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Bisphenol A, S or F mother's dermal impregnation impairs offspring immune responses in a dose and sex-specific manner in mice.

Abstract：

:Bisphenol (BP)A is an endocrine disruptor (ED) widely used in thermal papers. Regulatory restrictions have been established to prevent risks for human health, leading to BPA substitution by structural analogues, like BPS and BPF. We previously demonstrated that oral perinatal exposure to BPA had long-term consequences on immune responses later in life. It appears now essential to enhance our understanding on immune impact of different routes of BP exposure. In this study, we aimed at comparing the impact of mother dermal exposure to BPs on offspring immune system at adulthood. Gravid mice were dermally exposed to BPA, BPS or BPF at 5 or 50 μg/kg of body weight (BW)/day (d) from gestation day 15 to weaning of pups at post-natal day (PND)21. In offspring, BPs dermal impregnation of mothers led to adverse effects on immune response at intestinal and systemic levels that was dependent on the BP, the dose and offspring sex. These findings provide, for the first time, results on long-term consequences of dermal perinatal BPs exposure on immune responses in offspring. This work warns that it is mandatory to consider immune markers, dose exposure as well as sex in risk assessment associated with new BPA's alternatives.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Malaisé Y,Lencina C,Cartier C,Olier M,Ménard S,Guzylack-Piriou L

doi

10.1038/s41598-021-81231-6

subject

Has Abstract

pub_date

2021-01-18 00:00:00

pages

1650

issue

1

issn

2045-2322

pii

10.1038/s41598-021-81231-6

journal_volume

11

pub_type

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