Abstract：
:The seven-helical bundle of rhodopsin and other G-protein coupled receptors undergoes structural rearrangements as the transmembrane receptor protein is activated. These structural changes are known to involve tilting and bending of various transmembrane helices. However, the cause and effect relationship among structural events leading to a cytoplasmic crevasse for G-protein binding is less well defined. Here we present a mathematical model of the protein helix and a simple procedure to determine multiple parameters that offer precise depiction of a helical conformation. A comprehensive survey of bovine rhodopsin structures shows that the helical rearrangements during the activation of rhodopsin involve a variety of angular and linear motions such as torsion, unwinding, and sliding in addition to the previously reported tilting and bending. These hitherto undefined motion components unify the results obtained from different experimental approaches, and demonstrate conformational similarity between the active opsin structure and the photoactivated structures in crystallo near the retinal anchor despite their marked differences.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ren Z,Ren PX,Balusu R,Yang Xdoi
10.1038/srep34129subject
Has Abstractpub_date
2016-09-23 00:00:00pages
34129issn
2045-2322pii
srep34129journal_volume
6pub_type
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-03-14 00:00:00
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-11-25 00:00:00
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-07-26 00:00:00
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pub_type： 杂志文章
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更新日期：2015-10-15 00:00:00
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pub_type： 杂志文章
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更新日期：2016-07-22 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2020-07-08 00:00:00
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pub_type： 杂志文章
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更新日期：2019-05-24 00:00:00
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pub_type： 杂志文章
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更新日期：2017-08-30 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-11-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30609-0
更新日期：2018-08-21 00:00:00
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pub_type： 杂志文章
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更新日期：2020-05-21 00:00:00
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journal_title：Scientific reports
pub_type： 已发布勘误
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更新日期：2018-11-23 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-05-21 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-04-10 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-07-09 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19145-z
更新日期：2018-01-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73833-3
更新日期：2020-10-07 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22643
更新日期：2016-03-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39229
更新日期：2016-12-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48195-0
更新日期：2019-08-13 00:00:00
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journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep19021
更新日期：2016-02-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-07-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-10-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28940
更新日期：2016-06-29 00:00:00
