Abstract：
:Inflammatory processes have been implicated in the pathogenesis of Parkinson's disease (PD), including the development of PD-associated cognitive impairment. Whether genetic variants of inflammatory cytokine genes influence the risk of cognitive impairment in PD is unknown. In this study, we investigated single nucleotide polymorphisms (SNPs) in the IL-10 promoter (rs1800871 and rs1800872) and in the IL-18 promoter (rs1946518 and rs187238) in a Han Chinese cohort (N = 933). PD patients (N = 460) and controls (N = 473) were genotyped. Additionally, 268 PD patients were divided into three subgroups [cognitively normal (PD-NC), mild cognitive impairment (PD-MCI), and with dementia (PD-D)] on the basis of their performance on a battery of neuropsychological tests. No associations were found between the aforementioned polymorphisms and cognitive impairment in PD; thus no confirmatory evidence for the hypothesis of IL-10 and IL-18 alleles modulating the risk of cognitive impairment in Chinese PD patients was obtained.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu Z,Guo J,Wang Y,Li K,Kang J,Wei Y,Sun Q,Xu Q,Xu C,Yan X,Tang Bdoi
10.1038/srep19021subject
Has Abstractpub_date
2016-02-02 00:00:00pages
19021issn
2045-2322pii
srep19021journal_volume
6pub_type
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