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00155

    authors: Zhou W,Liang F,Shao Z,Chen J,Zhu Z

    更新日期:2011-01-01 00:00:00

  • Grafting cucumber onto luffa improves drought tolerance by increasing ABA biosynthesis and sensitivity.

    abstract::Balancing stomata-dependent CO2 assimilation and transpiration is a key challenge for increasing crop productivity and water use efficiency under drought stress for sustainable crop production worldwide. Here, we show that cucumber and luffa plants with luffa as rootstock have intrinsically increased water use efficie...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20212

    authors: Liu S,Li H,Lv X,Ahammed GJ,Xia X,Zhou J,Shi K,Asami T,Yu J,Zhou Y

    更新日期:2016-02-02 00:00:00

  • Engineering a Polyspecific Pyrrolysyl-tRNA Synthetase by a High Throughput FACS Screen.

    abstract::The Pyrrolysyl-tRNA synthetase (PylRS) and its cognate tRNAPyl are extensively used to add non-canonical amino acids (ncAAs) to the genetic code of bacterial and eukaryotic cells. However, new ncAAs often require a cumbersome de novo engineering process to generate an appropriate PylRS/tRNAPyl pair. We here report a s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48357-0

    authors: Hohl A,Karan R,Akal A,Renn D,Liu X,Ghorpade S,Groll M,Rueping M,Eppinger J

    更新日期:2019-08-19 00:00:00

  • Coronin7 regulates WASP and SCAR through CRIB mediated interaction with Rac proteins.

    abstract::Coronin7 (CRN7) stabilizes F-actin and is a regulator of processes associated with the actin cytoskeleton. Its loss leads to defects in phagocytosis, motility and development. It harbors a CRIB (Cdc42- and Rac-interactive binding) domain in each of its WD repeat domains which bind to Rac GTPases preferably in their GD...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14437

    authors: Swaminathan K,Stumpf M,Müller R,Horn AC,Schmidbauer J,Eichinger L,Müller-Taubenberger A,Faix J,Noegel AA

    更新日期:2015-09-28 00:00:00

  • Author Correction: Hidden diversity in the Brazilian Atlantic rainforest: the discovery of Jurasaidae, a new beetle family (Coleoptera, Elateroidea) with neotenic females.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-60629-8

    authors: Rosa SP,Costa C,Kramp K,Kundrata R

    更新日期:2020-02-25 00:00:00

  • Comparisons between multi-component myelin water fraction, T1w/T2w ratio, and diffusion tensor imaging measures in healthy human brain structures.

    abstract::Various MRI techniques, including myelin water imaging, T1w/T2w ratio mapping and diffusion-based imaging can be used to characterize tissue microstructure. However, surprisingly few studies have examined the degree to which these MRI measures are related within and between various brain regions. Therefore, whole-brai...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39199-x

    authors: Uddin MN,Figley TD,Solar KG,Shatil AS,Figley CR

    更新日期:2019-02-21 00:00:00

  • Advantages and limitations of microtiter biofilm assays in the model of antibiofilm activity of Klebsiella phage KP34 and its depolymerase.

    abstract::One of the potential antibiofilm strategies is to use lytic phages and phage-derived polysaccharide depolymerases. The idea is to uncover bacteria embedded in the biofilm matrix making them accessible and vulnerable to antibacterials and the immune system. Here we present the antibiofilm efficiency of lytic phage KP34...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-77198-5

    authors: Latka A,Drulis-Kawa Z

    更新日期:2020-11-23 00:00:00

  • Tracking COVID-19 using taste and smell loss Google searches is not a reliable strategy.

    abstract::Web search tools are widely used by the general public to obtain health-related information, and analysis of search data is often suggested for public health monitoring. We analyzed popularity of searches related to smell loss and taste loss, recently listed as symptoms of COVID-19. Searches on sight loss and hearing ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-77316-3

    authors: Asseo K,Fierro F,Slavutsky Y,Frasnelli J,Niv MY

    更新日期:2020-11-25 00:00:00

  • Capillary isoelectric focusing after sample enrichment with immunoaffinity chromatography in a single capillary.

    abstract::For accurate micro-scale quantification of a specific protein in biological fluids, immunoaffinity chromatography (IAC) and isoelectric focusing (IEF) were combined in a single fused-silica capillary. The inner wall of the capillary was coated with an anti-E-tag antibody at the inlet side to form an IAC column, and po...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep39221

    authors: Shimura K,Nagai T

    更新日期:2016-12-15 00:00:00

  • Application of biosurfactant from Bacillus subtilis C9 for controlling cladoceran grazers in algal cultivation systems.

    abstract::Open algal cultivation platforms often suffer crop losses to herbivorous grazers that have potential to devastate biomass production within a few days. While a number of studies suggest synthetic chemicals as control agents for voracious algal grazers, environmental and safety concerns associated with the use of these...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-23535-8

    authors: Yun JH,Cho DH,Lee B,Kim HS,Chang YK

    更新日期:2018-03-29 00:00:00

  • Predicting the Young's Modulus of Silicate Glasses using High-Throughput Molecular Dynamics Simulations and Machine Learning.

    abstract::The application of machine learning to predict materials' properties usually requires a large number of consistent data for training. However, experimental datasets of high quality are not always available or self-consistent. Here, as an alternative route, we combine machine learning with high-throughput molecular dyn...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45344-3

    authors: Yang K,Xu X,Yang B,Cook B,Ramos H,Krishnan NMA,Smedskjaer MM,Hoover C,Bauchy M

    更新日期:2019-06-19 00:00:00

  • A tyrosinase, mTyr-CNK, that is functionally available as a monophenol monooxygenase.

    abstract::Tyrosinase efficiently catalyzes the ortho-hydroxylation of monophenols and the oxidation of diphenols without any additional cofactors. Although it is of significant interest for the biosynthesis of catechol derivatives, the rapid catechol oxidase activity and inactivation of tyrosinase have hampered its practical ut...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17635-0

    authors: Do H,Kang E,Yang B,Cha HJ,Choi YS

    更新日期:2017-12-08 00:00:00

  • Endoplasmic reticulum stress preconditioning modifies intracellular mercury content by upregulating membrane transporters.

    abstract::Endoplasmic reticulum (ER) stress preconditioning protects cells against methylmercury (MeHg) cytotoxicity by inducing integrated stress responses such as eIF2α phosphorylation, ATF4 accumulation, and nonsense-mediated mRNA decay (NMD) suppression. Here we demonstrated that ER stress preconditioning results in the upr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-09435-3

    authors: Usuki F,Fujimura M,Yamashita A

    更新日期:2017-09-28 00:00:00

  • Same habitat types but different use: evidence of context-dependent habitat selection in roe deer across populations.

    abstract::With the surge of GPS-technology, many studies uncovered space use of mobile animals and shed light on the underlying behavioral mechanisms of habitat selection. Habitat selection and variation in either occurrence or strength of functional responses (i.e. how selection changes with availability) have given new insigh...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-23111-0

    authors: William G,Jean-Michel G,Sonia S,Christophe B,Atle M,Nicolas M,Maryline P,Clément C

    更新日期:2018-03-23 00:00:00

  • Morphological, genomic and transcriptomic responses of Klebsiella pneumoniae to the last-line antibiotic colistin.

    abstract::Colistin remains one of the few antibiotics effective against multi-drug resistant (MDR) hospital pathogens, such as Klebsiella pneumoniae. Yet resistance to this last-line drug is rapidly increasing. Characterized mechanisms of colR in K. pneumoniae are largely due to chromosomal mutations in two-component regulators...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-28199-y

    authors: Cain AK,Boinett CJ,Barquist L,Dordel J,Fookes M,Mayho M,Ellington MJ,Goulding D,Pickard D,Wick RR,Holt KE,Parkhill J,Thomson NR

    更新日期:2018-06-29 00:00:00

  • Magnetically controlled ferromagnetic swimmers.

    abstract::Microscopic swimming devices hold promise for radically new applications in lab-on-a-chip and microfluidic technology, diagnostics and drug delivery etc. In this paper, we demonstrate the experimental verification of a new class of autonomous ferromagnetic swimming devices, actuated and controlled solely by an oscilla...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep44142

    authors: Hamilton JK,Petrov PG,Winlove CP,Gilbert AD,Bryan MT,Ogrin FY

    更新日期:2017-03-09 00:00:00