TGFβ1 reinforces arterial aging in the vascular smooth muscle cell through a long-range regulation of the cytoskeletal stiffness.

abstract：:Rice (Oryza sativa L.) is one of the essential staple food crops and tillering, panicle branching and grain filling are three important traits determining the grain yield. Although miRNAs have been reported being regulating yield, no study has systematically investigated how miRNAs differentially function in high and ...

journal_title：Scientific reports

authors： Hu J,Zeng T,Xia Q,Qian Q,Yang C,Ding Y,Chen L,Wang W

更新日期：2018-05-31 00:00:00

abstract：:As a human fungal pathogen, Candida albicans can cause a wide variety of disease conditions ranging from superficial to systemic infections. Many of these infections are caused by an inherent ability of the pathogen to form biofilms on medical devices resulting in high mortality. Biofilms formed by C. albicans are a c...

journal_title：Scientific reports

authors： Kakade P,Sadhale P,Sanyal K,Nagaraja V

更新日期：2016-08-08 00:00:00

abstract：:The aim of this study was to identify mRNA targets of dysregulated miRNAs through the integrated analysis of miRNA and mRNA expression profiling in men with normal versus impaired spermatogenesis. The expression of mRNAs and miRNAs in testicular tissues obtained from males with non-obstructive azoospermia (NOA, n = 4)...

journal_title：Scientific reports

authors： Zhuang X,Li Z,Lin H,Gu L,Lin Q,Lu Z,Tzeng CM

更新日期：2015-01-28 00:00:00

abstract：:Photodynamic therapy (PDT), wherein light sensitive non-toxic agents are locally and selectively activated using light, has emerged as an appealing alternative to traditional cancer chemotherapy. Yet to date, PDT efficacy has been mostly characterized using 2D cultures. Compared to 2D cultures, 3D sphere culture gener...

journal_title：Scientific reports

authors： Chen YC,Lou X,Zhang Z,Ingram P,Yoon E

更新日期：2015-07-08 00:00:00

abstract：:The clinical presentation of diabetes sometimes overlaps, contributing to ambiguity in the diagnosis. Thus, circulating pancreatic islet-enriched microRNAs (miRNAs) might be useful biomarkers of β-cell injury/dysfunction that would allow more accurate subtyping of diabetes. We measured plasma levels of selected miRNAs...

journal_title：Scientific reports

authors： Seyhan AA,Nunez Lopez YO,Xie H,Yi F,Mathews C,Pasarica M,Pratley RE

更新日期：2016-08-25 00:00:00

abstract：:Breast cancer is the most frequently diagnosed malignancy among women, and triple-negative breast cancer (TNBC) is a highly aggressive subtype. Increasing evidence has shown that lncRNAs are involved in tumor growth, cell-cycle, and apoptosis through interactions with miRNAs or mRNAs. However, there is still limited d...

journal_title：Scientific reports

authors： Le K,Guo H,Zhang Q,Huang X,Xu M,Huang Z,Yi P

更新日期：2019-10-22 00:00:00

abstract：:Although gut microbiota and early life events are likely involved in the development of irritable bowel syndrome (IBS), it remains unclear how these factors interact in the pathophysiology of IBS. In the present study, using rats subjected to maternal separation (MS) as a model of IBS, we investigated interrelationshi...

journal_title：Scientific reports

authors： Fukui H,Oshima T,Tanaka Y,Oikawa Y,Makizaki Y,Ohno H,Tomita T,Watari J,Miwa H

更新日期：2018-08-17 00:00:00

abstract：:The psychrophilic (cold-loving) fungus Pseudogymnoascus destructans was discovered more than a decade ago to be the pathogen responsible for white-nose syndrome, an emerging disease of North American bats causing unprecedented population declines. The same species of fungus is found in Europe but without associated mo...

journal_title：Scientific reports

authors： Ren P,Rajkumar SS,Zhang T,Sui H,Masters PS,Martinkova N,Kubátová A,Pikula J,Chaturvedi S,Chaturvedi V

更新日期：2020-08-17 00:00:00

abstract：:High-density living is often associated with high disease risk due to density-dependent epidemic spread. Despite being paragons of high-density living, the social insects have largely decoupled the association with density-dependent epidemics. It is hypothesized that this is accomplished through prophylactic and induc...

journal_title：Scientific reports

authors： Quevillon LE,Hanks EM,Bansal S,Hughes DP

更新日期：2015-08-24 00:00:00

abstract：:We evaluate the track segment yield G' of typical water radiolysis products (eaq-, ·OH and H2O2) under heavy ions (He, C and Fe ions) using a Monte Carlo simulation code in the Geant4-DNA. Furthermore, we reproduce experimental results of ·OH of He and C ions around the Bragg peak energies (< 6 MeV/u). In the relative...

journal_title：Scientific reports

authors： Baba K,Kusumoto T,Okada S,Ogawara R,Kodaira S,Raffy Q,Barillon R,Ludwig N,Galindo C,Peaupardin P,Ishikawa M

更新日期：2021-01-15 00:00:00

abstract：:Physiological regulation of blood flow in bone marrow is important to maintain oxygen and glucose supplies but also the physiological hypoxic state of the hematopoietic stem cell (HSC) niche. However, regulatory mechanisms underlying microcirculation in the bone marrow (BM) niche remain unclear. Here, we identify vess...

journal_title：Scientific reports

authors： Morikawa T,Tamaki S,Fujita S,Suematsu M,Takubo K

更新日期：2020-04-14 00:00:00

abstract：:Global climate change has resulted in a warmer Arctic, with projections indicating accelerated modifications to permafrost in the near future. The thermal, hydrological, and mechanical physics of permafrost thaw have been hypothesized to couple in a complex fashion but data collection efforts to study these feedbacks ...

journal_title：Scientific reports

authors： Wagner AM,Lindsey NJ,Dou S,Gelvin A,Saari S,Williams C,Ekblaw I,Ulrich C,Borglin S,Morales A,Ajo-Franklin J

更新日期：2018-07-19 00:00:00

abstract：:Small heat shock proteins are ubiquitous molecular chaperones that form the first line of defence against the detrimental effects of cellular stress. Under conditions of stress they undergo drastic conformational rearrangements in order to bind to misfolded substrate proteins and prevent cellular protein aggregation. ...

journal_title：Scientific reports

authors： Mani N,Bhandari S,Moreno R,Hu L,Prasad BVV,Suguna K

更新日期：2016-04-07 00:00:00

abstract：:Enzymes that cleave polysaccharides in lignocellulose, i. e., cellulases, xylanases, and accessory enzymes, play crucial roles in the natural decomposition of plant-derived biomass and its efficient and sustainable processing into biofuels or other bulk chemicals. The analysis of open reading frame cthe_2195 from the ...

journal_title：Scientific reports

authors： Heinze S,Mechelke M,Kornberger P,Liebl W,Schwarz WH,Zverlov VV

更新日期：2017-09-11 00:00:00

abstract：:Bisphenol (BP)A is an endocrine disruptor (ED) widely used in thermal papers. Regulatory restrictions have been established to prevent risks for human health, leading to BPA substitution by structural analogues, like BPS and BPF. We previously demonstrated that oral perinatal exposure to BPA had long-term consequences...

journal_title：Scientific reports

authors： Malaisé Y,Lencina C,Cartier C,Olier M,Ménard S,Guzylack-Piriou L

更新日期：2021-01-18 00:00:00

abstract：:Although low socioeconomic status (SES) is related to poor glycemic control, the underlying mechanisms remain unclear. We examined potentially modifiable factors involved in the association between low SES and poor glycemic control using data from the baseline survey of a multicenter, prospective cohort study. Five hu...

journal_title：Scientific reports

authors： Rahman M,Nakamura K,Hasan SMM,Seino K,Mostofa G

更新日期：2020-04-21 00:00:00

abstract：:Corticofugal fibers target the subthalamic nucleus (STN), a component nucleus of the basal ganglia, in addition to the striatum, their main input. The cortico-subthalamic, or hyperdirect, pathway, is thought to supplement the cortico-striatal pathways in order to interrupt/change planned actions. To explore the previo...

journal_title：Scientific reports

authors： Froux L,Le Bon-Jego M,Miguelez C,Normand E,Morin S,Fioramonti S,Barresi M,Frick A,Baufreton J,Taupignon A

更新日期：2018-06-11 00:00:00

abstract：:Millions of individuals worldwide suffer from impaired vision, a condition with multiple origins that often impinge upon the light sensing cells of the retina, the photoreceptors, affecting their integrity. The molecular components contributing to this integrity are however not yet fully understood. Here we have asked...

journal_title：Scientific reports

authors： Cisneros E,di Marco F,Rueda-Carrasco J,Lillo C,Pereyra G,Martín-Bermejo MJ,Vargas A,Sanchez R,Sandonís Á,Esteve P,Bovolenta P

更新日期：2020-03-20 00:00:00

abstract：:We aimed to establish a highly sensitive method for measuring visual function using spatial-sweep steady-state pattern electroretinography (swpPERG). Overall, 35 eyes of 35 healthy adults (18 men; mean age, 32.3 years) were examined using swpPERG, and the data were recorded using spatial-patterned and contrast-reverse...

journal_title：Scientific reports

authors： Minami S,Nagai N,Suzuki M,Kurihara T,Sonobe H,Watanabe K,Shinoda H,Takagi H,Tsubota K,Ozawa Y

更新日期：2019-12-02 00:00:00

abstract：:Success of immunotherapeutic approaches using genetically engineered antibodies and T cells modified with chimeric antigen receptors (CARs) depends, among other things, on the selection of antigen binding domains with desirable expression and binding characteristics. We developed a luciferase-based assay, termed Malib...

journal_title：Scientific reports

authors： Natarajan V,Gopalakrishnan R,Matta H,Choi S,Gong S,Jeronimo A,Keerthipati PS,Morales A,Venkatesh H,Chaudhary PM

更新日期：2020-02-11 00:00:00

abstract：:Developing the high-efficient and green synthetic method for chiral amino alcohols is an intriguing target. We have developed the Mg(2+)-doped Cu/ZnO/Al2O3 catalyst for hydrogenation of L-phenylalanine methyl ester to chiral L-phenylalaninol without racemization. The effect of different L-phenylalanine esters on this ...

journal_title：Scientific reports

authors： Zhang S,Yu J,Li H,Mao D,Lu G

更新日期：2016-09-13 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Ihara T,Nakamura Y,Mitsui T,Tsuchiya S,Kanda M,Kira S,Nakagomi H,Sawada N,Kamiyama M,Shigetomi E,Shinozaki Y,Yoshiyama M,Nakao A,Koizumi S,Takeda M

更新日期：2019-11-08 00:00:00

abstract：:As part of an ongoing study of new insulin mimetic agents from medicinal plants, the 70% EtOH extract of Symplocos cochinchinensis was found to have a stimulatory effect on glucose uptake in 3T3-L1 adipocyte cells. The intensive targeted isolation of this active extract resulted in ten new hydroxyoleoside-type compoun...

journal_title：Scientific reports

authors： Lee BW,Ha TKQ,Pham HTT,Hoang QH,Tran VO,Oh WK

更新日期：2019-02-19 00:00:00

abstract：:Solar thermal energy conversion has attracted substantial renewed interest due to its applications in industrial heating, air conditioning, and electricity generation. Achieving stagnation temperatures exceeding 200 °C, pertinent to these technologies, with unconcentrated sunlight requires spectrally selective absorbe...

journal_title：Scientific reports

authors： Thomas NH,Chen Z,Fan S,Minnich AJ

更新日期：2017-07-13 00:00:00

abstract：:Methods that provide controlled influx of molecules into cells are of critical importance for uncovering cellular mechanisms, drug development and synthetic biology. However, reliable intracellular delivery without adversely affecting the cells is a major challenge. We developed a platform for on-demand intracellular ...

journal_title：Scientific reports

authors： Kavaldzhiev MN,Perez JE,Sougrat R,Bergam P,Ravasi T,Kosel J

更新日期：2018-07-02 00:00:00

abstract：:Lateral organ boundaries domain (LBD) proteins are plant-specific transcription factors that play a crucial role in growth and development, as well as metabolic processes. However, knowledge of the function of LBD proteins in Camellia sinensis is limited, and no systematic investigations of the LBD family have been re...

journal_title：Scientific reports

authors： Zhang X,He Y,He W,Su H,Wang Y,Hong G,Xu P

更新日期：2019-10-30 00:00:00

abstract：:Abscisic acid (ABA) is a phytohormone that is necessary for stress adaptation. Recent studies have reported that attenuated levels of ABA improved grain yield and seedling growth under low temperature in cereals. To improve plant growth under low temperature, we attempted to generate ABA-insensitive transgenic rice by...

journal_title：Scientific reports

authors： Endo A,Egawa C,Oohashi M,Meguro-Maoka A,Shimosaka E,Sato Y

更新日期：2018-08-17 00:00:00

abstract：:The North Atlantic is characterized by diatom-dominated spring blooms that results in significant transfer of carbon to higher trophic levels and the deep ocean. These blooms are terminated by limiting silicate concentrations in summer. Numerous regional studies have demonstrated phytoplankton community shifts to ligh...

journal_title：Scientific reports

authors： Hátún H,Azetsu-Scott K,Somavilla R,Rey F,Johnson C,Mathis M,Mikolajewicz U,Coupel P,Tremblay JÉ,Hartman S,Pacariz SV,Salter I,Ólafsson J

更新日期：2017-11-06 00:00:00

abstract：:A bubble merged from two parent bubbles with different size tends to be placed closer to the larger parent. This phenomenon is known as the coalescence preference. Here we demonstrate that the coalescence preference can be blocked inside a densely packed cluster of bubbles. We utilized high-speed high-resolution X-ray...

journal_title：Scientific reports

authors： Kim Y,Lim SJ,Gim B,Weon BM

更新日期：2015-01-13 00:00:00

abstract：:Inhomogeneity in the ground state is an intriguing, emergent phenomenon in magnetism. Recently, it has been observed in the magnetostructural channel of the geometrically frustrated α-NaMnO2, for the first time in the absence of active charge degrees of freedom. Here we report an in-depth numerical and local-probe exp...

journal_title：Scientific reports

authors： Zorko A,Kokalj J,Komelj M,Adamopoulos O,Luetkens H,Arčon D,Lappas A

更新日期：2015-03-19 00:00:00