HSPD1 repressed E-cadherin expression to promote cell invasion and migration for poor prognosis in oral squamous cell carcinoma.

abstract：:Mouse embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs) represent naive and primed pluripotency states, respectively, and are maintained in vitro by specific signalling pathways. Furthermore, ESCs cultured in serum-free medium with two kinase inhibitors (2i-ESCs) are thought to be the ground naïve pluripote...

journal_title：Scientific reports

authors： Tosolini M,Brochard V,Adenot P,Chebrout M,Grillo G,Navia V,Beaujean N,Francastel C,Bonnet-Garnier A,Jouneau A

更新日期：2018-04-10 00:00:00

abstract：:This study aimed to examine hemodynamic responses and the necessity of breaks under long working hours. Thirty-eight healthy males conducted PC-based work from 9:10 to 22:00. Nine 10-minute short breaks and two long breaks (a 1-hour break and a 50-minute break) were provided, and hemodynamic responses were measured re...

journal_title：Scientific reports

authors： Liu X,Ikeda H,Oyama F,Wakisaka K,Takahashi M

更新日期：2018-09-28 00:00:00

abstract：:The amphibian chytrid fungus Batrachochytrium dendrobatidis is an emerging infectious pathogen present on every continent except Antarctica. It causes the disease chytridiomycosis in a subset of species but does not always result in disease or death for every host. Ambient temperature influences both amphibian metabol...

journal_title：Scientific reports

authors： Campbell L,Bower DS,Clulow S,Stockwell M,Clulow J,Mahony M

更新日期：2019-01-14 00:00:00

abstract：:Rassf1A/5 tumor suppressors serve as adaptor proteins possessing a modular architecture with the C-terminal consisting of a coiled-coil SARAH (Salvador-Rassf-Hippo) domain and the central portion being composed of Ras associated (RA) domain. Here, we investigate the effect of Rassf effectors on Mst1 function by mappin...

journal_title：Scientific reports

authors： Bitra A,Sistla S,Mariam J,Malvi H,Anand R

更新日期：2017-03-22 00:00:00

abstract：:Accumulating evidence indicates that cancer cells show specific alterations in phospholipid metabolism that contribute to tumour progression in several types of cancer, including colorectal cancer. Questions still remain as to what lipids characterize the outer edge of cancer tissues and whether those cancer outer edg...

journal_title：Scientific reports

authors： Hiraide T,Ikegami K,Sakaguchi T,Morita Y,Hayasaka T,Masaki N,Waki M,Sugiyama E,Shinriki S,Takeda M,Shibasaki Y,Miyazaki S,Kikuchi H,Okuyama H,Inoue M,Setou M,Konno H

更新日期：2016-07-20 00:00:00

abstract：:Live birth is the most important concern for assisted reproductive technology (ART) patients. Therefore, in the medical reproductive centre, obstetricians often need to answer the following question: "What are the chances that I will have a healthy baby after ART treatment?" To date, our obstetricians have no referenc...

journal_title：Scientific reports

authors： Gao H,Liu DE,Li Y,Wu X,Tan H

更新日期：2021-01-11 00:00:00

abstract：:N-doped carbon nanosheets/vanadium nitride nanoparticles (N-CNS/VNNPs) are synthesized via a novel method combining surface-initiated in-situ intercalative polymerization and thermal-treatment process in NH3/N2 atmosphere. The pH value of the synthesis system plays a critical role in constructing the structure and enh...

journal_title：Scientific reports

authors： Tan Y,Liu Y,Tang Z,Wang Z,Kong L,Kang L,Liu Z,Ran F

更新日期：2018-02-13 00:00:00

abstract：:We study the impact of the direction of magnetic flux on the electron motion in GaAs/InAs core/shell nanowires. At small tilt angles, when the magnetic field is aligned nearly parallel to the nanowire axis, we observe Aharonov-Bohm type h/e flux periodic magnetoconductance oscillations. These are attributed to transpo...

journal_title：Scientific reports

authors： Haas F,Wenz T,Zellekens P,Demarina N,Rieger T,Lepsa M,Grützmacher D,Lüth H,Schäpers T

更新日期：2016-04-19 00:00:00

abstract：:Large amounts of anthropogenic CO2 in the atmosphere are taken up by the ocean, which leads to 'ocean acidification' (OA). In addition, the increasing application of nanoparticles inevitably leads to their increased release into the aquatic environment. However, the impact of OA on the bioaccumulation of nanoparticles...

journal_title：Scientific reports

authors： Shi W,Han Y,Guo C,Su W,Zhao X,Zha S,Wang Y,Liu G

更新日期：2019-03-05 00:00:00

abstract：:The recent development of a CRISPR-Cas9-based homing system for the suppression of Anopheles gambiae is encouraging; however, with current designs, the slow emergence of homing-resistant alleles is expected to result in suppressed populations rapidly rebounding, as homing-resistant alleles have a significant fitness a...

journal_title：Scientific reports

authors： Marshall JM,Buchman A,Sánchez C HM,Akbari OS

更新日期：2017-06-19 00:00:00

abstract：:Prostate-specific antigen (PSA) kinetics predicts survival in castration-resistant prostate cancer (CRPC); however, the influence of prior treatment on this relationship is unclear. Patients with CRPC were stratified according to time to PSA nadir and time to CRPC progression to investigate their prognostic significan...

journal_title：Scientific reports

authors： Hah YS,Lee JS,Rha KH,Hong SJ,Chung BH,Koo KC

更新日期：2019-08-15 00:00:00

abstract：:Periventricular nodular heterotopia (PNH) is a neural migration disorder which often presents clinically with seizures. However, the underlying functional neural basis of PNH is still unclear. We aimed to explore the underlying pathological mechanism of PNH by combining both whole brain functional connectivity (FC) an...

journal_title：Scientific reports

authors： Liu W,Hu X,An D,Zhou D,Gong Q

更新日期：2019-12-05 00:00:00

abstract：:Hepatocellular carcinoma is a common type of malignancy with a poor prognosis. Identification and utilisation of markers for monitoring and diagnosis are urgently needed. Alpha-fetoprotein (AFP) and Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II) have been proved to be efficient biomarkers for hepatit...

journal_title：Scientific reports

authors： Wang G,Lu X,Du Q,Zhang G,Wang D,Wang Q,Guo X

更新日期：2020-08-11 00:00:00

abstract：:"Missing heritability" in genome wide association studies, the failure to account for a considerable fraction of heritability by the variants detected, is a current puzzle in human genetics. For solving this puzzle the involvement of genetic variants like rare single nucleotide polymorphisms (SNPs) and copy number var...

journal_title：Scientific reports

authors： Nagao Y

更新日期：2015-11-24 00:00:00

abstract：:Nuclear factor-kB (NF-kB) is a crucial transcription factor in the signal transduction cascade of the inflammatory signaling. Activation of NF-κB depends on the phosphorylation of IκBα by IκB kinase (IKKβ) followed by subsequent ubiquitination and degradation. This leads to the nuclear translocation of the p50- p65 su...

journal_title：Scientific reports

authors： Baig MS,Roy A,Saqib U,Rajpoot S,Srivastava M,Naim A,Liu D,Saluja R,Faisal SM,Pan Q,Turkowski K,Darwhekar GN,Savai R

更新日期：2018-08-20 00:00:00

abstract：:Aggression and responsiveness to noxious stimuli are adaptable traits that are ubiquitous throughout the animal kingdom. Like vertebrate animals, some invertebrates have been shown to exhibit anxiety-like behaviour and altered levels of aggression that are modulated by the neurotransmitter serotonin. To investigate wh...

journal_title：Scientific reports

authors： Hamilton TJ,Kwan GT,Gallup J,Tresguerres M

更新日期：2016-01-25 00:00:00

abstract：:Across multiple taxa, population structure and dynamics depend on effective signalling between individuals. Among mammals, chemical communication is arguably the most important sense, underpinning mate choice, parental care, territoriality and even disease transmission. There is a growing body of evidence that odours ...

journal_title：Scientific reports

authors： Kean EF,Bruford MW,Russo IM,Müller CT,Chadwick EA

更新日期：2017-10-19 00:00:00

abstract：:Tin selenide has attracted much research interest due to its unprecedentedly high thermoelectric figure of merit (ZT). For real applications, it is desirable to increase the ZT value in the lower-temperature range, as the peak ZT value currently exists near the melting point. It is shown in this paper that the structu...

journal_title：Scientific reports

authors： Yu H,Dai S,Chen Y

更新日期：2016-05-19 00:00:00

abstract：:The purpose of this study was to investigate a preclinical spectral photon-counting CT (SPCCT) prototype compared to conventional CT for pulmonary imaging. A custom-made lung phantom, including nodules of different sizes and shapes, was scanned with a preclinical SPCCT and a conventional CT in standard and high-resolu...

journal_title：Scientific reports

authors： Kopp FK,Daerr H,Si-Mohamed S,Sauter AP,Ehn S,Fingerle AA,Brendel B,Pfeiffer F,Roessl E,Rummeny EJ,Pfeiffer D,Proksa R,Douek P,Noël PB

更新日期：2018-11-26 00:00:00

abstract：:We aimed to evaluate the etiologies of constipation in patients with anorectal malformations having a good prognosis for bowel control but a high risk of constipation. We included twenty-five patients from the Odense university hospital in Denmark. Patients were subjected to colon transit time examination and high res...

journal_title：Scientific reports

authors： Bjørsum-Meyer T,Christensen P,Baatrup G,Jakobsen MS,Asmussen J,Qvist N

更新日期：2020-11-12 00:00:00

abstract：:We demonstrate a label-free imaging approach to study cardiac remodeling of fibrotic and hypertrophic hearts, bridging scales from the whole organ down to the molecular level. To this end, we have used mice subjected to transverse aortic constriction and imaged adjacent cardiac tissue sections by microfocus X-ray diff...

journal_title：Scientific reports

authors： Nicolas JD,Khan A,Markus A,Mohamed BA,Toischer K,Alves F,Salditt T

更新日期：2020-11-09 00:00:00

abstract：:The heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is considered as a human carcinogenic or mutagenic compound that is produced from the co-condensation of creatinine and amino acids as meats cook at high temperatures. The cooking of meats at high temperatures produces fumes, and these fumes...

journal_title：Scientific reports

authors： Poudel BK,Choi J,Park JH,Doh KO,Byeon JH

更新日期：2017-09-07 00:00:00

abstract：:Glucocorticoid receptor is a transcription factor that is ubiquitously expressed. Glucocorticoids are circadian steroids that regulate a wide range of bodily functions, including immunity. Here we report that synthetic glucocorticoids affect 1035 mRNAs in isolated healthy human blood monocytes but only 165 in the resp...

journal_title：Scientific reports

authors： Wang C,Nanni L,Novakovic B,Megchelenbrink W,Kuznetsova T,Stunnenberg HG,Ceri S,Logie C

更新日期：2019-02-26 00:00:00

abstract：:Pesticides are the main tactics for pest control because they reduce the pest population very fast and their efficiency does not depend on abiotic factors. However, the indiscriminate use of these substances can speed up the development of resistant populations and causing environmental contamination. Therefore, alter...

journal_title：Scientific reports

authors： Campos EVR,Proença PLF,Oliveira JL,Pereira AES,de Morais Ribeiro LN,Fernandes FO,Gonçalves KC,Polanczyk RA,Pasquoto-Stigliani T,Lima R,Melville CC,Della Vechia JF,Andrade DJ,Fraceto LF

更新日期：2018-05-16 00:00:00

abstract：:Sensitivity to sounds is one frequent symptom of a sport-related concussion, but its assessment rarely goes beyond a single question. Here we examined sensitivity to sounds using psychoacoustic and psychometric outcomes in athletes beyond the acute phase of injury. Fifty-eight college athletes with normal hearing who ...

journal_title：Scientific reports

authors： Assi H,Moore RD,Ellemberg D,Hébert S

更新日期：2018-07-02 00:00:00

abstract：:A universal technology for the encapsulative protection of unstable anionic species by highly stable layered metal oxide has been developed via the surface modification of a metal oxide nanosheet. The surface anchoring of (3-aminopropyl)triethoxysilane (APTES) on exfoliated titanate nanosheet yields a novel cationic m...

journal_title：Scientific reports

authors： Kim TW,Kim IY,Park DH,Choy JH,Hwang SJ

更新日期：2016-02-24 00:00:00

abstract：:In this article, we report the first observation of nanosecond laser induced transient dual absorption bands, one in the bandgap (TA₁) and another in the sub-bandgap (TA₂) regions of a-Ge₅As₃₀Se₆₅ thin films. Strikingly, these bands are thermally tunable and exhibit a unique contrasting characteristic: the magnitude o...

journal_title：Scientific reports

authors： Khan P,Saxena T,Jain H,Adarsh KV

更新日期：2014-10-10 00:00:00

abstract：:MBL2 gene encodes mannose-binding lectin, is a member of innate immune system. Earlier studies revealed that MBL2 gene variants, rs1800451, rs1800450, rs5030737, rs7096206, rs11003125 and rs7095891 are associated with impaired serum level and susceptibility to TB, but their results are inconsistent. A meta-analysis wa...

journal_title：Scientific reports

authors： Areeshi MY,Mandal RK,Akhter N,Dar SA,Jawed A,Wahid M,Mahto H,Panda AK,Lohani M,Haque S

更新日期：2016-11-23 00:00:00

abstract：:Antibody phage display has been pivotal in the quest to generate human monoclonal antibodies for biomedical and research applications. Target antigen preparation is a main bottleneck associated with the panning process. This includes production complexity, downstream purification, quality and yield. In many instances,...

journal_title：Scientific reports

authors： Lim CC,Woo PCY,Lim TS

更新日期：2019-04-15 00:00:00

abstract：:Microinjection is commonly performed to achieve fish transgenesis; however, due to difficulties associated with this technique, new strategies are being developed. Here we evaluate the potential of lentiviral particles to genetically modify Nile tilapia cells to achieve transgenesis using three different approaches: s...

journal_title：Scientific reports

authors： Tonelli FM,Lacerda SM,Procópio MS,Lemos BL,de França LR,Resende RR

更新日期：2017-03-20 00:00:00