Abstract:
:CD96 is a promising candidate for immunotherapy. However, its role and importance in glioma remains unknown. We thus aimed to genetically and clinically characterize CD96 expression in gliomas. For this, we extracted RNA-seq data of 699 glioma samples from the TCGA dataset and validated these findings using the CGGA dataset comprising 325 glioma samples. Clinical and isocitrate dehydrogenase (IDH) mutation status were also analyzed. Various packages in R language were mainly used for statistical analysis. CD96 expression was significantly up-regulated in high-grade, IDH-wildtype, and mesenchymal-molecular subtype gliomas based on TCGA data, which was validated using the CGGA dataset. Subsequent gene ontology analysis of both datasets suggested that genes relevant to CD96 are mainly involved in immune functions in glioma as such genes were positively correlated with CD96 expression. To further explore the relationship between CD96 and immune responses, we selected seven immune-related metagenes and found that CD96 expression was positively correlated with HCK, LCK, and MHC II in the CGGA and TCGA cohorts but negatively associated with IgG. Further, Pearson correlation analysis showed that CD96 is associated with TIGIT, CD226, CRTAM, TIM-3, PD-L1, CTLA-4, and STAT3, indicating the additive antitumoral effects of these checkpoint proteins. CD96 was also suggested to play an important role in immune responses and positively collaborate with other checkpoint members. These findings show that CD96 is promising candidate for immunotherapy, and that such agents could complement current immunotherapy strategies for glioma.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu F,Huang J,He F,Ma X,Fan F,Meng M,Zhuo Y,Zhang Ldoi
10.1038/s41598-020-66806-zsubject
Has Abstractpub_date
2020-07-01 00:00:00pages
10768issue
1issn
2045-2322pii
10.1038/s41598-020-66806-zjournal_volume
10pub_type
杂志文章abstract::Gravity perception plays a key role in how plants develop and adapt to environmental changes. However, more than a century after the pioneering work of Darwin, little is known on the sensing mechanism. Using a centrifugal device combined with growth kinematics imaging, we show that shoot gravitropic responses to stead...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35431
更新日期:2016-10-14 00:00:00
abstract::Diffusion processes are widespread in biological and chemical systems, where they play a fundamental role in the exchange of substances at the cellular level and in determining the rate of chemical reactions. Recently, the classical picture that portrays diffusion as random uncorrelated motion of molecules has been re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14486
更新日期:2015-09-30 00:00:00
abstract::The Langendorff-perfused heart technique has become the model of choice for multiparametric optical mapping of cardiac function and electrophysiology. However, photon scattering in tissues represents a significant drawback of the optical imaging approach, fundamentally limiting its mapping capacity to the heart surfac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32317-1
更新日期:2018-09-20 00:00:00
abstract::The development of microstructure during melting, reactive wetting and solidification of solder pastes on Cu-plated printed circuit boards has been studied by synchrotron radiography. Using Sn-3.0Ag-0.5Cu/Cu and Sn-0.7Cu/Cu as examples, we show that the interfacial Cu6Sn5 layer is present within 0.05 s of wetting, and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40010
更新日期:2017-01-12 00:00:00
abstract::Skeletal muscle thickness is a valuable indicator of several aspects of a muscle's functional capabilities. We used computational analysis of ultrasound images, recorded from 10 humans walking and running at a range of speeds (0.7-5.0 m s-1), to quantify interactions in thickness change between three ankle plantar fle...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-019-51510-4
更新日期:2019-10-21 00:00:00
abstract::To develop a clinic-relevant protocol for systemic up-regulation of NFE2-related factor 2 (Nrf2) to prevent diabetic cardiomyopathy (DCM), male db/db and age-matched wild-type (WT) mice were given sulforaphane (SFN, an Nrf2 activator) and its natural source, broccoli sprout extract (BSE) by gavage every other day for ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30252
更新日期:2016-07-26 00:00:00
abstract::Migration and interactions of immune cells are routinely studied by time-lapse microscopy of in vitro migration and confrontation assays. To objectively quantify the dynamic behavior of cells, software tools for automated cell tracking can be applied. However, many existing tracking algorithms recognize only rather sh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39725-x
更新日期:2019-03-01 00:00:00
abstract::Recent reports have demonstrated the role of phyto-constituents in modulating inflammatory responses. Mangiferin isolated from Mangifera indica is known to induce potent anti-oxidative, anti-diabetic and anti-inflammatory activity. However, the molecular mechanism of its anti-inflammatory activity is not properly unde...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42683
更新日期:2017-02-20 00:00:00
abstract::Various neurophysiological and cognitive functions are based on transferring information between spiking neurons via a complex system of synaptic connections. In particular, the capacity of presynaptic inputs to influence the postsynaptic outputs-the efficacy of the synapses-plays a principal role in all aspects of hi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36807-0
更新日期:2019-01-24 00:00:00
abstract::Understanding coupling of ferroic properties over grain boundaries and within clusters of grains in polycrystalline materials is hindered due to a lack of direct experimental methods to probe the behaviour of individual grains in the bulk of a material. Here, a variant of three-dimensional X-ray diffraction (3D-XRD) i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22820
更新日期:2016-03-09 00:00:00
abstract::Linear dichroism - the polarization dependent absorption of electromagnetic waves- is routinely exploited in applications as diverse as structure determination of DNA or polarization filters in optical technologies. Here filamentary absorbers with a large length-to-width ratio are a prerequisite. For magnetization dyn...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07020-2
更新日期:2017-08-01 00:00:00
abstract::Patient-matched transcriptomic studies using tumour samples before and after treatment allow inter-patient heterogeneity to be controlled, but tend not to include an untreated comparison. Here, Illumina BeadArray technology was used to measure dynamic changes in gene expression from thirty-seven paired diagnostic core...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29434
更新日期:2016-07-07 00:00:00
abstract::Self-aggregated Li4Ti5O12 particles sandwiched between graphene nanosheets (GNSs) and single-walled carbon nanotubes (SWCNTs) network are reported as new hybrid electrodes for high power Li-ion batteries. The multi-layer electrodes are fabricated by sequential process comprising air-spray coating of GNSs layer and the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07334
更新日期:2014-12-05 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-23132-9
更新日期:2018-03-19 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-62443-8
更新日期:2020-03-24 00:00:00
abstract::Although the growth of graphene by chemical vapor deposition is a production technique that guarantees high crystallinity and superior electronic properties on large areas, it is still a challenge for manufacturers to efficiently scale up the production to the industrial scale. In this context, issues related to the p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09811-z
更新日期:2017-08-30 00:00:00
abstract::Due to the globalization and computerization of financial and economic activities, numerous repetitive leveraged investments have become possible in stock markets and currency exchanges. In reality, repeated leveraged investments up to 100 times/day are possible via online access. With computer-aided programs, this re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50237-6
更新日期:2019-09-24 00:00:00
abstract::Maternal obesity and overnutrition during pregnancy and lactation can program an increased risk of obesity in offspring. In this context, improving maternal metabolism may help reduce the intergenerational transmission of obesity. Here we show that, in Sprague-Dawley rats, selectively altering obese maternal gut micro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20683
更新日期:2016-02-12 00:00:00
abstract::A fundamental task in cancer research aims at the identification of new pharmacological therapies that can affect tumor growth. Differentiation therapy might exploit this function not only for hematological diseases, such as acute promyelocytic leukemia (APML) but also for epithelial tumors, including lung cancer. Her...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05047-z
更新日期:2017-07-06 00:00:00
abstract::Delivering and expressing a gene of interest in cells or living animals has become a pivotal technique in biomedical research and gene therapy. Among viral delivery systems, adeno-associated viruses (AAVs) are relatively safe and demonstrate high gene transfer efficiency, low immunogenicity, stable long-term expressio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49624-w
更新日期:2019-09-19 00:00:00
abstract::Antimicrobial peptides (AMPs) represent a promising class of novel antimicrobial agents owing to their potent antimicrobial activity. In this study, two lead peptides from unrelated classes of AMPs were systematically hybridized into a series of five hybrid peptides (DM1-DM5) with conserved N- and C-termini. This appr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09761
更新日期:2015-05-18 00:00:00
abstract::The control for the processing of precursor liquids determines whether the properties and functions of the final material product can be engineered. An inherent challenge of processing viscous liquids arises from their large resistance to deform. Here, we report on the discovery of an electric approach that can signif...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19606
更新日期:2016-02-10 00:00:00
abstract::The present work conducted laboratory experiments of fracturing in fat coals, anthracites, and mudstones. Three different fluids were selected as the fracturing fluids, including water, liquid CO2 (L-CO2), and supercritical CO2 (Sc-CO2). The resulting fracture morphologies and fracture apertures of the coal specimens ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75787-y
更新日期:2020-10-29 00:00:00
abstract::The tumour suppressor p53 is mutated in cancer, including over 96% of high-grade serous ovarian cancer (HGSOC). Mutations cause loss of wild-type p53 function due to either gain of abnormal function of mutant p53 (mutp53), or absent to low mutp53. Massively parallel sequencing (MPS) enables increased accuracy of detec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26191
更新日期:2016-05-18 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-57833-x
更新日期:2020-01-15 00:00:00
abstract::Recent advances in fluorescent protein technology provide a wide variety of biological imaging applications; however current tools for bio-imaging in the Gram-positive bacterium Staphylococcus aureus has necessitated further developments for fluorescence intensity and for a multicolor palette of fluorescent proteins. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02930-7
更新日期:2017-06-06 00:00:00
abstract::The shallow oxidized asthenosphere may contain a small fraction of potassic silicate melts that are enriched in incompatible trace elements and volatiles. Here, to determine the chemical composition of such melt, we analysed fossilized melt inclusions, preserved as multiphase solid inclusions, from an orogenic garnet ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28264-6
更新日期:2018-07-04 00:00:00
abstract::Facial emotion perception plays a key role in interpersonal communication and is a precursor for a variety of socio-cognitive abilities. One brain region thought to support emotion perception is the inferior frontal cortex (IFC). The current study aimed to examine whether modulating neural activity in the IFC using hi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11578-2
更新日期:2017-09-12 00:00:00
abstract::Nitric oxide synthase like enzyme (NOS-like enzyme), which produces nitric oxide, participates in many biological processes. However it remains unidentified and highly controversial that plants do possess a NOS-like enzyme. In this paper, a novel arginine analogue NP1 was designed and developed for the direct identifi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32630
更新日期:2016-09-02 00:00:00
abstract::Respiratory sensations such as breathlessness are prevalent in many diseases and are amplified by increased levels of anxiety. Cortical activation in response to inspiratory occlusions in high- and low-anxious individuals was found different in previous studies using the respiratory-related evoked potential method. Ho...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51396-2
更新日期:2019-10-21 00:00:00