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White matter microstructure is associated with functional, cognitive and emotional symptoms 12 months after mild traumatic brain injury.

Abstract：

:Identifying patients at risk of poor outcome after mild traumatic brain injury (MTBI) is essential to aid prognostics and treatment. Diffuse axonal injury (DAI) may be the primary pathologic feature of MTBI but is normally not detectable by conventional imaging technology. This lack of sensitivity of clinical imaging techniques has impeded a pathophysiologic understanding of the long-term cognitive and emotional consequences of MTBI, which often remain unnoticed and are attributed to factors other than the injury. Diffusion tensor imaging (DTI) is sensitive to microstructural properties of brain tissue and has been suggested to be a promising candidate for the detection of DAI in vivo. In this study, we report strong associations between brain white matter DTI and self-reported cognitive, somatic and emotional symptoms at 12 months post-injury in 134 MTBI patients. The anatomical distribution suggested global associations, in line with the diffuse symptomatology, although the strongest effects were found in frontal regions including the genu of the corpus callosum and the forceps minor. These findings support the hypothesis that DTI may provide increased sensitivity to the diffuse pathophysiology of MTBI and suggest an important role of advanced Magnetic Resonance Imaging (MRI) in trauma care.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Hellstrøm T,Westlye LT,Kaufmann T,Trung Doan N,Søberg HL,Sigurdardottir S,Nordhøy W,Helseth E,Andreassen OA,Andelic N

doi

10.1038/s41598-017-13628-1

subject

Has Abstract

pub_date

2017-10-23 00:00:00

pages

13795

issue

1

issn

2045-2322

pii

10.1038/s41598-017-13628-1

journal_volume

7

pub_type

杂志文章

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