Abstract:
:Macrophages play a crucial role in the control and elimination of invading Mycobacterium tuberculosis (Mtb), and also serve as the major residence for Mtb. However, the interaction between macrophages and Mtb remains to be clearly determined. Although long noncoding RNAs (lncRNAs) have emerged as key regulators in many biological processes, their roles in anti-mycobacterial responses of macrophages remain to be elucidated. Here, we applied microarray analysis to examine lncRNA and mRNA expression profiles in human primary macrophages after 72 h of infection with H37Ra or H37Rv. Our results revealed that many lncRNAs were differentially expressed in macrophages after H37Ra or H37Rv infection, indicating a possible role for lncRNAs in immune responses induced by Mtb infection and providing important cues for further functional studies. Furthermore, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) biological pathway analysis of the differentially expressed mRNAs showed the potential functions and pathways related to the pathogenesis of Mtb infection. Finally, two lncRNAs, MIR3945HG V1 and MIR3945HG V2, were identified as novel candidate diagnostic markers for tuberculosis. Our results provide novel insight into the mechanisms of the pivotal Mtb-macrophage interactions, and reveal potential targets for diagnostics and the treatment of tuberculosis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yang X,Yang J,Wang J,Wen Q,Wang H,He J,Hu S,He W,Du X,Liu S,Ma Ldoi
10.1038/srep38963subject
Has Abstractpub_date
2016-12-14 00:00:00pages
38963issn
2045-2322pii
srep38963journal_volume
6pub_type
杂志文章abstract::Identifying patients at risk of poor outcome after mild traumatic brain injury (MTBI) is essential to aid prognostics and treatment. Diffuse axonal injury (DAI) may be the primary pathologic feature of MTBI but is normally not detectable by conventional imaging technology. This lack of sensitivity of clinical imaging ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13628-1
更新日期:2017-10-23 00:00:00
abstract::The graft-versus-leukemia effect reminds us to observe the allogeneic cell elicited anti-tumor immune responses. Here we immunized recipient B6 mice with different types of allogenic leukocytes and found that vaccination with allogenic dendritic cells (alloDC) elicited the most efficient protection against broad-spect...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52151-3
更新日期:2019-10-29 00:00:00
abstract::MicroRNAs (miRNAs) have been considered to be potent biomarkers for early disease diagnosis and for cancer therapy. The rapid and selective detection of miRNAs without reverse transcription and labelling is highly desired. Herein, we report a simple and label-free miRNA detection method that is based on the Duplex-Spe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07400
更新日期:2014-12-10 00:00:00
abstract::A three-dimensional multiscale modeling framework is developed to analyze the failure procedure of radially aligned zinc oxide (ZnO) enhanced single fiber composites (SFC) under tensile loading to understand the interfacial improvement between the fiber and the matrix. The model introduces four levels in the computati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56503-x
更新日期:2019-12-27 00:00:00
abstract::Semen fertilizing potential is dependent upon the morphological, functional and molecular attributes of sperm. Sperm microRNAs (miRNAs) were recently shown to hold promise regarding their association with different fertility phenotypes. However, their role in fertility regulation remains to be determined. We postulate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46775-8
更新日期:2019-07-17 00:00:00
abstract::Microvascular endothelial cell heterogeneity and its relationship to hemodynamics remains poorly understood due to a lack of sufficient methods to examine these parameters in vivo at high resolution throughout an angiogenic network. The availability of surrogate markers for functional vascular proteins, such as green ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08982-z
更新日期:2017-08-22 00:00:00
abstract::One of the major drawbacks of cheminformatics is a large amount of information present in the datasets. In the majority of cases, this information contains redundant instances that affect the analysis of similarity measurements with respect to drug design and discovery. Therefore, using classical methods such as the p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71502-z
更新日期:2020-09-02 00:00:00
abstract::Extreme weather events and pest outbreaks decrease rice yields and increase their variability, presenting challenges for the agricultural agenda to increase rice productivity and yield stability in Asia. The integration of azolla, fish and ducks has been shown to create robust systems that maintain high yields under h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32915-z
更新日期:2018-10-03 00:00:00
abstract::Recognition of the potential for vegetated coastal ecosystems to store and sequester carbon has led to their increasing inclusion into global carbon budgets and carbon offset schemes. However, kelp forests have been overlooked in evaluations of this 'blue carbon', which have been limited to tidal marshes, mangrove for...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69258-7
更新日期:2020-07-23 00:00:00
abstract::Transcriptional enhancers are non-coding segments of DNA that play a central role in the spatiotemporal regulation of gene expression programs. However, systematically and precisely predicting enhancers remain a major challenge. Although existing methods have achieved some success in enhancer prediction, they still su...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28517
更新日期:2016-06-22 00:00:00
abstract::Campylobacter hyointestinalis is a member of an emerging group of zoonotic Campylobacter spp. that are increasingly identified in both gastric and non-gastric disease in humans. Here, we discovered C. hyointestinalis in three separate classes of New Zealand ruminant livestock; cattle, sheep and deer. To investigate th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20889-x
更新日期:2018-02-05 00:00:00
abstract::The interplay between spin states and metallization in compressed CoCl2 is investigated by combining diffraction, resistivity and spectroscopy techniques under high-pressure conditions and ab-initio calculations. A pressure-induced metallization along with a Co2+ high-spin (S = 3/2) to low-spin (S = 1/2) crossover tra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41337-4
更新日期:2019-04-01 00:00:00
abstract::While there is a rich literature on transcription dynamics during the development of many organisms, protein data is limited. We used iTRAQ isotopic labeling and mass spectrometry to generate the largest developmental proteomic dataset for any animal. Expression dynamics of nearly 4,000 proteins of Xenopus laevis was ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04365
更新日期:2014-03-14 00:00:00
abstract::Cutaneous allodynia (CA) is a pain in response to non-nociceptive stimulation and a marker of central sensitisation. Probable migraine (PM) is a migraine subtype that fulfils all but one criterion of migraine. Headache intensity and the disability of individuals with PM are similar or lower than individuals with migra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-82080-z
更新日期:2021-01-28 00:00:00
abstract::Both attraction and repulsion from linearly polarized light have been observed in zooplankton. A dichotomous choice experiment, consisting of plankton light traps deployed in natural waters at a depth of 30 m that projected either polarized or unpolarized light of the same intensity, was used to test the hypothesis th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35891
更新日期:2016-10-20 00:00:00
abstract::This study investigates the association between an index of mesozooplankton biomass, derived from the Continuous Plankton Recorder survey and satellite-derived productivity fronts in the North Atlantic. While chlorophyll-a content (CHL) is commonly described as a proxy for phytoplankton biomass, the size of productivi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41212-2
更新日期:2019-03-18 00:00:00
abstract::When trying to conceive 1% of couples have recurrent miscarriages, defined as three or more consecutive pregnancy losses. This is not accounted for by the known incidence of chromosomal aneuploidy in miscarriage, and it has been suggested that there is an immunological aetiology. The endometrial mucosa is populated by...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41335
更新日期:2017-01-23 00:00:00
abstract::The article aims to describe the association between midlife body mass index (BMI) and cardiovascular disease (CVD)- and all-cause mortality, and to use early adulthood BMI as an instrumental variable for midlife BMI, in order to obtain an estimate less distorted by midlife confounders and reverse causality. Data from...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29089-z
更新日期:2018-07-31 00:00:00
abstract::Fetal cardiomyocytes actively proliferate to form the primitive heart in utero in mammals, but they stop dividing shortly after birth. The identification of essential molecules maintaining this active cardiomyocyte proliferation is indispensable for potential adult heart regeneration. A recent study has shown that thi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04823-1
更新日期:2017-06-30 00:00:00
abstract::Bacterial pneumonia is a major cause of acute lung injury and acute respiratory distress syndrome, characterized by alveolar barrier disruption. NLRP3 is best known for its ability to form inflammasomes and to regulate IL-1β and IL-18 production in myeloid cells. Here we show that NLRP3 protects the integrity of the a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30943
更新日期:2016-08-01 00:00:00
abstract::The advent of flexible optoelectronic devices has accelerated the development of semiconducting polymeric materials. We seek to replace conventional expensive semiconducting photodetector materials with our cost-effective composite system. We demonstrate in this work the successful fabrication of a photoconductive com...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16761
更新日期:2015-11-16 00:00:00
abstract::The most common surgical emergency is suspected acute appendicitis, the lifetime risk of acute appendicitis is estimated to be 8.6% for men and 6.7% for women, with a male to female ratio of 1.4:1; correct diagnosis can be made in 70-80% of patients after the operations about 32% of appendectomies revealed normal appe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58847-1
更新日期:2020-02-06 00:00:00
abstract::Carbon quantum dots (C-QDs) are becoming a desirable alternative to metal-based QDs and dye probes owing to their high biocompatibility, low toxicity, ease of preparation, and unique photophysical properties. Herein, we describe fluorescence bioimaging of zebrafish using C-QDs as probe in terms of the preparation of C...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11835
更新日期:2015-07-02 00:00:00
abstract::The autoimmune disorder Aicardi-Goutières syndrome (AGS) is characterized by a constitutive type I interferon response. SAMHD1 possesses both dNTPase and RNase activities and mutations in SAMHD1 cause AGS; however, how SAMHD1-deficiency causes the type I interferon response in patients with AGS remains unknown. Here, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18308-8
更新日期:2018-01-08 00:00:00
abstract::The growth dynamics of Ga(In)N semiconductors by Plasma-Assisted Molecular Beam Epitaxy (PAMBE) at low temperatures (T = 450 °C) is here investigated. The presence of droplets at the growth surface strongly affects the adatom incorporation dynamics, making the growth rate a decreasing function of the metal flux imping...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28984-9
更新日期:2018-07-26 00:00:00
abstract::This study presents atomic scale characterization of grain boundary defect structure in a functional oxide with implications for a wide range of electrochemical and electronic behavior. Indeed, grain boundary engineering can alter transport and kinetic properties by several orders of magnitude. Here we report experime...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02680
更新日期:2013-01-01 00:00:00
abstract::Recurrent genetic mutations occur in acute myeloid leukemia (AML) and have been incorporated into risk stratification to predict the prognoses of AML patients. The bone marrow microenvironment plays a critical role in the development and progression of AML. However, the characteristics of the genetic mutation-associat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76048-8
更新日期:2020-11-04 00:00:00
abstract::We study the dynamical Casimir-Polder force on a two-level atom with different initial states in the one-dimensional dielectric cavity with output coupling, and obtain the analytical expression of the expectation value of dynamical Casimir-Polder force. Results show that the expectation values of dynamical Casimir-Pol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68546-6
更新日期:2020-07-20 00:00:00
abstract::To date there are thirteen species validly assigned to the genus Anaerococcus. Most of the species in this genus are anaerobic and of human origin. Anaerococcus urinimassiliensis sp. nov., strain Marseille-P2143T is member of family Peptoniphilaceae, which was isolated from the urine of a 17-year-old boy affected by a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-82420-z
更新日期:2021-01-29 00:00:00
abstract::Neutrophils play an important role in the occurrence and development of acute lung injury (ALI). Leukotriene B4 (LTB4), a hydrolysis product of epoxide leukotriene A4 (LTA4) catalyzed by LTA4 hydrolase (LTA4H), is one of the most potent chemoattractants for neutrophil. Bufexamac is a drug widely used as an anti-inflam...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25298
更新日期:2016-04-29 00:00:00