当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Manassantin B shows antiviral activity against coxsackievirus B3 infection by activation of the STING/TBK-1/IRF3 signalling pathway.

Manassantin B shows antiviral activity against coxsackievirus B3 infection by activation of the STING/TBK-1/IRF3 signalling pathway.

Abstract：

:Coxsackievirus B3 (CVB3) is an important human pathogen associated with the development of acute pancreatitis, myocarditis, and type 1 diabetes. Currently, no vaccines or antiviral therapeutics are approved for the prevention and treatment of CVB3 infection. We found that Saururus chinensis Baill extract showed critical antiviral activity against CVB3 infection in vitro. Further, manassantin B inhibited replication of CVB3 and suppressed CVB3 VP1 protein expression in vitro. Additionally, oral administration of manassantin B in mice attenuated CVB3 infection-associated symptoms by reducing systemic production of inflammatory cytokines and chemokines including TNF-α, IL-6, IFN-γ, CCL2, and CXCL-1. We found that the antiviral activity of manassantin B is associated with increased levels of mitochondrial ROS (mROS). Inhibition of mROS generation attenuated the antiviral activity of manassantin B in vitro. Interestingly, we found that manassantin B also induced cytosolic release of mitochondrial DNA based on cytochrome C oxidase DNA levels. We further confirmed that STING and IRF-3 expression and STING and TBK-1 phosphorylation were increased by manassantin B treatment in CVB3-infected cells. Collectively, these results suggest that manassantin B exerts antiviral activity against CVB3 through activation of the STING/TKB-1/IRF3 antiviral pathway and increased production of mROS.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Song JH,Ahn JH,Kim SR,Cho S,Hong EH,Kwon BE,Kim DE,Choi M,Choi HJ,Cha Y,Chang SY,Ko HJ

doi

10.1038/s41598-019-45868-8

subject

Has Abstract

pub_date

2019-06-28 00:00:00

pages

9413

issue

1

issn

2045-2322

pii

10.1038/s41598-019-45868-8

journal_volume

9

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Integrative omics analysis in Pandanus odorifer (Forssk.) Kuntze reveals the role of Asparagine synthetase in salinity tolerance.

    abstract：:Pandanus odorifer (Forssk) Kuntze grows naturally along the coastal regions and withstands salt-sprays as well as strong winds. A combination of omics approaches and enzyme activity studies was employed to comprehend the mechanistic basis of high salinity tolerance in P. odorifer. The young seedlings of P. odorifer we...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37039-y

    authors： Rashmi D,Barvkar VT,Nadaf A,Mundhe S,Kadoo NY

    更新日期：2019-01-30 00:00:00

  • Increased regulatory B cells are involved in immune evasion in patients with gastric cancer.

    abstract：:Accumulating evidence has indicated that immune regulatory cells are involved in the establishment of tumoral immune evasion. However, the role of regulatory B cells (Bregs) in this remains unclear. Here, we identified a role for Bregs in immune evasion in gastric cancer (GC) patients. The frequency of peripheral Breg...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49581-4

    authors： Murakami Y,Saito H,Shimizu S,Kono Y,Shishido Y,Miyatani K,Matsunaga T,Fukumoto Y,Ashida K,Sakabe T,Nakayama Y,Fujiwara Y

    更新日期：2019-09-11 00:00:00

  • Publisher Correction: The effect of attention and working memory on the estimation of elapsed time.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-019-53224-z

    authors： Polti I,Martin B,van Wassenhove V

    更新日期：2019-11-18 00:00:00

  • A humanized anti-DLL4 antibody promotes dysfunctional angiogenesis and inhibits breast tumor growth.

    abstract：:Blockage of Delta-like 4 (DLL4)-directed Notch signaling induces excessive tip cell formation and endothelial proliferation resulting in dysfunctional angiogenesis in tumors. MMGZ01, as a murine anti-human DLL4 monoclonal antibody, specifically binds to human DLL4 and blocks Notch pathway. Here, the structure of MMGZ0...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27985

    authors： Jia X,Wang W,Xu Z,Wang S,Wang T,Wang M,Wu M

    更新日期：2016-06-15 00:00:00

  • Shift of bacterial community structure along different coastal reclamation histories in Jiangsu, Eastern China.

    abstract：:Tideland reclamation has drastic effects on coastal ecosystem involved in soil microorganisms. However, the knowledge regarding temporal variations of microbial community along reclamation chronosequence and their environmental variable predictor is still poorly known. Using Illumina sequencing, we qualified bacterial...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10608-3

    authors： Hua J,Feng Y,Jiang Q,Bao X,Yin Y

    更新日期：2017-08-30 00:00:00

  • SMAD6 overexpression leads to accelerated myogenic differentiation of LMNA mutated cells.

    abstract：:LMNA gene encodes lamins A and C, two major components of the nuclear lamina, a network of intermediate filaments underlying the inner nuclear membrane. Most of LMNA mutations are associated with cardiac and/or skeletal muscles defects. Muscle laminopathies include Emery-Dreifuss Muscular Dystrophy, Limb-Girdle Muscul...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-23918-x

    authors： Janin A,Bauer D,Ratti F,Valla C,Bertrand A,Christin E,Chopin E,Streichenberger N,Bonne G,Gache V,Cohen T,Méjat A

    更新日期：2018-04-04 00:00:00

  • Author Correction: Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-019-42948-7

    authors： Röttgerding F,Wagemakers A,Koetsveld J,Fingerle V,Kirschfink M,Hovius JW,Zipfel PF,Wallich R,Kraiczy P

    更新日期：2019-05-02 00:00:00

  • Acupuncture elicits neuroprotective effect by inhibiting NAPDH oxidase-mediated reactive oxygen species production in cerebral ischaemia.

    abstract：:In the current study, we aimed to investigate whether NADPH oxidase, a major ROS-producing enzyme, was involved in the antioxidant effect of acupuncture on cognitive impairment after cerebral ischaemia. The cognitive function, infract size, neuron cell loss, level of superoxide anion and expression of NADPH oxidase su...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep17981

    authors： Shi GX,Wang XR,Yan CQ,He T,Yang JW,Zeng XH,Xu Q,Zhu W,Du SQ,Liu CZ

    更新日期：2015-12-10 00:00:00

  • Combined application of NMR- and GC-MS-based metabonomics yields a superior urinary biomarker panel for bipolar disorder.

    abstract：:Bipolar disorder (BD) is a debilitating mental disorder that cannot be diagnosed by objective laboratory-based modalities. Our previous studies have independently used nuclear magnetic resonance (NMR)-based and gas chromatography-mass spectrometry (GC-MS)-based metabonomic methods to characterize the urinary metabolic...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05855

    authors： Chen JJ,Liu Z,Fan SH,Yang DY,Zheng P,Shao WH,Qi ZG,Xu XJ,Li Q,Mu J,Yang YT,Xie P

    更新日期：2014-07-28 00:00:00

  • P130Cas/bcar1 mediates zebrafish caudal vein plexus angiogenesis.

    abstract：:P130CAS/BCAR1 belongs to the CAS family of adaptor proteins, with important regulatory roles in cell migration, cell cycle control, and apoptosis. Previously, we and others showed that P130CAS mediates VEGF-A and PDGF signalling in vitro, but its cardiovascular function in vivo remains relatively unexplored. We charac...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71753-w

    authors： Wisniewski L,French V,Lockwood N,Valdivia LE,Frankel P

    更新日期：2020-09-24 00:00:00

  • A new structure of two-dimensional allotropes of group V elements.

    abstract：:The elemental two-dimensional (2D) materials such as graphene, silicene, germanene, and black phosphorus have attracted considerable attention due to their fascinating physical properties. Structurally they possess the honeycomb or distorted honeycomb lattices, which are composed of six-atom rings. Here we find a new ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25423

    authors： Li P,Luo W

    更新日期：2016-05-06 00:00:00

  • Combined network pharmacology and virtual reverse pharmacology approaches for identification of potential targets to treat vascular dementia.

    abstract：:Dementia is a major cause of disability and dependency among older people. If the lives of people with dementia are to be improved, research and its translation into druggable target are crucial. Ancient systems of healthcare (Ayurveda, Siddha, Unani and Sowa-Rigpa) have been used from centuries for the treatment vasc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-57199-9

    authors： Lagunin AA,Ivanov SM,Gloriozova TA,Pogodin PV,Filimonov DA,Kumar S,Goel RK

    更新日期：2020-01-14 00:00:00

  • Association of plasma free amino acids with hyperuricemia in relation to diabetes mellitus, dyslipidemia, hypertension and metabolic syndrome.

    abstract：:Previous studies demonstrated independent contributions of plasma free amino acids (PFAAs) and high uric acid (UA) concentrations to increased risks of lifestyle-related diseases (LSRDs), but the important associations between these factors and LSRDs remain unknown. We quantified PFAAs and UA amongst Japanese subjects...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17710-6

    authors： Mahbub MH,Yamaguchi N,Takahashi H,Hase R,Ishimaru Y,Sunagawa H,Amano H,Kobayashi-Miura M,Kanda H,Fujita Y,Yamamoto H,Yamamoto M,Kikuchi S,Ikeda A,Kageyama N,Nakamura M,Tanabe T

    更新日期：2017-12-15 00:00:00

  • Polymorphism in the gene encoding toll-like receptor 10 may be associated with asthma after bronchiolitis.

    abstract：:Toll-like receptors (TLRs) recognise microbes that contribute to the severity of bronchiolitis and the subsequent risk of asthma. We evaluated whether post-bronchiolitis asthma was associated with polymorphisms in the TLR3 rs3775291, TLR4 rs4986790, TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084, and TLR10 rs4129009 gen...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03429-x

    authors： Törmänen S,Korppi M,Teräsjärvi J,Vuononvirta J,Koponen P,Helminen M,He Q,Nuolivirta K

    更新日期：2017-06-07 00:00:00

  • Ubiquitin carboxyl-terminal hydrolases are required for period maintenance of the circadian clock at high temperature in Arabidopsis.

    abstract：:Protein ubiquitylation participates in a number of essential cellular processes including signal transduction and transcription, often by initiating the degradation of specific substrates through the 26S proteasome. Within the ubiquitin-proteasome system, deubiquitylating enzymes (DUBs) not only help generate and main...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-53229-8

    authors： Hayama R,Yang P,Valverde F,Mizoguchi T,Furutani-Hayama I,Vierstra RD,Coupland G

    更新日期：2019-11-19 00:00:00

  • Dynamic impact of temporal context of Ca²⁺ signals on inhibitory synaptic plasticity.

    abstract：:Neuronal activity-dependent synaptic plasticity, a basis for learning and memory, is tightly correlated with the pattern of increase in intracellular Ca(2+) concentration ([Ca(2+)](i)). Here, using combined application of electrophysiological experiments and systems biological simulation, we show that such a correlati...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00143

    authors： Kawaguchi SY,Nagasaki N,Hirano T

    更新日期：2011-01-01 00:00:00

  • Immunization with a 22-kDa outer membrane protein elicits protective immunity to multidrug-resistant Acinetobacter baumannii.

    abstract：:A. baumannii infections are becoming more and more serious health issues with rapid emerging of multidrug and extremely drug resistant strains, and therefore, there is an urgent need for the development of nonantibiotic-based intervention strategies. This study aimed at identifying whether an outer membrane protein wi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep20724

    authors： Huang W,Yao Y,Wang S,Xia Y,Yang X,Long Q,Sun W,Liu C,Li Y,Chu X,Bai H,Yao Y,Ma Y

    更新日期：2016-02-08 00:00:00

  • The interaction between the proliferating macroalga Asparagopsis taxiformis and the coral Astroides calycularis induces changes in microbiome and metabolomic fingerprints.

    abstract：:Mediterranean Sea ecosystems are considered as hotspots of biological introductions, exposed to possible negative effects of non-indigenous species. In such temperate marine ecosystems, macroalgae may be dominant, with a great percentage of their diversity represented by introduced species. Their interaction with temp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42625

    authors： Greff S,Aires T,Serrão EA,Engelen AH,Thomas OP,Pérez T

    更新日期：2017-02-20 00:00:00

  • Topological constraints of structural elements in regulation of catalytic activity in HDV-like self-cleaving ribozymes.

    abstract：:Self-cleaving ribozymes fold into intricate structures, which orient active site groups into catalytically competent conformations. Most ribozyme families have distinct catalytic cores stabilized by tertiary interactions between domains peripheral to those cores. We show that large hepatitis delta virus (HDV)-like rib...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep28179

    authors： Webb CH,Nguyen D,Myszka M,Lupták A

    更新日期：2016-06-15 00:00:00

  • Endocrine disrupter chemicals affect the humoral antimicrobial activities of gilthead seabream males even upon the cease of the exposure.

    abstract：:17α-ethynilestradiol (EE2) and tamoxifen (Tmx) are pollutants world-wide distributed in aquatic environments. Gilthead seabream, Sparus aurata L., is highlighted as a species model of intensively culture in anthropogenic disturbed environments. The effects of these pollutants on gilthead seabream reproduction and some...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-64522-2

    authors： Valero Y,López-Cánovas AE,Rodenas MC,Cabas I,García-Hernández P,Arizcun M,García-Ayala A,Chaves-Pozo E

    更新日期：2020-05-14 00:00:00

  • Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis.

    abstract：:Rheumatoid arthritis is characterised by synovial inflammation and proliferation of fibroblast-like synoviocytes. The induction of apoptosis has long been proposed as a target for proliferative autoimmune diseases, and has further been shown to act as a successful treatment of experimental models of arthritis, such as...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep31441

    authors： Hellvard A,Zeitlmann L,Heiser U,Kehlen A,Niestroj A,Demuth HU,Koziel J,Delaleu N,Jan Potempa,Mydel P

    更新日期：2016-08-11 00:00:00

  • Fecal microbiome and metabolome of infants fed bovine MFGM supplemented formula or standard formula with breast-fed infants as reference: a randomized controlled trial.

    abstract：:Human milk delivers an array of bioactive components that safeguard infant growth and development and maintain healthy gut microbiota. Milk fat globule membrane (MFGM) is a biologically functional fraction of milk increasingly linked to beneficial outcomes in infants through protection from pathogens, modulation of th...

    journal_title：Scientific reports

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/s41598-019-47953-4

    authors： He X,Parenti M,Grip T,Lönnerdal B,Timby N,Domellöf M,Hernell O,Slupsky CM

    更新日期：2019-08-12 00:00:00

  • A feasibility study on non-invasive oxidative metabolism detection and acoustic assessment of human vocal cords by using optical technique.

    abstract：:Voice disorder such as vocal fatigue is a common and complex multifaceted clinical problem that presents a significant impact on quality of life. In this study, the functional near-infrared diffuse optical technique (fNIRS-DOT) was proposed as a novel approach for human vocal cords oxidative metabolism detection and a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-16807-2

    authors： Lin TC,Chen JC,Liu CH,Lee CY,Tsou YA,Chuang CC

    更新日期：2017-12-05 00:00:00

  • Characterization of a highly specific NQO1-activated near-infrared fluorescent probe and its application for in vivo tumor imaging.

    abstract：:The Near-infrared Fluorescence (NIRF) molecular imaging of cancer is known to be superior in sensitivity, deeper penetration, and low phototoxicity compared to other imaging modalities. In view of an increased need for efficient and targeted imaging agents, we synthesized a NAD(P)H quinone oxidoreductase 1 (NQO1)-acti...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44111-8

    authors： Punganuru SR,Madala HR,Arutla V,Zhang R,Srivenugopal KS

    更新日期：2019-06-12 00:00:00

  • Comparative analysis of rhizosphere soil physiochemical characteristics and microbial communities between rusty and healthy ginseng root.

    abstract：:Ginseng rusty root (GRR) symptom is one of the primary diseases of ginseng. There has been a problem of ginseng rusty root, leading to a severe decline in the quality of ginseng. To clarify the relationship between root symptoms of ginseng rust and soil, the physical and chemical properties, enzyme activity, community...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71024-8

    authors： Bian X,Xiao S,Zhao Y,Xu Y,Yang H,Zhang L

    更新日期：2020-09-25 00:00:00

  • Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors.

    abstract：:Previously, Aznar et al., showed that Daple/CCDC88C enables Wnt receptors to transactivate trimeric G-proteins during non-canonical Wnt signaling via a novel G-protein binding and activating (GBA) motif. By doing so, Daple serves two opposing roles; earlier during oncogenesis it suppresses neoplastic transformation an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-48420-w

    authors： Ear J,Dunkel Y,Mittal Y,Lim BBC,Liu L,Holda MK,Nitsche U,Barbazán J,Goel A,Janssen KP,Aznar N,Ghosh P

    更新日期：2019-08-20 00:00:00

  • High precision computer-generated moiré profilometry.

    abstract：:Recently, a computer-generated moiré profilometry was proposed by our research group. It can effectively avoid the influence of the transient caused by moiré fringes' direct acquisition and generally owns a higher accuracy. But when the spatial spectrum of the captured deformed pattern is severely aliased caused by th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44186-3

    authors： Li C,Cao Y,Wang L,Wan Y,Fu G,Wang Y,Chen C

    更新日期：2019-05-24 00:00:00

  • In ovo injection of betaine alleviates corticosterone-induced fatty liver in chickens through epigenetic modifications.

    abstract：:Betaine alleviates high-fat diet-induced fatty liver and prenatal betaine programs offspring hepatic lipid metabolism. Excessive corticosterone (CORT) exposure causes fatty liver in chickens, yet it remains unknown whether and how prenatal betaine modulates the susceptibility of CORT-induced fatty liver later in life....

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40251

    authors： Hu Y,Sun Q,Liu J,Jia Y,Cai D,Idriss AA,Omer NA,Zhao R

    更新日期：2017-01-06 00:00:00

  • Seismic surveys reduce cetacean sightings across a large marine ecosystem.

    abstract：:Noise pollution is increasing globally, and as oceans are excellent conductors of sound, this is a major concern for marine species reliant on sound for key life functions. Loud, impulsive sounds from seismic surveys have been associated with impacts on many marine taxa including mammals, crustaceans, cephalopods, and...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-55500-4

    authors： Kavanagh AS,Nykänen M,Hunt W,Richardson N,Jessopp MJ

    更新日期：2019-12-16 00:00:00

  • Stratification-induced reorientation of disk settling through ambient density transition.

    abstract：:Settling due to gravity force is a basic transport mechanism of solid particles in fluids in the Earth. A large portion of particles occurring in nature and used in technical applications are non-spherical. Settling of particles is usually studied in homogeneous ambient conditions, however, stratification is inherent ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-18654-7

    authors： Mrokowska MM

    更新日期：2018-01-11 00:00:00