Abstract：
:The LC8 family of small ~8 kD proteins are highly conserved and interact with multiple protein partners in eukaryotic cells. LC8-binding modulates target protein activity, often through induced dimerization via LC8:LC8 homodimers. Although many LC8-interactors have roles in signaling cascades, LC8's role in developing epithelia is poorly understood. Using the Drosophila wing as a developmental model, we find that the LC8 family member Cut up (Ctp) is primarily required to promote epithelial growth, which correlates with effects on the pro-growth factor dMyc and two genes, diap1 and bantam, that are classic targets of the Hippo pathway coactivator Yorkie. Genetic tests confirm that Ctp supports Yorkie-driven tissue overgrowth and indicate that Ctp acts through Yorkie to control bantam (ban) and diap1 transcription. Quite unexpectedly however, Ctp loss has inverse effects on ban and diap1: it elevates ban expression but reduces diap1 expression. In both cases these transcriptional changes map to small segments of these promoters that recruit Yorkie. Although LC8 complexes with Yap1, a Yorkie homolog, in human cells, an orthologous interaction was not detected in Drosophila cells. Collectively these findings reveal that that Drosophila Ctp is a required regulator of Yorkie-target genes in vivo and suggest that Ctp may interact with a Hippo pathway protein(s) to exert inverse transcriptional effects on Yorkie-target genes.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Barron DA,Moberg Kdoi
10.1038/srep22726subject
Has Abstractpub_date
2016-03-14 00:00:00pages
22726issn
2045-2322pii
srep22726journal_volume
6pub_type
杂志文章abstract：:It has been shown that bamboo leaf flavone (BLF) displays biological and pharmacological activities in mammals. However, the effects of BLF on broiler gut microbiota and related immune function have not been investigated. The aim of this study was to test our hypothesis that BLF can improve the health status of broile...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69010-1
更新日期：2020-07-23 00:00:00
abstract：:Airway mucus overproduction is one of the most common symptoms of asthma that causes severe clinical outcomes in patients. Despite the effectiveness of general asthma therapies, specific treatments that prevent mucus overproduction in asthma patients remain lacking. Recent studies have found that activation of GABAA r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32756
更新日期：2016-09-06 00:00:00
abstract：:Bacillus megaterium is a microorganism widely used in industrial biotechnology for production of enzymes and recombinant proteins, as well as in bioleaching processes. Precise understanding of its metabolism is essential for designing engineering strategies to further optimize B. megaterium for biotechnology applicati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55041-w
更新日期：2019-12-10 00:00:00
abstract：:Copy Number Variants (CNVs) are a class of structural variations of DNA. Germline CNVs are known to confer disease susceptibility, but their role in breast cancer warrants further investigations. We hypothesized that breast cancer associated germline CNVs contribute to disease risk through gene dosage or other post-tr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25801-1
更新日期：2018-05-14 00:00:00
abstract：:Plants deploy several ammonium transporter (AMT) and nitrate transporter (NRT) genes to acquire NH4+ and NO3- from the soil into the roots and then transport them to other plant organs. Coding sequences of wheat genes obtained from ENSEMBL were aligned to known AMT and NRT sequences of Arabidopsis, barley, maize, rice...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25430-8
更新日期：2018-05-04 00:00:00
abstract：:A frequency reconfigurable dipole antenna based on a silicon radiator is presented. The silicon radiator is activated with the aid of highly dense solid-state plasma by injecting carriers into the intrinsic region of p-i-n diodes. The fabrication and design guideline of the reconfigurable dipole antenna with this plas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33278-1
更新日期：2018-10-09 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41598-017-18751-7
更新日期：2018-01-08 00:00:00
abstract：:Various neurophysiological and cognitive functions are based on transferring information between spiking neurons via a complex system of synaptic connections. In particular, the capacity of presynaptic inputs to influence the postsynaptic outputs-the efficacy of the synapses-plays a principal role in all aspects of hi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36807-0
更新日期：2019-01-24 00:00:00
abstract：:This is a systematical report on the potential health risk of heavy metals from the leather industries in Pakistan based on multiple biological matrices of the exposed workers and indoor dust samples. The adverse impacts of heavy metals on the oxidative enzyme and their risks to workers' health were also explored. Our...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09075-7
更新日期：2017-08-18 00:00:00
abstract：:Melanosomes (melanin-bearing organelles) are common in the fossil record occurring as dense packs of globular microbodies. The organic component comprising the melanosome, melanin, is often preserved in fossils, allowing identification of the chemical nature of the constituent pigment. In present-day vertebrates, mela...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52318-y
更新日期：2019-11-04 00:00:00
abstract：:Protein electrochemistry represents a powerful technique for investigating the function and structure of proteins. Currently available biochemical assays provide limited information related to the conformational state of proteins and high costs. This work provides novel insights into the electrochemical investigation ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53994-6
更新日期：2019-11-22 00:00:00
abstract：:Endovascular sealing is a new technique for the repair of abdominal aortic aneurysms. Commercially available in Europe since 2013, it takes a revolutionary approach to aneurysm repair through minimally invasive techniques. Although aneurysm sealing may be thought as more stable than conventional endovascular stent gra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17759-3
更新日期：2017-12-18 00:00:00
abstract：:The combination of biomaterials and stem cells for clinical applications constitute a great challenge in bone tissue engineering. Hence, cellular networks derived from cells-biomaterials crosstalk have a profound influence on cell behaviour and communication, preceding proliferation and differentiation. The purpose of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73428-y
更新日期：2020-10-05 00:00:00
abstract：:We extend an agent-based multiscale model of vascular tumour growth and angiogenesis to describe transarterial chemoembolisation (TACE) therapies. The model accounts for tumour and normal cells that are both nested in a vascular system that changes its structure according to tumour-related growth factors. Oxygen promo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65012-1
更新日期：2020-06-29 00:00:00
abstract：:The controlled preparation of Au nanoparticles (NPs) in the size range of 6 to 22 nm is explored in this study. The Au NPs were prepared by the reduction of tetrachloroauric acid using maltose in the presence of nonionic surfactant Tween 80 at various concentrations to control the size of the resulting Au NPs. With in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22976-5
更新日期：2018-03-15 00:00:00
abstract：:Sepsis is associated with thrombocytopenia and microvascular thrombosis. Studies have described platelets implication in this pathology but their kinetics of activation and behavior remain poorly known. We show in a mouse model of peritonitis, the appearance of platelet-rich thrombi in organ microvessels and organ dam...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31910-8
更新日期：2018-09-10 00:00:00
abstract：:The complex phase transitions of vanadium dioxide (VO2) have drawn continual attention for more than five decades. Dynamically, ultrafast electron diffraction (UED) with atomic-scale spatiotemporal resolution has been employed to study the reaction pathway in the photoinduced transition of VO2, using bulk and strain-f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10217-0
更新日期：2017-08-30 00:00:00
abstract：:This retrospective cohort study investigated the association between in-hospital survival and two-dimensional (2D) echocardiography within 24 hours after the return of spontaneous circulation (ROSC) in patients who underwent in-hospital cardiopulmonary resuscitation (ICPR) after in-hospital cardiopulmonary arrest (IHC...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56153-z
更新日期：2020-01-08 00:00:00
abstract：:Epilepsy is a chronic neurological disease with a variable therapeutic response. To design effective treatment strategies for epilepsy, it is important to understand treatment responses and predictive factors. However, limited data are available in Africa, including Ethiopia. The aim of this study was therefore to ass...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52574-y
更新日期：2019-11-07 00:00:00
abstract：:The aim of the present study was to evaluate the association between statin use and the risk of age-related macular degeneration (AMD). A systematic search of the PubMed, EMBASE and ISI web of science databases was used to identify eligible published literatures without language restrictions up to April 2015. Summary ...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep18280
更新日期：2015-12-14 00:00:00
abstract：:Chemical reagents used in traditional mineral processing can be toxic and hazardous for the environment. Therefore, the use of biotechnological methods is becoming increasingly important. Great hopes are being placed in the use of microorganisms for bio-beneficiation of raw materials. However, assessment of adhesion a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49406-4
更新日期：2019-09-10 00:00:00
abstract：:Since temperature is a key factor affecting photosynthetic and respiration rates, the rates of gross primary production (GPP) and ecosystem respiration (ER) are expected to be lower for rivers at higher latitudes, while the net ecosystem production (NEP) rate likely decrease in rivers at lower latitude due to higher s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41427-3
更新日期：2019-03-20 00:00:00
abstract：:To achieve a better understanding of the "vinegar syndrome" phenomenon, which has caused serious damage to triacetyl cellulose-based motion picture films, the white powder obtained from damaged film surfaces was analysed in this study. The powder was found to be soluble in acetone, diethyl ether, dimethylformamide, an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80498-5
更新日期：2021-01-15 00:00:00
abstract：:Identification of novel photosynthetic proteins is important for understanding and improving photosynthetic efficiency. Synergistically, genome neighborhood can provide additional useful information to identify photosynthetic proteins. We, therefore, expected that applying a computational approach, particularly machin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64053-w
更新日期：2020-04-28 00:00:00
abstract：:Riboflavin (Rf) is a vitamin and endogenous photosensitizer capable to generate reactive oxygen species (ROS) under UV-blue irradiation and kill cancer cells, which are characterized by the enhanced uptake of Rf. We confirmed its phototoxicity on human breast adenocarcinoma cells SK-BR-3 preincubated with 30-μM Rf and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35103
更新日期：2016-10-12 00:00:00
abstract：:The recent Paris UNFCCC climate meeting discussed the possibility of limiting global warming to 2 °C since pre-industrial times, or possibly even 1.5 °C, which would require major future emissions reductions. However, even if climate is stabilised at current atmospheric greenhouse gas (GHG) concentrations, those warmi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30294
更新日期：2016-07-27 00:00:00
abstract：:Cell counts decrease with sediment depth. Typical explanations consider limiting factors such as water availability and chemistry, carbon source, nutrients, energy and temperature, and overlook the role of pore size. Our analyses consider sediment self-compaction, the evolution of pore size with depth, and the probabi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78714-3
更新日期：2020-12-10 00:00:00
abstract：:In this study, we aimed to elucidate the origin of domestic chickens and their evolutionary history over the course of their domestication. We conducted a large-scale genetic study using mitochondrial DNA D-loop sequences and 28 microsatellite DNA markers to investigate the diversity of 298 wild progenitor red junglef...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81589-7
更新日期：2021-01-21 00:00:00
abstract：:Capacitive, inductive and resistive loads of an ion-trap system, which can be modelled as LCR circuits, are important to know for building a high accuracy experiment. Accurate estimation of these loads is necessary for delivering the desired radio frequency (RF) signal to an ion trap via an RF resonator. Of particular...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35234-5
更新日期：2018-11-15 00:00:00
abstract：:Development of novel anti-influenza A virus (IAV) drugs with high efficiency and low toxicity is critical for preparedness against influenza outbreaks. Herein, we investigated the anti-IAV activities and mechanisms of fucoidan in vitro and in vivo. The results showed that a fucoidan KW derived from brown algae Kjellma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40760
更新日期：2017-01-17 00:00:00
