The differential effects of isoflurane and sevoflurane on neonatal mice.

Abstract:

:Previous research has shown that exposure to volatile anesthetics can induce acute neuroinflammation and neuroapoptopsis in neonatal rodents and that these events can lead to cognitive dysfunction at later stages. Isoflurane and sevoflurane are two of the most popular anesthetics used in the field of pediatrics. However, the relative impact of these two anesthetics on the developing brain at distinct time points after the induction of anesthesia has not been compared. In the present study, we exposed 7-day-old mice to clinically equivalent doses of isoflurane (1.5%) and sevoflurane (2.5%) for 4 h and then investigated consequential changes in the brains of these mice at six different time points. We analyzed the levels of proteins that are directly related to neuroapoptosis, neuroinflammation, synaptic function, and memory, in the brains of neonatal mice. Exposure of neonatal mice to isoflurane and sevoflurane resulted in acute neuronal apoptosis. Our analysis observed significant levels of neuroinflammation and changes in the expression levels of proteins associated with both synaptic transmission and memory in mice from the isoflurane group but not the sevoflurane group. Our results therefore indicate that isoflurane and sevoflurane induce differential effects in the brains of neonatal mice.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Zhao S,Fan Z,Hu J,Zhu Y,Lin C,Shen T,Li Z,Li K,Liu Z,Chen Y,Zhang B

doi

10.1038/s41598-020-76147-6

subject

Has Abstract

pub_date

2020-11-09 00:00:00

pages

19345

issue

1

issn

2045-2322

pii

10.1038/s41598-020-76147-6

journal_volume

10

pub_type

杂志文章
  • Room temperature 90° phase-matching in zirconium and magnesium co-doped lithium niobate crystals.

    abstract::Laser has been widely used in many aspects, by now it is difficult to get each frequency that we want, and frequency conversion is an effective way to obtain different frequency laser through a nonlinear optical crystal. MgO-doped LiNbO3 (Mg:LN) crystal has usually been used for second harmonic generation (SHG) throug...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-22205-z

    authors: Kong T,Liu H,Ge X,Qu D,Liu S,Chen S,Zhang L,Kong Y,Rupp R,Xu J

    更新日期:2018-03-01 00:00:00

  • Mirror-backed Dark Alumina: A Nearly Perfect Absorber for Thermoelectronics and Thermophotovotaics.

    abstract::We present here a broadband, wide-angle, and polarization-independent nearly perfect absorber consisting of mirror-backed nanoporous alumina. By electrochemically anodizing the disordered multicomponent aluminum and properly tailoring the thickness and air-filling fraction of nanoporous alumina, according to the Maxwe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep19984

    authors: Farhat M,Cheng TC,Le KQ,Cheng MM,Bağcı H,Chen PY

    更新日期:2016-01-28 00:00:00

  • Neuronal imaging with ultrahigh dynamic range multiphoton microscopy.

    abstract::Multiphoton microscopes are hampered by limited dynamic range, preventing weak sample features from being detected in the presence of strong features, or preventing the capture of unpredictable bursts in sample strength. We present a digital electronic add-on technique that vastly improves the dynamic range of a multi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-06065-7

    authors: Yang R,Weber TD,Witkowski ED,Davison IG,Mertz J

    更新日期:2017-07-19 00:00:00

  • Uncertainty analysis for an effluent trading system in a typical nonpoint-sources-polluted watershed.

    abstract::Conventional effluent trading systems (ETSs) between point sources (PSs) and nonpoint sources (NPSs) are often unreliable because of the uncertain characteristics of NPSs. In this study, a new framework was established for PS-NPS ETSs, and a comprehensive analysis was conducted by quantifying the impacts of the uncert...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29398

    authors: Chen L,Han Z,Wang G,Shen Z

    更新日期:2016-07-11 00:00:00

  • Evaluating the effect of overharvesting on genetic diversity and genetic population structure of the coconut crab.

    abstract::Birgus latro (coconut crab) is an edible crustacean that has experienced serious overharvesting throughout its whole habitat range; however, the negative effects of overharvesting on the genetic diversity within B. latro populations have not been elucidated. Here, we report sex ratio, body size, and genetic diversity ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-66712-4

    authors: Yorisue T,Iguchi A,Yasuda N,Yoshioka Y,Sato T,Fujita Y

    更新日期:2020-06-22 00:00:00

  • Pet dogs' relationships vary rather individually than according to partner's species.

    abstract::Most dogs worldwide are free-ranging animals that form relationships mainly with conspecifics, yet research has focused mainly on the dog-human bond, leading to the hypothesis that dogs evolved specific abilities to form a unique relationship with humans. Although widespread, this hypothesis has not, as yet, been test...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40164-x

    authors: Cimarelli G,Marshall-Pescini S,Range F,Virányi Z

    更新日期:2019-03-05 00:00:00

  • Cross sectional evaluation of the gut-microbiome metabolome axis in an Italian cohort of IBD patients.

    abstract::Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract of uncertain origin, which includes ulcerative colitis (UC) and Crohn's disease (CD). The composition of gut microbiota may change in IBD affected individuals, but whether dysbiosis is the cause or the consequence of infla...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10034-5

    authors: Santoru ML,Piras C,Murgia A,Palmas V,Camboni T,Liggi S,Ibba I,Lai MA,Orrù S,Blois S,Loizedda AL,Griffin JL,Usai P,Caboni P,Atzori L,Manzin A

    更新日期:2017-08-25 00:00:00

  • Involvement of AMP-activated protein kinase and Death Receptor 5 in TRAIL-Berberine-induced apoptosis of cancer cells.

    abstract::Our previous studies indicated that combination of Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and PPARγ ligand Troglitazone (TZD), can induce significant apoptosis in various TRAIL-resistant prostate and hepatocellular carcinoma (HCC) cells. These also suggested serine/threonine kinase AMP-activat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-23780-x

    authors: Ke R,Vishnoi K,Viswakarma N,Santha S,Das S,Rana A,Rana B

    更新日期:2018-04-03 00:00:00

  • Tuning Metamaterials by using Amorphous Magnetic Microwires.

    abstract::In this work, we demonstrate theoretically and experimentally the possibility of tuning the electromagnetic properties of metamaterials with magnetic fields by incorporating amorphous magnetic microwires. The large permeability of these wires at microwave frequencies allows tuning the resonance of the metamaterial by ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-09665-5

    authors: Lopez-Dominguez V,Garcia MA,Marin P,Hernando A

    更新日期:2017-08-24 00:00:00

  • Low-Dose Tacrolimus Prevents Dysregulated Peri-Conceptional Ovarian and Systemic Immune Cellular Homeostasis in Subjects with PCOS.

    abstract::Polycystic ovary syndrome (PCOS) is characterized by failure of ovulation and is associated with obesity and chronic inflammation. Recent evidence suggests that anomalous activation of ovarian macrophages and numerical and functional deficits in the Th17 (CD4+IL17A+) and the CD4+CD25+CD127low Tregs plays crucial role ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42960-x

    authors: Albaghdadi AJH,Feeley CA,Kan FWK

    更新日期:2019-04-25 00:00:00

  • Maximal rectification ratios for idealized bi-segment thermal rectifiers.

    abstract::Thermal rectifiers whose forward heat fluxes are greater than reverse counterparts have been extensively studied. Here we have discovered, idealized, and derived the ultimate limit of such rectification ratios, which are partially validated by numerical simulations, experiments, and micro-scale Hamiltonian-oscillator ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12677

    authors: Shih TM,Gao Z,Guo Z,Merlitz H,Pagni PJ,Chen Z

    更新日期:2015-08-04 00:00:00

  • Evolution of topological surface states in antimony ultra-thin films.

    abstract::Based on an inverted bulk band order, antimony thin films presumably could become topological insulators if quantum confinement effect opens up a gap in the bulk bands. Coupling between topological surface states (TSS) from opposite surfaces, however, tends to degrade or even destroy their novel characters. Here the e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep02010

    authors: Yao G,Luo Z,Pan F,Xu W,Feng YP,Wang XS

    更新日期:2013-01-01 00:00:00

  • The RNA-binding protein CsrA plays a central role in positively regulating virulence factors in Erwinia amylovora.

    abstract::The GacS/GacA two-component system (also called GrrS/GrrA) is a global regulatory system which is highly conserved among gamma-proteobacteria. This system positively regulates non-coding small regulatory RNA csrB, which in turn binds to the RNA-binding protein CsrA. However, how GacS/GacA-Csr system regulates virulenc...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep37195

    authors: Ancona V,Lee JH,Zhao Y

    更新日期:2016-11-15 00:00:00

  • Gene expression profile changes in the jejunum of weaned piglets after oral administration of Lactobacillus or an antibiotic.

    abstract::The small intestine plays an essential role in the health and well-being of animals. Previous studies have shown that Lactobacillus has a protective effect on intestinal morphology, intestinal epithelium integrity and appropriate maturation of gut-associated tissues. Here, gene expression in jejunum tissue of weaned p...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16158-y

    authors: Zhang D,Shang T,Huang Y,Wang S,Liu H,Wang J,Wang Y,Ji H,Zhang R

    更新日期:2017-11-17 00:00:00

  • Adipose cell size changes are associated with a drastic actin remodeling.

    abstract::Adipose tissue plays a major role in regulating whole-body insulin sensitivity and energy metabolism. To accommodate surplus energy, the tissue rapidly expands by increasing adipose cell size (hypertrophy) and cell number (hyperplasia). Previous studies have shown that enlarged, hypertrophic adipocytes are less respon...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-49418-0

    authors: Hansson B,Morén B,Fryklund C,Vliex L,Wasserstrom S,Albinsson S,Berger K,Stenkula KG

    更新日期:2019-09-10 00:00:00

  • A convolutional neural network-based system to prevent patient misidentification in FDG-PET examinations.

    abstract::Patient misidentification in imaging examinations has become a serious problem in clinical settings. Such misidentification could be prevented if patient characteristics such as sex, age, and body weight could be predicted based on an image of the patient, with an alert issued when a mismatch between the predicted and...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43656-y

    authors: Kawauchi K,Hirata K,Katoh C,Ichikawa S,Manabe O,Kobayashi K,Watanabe S,Furuya S,Shiga T

    更新日期:2019-05-10 00:00:00

  • Circadian rhythmicity persists through the Polar night and midnight sun in Svalbard reindeer.

    abstract::Studies of locomotor activity in Svalbard reindeer reported the temporary absence of diel rhythms under Arctic photic conditions. However, using Lomb-Scargle periodogram analyses with high statistical power we found diel or circadian rhythmicity throughout the entire year in measures of behaviour, temperature in the r...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32778-4

    authors: Arnold W,Ruf T,Loe LE,Irvine RJ,Ropstad E,Veiberg V,Albon SD

    更新日期:2018-09-27 00:00:00

  • Akting up in the GABA hypothesis of schizophrenia: Akt1 deficiency modulates GABAergic functions and hippocampus-dependent functions.

    abstract::Accumulating evidence implies that both AKT1 and GABAA receptor (GABAAR) subunit genes are involved in schizophrenia pathogenesis. Activated Akt promotes GABAergic neuron differentiation and increases GABAAR expression on the plasma membrane. To elucidate the role of Akt1 in modulating GABAergic functions and schizoph...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep33095

    authors: Chang CY,Chen YW,Wang TW,Lai WS

    更新日期:2016-09-12 00:00:00

  • Identification of individual subjects on the basis of their brain anatomical features.

    abstract::We examined whether it is possible to identify individual subjects on the basis of brain anatomical features. For this, we analyzed a dataset comprising 191 subjects who were scanned three times over a period of two years. Based on FreeSurfer routines, we generated three datasets covering 148 anatomical regions (corti...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-23696-6

    authors: Valizadeh SA,Liem F,Mérillat S,Hänggi J,Jäncke L

    更新日期:2018-04-04 00:00:00

  • Effects of glucose metabolism during in vitro maturation on cytoplasmic maturation of mouse oocytes.

    abstract::Although there are many reports on the effect of glucose metabolism on oocyte nuclear maturation, there are few studies on its effect on ooplasmic maturation. By manipulating glucose metabolism pathways using a maturation medium that could support oocyte nuclear maturation but only a limited blastocyst formation witho...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20764

    authors: Xie HL,Wang YB,Jiao GZ,Kong DL,Li Q,Li H,Zheng LL,Tan JH

    更新日期:2016-02-09 00:00:00

  • Influence of OATP1B1 and BCRP polymorphisms on the pharmacokinetics and pharmacodynamics of rosuvastatin in elderly and young Korean subjects.

    abstract::A lack of information regarding whether genetic polymorphisms of SLCO1B1 and ABCG2 affect the pharmacokinetics (PKs)/pharmacodynamics (PDs) of rosuvastatin in elderly subjects prevents optimal individualized pharmacotherapy of rosuvastatin in clinical settings. This study aimed to investigate the effect of age and gen...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章

    doi:10.1038/s41598-019-55562-4

    authors: Kim Y,Yoon S,Choi Y,Yoon SH,Cho JY,Jang IJ,Yu KS,Chung JY

    更新日期:2019-12-19 00:00:00

  • Features of an altered AMPK metabolic pathway in Gilbert's Syndrome, and its role in metabolic health.

    abstract::Energy metabolism, involving the ATP-dependent AMPK-PgC-Ppar pathway impacts metabolic health immensely, in that its impairment can lead to obesity, giving rise to disease. Based on observations that individuals with Gilbert's syndrome (GS; UGT1A1(*)28 promoter mutation) are generally lighter, leaner and healthier tha...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30051

    authors: Mölzer C,Wallner M,Kern C,Tosevska A,Schwarz U,Zadnikar R,Doberer D,Marculescu R,Wagner KH

    更新日期:2016-07-21 00:00:00

  • A novel Mitosomal β-barrel Outer Membrane Protein in Entamoeba.

    abstract::Entamoeba possesses a highly divergent mitochondrion-related organelle known as the mitosome. Here, we report the discovery of a novel protein in Entamoeba, which we name Mitosomal β-barrel Outer Membrane Protein of 30 kDa (MBOMP30). Initially identified through in silico analysis, we experimentally confirmed that MBO...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08545

    authors: Santos HJ,Imai K,Makiuchi T,Tomii K,Horton P,Nozawa A,Ibrahim M,Tozawa Y,Nozaki T

    更新日期:2015-02-25 00:00:00

  • Systems-level understanding of ethanol-induced stresses and adaptation in E. coli.

    abstract::Understanding ethanol-induced stresses and responses in biofuel-producing bacteria at systems level has significant implications in engineering more efficient biofuel producers. We present a computational study of transcriptomic and genomic data of both ethanol-stressed and ethanol-adapted E. coli cells with computati...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep44150

    authors: Cao H,Wei D,Yang Y,Shang Y,Li G,Zhou Y,Ma Q,Xu Y

    更新日期:2017-03-16 00:00:00

  • Hydrogen Bond Variations of Influenza A Viruses During Adaptation in Human.

    abstract::Many host specific mutations have been detected in influenza A viruses (IAVs). However, their effects on hydrogen bond (H-bond) variations have rarely been investigated. In this study, 60 host specific sites were identified in the internal proteins of avian and human IAVs, 27 of which contained mutations with effects ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-14533-3

    authors: Luo J,Deng L,Ding X,Quan L,Wu A,Jiang T

    更新日期:2017-10-30 00:00:00

  • Early urban impact on Mediterranean coastal environments.

    abstract::A common belief is that, unlike today, ancient urban areas developed in a sustainable way within the environmental limits of local natural resources and the ecosystem's capacity to respond. This long-held paradigm is based on a weak knowledge of the processes underpinning the emergence of urban life and the rise of an...

    journal_title:Scientific reports

    pub_type: 历史文章,杂志文章

    doi:10.1038/srep03540

    authors: Kaniewski D,Van Campo E,Morhange C,Guiot J,Zviely D,Shaked I,Otto T,Artzy M

    更新日期:2013-12-18 00:00:00

  • Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling.

    abstract::It remains unclear how infantile febrile seizures (FS) enhance adult seizure susceptibility. Here we showed that the transient increase of interleukin-1β (IL-1β) after prolonged FS promoted adult seizure susceptibility, which was blocked by interleukin-1 receptor antagonist (IL-1Ra) within a critical time window. Post...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep21931

    authors: Feng B,Tang Y,Chen B,Xu C,Wang Y,Dai Y,Wu D,Zhu J,Wang S,Zhou Y,Shi L,Hu W,Zhang X,Chen Z

    更新日期:2016-02-23 00:00:00

  • Hot electron energy relaxation time in vanadium nitride superconducting film structures under THz and IR radiation.

    abstract::The paper presents the experimental results of studying the dynamics of electron energy relaxation in structures made of thin (d ≈ 6 nm) disordered superconducting vanadium nitride (VN) films converted to a resistive state by high-frequency radiation and transport current. Under conditions of quasi-equilibrium superco...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-73850-2

    authors: Pentin I,Vakhtomin Y,Seleznev V,Smirnov K

    更新日期:2020-10-08 00:00:00

  • Short and long-term evaluation of the impact of proton minibeam radiation therapy on motor, emotional and cognitive functions.

    abstract::Radiotherapy (RT) is one of the most frequently used methods for cancer treatment. Despite remarkable advancements in RT techniquesthe treatment of radioresistant tumours (i.e. high-grade gliomas) is not yet satisfactory. Finding novel approaches less damaging for normal tissues is of utmost importance. This would mak...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70371-w

    authors: Lamirault C,Doyère V,Juchaux M,Pouzoulet F,Labiod D,Dendale R,Patriarca A,Nauraye C,Le Dudal M,Jouvion G,Hardy D,Massioui NE,Prezado Y

    更新日期:2020-08-11 00:00:00

  • Early weaning increases anxiety via brain-derived neurotrophic factor signaling in the mouse prefrontal cortex.

    abstract::Deprivation of maternal care during early development markedly affects emotional development, but the underlying neuromolecular mechanisms are not fully understood. In a mouse model of disrupted mother-infant relationship, early weaning causes long-term impacts on pups to exhibit increased corticosterone secretion, an...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40530-9

    authors: Kikusui T,Kanbara N,Ozaki M,Hirayama N,Ida K,Tokita M,Tanabe N,Mitsuyama K,Abe H,Yoshida M,Nagasawa M,Mogi K

    更新日期:2019-03-08 00:00:00