Increasing the distance between two monomers of topoisomerase IIβ under the action of antitumor agent 4β-sulfur-(benzimidazole) 4'-demethylepipodophyllotoxin.

abstract：:In this study, we identified a CD105+CD90.1-CD133-CD55- (CD133-CD55-) population in the fetal skeletal element that can generate bone and bone marrow. Besides osteoblasts and chondrocytes, the CD133-CD55- common progenitors can give rise to marrow reticular stromal cells and perivascular mesenchymal progenitors sugges...

journal_title：Scientific reports

authors： Weng L,Hu X,Kumar B,Garcia M,Todorov I,Jung X,Marcucci G,Forman SJ,Chen CC

更新日期：2016-12-08 00:00:00

abstract：:The ability to inhibit previously employed strategies and flexibly adjust behavioural responses to external conditions may be critical for individual survival. However, it is unclear which factors predict their distribution across species. Here, we investigated social inhibition and behavioural flexibility in six prim...

journal_title：Scientific reports

authors： Amici F,Call J,Watzek J,Brosnan S,Aureli F

更新日期：2018-02-15 00:00:00

abstract：:The hepatitis C virus (HCV) is one of the leading causes of chronic hepatitis, liver cirrhosis and hepatocellular carcinomas and infects approximately 170 million people worldwide. Although several reporter systems have been developed, many shortcomings limit their use in the assessment of HCV infections. Here, we rep...

journal_title：Scientific reports

authors： Ren Q,Li C,Yuan P,Cai C,Zhang L,Luo GG,Wei W

更新日期：2015-03-09 00:00:00

abstract：:To identify a vegetation configuration pattern with a high-efficiency purification ability for total nitrogen (TN), available nitrogen (AN), total phosphorous (TP), available phosphorous (AP), and chemical oxygen demand (COD) based on comprehensive assessment results, a water discharge experiment was performed in the ...

journal_title：Scientific reports

authors： Hou G,Bi H,Yu X,Jia G,Wang D,Zhang Z,Liu Z

更新日期：2019-02-20 00:00:00

abstract：:Photosynthetic activity is indispensable for plant growth and survival and it depends on the synthesis of plastidial isoprenoids as chlorophylls and carotenoids. In the non-mevalonate pathway (MEP), the 1-deoxy-D-xylulose-5-phosphate synthase 1 (DXS1) enzyme has been postulated to catalyze the rate-limiting step in th...

journal_title：Scientific reports

authors： García-Alcázar M,Giménez E,Pineda B,Capel C,García-Sogo B,Sánchez S,Yuste-Lisbona FJ,Angosto T,Capel J,Moreno V,Lozano R

更新日期：2017-03-28 00:00:00

abstract：:Separation of CO2 from other gasses offers environmental benefits since CO2 gas is the main contributor to global warming. Recently, graphene oxide (GO) based gas separation membranes are of interest due to their selective barrier properties. However, maintaining selectivity without sacrificing permeance is still chal...

journal_title：Scientific reports

authors： Heo J,Choi M,Chang J,Ji D,Kang SW,Hong J

更新日期：2017-03-28 00:00:00

abstract：:Macrophages play a crucial role in the control and elimination of invading Mycobacterium tuberculosis (Mtb), and also serve as the major residence for Mtb. However, the interaction between macrophages and Mtb remains to be clearly determined. Although long noncoding RNAs (lncRNAs) have emerged as key regulators in man...

journal_title：Scientific reports

authors： Yang X,Yang J,Wang J,Wen Q,Wang H,He J,Hu S,He W,Du X,Liu S,Ma L

更新日期：2016-12-14 00:00:00

abstract：:Alpha melanocyte stimulating hormone (α-MSH) and Forkhead box C2 protein (Foxc2) enhance lipolysis in multiple tissues. However, their relationship in adipose fatty acid oxidation (FAO) remains unclear. Here, we demonstrated that α-MSH and Foxc2 increased palmitate oxidation to CO2 in white (WAT) and brown adipose tis...

journal_title：Scientific reports

authors： Gan L,Liu Z,Chen Y,Dan Luo,Feng F,Liu G,Sun C

更新日期：2016-11-07 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are a family of secreted endopeptidases expressed by neurons and glia. Regulated MMP activity contributes to physiological synaptic plasticity, while dysregulated activity can stimulate injury. Disentangling the role individual MMPs play in synaptic plasticity is difficult due to overl...

journal_title：Scientific reports

authors： Allen M,Ghosh S,Ahern GP,Villapol S,Maguire-Zeiss KA,Conant K

更新日期：2016-10-20 00:00:00

abstract：:Given the prevalence of poor adherence to therapy and the biases of self-reporting across healthcare, we hypothesized that an engaging, personalized therapy may improve adherence and treatment outcomes in the home. We tested this hypothesis in the initial indication of amblyopia, a neurodevelopmental disorder for whic...

journal_title：Scientific reports

authors： Xiao S,Gaier ED,Mazow ML,Stout AU,Travers DA,Angjeli E,Wu HC,Binenbaum G,Hunter DG

更新日期：2020-05-20 00:00:00

abstract：:It is recognized that T helper 2 (Th2) polarization plays a critical role in a large number of immune disorders. Yet, the remedies for reconciling the established Th2 polarization are still limited currently. Published data indicate that micro RNA-17-92 cluster is associated with the skewed immune response; 25 vitamin...

journal_title：Scientific reports

authors： Yu ZJ,Zeng L,Luo XQ,Geng XR,Xu R,Chen K,Yang G,Luo X,Liu ZQ,Liu ZG,Liu DB,Yang PC,Li HB

更新日期：2017-04-03 00:00:00

abstract：:Land cover change analyses are common and, especially in the absence of explanatory variables, they are mainly carried out by employing qualitative methods such as transition matrices or raster operations. These methods do not provide any estimation of the statistical significance of the changes, or the uncertainty of...

journal_title：Scientific reports

authors： Dettori S,Filigheddu MR,Deplano G,Molgora JE,Ruiu M,Sedda L

更新日期：2018-11-16 00:00:00

abstract：:We have sequenced the genome of the largest freshwater fish species of the world, the arapaima. Analysis of gene family dynamics and signatures of positive selection identified genes involved in the specific adaptations and unique features of this iconic species, in particular it's large size and fast growth. Genome s...

journal_title：Scientific reports

authors： Du K,Wuertz S,Adolfi M,Kneitz S,Stöck M,Oliveira M,Nóbrega R,Ormanns J,Kloas W,Feron R,Klopp C,Parrinello H,Journot L,He S,Postlethwait J,Meyer A,Guiguen Y,Schartl M

更新日期：2019-03-28 00:00:00

abstract：:The aim of this paper is to investigate the effect that bone marrow mesenchymal stem cells (BMMSCs) - endothelial progenitor cells (EPCs), BMMSCs and EPCs sheets have on repairing maxillary alveolar defects in ovariectomized (OVX) rats. In this study, after identification using multi-lineage differentiation and flow c...

journal_title：Scientific reports

authors： Wen Y,Yang H,Liu Y,Liu Q,Wang A,Ding Y,Jin Z

更新日期：2017-11-29 00:00:00

abstract：:Osteoporosis is associated with reduced density and quality of bone leading to weakened skeleton thereby increasing the risk of fractures responsible for increased morbidity and mortality. Due to preference for western food style the consumption of salt intake in our diets has increased many folds. High dietary salt i...

journal_title：Scientific reports

authors： Dar HY,Singh A,Shukla P,Anupam R,Mondal RK,Mishra PK,Srivastava RK

更新日期：2018-02-06 00:00:00

abstract：:Glycosyltransferases (GTs) are bidirectional biocatalysts catalyzing the glycosylation of diverse molecules. However, the extensive applications of GTs in glycosides formation are limited due to their requirements of expensive nucleotide diphosphate (NDP)-sugars or NDP as the substrates. Here, in an effort to characte...

journal_title：Scientific reports

authors： Yuan S,Yin S,Liu M,Kong JQ

更新日期：2018-04-12 00:00:00

abstract：:All real networks are different, but many have some structural properties in common. There seems to be no consensus on what the most common properties are, but scale-free degree distributions, strong clustering, and community structure are frequently mentioned without question. Surprisingly, there exists no simple gen...

journal_title：Scientific reports

authors： Zuev K,Boguñá M,Bianconi G,Krioukov D

更新日期：2015-04-29 00:00:00

abstract：:To develop an electronic navigation system to increase reliability and comparability in the ultrasound screening of developmental dysplasia of the hip (DDH). The impact of the navigation system on transducer positioning and on sonographic measurements according to Graf was analyzed. Twenty hips in newborns were examin...

journal_title：Scientific reports

authors： Kolb A,Chiari C,Schreiner M,Heisinger S,Willegger M,Rettl G,Windhager R

更新日期：2020-10-02 00:00:00

abstract：:CD96 is a promising candidate for immunotherapy. However, its role and importance in glioma remains unknown. We thus aimed to genetically and clinically characterize CD96 expression in gliomas. For this, we extracted RNA-seq data of 699 glioma samples from the TCGA dataset and validated these findings using the CGGA d...

journal_title：Scientific reports

authors： Liu F,Huang J,He F,Ma X,Fan F,Meng M,Zhuo Y,Zhang L

更新日期：2020-07-01 00:00:00

abstract：:Oceanic physics at fine scale; e.g. eddies, fronts, filaments; are notoriously difficult to sample. However, an increasing number of theoretical approaches hypothesize that these processes affect phytoplankton diversity which have cascading effects on regional ecosystems. In 2015, we targeted the Iroise Sea (France) a...

journal_title：Scientific reports

authors： Ramond P,Siano R,Schmitt S,de Vargas C,Marié L,Memery L,Sourisseau M

更新日期：2021-01-29 00:00:00

abstract：:The intrinsic atomic mechanisms responsible for electronic doping of epitaxial graphene Moirés on transition metal surfaces is still an open issue. To better understand this process we have carried out a first-principles full characterization of the most representative Moiré superstructures observed on the Gr/Pt(111) ...

journal_title：Scientific reports

authors： Martínez JI,Merino P,Pinardi AL,Gonzalo OI,López MF,Méndez J,Martín-Gago JA

更新日期：2016-02-08 00:00:00

abstract：:Prestin in the lateral membrane of outer hair cells, is responsible for electromotility (EM) and a corresponding nonlinear capacitance (NLC). Prestin's voltage sensitivity is influenced by intracellular chloride. A regulator of intracellular chloride is a stretch-sensitive, non-selective conductance within the lateral...

journal_title：Scientific reports

authors： Bai JP,Moeini-Naghani I,Zhong S,Li FY,Bian S,Sigworth FJ,Santos-Sacchi J,Navaratnam D

更新日期：2017-04-19 00:00:00

abstract：:Indoleamine 2,3 dioxygenase-1 (IDO-1) is an enzyme in the kynurenine pathway which augments tumor-induced immune tolerance. Previous studies in childhood acute myeloid leukemia (AML) have shown a negative correlation of IDO-1 mRNA expression with outcomes. The aim of our study was to develop a practical and objective ...

journal_title：Scientific reports

authors： Mangaonkar A,Mondal AK,Fulzule S,Pundkar C,Park EJ,Jillella A,Kota V,Xu H,Savage NM,Shi H,Munn D,Kolhe R

更新日期：2017-10-16 00:00:00

abstract：:High-performance locally resonant metamaterials represent the next frontier in materials technology due to their extraordinary properties obtained through materials design, enabling a variety of potential applications. The most exceptional feature of locally resonant metamaterials is the subwavelength size of their un...

journal_title：Scientific reports

authors： Zega V,Silva PB,Geers MGD,Kouznetsova VG

更新日期：2020-07-21 00:00:00

abstract：:At mid-ocean ridges volcanism generally decreases with spreading rate but surprisingly massive volcanic centres occur at the slowest spreading ridges. These volcanoes can host unexpectedly strong earthquakes and vigorous, explosive submarine eruptions. Our understanding of the geodynamic processes forming these volcan...

journal_title：Scientific reports

authors： Schmid F,Schlindwein V,Koulakov I,Plötz A,Scholz JR

更新日期：2017-02-20 00:00:00

abstract：:Grain yield is a complicated trait, which is highly associated with biomass productivity. The cell wall is a central element of biomass, and its biogenesis contributes to plant architecture and development. However, the genetic link between cell-wall property and grain yield is largely unclear. Here, we report on iden...

journal_title：Scientific reports

authors： Xu Z,Li S,Zhang C,Zhang B,Zhu K,Zhou Y,Liu Q

更新日期：2017-10-02 00:00:00

abstract：:Hydrogen sulfide (H2S) is an important biological messenger, but few biologically-compatible methods are available for its detection in aqueous solution. Herein, we report a highly water-soluble naphthalimide-based fluorescent probe (L1), which is a highly versatile building unit that absorbs and emits at long wavelen...

journal_title：Scientific reports

authors： Choi SA,Park CS,Kwon OS,Giong HK,Lee JS,Ha TH,Lee CS

更新日期：2016-05-18 00:00:00

abstract：:Active immunotherapy targeting β-amyloid (Aβ) is the most promising strategy to prevent or treat Alzheimer's disease (AD). Based on pre-clinical studies and clinical trials, a safe and effective AD vaccine requires a delicate balance between providing therapeutically adequate anti-Aβ antibodies and eliminating or supp...

journal_title：Scientific reports

authors： Liu S,Shi D,Wang HC,Yu YZ,Xu Q,Sun ZW

更新日期：2015-01-14 00:00:00

abstract：:Rab small GTPases play key roles in intracellular membrane trafficking. Rab33a promotes axon outgrowth of cultured rat hippocampal neurons by mediating the anterograde axonal transport of Golgi-derived vesicles and the concomitant exocytosis of these vesicles at the growth cone. However, the functions of Rab33 in vivo...

journal_title：Scientific reports

authors： Huang L,Urasaki A,Inagaki N

更新日期：2019-02-12 00:00:00

abstract：:Gestational diabetes mellitus (GDM) is a common health problem during pregnancy and its prevalence is increasing globally, especially in China. The aim of this study was to investigate socioeconomic, environmental and lifestyle factors associated with GDM in Chinese women. A matched pair case-control study was conduct...

journal_title：Scientific reports

authors： Carroll X,Liang X,Zhang W,Zhang W,Liu G,Turner N,Leeper-Woodford S

更新日期：2018-05-25 00:00:00