Abstract:
:Tyrosine hydroxylase (TH) catalyzes the hydroxylation of L-tyrosine to L-DOPA. This is the rate-limiting step in the biosynthesis of the catecholamines - dopamine (DA), norepinephrine (NE), and epinephrine (EP). Catecholamines (CA) play a key role as neurotransmitters and hormones. Aberrant levels of CA are associated with multiple medical conditions, including Parkinson's disease. Palm Fruit Bioactives (PFB) significantly increased the levels of tyrosine hydroxylase in the brain of the Nile Grass rat (NGR), a novel and potentially significant finding, unique to PFB among known botanical sources. Increases were most pronounced in the basal ganglia, including the caudate-putamen, striatum and substantia nigra. The NGR represents an animal model of diet-induced Type 2 Diabetes Mellitus (T2DM), exhibiting hyperglycemia, hyperinsulinemia, and insulin resistance associated with hyperphagia and accelerated postweaning weight gain induced by a high-carbohydrate diet (hiCHO). The PFB-induced increase of TH in the basal ganglia of the NGR was documented by immuno-histochemical staining (IHC). This increase in TH occurred equally in both diabetes-susceptible and diabetes-resistant NGR fed a hiCHO. PFB also stimulated growth of the colon microbiota evidenced by an increase in cecal weight and altered microbiome. The metabolites of colon microbiota, e.g. short-chain fatty acids, may influence the brain and behavior significantly.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Weinberg RP,Koledova VV,Subramaniam A,Schneider K,Artamonova A,Sambanthamurthi R,Hayes KC,Sinskey AJ,Rha Cdoi
10.1038/s41598-019-54461-ysubject
Has Abstractpub_date
2019-12-09 00:00:00pages
18625issue
1issn
2045-2322pii
10.1038/s41598-019-54461-yjournal_volume
9pub_type
杂志文章abstract::In the developing central nervous system (CNS), oligodendrocyte precursor cells (OPCs) migrate along blood vessels and are widely distributed in the CNS. Meanwhile, OPCs require survival factors from the extracellular microenvironment. In other tissues, laminins, heterotrimetric (αβγ) extracellular matrix proteins, pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56488-7
更新日期:2019-12-27 00:00:00
abstract::Most pancreatic cancer (PC) patients manifest multiple liver metastases at the time of diagnosis. Activated platelets play a key role in tumor growth and tumor metastases. Mean platelet volume (MPV) is a platelet index and is altered in patients with malignancies. This study aimed to evaluate whether MPV can effective...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24539-0
更新日期:2018-04-16 00:00:00
abstract::Fourier ptychographic microscopy (FPM) is a novel computational coherent imaging technique for high space-bandwidth product imaging. Mathematically, Fourier ptychographic (FP) reconstruction can be implemented as a phase retrieval optimization process, in which we only obtain low resolution intensity images correspond...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27384
更新日期:2016-06-10 00:00:00
abstract::Complex networks are ubiquitous in biological, physical and social sciences. Network robustness research aims at finding a measure to quantify network robustness. A number of Wiener type indices have recently been incorporated as distance-based descriptors of complex networks. Wiener type indices are known to depend b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19066
更新日期:2016-01-11 00:00:00
abstract::The limits of mammography have led to an increasing interest on possible alternatives such as the breast Computed Tomography (bCT). The common goal of all X-ray imaging techniques is to achieve the optimal contrast resolution, measured through the Contrast to Noise Ratio (CNR), while minimizing the radiological risks,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49351-2
更新日期:2019-09-11 00:00:00
abstract::The CRISPR/Cas9 system is widely used to generate gene-edited animals. Here, we developed an efficient system for generating genetically modified mice using maternal Cas9 from Cas9 transgenic mice. Using this system, we achieved lower mosaicism and higher rates of knock-in success, gene-editing, and birth compared to ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57996-7
更新日期:2020-01-23 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-36016-9
更新日期:2018-11-23 00:00:00
abstract::Although most papillary thyroid carcinomas (PTCs) have a good prognosis, a small but certain fraction shows aggressive behavior. Therefore, a novel and well-performing molecular marker is needed. In the present study, we assessed the impact of the combination of the TERT promoter/BRAF mutations and Ki-67 labeling inde...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41752
更新日期:2017-02-02 00:00:00
abstract::Given the speed of air travel, diseases even with a short viremia such as dengue can be easily exported to dengue naïve areas within 24 hours. We set out to estimate the risk of dengue virus introductions via travelers into Europe and number of secondary autochthonous cases as a result of the introduction. We applied ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22590-5
更新日期:2018-03-15 00:00:00
abstract::In spite of its prevalence in animals and plants, endogenous nitric oxide (NO) has been rarely reported in fungi. We present here our observations on production of intracellular NO and its possible roles during development of Neurospora crassa, a model filamentous fungus. Intracellular NO was detected in hypha 8-16 ho...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30037
更新日期:2016-07-18 00:00:00
abstract::M2BP (also called 90K) is an interferon-stimulated gene product that is upregulated in HIV-1 infection. A recent study revealed that M2BP reduces the infectivity of HIV-1 by inhibiting the processing of the viral envelope protein. Here we report that in addition to reducing viral infectivity, M2BP inhibits HIV-1 virio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32736
更新日期:2016-09-08 00:00:00
abstract::Coincident climatic and human effects strongly influence water-quality properties in estuarine-coastal ecosystems around the world. Time-series data for a number of ecosystems reveal high spatio-temporal variability superimposed on secular trends traceable to nutrient over-enrichment. In this paper, we present new ana...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43036-6
更新日期:2019-04-30 00:00:00
abstract::How the human auditory system learns to map complex pinna-induced spectral-shape cues onto veridical estimates of sound-source elevation in the median plane is still unclear. Earlier studies demonstrated considerable sound-localisation plasticity after applying pinna moulds, and to altered vision. Several factors may ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36422-z
更新日期:2018-12-18 00:00:00
abstract::We present the continuous-time evolution of an online organism network from birth to death which crosses all organizational and temporal scales, from individual components through to the mesoscopic and entire system scale. These continuous-time data reveal a lifespan driven by punctuated, real-time co-evolution of the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22027-z
更新日期:2018-02-23 00:00:00
abstract::The lack of bone morphological markers associated with the human control of wild animals has prevented the documentation of incipient animal domestication in archaeology. Here, we assess whether direct environmental changes (i.e. mobility reduction) could immediately affect ontogenetic changes in long bone structure, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75496-6
更新日期:2020-11-04 00:00:00
abstract::The two most important and studied phytocannabinoids present in Cannabis sativa L. are undoubtedly cannabidiol (CBD), a non-psychotropic compound, but with other pharmacological properties, and Δ9-tetrahydrocannabinol (Δ9-THC), which instead possesses psychotropic activity and is responsible for the recreative use of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79042-2
更新日期:2020-12-16 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-46785-6
更新日期:2019-07-17 00:00:00
abstract::Sublingual immunization is emerging as an alternative to nasal immunization and induction of mucosal IgA responses. Using Bacillus anthracis edema toxin (EdTx) as an adjuvant, we previously showed that innate responses triggered after sublingual immunization could limit generation of IgA responses. We tested whether c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36370-8
更新日期:2019-01-24 00:00:00
abstract::Molecular imaging is a powerful tool for investigating intracellular signalling, but it is difficult to acquire conventional fluorescence imaging from photoreceptive cells. Here we demonstrated that human opsin5 (OPN5) photoreceptor mediates light-induced Ca(2+) response in human embryonic kidney (HEK293) and mouse ne...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05352
更新日期:2014-06-19 00:00:00
abstract::The centrosome is the microtubule organizing center of human cells and facilitates a myriad of cellular functions including organization of the mitotic spindle to ensure faithful chromosome segregation during mitosis, cell polarization and migration, and primary cilia formation. A numerical increase in centrosomes, or...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68629-4
更新日期:2020-07-17 00:00:00
abstract::It is generally believed that anthropogenic aerosols cool the atmosphere; therefore, they offset the global warming resulting from greenhouse gases to some extent. Reduction in sulphate, a primary anthropogenic aerosol, is necessary for mitigating air pollution, which causes atmospheric warming. Here, the changes in t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78805-1
更新日期:2020-12-10 00:00:00
abstract::Better risk prediction and new molecular targets are key priorities in type 2 diabetes (T2D) research. Little is known about the role of the urine metabolome in predicting the risk of T2D. We aimed to use non-targeted urine metabolomics to discover biomarkers and improve risk prediction for T2D. Urine samples from two...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72456-y
更新日期:2020-10-05 00:00:00
abstract::Omalizumab (OmAb) is a humanized anti-IgE antibody approved for the treatment of chronic spontaneous urticaria (CSU). OmAb's mechanism of action is known to include actions on free IgE and on pre-bound IgE. However, OmAb is equally and rapidly effective against autoimmune and non-autoimmune urticaria where IgE involve...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09361-4
更新日期:2017-08-21 00:00:00
abstract::Hydrogen has therapeutic and preventive effects against various diseases. Although animal and clinical studies have reported promising results, hydrogen distribution in organs after administration remains unclear. Herein, the sequential changes in hydrogen concentration in tissues over time were monitored using a high...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38180-4
更新日期:2019-02-04 00:00:00
abstract::Restoration of hard tissue in conjunction with adhesive is a globally challenging issue in medicine and dentistry. Common clinical therapies involving application of adhesive and substitute material for functional or anatomical recovery are still suboptimal. Biomaterials with bioactivity and inhibitory effects of enzy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23939-6
更新日期:2018-04-04 00:00:00
abstract::Quantifying how close two datasets are to each other is a common and necessary undertaking in scientific research. The Pearson product-moment correlation coefficient r is a widely used measure of the degree of linear dependence between two data series, but it gives no indication of how similar the values of these seri...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19401
更新日期:2016-01-14 00:00:00
abstract::Recently, CuZr-based bulk metallic glass (BMG) composites reinforced by the TRIP (transformation-induced plasticity) effect have been explored in attempt to accomplish an optimal of trade-off between strength and ductility. However, the design of such BMG composites with advanced mechanical properties still remains a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42518
更新日期:2017-02-13 00:00:00
abstract::Neutrophil gelatinase-associated lipocalin (NGAL, lipocalin 2 or LCN2) is an iron carrier protein whose circulating level is increased by kidney injury, bacterial infection and obesity, but its metabolic consequence remains elusive. To study physiological role of LCN2 in energy homeostasis, we challenged female Lcn2 k...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15825-4
更新日期:2017-11-14 00:00:00
abstract::Visual evoked potential-based brain-computer interfaces (BCIs) have been widely investigated because of their easy system configuration and high information transfer rate (ITR). However, the uncomfortable flicker or brightness modulation of existing methods restricts the practical interactivity of BCI applications. In...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24008-8
更新日期:2018-04-11 00:00:00
abstract::Transthyretin (TTR) is a blood and cerebrospinal fluid transporter of thyroxine and retinol. Gene expression profiling revealed an elevation of Ttr expression in the dorsomedial hypothalamus (DMH) of rats with exercise-induced anorexia, implying that central TTR may also play a functional role in modulating food intak...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24238
更新日期:2016-04-07 00:00:00