Abstract：
:Previously, Aznar et al., showed that Daple/CCDC88C enables Wnt receptors to transactivate trimeric G-proteins during non-canonical Wnt signaling via a novel G-protein binding and activating (GBA) motif. By doing so, Daple serves two opposing roles; earlier during oncogenesis it suppresses neoplastic transformation and tumor growth, but later it triggers epithelial-to-mesenchymal-transition (EMT). We have identified and characterized two isoforms of the human Daple gene. While both isoforms cooperatively suppress tumor growth via their GBA motif, only the full-length transcript triggers EMT and invasion. Both isoforms are suppressed during colon cancer progression, and their reduced expression carries additive prognostic significance. These findings provide insights into the opposing roles of Daple during cancer progression and define the G-protein regulatory GBA motif as one of the minimal modules essential for Daple's role as a tumor suppressor.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ear J,Dunkel Y,Mittal Y,Lim BBC,Liu L,Holda MK,Nitsche U,Barbazán J,Goel A,Janssen KP,Aznar N,Ghosh Pdoi
10.1038/s41598-019-48420-wsubject
Has Abstractpub_date
2019-08-20 00:00:00pages
12124issue
1issn
2045-2322pii
10.1038/s41598-019-48420-wjournal_volume
9pub_type
杂志文章abstract：:CLE peptide hormones are critical regulators of many cell proliferation and differentiation mechanisms in plants. These 12-13 amino acid glycosylated peptides play vital roles in a diverse range of plant tissues, including the shoot, root and vasculature. CLE peptides are also involved in controlling legume nodulation...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09296-w
更新日期：2017-08-24 00:00:00
abstract：:The effect of the surface area of palm kernel shell activated carbon (PKSAC) on the properties of n-octadecane-encapsulated shape stabilized phase change material (SSPCM) for thermal energy storage (TES) application were studied. Various surface areas of the PKSAC were prepared using different amounts of H3PO4 treatme...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72019-1
更新日期：2020-09-14 00:00:00
abstract：:Over the past few decades, two-dimensional (2D) and layered materials have emerged as new fields. Due to the zero-band-gap nature of graphene and the low photocatalytic performance of MoS2, more advanced semiconducting 2D materials have been prompted. As a result, semiconductor black phosphorus (BP) is a derived cutti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08691
更新日期：2015-03-03 00:00:00
abstract：:The present study reports a natural infection of emus, Dromaius novaehollandiae, by the nematode Procyrnea uncinipenis. Five adult emus from a scientific breeding farm at North Fluminense State University located in the city of Campos dos Goytacazes, Rio de Janeiro state, Brazil were necropsied, and their gastrointest...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73754-1
更新日期：2020-10-06 00:00:00
abstract：:NF-κB signaling pathway has important roles in the regulation of growth and development of nervous system. This pathway has also been shown to participate in the pathogenesis of schizophrenia. Meanwhile, activity of NF-κB signaling pathway is regulated by several factors including non-coding RNAs (lncRNAs). In the cur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75333-w
更新日期：2020-10-22 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-42195-w
更新日期：2019-04-10 00:00:00
abstract：:Global ocean acidification is expected to chronically lower the pH to 7.3 (>2200 µatm seawater pCO2) by the year 2300. Acute hypercapnia already occurs along the South African west and south coasts due to upwelling- and low-oxygen events, with increasing frequency. In the present project we investigated the impact of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54795-7
更新日期：2019-12-19 00:00:00
abstract：:A. baumannii infections are becoming more and more serious health issues with rapid emerging of multidrug and extremely drug resistant strains, and therefore, there is an urgent need for the development of nonantibiotic-based intervention strategies. This study aimed at identifying whether an outer membrane protein wi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20724
更新日期：2016-02-08 00:00:00
abstract：:Current and expected changes in global climate are major threat for biological diversity affecting individuals, communities and ecosystems. However, there is no general trend in the plants response to the climate change. The aim of present study was to evaluate impact of the future climate changes on the distribution ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13088-7
更新日期：2017-10-05 00:00:00
abstract：:A new and facile approach to selectively functionalize the internal and external surfaces of porous silicon (pSi) for drug delivery applications is reported. To provide a surface that is suitable for sustained drug release of the hydrophobic cancer chemotherapy drug camptothecin (CPT), the internal surfaces of pSi fil...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37750-w
更新日期：2019-02-04 00:00:00
abstract：:The Centiloid (CL) is a method for standardizing amyloid beta (Aβ) quantification through different ligands and methods. To find the most appropriate reference region to reduce the variance in the Aβ CL unit between 18F-florbetaben (FBB) and 18F-flutemetamol (FMM), we conducted head-to-head comparisons from 56 partici...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70978-z
更新日期：2020-09-11 00:00:00
abstract：:Amorphous silicon oxycarbide (SiOC) is of great technological interest. However, its atomic-level structure is not well understood. Using density functional theory calculations, we show that the clustering tendency of C atoms in SiOC is extremely sensitive to hydrogen (H): without H, the C-C interaction is attractive,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13051
更新日期：2015-08-13 00:00:00
abstract：:Childhood obesity is a risk factor for asthma, but the molecular mechanisms linking both remain elusive. Since obesity leads to chronic low-grade inflammation and affects metabolic signaling we hypothesized that postnatal hyperalimentation (pHA) induced by maternal high-fat-diet during lactation leads to early-onset o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24168
更新日期：2016-04-18 00:00:00
abstract：:The mechanisms of pattern formation during embryonic development remain poorly understood. Embryonic stem cells in culture self-organise to form spatial patterns of gene expression upon geometrical confinement indicating that patterning is an emergent phenomenon that results from the many interactions between the cell...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73228-4
更新日期：2020-10-01 00:00:00
abstract：:Chloroquine (CQ) is widely used as an anti-inflammatory therapeutic for rheumatic diseases. Although its modes of action on the innate immune system are well described, there is still insufficient knowledge about its direct effects on the adaptive immune system. Thus, we evaluated the influence of CQ on activation par...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42191
更新日期：2017-02-07 00:00:00
abstract：:Graphene oxide-iron oxide (GO-Fe3O4) nanocomposites were synthesised by co-precipitating iron salts onto GO sheets in basic solution. The results showed that formation of two distinct structures was dependent upon the GO loading. The first structure corresponds to a low GO loading up to 10 wt%, associated with the ben...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04594
更新日期：2014-04-04 00:00:00
abstract：:Ribosome biogenesis and turnover are processes necessary for cell viability and proliferation, and many kinds of proteins are known to regulate these processes. However, many questions still remain, especially in the Archaea. Generally, several ribonucleases are required to process precursor rRNAs to their mature form...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13062-3
更新日期：2017-10-04 00:00:00
abstract：:DNA-based data storage has emerged as a promising method to satisfy the exponentially increasing demand for information storage. However, practical implementation of DNA-based data storage remains a challenge because of the high cost of data writing through DNA synthesis. Here, we propose the use of degenerate bases a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43105-w
更新日期：2019-04-29 00:00:00
abstract：:Gold nanoparticle radiosensitization represents a novel technique in enhancement of ionising radiation dose and its effect on biological systems. Variation between theoretical predictions and experimental measurement is significant enough that the mechanism leading to an increase in cell killing and DNA damage is stil...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19442
更新日期：2016-01-20 00:00:00
abstract：:Air pollution has been classified as a group 1 carcinogen in humans, but the underlying tumourigenic mechanisms remain unclear. In Xuanwei city of Yunnan Province, the lung cancer incidence is among the highest in China, owing to severe air pollution generated by the combustion of smoky coal, providing a unique opport...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14331
更新日期：2015-09-23 00:00:00
abstract：:This paper addresses the issue of the sorption process on coal concerning propylene released from the source of coal heating in the deposit. In this study, the interaction between Polish coals and propylene molecules, as well as three other hydrocarbons (ethylene, ethane, and propane) with the application of a fixed-b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67472-x
更新日期：2020-07-09 00:00:00
abstract：:Early-life stress in adolescence has a long-lasting influence on brain function in adulthood, and it is mostly recognized as a predisposing factor for mental illnesses, such as anxiety and posttraumatic stress disorder. Previous studies also indicated that adolescent predictable chronic mild stress (PCMS) in early lif...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08017-7
更新日期：2017-08-10 00:00:00
abstract：:We describe a spin wave modulator - spintronic device aimed to control spin wave propagation by an electric field. The modulator consists of a ferromagnetic film serving as a spin wave bus combined with a synthetic multiferroic comprising piezoelectric and magnetostrictive materials. Its operation is based on the stre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28878-w
更新日期：2018-07-18 00:00:00
abstract：:Combining endurance training with resistance training (RT) may attenuate skeletal muscle hypertrophic adaptation versus RT alone; however, the underlying mechanisms are unclear. We investigated changes in markers of ribosome biogenesis, a process linked with skeletal muscle hypertrophy, following concurrent training v...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18887-6
更新日期：2018-01-12 00:00:00
abstract：:Early detection of breast cancer and its correct stage determination are important for prognosis and rendering appropriate personalized clinical treatment to breast cancer patients. However, despite considerable efforts and progress, there is a need to identify the specific genomic factors responsible for, or accompan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60740-w
更新日期：2020-03-05 00:00:00
abstract：:Polymer-supported nanozero-valent iron composites (D001-nZVI) were fabricated for the removal of lead ions from aqueous solutions by embedding nZVI into the porous polystyrene anion exchanger D001. Humic acid (HA) was selected as a model species because of its ubiquitous existence to gain insight into the influencing ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76362-1
更新日期：2020-11-12 00:00:00
abstract：:Hepatocellular carcinoma is a common type of malignancy with a poor prognosis. Identification and utilisation of markers for monitoring and diagnosis are urgently needed. Alpha-fetoprotein (AFP) and Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II) have been proved to be efficient biomarkers for hepatit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70241-5
更新日期：2020-08-11 00:00:00
abstract：:Sixty norovirus outbreaks that occurred in Pudong District, Shanghai in 2017 and affected 959 people were summarised. Of the outbreaks, 29 (48.3%), 27 (45.0%), and 4 (6.7%) occurred in kindergartens, primary schools, and middle schools, respectively. Although the total number of outbreaks peaked in March (13/60, 21.7%...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33724-0
更新日期：2018-10-15 00:00:00
abstract：:Notarchirico (Southern Italy) has yielded the earliest evidence of Acheulean settlement in Italy and four older occupation levels have recently been unearthed, including one with bifaces, extending the roots of the Acheulean in Italy even further back in time. New 40Ar/39Ar on tephras and ESR dates on bleached quartz ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68617-8
更新日期：2020-08-14 00:00:00
abstract：:Several studies have shown that the human gaze, but not the robot gaze, has significant effects on infant social cognition and facilitate social engagement. The present study investigates early understanding of the referential nature of gaze by comparing-through the eye-tracking technique-infants' response to human an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69140-6
更新日期：2020-07-17 00:00:00
