当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Extensive epigenomic integration of the glucocorticoid response in primary human monocytes and in vitro derived macrophages.

Extensive epigenomic integration of the glucocorticoid response in primary human monocytes and in vitro derived macrophages.

Abstract：

:Glucocorticoid receptor is a transcription factor that is ubiquitously expressed. Glucocorticoids are circadian steroids that regulate a wide range of bodily functions, including immunity. Here we report that synthetic glucocorticoids affect 1035 mRNAs in isolated healthy human blood monocytes but only 165 in the respective six day-old monocyte-derived macrophages. The majority of the glucocorticoid response in monocytes concerns genes that are dynamic upon monocyte to macrophage differentiation, whereby macrophage-like mRNA levels are often reached in monocytes within four hours of treatment. Concomitantly, over 5000 chromosomal H3K27ac regions undergo remodelling, of which 60% involve increased H3K27ac signal. We find that chromosomal glucocorticoid receptor binding sites correlate with positive but not with negative local epigenomic effects. To investigate further we assigned our data to topologically associating domains (TADs). This shows that about 10% of macrophage TADs harbour at least one GR binding site and that half of all the glucocorticoid-induced H3K27ac regions are confined to these TADs. Our analyses are therefore consistent with the notion that TADs naturally accommodate information from sets of distal glucocorticoid response elements.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wang C,Nanni L,Novakovic B,Megchelenbrink W,Kuznetsova T,Stunnenberg HG,Ceri S,Logie C

doi

10.1038/s41598-019-39395-9

subject

Has Abstract

pub_date

2019-02-26 00:00:00

pages

2772

issue

1

issn

2045-2322

pii

10.1038/s41598-019-39395-9

journal_volume

9

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Differential depression of neuronal network activity by midazolam and its main metabolite 1-hydroxymidazolam in cultured neocortical slices.

    abstract：:The benzodiazepine midazolam is widely used in critical care medicine. Midazolam has a clinically active metabolite, 1-hydroxymidazolam. The contribution of 1-hydroxymidazolam to the effects of midazolam is controversial. The aim of the current study was to compare the actions of midazolam and 1-hydroxymidazolam on ne...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03154-5

    authors： Balk M,Hentschke H,Rudolph U,Antkowiak B,Drexler B

    更新日期：2017-06-14 00:00:00

  • Production of genetically engineered mice with higher efficiency, lower mosaicism, and multiplexing capability using maternally expressed Cas9.

    abstract：:The CRISPR/Cas9 system is widely used to generate gene-edited animals. Here, we developed an efficient system for generating genetically modified mice using maternal Cas9 from Cas9 transgenic mice. Using this system, we achieved lower mosaicism and higher rates of knock-in success, gene-editing, and birth compared to ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-57996-7

    authors： Sakurai T,Kamiyoshi A,Kawate H,Watanabe S,Sato M,Shindo T

    更新日期：2020-01-23 00:00:00

  • Predicting Microstructural Void Nucleation in Discontinuous Fiber Composites through Coupled in-situ X-ray Tomography Experiments and Simulations.

    abstract：:Composite materials have become widely used in engineering applications, in order to reduce the overall weight of structures while retaining their required strength. In this work, a composite material consisting of discontinuous glass fibers in a polypropylene matrix is studied at the microstructural level through cou...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-60368-w

    authors： Hanhan I,Agyei RF,Xiao X,Sangid MD

    更新日期：2020-02-27 00:00:00

  • Identification of lncRNA functions in lung cancer based on associated protein-protein interaction modules.

    abstract：:Long non-coding RNAs (lncRNAs) have been found to play important roles in various biological processes; however, many of their functions remain unclear. In this study, we present a novel approach to identify the lncRNA-associated protein-protein interaction (PPI) modules and ascertain their functions in human lung squ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep35939

    authors： Wu CH,Hsu CL,Lu PC,Lin WC,Juan HF,Huang HC

    更新日期：2016-10-27 00:00:00

  • Detection of replicative Kashmir Bee Virus and Black Queen Cell Virus in Asian hornet Vespa velutina (Lepelieter 1836) in Italy.

    abstract：:Information concerning the pathogenic role of honey bee viruses in invasive species are still scarce. The aim of this investigation was to assess the presence of several honey bee viruses, such as Black Queen Cell Virus (BQCV), Kashmir Bee Virus (KBV), Slow Paralysis Virus (SPV), Sac Brood Virus (SBV), Israeli Acute P...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46565-2

    authors： Mazzei M,Cilia G,Forzan M,Lavazza A,Mutinelli F,Felicioli A

    更新日期：2019-07-12 00:00:00

  • Controlled mud-crack patterning and self-organized cracking of polydimethylsiloxane elastomer surfaces.

    abstract：:Exploiting pattern formation - such as that observed in nature - in the context of micro/nanotechnology could have great benefits if coupled with the traditional top-down lithographic approach. Here, we demonstrate an original and simple method to produce unique, localized and controllable self-organised patterns on e...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep14787

    authors： Seghir R,Arscott S

    更新日期：2015-10-06 00:00:00

  • Relationship between frequency of hypoglycemic episodes and changes in carotid atherosclerosis in insulin-treated patients with type 2 diabetes mellitus.

    abstract：:The effect of hypoglycemia on the progression of atherosclerosis in patients with type 2 diabetes mellitus (T2DM) remains largely unknown. This is a post hoc analysis of a randomized trial to investigate the relationship between hypoglycemic episodes and changes in carotid intima-media thickness (IMT). Among 274 study...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep39965

    authors： Mita T,Katakami N,Shiraiwa T,Yoshii H,Kuribayashi N,Osonoi T,Kaneto H,Kosugi K,Umayahara Y,Gosho M,Shimomura I,Watada H

    更新日期：2017-01-09 00:00:00

  • Impact of drought stress on simultaneously occurring pathogen infection in field-grown chickpea.

    abstract：:Drought stress and pathogen infection simultaneously occur in the field. In this study, the interaction of these two stresses with chickpea, their individual and combined effect and the net impact on plant growth and yield traits were systematically assessed under field and confined pot experiments. The field experime...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41463-z

    authors： Sinha R,Irulappan V,Mohan-Raju B,Suganthi A,Senthil-Kumar M

    更新日期：2019-04-03 00:00:00

  • A novel immune prognostic index for stratification of high-risk patients with early breast cancer.

    abstract：:The prognostic value of current multigene assays for breast cancer is limited to hormone receptor-positive, human epidermal growth factor receptor 2-negative early breast cancer. Despite the prognostic significance of immune response-related genes in breast cancer, immune gene signatures have not been incorporated int...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80274-5

    authors： Lee H,Kwon MJ,Koo BM,Park HG,Han J,Shin YK

    更新日期：2021-01-08 00:00:00

  • Lead palladium titanate: A room temperature nanoscale multiferroic thin film.

    abstract：:The discovery of single-phase multiferroic materials and the understanding of coupling mechanisms between their spin and polarization is important from the point of view of next generation logic and memory devices. Herein we report the fabrication, dielectric, ferroelectric, piezo-response force microscopy, and magnet...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59961-w

    authors： Mishra KK,Instan AA,Kumari S,Scott JF,Katiyar RS

    更新日期：2020-02-19 00:00:00

  • Ti12C68: A stable T h -symmetry hollow cage.

    abstract：:A stable T h -symmetry Ti12C68 cage was systemically investigated using density functional theory. The structure of Ti12C68 is a hollow cage with twelve TiC13 subunit of three pentagons and one hexagon. The calculated frequencies are in the range 95.1 cm-1-1423.9 cm-1. There are no imaginary frequencies, showing its k...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-22381-y

    authors： Ai LY,Zhao HY,Ma HM,Wang J,Liu Y

    更新日期：2018-03-08 00:00:00

  • Analysis of Bioactive Amino Acids from Fish Hydrolysates with a New Bioinformatic Intelligent System Approach.

    abstract：:The current economics of the fish protein industry demand rapid, accurate and expressive prediction algorithms at every step of protein production especially with the challenge of global climate change. This help to predict and analyze functional and nutritional quality then consequently control food allergies in hype...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10890-1

    authors： Elaziz MA,Hemdan AM,Hassanien A,Oliva D,Xiong S

    更新日期：2017-09-07 00:00:00

  • Satellite gravity measurement monitoring terrestrial water storage change and drought in the continental United States.

    abstract：:We use satellite gravity measurements in the Gravity Recovery and Climate Experiment (GRACE) to estimate terrestrial water storage (TWS) change in the continental United States (US) from 2003 to 2012, and establish a GRACE-based Hydrological Drought Index (GHDI) for drought monitoring. GRACE-inferred TWS exhibits oppo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19909

    authors： Yi H,Wen L

    更新日期：2016-01-27 00:00:00

  • Alteration of PD-L1 expression and its prognostic impact after concurrent chemoradiation therapy in non-small cell lung cancer patients.

    abstract：:Concurrent chemoradiation therapy (CCRT) is the treatment of choice for locally advanced non-small cell lung cancer (LA-NSCLC). Several clinical trials that combine programmed cell death 1 (PD-1) axis inhibitors with radiotherapy are in development for patients with LA-NSCLC. However, the effect of CCRT on programmed ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-11949-9

    authors： Fujimoto D,Uehara K,Sato Y,Sakanoue I,Ito M,Teraoka S,Nagata K,Nakagawa A,Kosaka Y,Otsuka K,Imai Y,Hamakawa H,Takahashi Y,Kokubo M,Tomii K

    更新日期：2017-09-12 00:00:00

  • Studies of the oligomerisation mechanism of a cystatin-based engineered protein scaffold.

    abstract：:Engineered protein scaffolds are an alternative to monoclonal antibodies in research and drug design due to their small size, ease of production, versatility, and specificity for chosen targets. One key consideration when engineering such proteins is retaining the original scaffold structure and stability upon inserti...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45565-6

    authors： Zalar M,Indrakumar S,Levy CW,Tunnicliffe RB,Peters GHJ,Golovanov AP

    更新日期：2019-06-21 00:00:00

  • Fukushima radionuclides in the NW Pacific, and assessment of doses for Japanese and world population from ingestion of seafood.

    abstract：:Variations of Fukushima-derived radionuclides ((90)Sr, (134)Cs and (137)Cs) in seawater and biota offshore Fukushima and in the NW Pacific Ocean were investigated and radiation doses to the Japanese and world population from ingestion of seafood contaminated by Fukushima radionuclides were estimated and compared with ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09016

    authors： Povinec PP,Hirose K

    更新日期：2015-03-12 00:00:00

  • The effectiveness of virtual reality based interventions for symptoms of anxiety and depression: A meta-analysis.

    abstract：:We report a meta-analysis of virtual reality (VR) interventions for anxiety and depression outcomes, as well as treatment attrition. We included randomized controlled trials comparing VR interventions, alone or in combination, to control conditions or other active psychological interventions. Effects sizes (Hedges' g)...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41598-018-28113-6

    authors： Fodor LA,Coteț CD,Cuijpers P,Szamoskozi Ș,David D,Cristea IA

    更新日期：2018-07-09 00:00:00

  • A novel process of viral vector barcoding and library preparation enables high-diversity library generation and recombination-free paired-end sequencing.

    abstract：:Detailed characterization and mapping of oligonucleotide function in vivo is generally a very time consuming effort that only allows for hypothesis driven subsampling of the full sequence to be analysed. Recent advances in deep sequencing together with highly efficient parallel oligonucleotide synthesis and cloning te...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37563

    authors： Davidsson M,Diaz-Fernandez P,Schwich OD,Torroba M,Wang G,Björklund T

    更新日期：2016-11-22 00:00:00

  • Morphological Detection and Functional Assessment of Regenerated Nerve after Neural Prosthesis with a PGLA Nerve Conduit.

    abstract：:This study aimed to observe the morphological characteristics of a PGLA [poly(glycolide-co-L-lactide)] nerve conduit and regenerated nerve bundle in the human body using high-frequency ultrasound and examine functional recovery of the regenerated nerve using functional magnetic resonance imaging (fMRI) after neural pr...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/srep46403

    authors： Gao D,Jiang JJ,Gu SH,Lu JZ,Xu L

    更新日期：2017-04-13 00:00:00

  • Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites.

    abstract：:Activation-induced cytidine deaminase (AID) triggers antibody diversification in B cells by catalysing deamination and subsequently mutating immunoglobulin (Ig) genes. Association of AID with RNA Pol II and occurrence of epigenetic changes during Ig gene diversification suggest participation of AID in epigenetic regul...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07380-9

    authors： Rodríguez-Cortez VC,Martínez-Redondo P,Català-Moll F,Rodríguez-Ubreva J,Garcia-Gomez A,Poorani-Subramani G,Ciudad L,Hernando H,Pérez-García A,Company C,Urquiza JM,Ramiro AR,Di Noia JM,Vaquero A,Ballestar E

    更新日期：2017-08-08 00:00:00

  • Task-dependent functional organizations of the visual ventral stream.

    abstract：:The visual hierarchy of the ventral stream has been widely studied. However, it remains unclear how the hierarchical system organizes its functional coupling during top-down cognitive process. The present fMRI study investigated task-dependent functional connectivity along the ventral stream, while twenty-eight partic...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45707-w

    authors： Jo HG,Ito J,Schulte Holthausen B,Baumann C,Grün S,Habel U,Kellermann T

    更新日期：2019-06-27 00:00:00

  • Transient photothermal inactivation of Escherichia coli stained with visible dyes by using a nanosecond pulsed laser.

    abstract：:Efficient inactivation of Escherichia coli (E. coli) under visible (532 nm) pulsed light irradiation was achieved by fusion of a visible light-absorbing dye with E. coli. Inactivation experiments showed that 3-log inactivation of E. coli was obtained within 20 min under a 50 kJ/cm2 dose. This treatment time and dose m...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-74714-5

    authors： Kohmura Y,Igami N,Tatsuno I,Hasegawa T,Matsumoto T

    更新日期：2020-10-20 00:00:00

  • Test-retest reproducibility of cardiac magnetic resonance imaging in healthy mice at 7-Tesla: effect of anesthetic procedures.

    abstract：:Cardiac magnetic resonance (CMR) has emerged as a powerful tool for in vivo assessments of cardiac parameters in experimental animal models of cardiovascular diseases, but its reproducibility in this setting remains poorly explored. To address this issue, we investigated the test-retest reproducibility of preclinical ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07083-1

    authors： Joubert M,Tager P,Legallois D,Defourneaux E,Le Guellec B,Gerber B,Morello R,Manrique A

    更新日期：2017-07-27 00:00:00

  • Lipid-II forms potential "landing terrain" for lantibiotics in simulated bacterial membrane.

    abstract：:Bacterial cell wall is targeted by many antibiotics. Among them are lantibiotics, which realize their function via interaction with plasma membrane lipid-II molecule - a chemically conserved part of the cell wall synthesis pathway. To investigate structural and dynamic properties of this molecule, we have performed a ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep01678

    authors： Chugunov A,Pyrkova D,Nolde D,Polyansky A,Pentkovsky V,Efremov R

    更新日期：2013-01-01 00:00:00

  • Clinical characteristics in patients with ossification of the posterior longitudinal ligament: A prospective multi-institutional cross-sectional study.

    abstract：:Ossification of the posterior longitudinal ligament (OPLL) can occur throughout the entire spine and can sometimes lead to spinal disorder. Although patients with OPLL sometimes develop physical limitations because of pain, the characteristics of pain and effects on activities of daily living (ADL) have not been preci...

    journal_title：Scientific reports

    pub_type： 杂志文章,多中心研究

    doi：10.1038/s41598-020-62278-3

    authors： Hirai T,Yoshii T,Ushio S,Mori K,Maki S,Katsumi K,Nagoshi N,Takeuchi K,Furuya T,Watanabe K,Nishida N,Watanabe K,Kaito T,Kato S,Nagashima K,Koda M,Ito K,Imagama S,Matsuoka Y,Wada K,Kimura A,Ohba T,Katoh H,Mats

    更新日期：2020-03-26 00:00:00

  • Silicon moderated the K deficiency by improving the plant-water status in sorghum.

    abstract：:Although silicon (Si) has been widely reported to alleviate plant nutrient deficiency, the underlying mechanism in potassium (K) deficiency is poorly understood. In this study, sorghum seedlings were treated with Si under a K deficiency condition for 15 days. Under control conditions, plant growth was not affected by ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep22882

    authors： Chen D,Cao B,Wang S,Liu P,Deng X,Yin L,Zhang S

    更新日期：2016-03-10 00:00:00

  • Identification of significant precursor gases of secondary organic aerosols from residential wood combustion.

    abstract：:Organic gases undergoing conversion to form secondary organic aerosol (SOA) during atmospheric aging are largely unidentified, particularly in regions influenced by anthropogenic emissions. SOA dominates the atmospheric organic aerosol burden and this knowledge gap contributes to uncertainties in aerosol effects on cl...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27881

    authors： Bruns EA,El Haddad I,Slowik JG,Kilic D,Klein F,Baltensperger U,Prévôt AS

    更新日期：2016-06-17 00:00:00

  • Low energy cost for cultured pearl formation in grafted chimeric Pinctada margaritifera.

    abstract：:The pearl oyster is one of the rare animal models that support two distinct genomes, through the surgical graft process operated for culture pearl production. This grafted organism is assimilated to a chimera whose physiological functioning remains poorly known. The question of the energy expenditure comparison betwee...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-25360-5

    authors： Le Moullac G,Soyez C,Ky CL

    更新日期：2018-05-14 00:00:00

  • Development and characterization of a duplex PCR assay in Chinese sturgeon (Acipenser sinensis) for genetic analysis.

    abstract：:Chinese sturgeon (Acipenser sinensis) has been listed as a critically endangered species on the IUCN Red List and is an endemic fish of China. Five sets of duplex polymerase chain reactions (PCR) assays were developed with 10 tetranucleotide microsatellites for Chinese sturgeon. The size of CS57, ZHX43, ZHX69, AS105, ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-60401-y

    authors： Hu Y,Liu X,Yang J,Xiao K,Wang B,Du H

    更新日期：2020-02-26 00:00:00

  • Hematocrit, hemoglobin and red blood cells are associated with vascular function and vascular structure in men.

    abstract：:High and low hematocrit (Hct) and hemoglobin (Hb) levels are associated with the risk of cardiovascular disease. The purpose of this study was to determine the relationships of Hct, Hb and red blood cells (RBCs) with vascular function and structure. We measured flow-mediated vasodilation (FMD), nitroglycerin-induced v...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-68319-1

    authors： Kishimoto S,Maruhashi T,Kajikawa M,Matsui S,Hashimoto H,Takaeko Y,Harada T,Yamaji T,Han Y,Kihara Y,Chayama K,Goto C,Yusoff FM,Nakashima A,Higashi Y

    更新日期：2020-07-10 00:00:00