Abstract:
:Developing the high-efficient and green synthetic method for chiral amino alcohols is an intriguing target. We have developed the Mg(2+)-doped Cu/ZnO/Al2O3 catalyst for hydrogenation of L-phenylalanine methyl ester to chiral L-phenylalaninol without racemization. The effect of different L-phenylalanine esters on this title reaction was studied, verifying that Cu/ZnO/Al2O3 is an excellent catalyst for the hydrogenation of amino acid esters to chiral amino alcohols. DFT calculation was used to study the adsorption of substrate on the catalyst, and showed that the substrate adsorbs on the surface active sites mainly by amino group (-NH2) absorbed on Al2O3, and carbonyl (C=O) and alkoxy (RO-) group oxygen absorbed on the boundary of Cu and Al2O3. This catalytic hydrogenation undergoes the formation of a hemiacetal intermediate and the cleavage of the C-O bond (rate-determining step) by reacting with dissociated H to obtain amino aldehyde and methanol ad-species. The former is further hydrogenated to amino alcohols, and the latter desorbs from the catalyst surface.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhang S,Yu J,Li H,Mao D,Lu Gdoi
10.1038/srep33196subject
Has Abstractpub_date
2016-09-13 00:00:00pages
33196issn
2045-2322pii
srep33196journal_volume
6pub_type
杂志文章abstract::Curvature components derived from satellite gravity gradients provide new global views of Earth's structure. The satellite gravity gradients are based on the GOCE satellite mission and we illustrate by curvature images how the Earth is seen differently compared to seismic imaging. Tectonic domains with similar seismic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34733-9
更新日期:2018-11-05 00:00:00
abstract::The helicene is constructed by twisted benzene or other aromatic rings, exhibiting a helical structure. Using first-principles calculations, we investigate the electronic transport of helicenes under stretching or compressing. Interestingly, a U-shaped curve of the current against d (the pitch of a helicene) is observ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16731
更新日期:2015-11-19 00:00:00
abstract::Oxygen tolerance of selenium-containing [NiFeSe] hydrogenases (Hases) is attributable to the high reducing power of the selenocysteine residue, which sustains the bimetallic Ni-Fe catalytic center in the large subunit. Genes encoding [NiFeSe] Hases are inherited by few sulphate-reducing δ-proteobacteria globally distr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19742
更新日期:2016-01-28 00:00:00
abstract::Huntington's disease (HD) is a genetically-determined neurodegenerative disease. Characterising neuropathology in mouse models of HD is commonly restricted to cross-sectional ex vivo analyses, beset by tissue fixation issues. In vivo longitudinal magnetic resonance imaging (MRI) allows for disease progression to be pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32423
更新日期:2016-09-01 00:00:00
abstract::The properties of the human mind affect the quality of scientific knowledge through the insertion of unconscious biases during the research process. These biases frequently cause overestimation of the effects under study, thereby violating the reproducibility of the research and potentially leading to incorrect conclu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80677-4
更新日期:2021-01-08 00:00:00
abstract::Pilonidal sinus disease (PSD) is increasing globally. A recent meta-analysis and merged-data analysis showed that recurrence rates in PSD depend essentially on follow-up time and specific surgical procedures. However, the global distribution of surgical approaches and respective recurrence rates have never been studie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51159-z
更新日期:2019-10-22 00:00:00
abstract::Inhibition of DYRK1A kinase, produced by chromosome 21 and consequently overproduced in trisomy 21 subjects, has been suggested as a therapeutic approach to treating the cognitive deficiencies observed in Down syndrome (DS). We now report the synthesis and potent DYRK1A inhibitory activities of fluoro derivatives of 3...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20984-z
更新日期:2018-02-12 00:00:00
abstract::Regime shift from grasslands to shrub-dominated landscapes occur worldwide driven by altered land-use and climate change, affecting landscape function, biodiversity, and productivity. Warming winter temperatures are a main driver of expansion of the native, evergreen shrub, Morella cerifera, in coastal landscapes. Shr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65161-3
更新日期:2020-05-19 00:00:00
abstract::Understanding the factors that modulate bacterial community assembly in natural soils is a longstanding challenge in microbial community ecology. In this work, we compared two microbial co-occurrence networks representing bacterial soil communities from two different sections of a pH, temperature and humidity gradient...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23931-0
更新日期:2018-04-12 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-42462-w
更新日期:2019-04-17 00:00:00
abstract::Single epitaxially-grown semiconductor quantum dots have great potential as single photon sources for photonic quantum technologies, though in practice devices often exhibit nonideal behavior. Here, we demonstrate that amplitude modulation can improve the performance of quantum-dot-based sources. Starting with a brigh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01397
更新日期:2013-01-01 00:00:00
abstract::Peritrichs are a major group of ciliates with worldwide distribution. Yet, its internal phylogeny remains unresolved owing to limited sampling. Additionally, ecological distributions of peritrichs are poorly known. We performed substantially expanded phylogenetic analyses of peritrichs that incorporated SSU rDNA seque...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21695
更新日期:2016-02-16 00:00:00
abstract::Abiotic emergence of ordered information stored in the form of RNA is an important unresolved problem concerning the origin of life. A polymer longer than 40-100 nucleotides is necessary to expect a self-replicating activity, but the formation of such a long polymer having a correct nucleotide sequence by random react...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58060-0
更新日期:2020-02-03 00:00:00
abstract::Seagrass meadows are among the four most productive marine ecosystems in the world. Zostera japonica (Z. japonica) is the most widely distributed species of seagrass in China. However, there is no reference genome or transcriptome available for Z. japonica, impeding progress in functional genomic and molecular ecology...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51176-y
更新日期:2019-10-10 00:00:00
abstract::Two-photon polymerization (TPP) is capable of fabricating 3D structures with dimensions from sub-µm to a few hundred µm. As a direct laser writing (DLW) process, fabrication time of 3D TPP structures scale with the third order, limiting its use in large volume fabrication. Here, we report on a scalable fabrication met...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64955-9
更新日期:2020-05-26 00:00:00
abstract::The field of genome editing was founded on the establishment of methods, such as the clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated protein (CRISPR/Cas) system, used to target DNA double-strand breaks (DSBs). However, the efficiency of genome editing also largely depends on the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58893-9
更新日期:2020-02-13 00:00:00
abstract::Arabidopsis thaliana contains the putative K+ efflux transporters KEA1-KEA6, similar to KefB and KefC of Escherichia coli. KEA1-KEA3 are involved in the regulation of photosynthetic electron transport and chloroplast development. KEA4-KEA6 mediate pH regulation of the endomembrane network during salinity stress. Howev...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46463-7
更新日期:2019-07-11 00:00:00
abstract::Obese individuals can be categorized as "healthy obese" (MHO) and "unhealthy obese" (MUO) based on the presence or absence of metabolic abnormality. This study sets out to assess potential genetic causes behind persistence of healthy metabolic status in individuals categorized as "healthy obese". This study was conduc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70627-5
更新日期:2020-08-12 00:00:00
abstract::In this paper, we investigate the high frequency performance of Co90Zr10/SiO2/Co90Zr10 trilayers. It is demonstrated that the in-plane isotropic microwave performance is theoretically derived from the solution of the Landau-Lifshitz-Gilbert equation and experimentally achieved in that sandwich structured film. The val...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21327
更新日期:2016-02-17 00:00:00
abstract::Hippocampal volumes are smaller in psychiatric disorder patients and lower levels of hippocampal neurogenesis are the hypothesized cause. Understanding which molecular processes regulate hippocampal progenitor differentiation might aid in the identification of novel drug targets that can promote larger hippocampal vol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15042-z
更新日期:2017-11-08 00:00:00
abstract::Mucosal-associated invariant T (MAIT) cells help combat opportunistic infections. Thus, MAIT cells are of interest in HIV/SIV vaccination and infection. We investigated MAIT cell dynamics and function in rhesus macaque blood and bronchoalveolar lavage (BAL) following mucosal adenovirus (Ad)-SIV recombinant priming, in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66964-0
更新日期:2020-06-22 00:00:00
abstract::A practical quantum computer must be capable of performing high fidelity quantum gates on a set of quantum bits (qubits). In the presence of noise, the realization of such gates poses daunting challenges. Geometric phases, which possess intrinsic noise-tolerant features, hold the promise for performing robust quantum ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18414
更新日期:2015-12-21 00:00:00
abstract::Albuminuria is widely used to indicate early phases of diabetic nephropathy although it is limited by the fact that structural damage might precede albumin excretion. This necessitates identifying better biomarkers that diagnose or predict diabetic nephropathy. This is a cross-sectional hospital based study recruiting...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02421-9
更新日期:2017-06-02 00:00:00
abstract::In solid state science, multifunctional materials and especially multiferroics have attracted a great deal of attention, as they open the possibility for next generation spintronic and data storage devices. Interestingly, while many of them host coexisting 3d and 4f elements, the role of the coupling between these two...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15150-w
更新日期:2017-11-06 00:00:00
abstract::The serotonin transporter (SERT) is an integral membrane protein that exploits preexisting sodium-, chloride-, and potassium ion gradients to catalyze the thermodynamically unfavorable movement of synaptic serotonin into the presynaptic neuron. SERT has garnered significant clinical attention partly because it is the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23789
更新日期:2016-04-01 00:00:00
abstract::In the developing central nervous system (CNS), oligodendrocyte precursor cells (OPCs) migrate along blood vessels and are widely distributed in the CNS. Meanwhile, OPCs require survival factors from the extracellular microenvironment. In other tissues, laminins, heterotrimetric (αβγ) extracellular matrix proteins, pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56488-7
更新日期:2019-12-27 00:00:00
abstract::Uterosacral ligaments (USLs) provide structural support to the female pelvic floor, and a loss of USL structural integrity or biomechanical function may induce pelvic organ prolapse (POP). Alterations in extracellular matrix composition and organization dictate USL mechanical function. Changes in USL microstructure an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64192-0
更新日期:2020-04-30 00:00:00
abstract::While molecular-targeted drugs have demonstrated strong therapeutic efficacy against diverse diseases such as cancer and infection, the appearance of drug resistance associated with genetic variations in individual patients or pathogens has severely limited their clinical efficacy. Therefore, precision medicine approa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58877-9
更新日期:2020-02-07 00:00:00
abstract::A high-performance and novel photocatalyst of BiVO4-reduced Graphene Oxide (BiVO4-rGO) nanocomposite was prepared by a facile hydrothermal method. The photocatalyst was characterized by X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electronic microscopy, UV-Vis diffusi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07342-1
更新日期:2017-08-11 00:00:00
abstract::Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been known as a promising agent for cancer therapy due to its specific apoptosis-inducing effect on tumor cells rather than most normal cells. However, systemically delivered TRAIL suffers from a rapid clearance from the body with an extremely short h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41904
更新日期:2017-02-22 00:00:00