Gauss's law for networks directly reveals community boundaries.

Abstract:

:The study of network topology provides insight into the function and behavior of physical, social, and biological systems. A natural step towards discovering the organizing principles of these complex topologies is to identify a reduced network representation using cohesive subgroups or communities. This procedure often uncovers the underlying mechanisms governing the functional assembly of complex networks. A community is usually defined as a subgraph or a set of nodes that has more edges than would be expected from a simple, null distribution of edges over the graph. This view drives objective such as modularity. Another perspective, corresponding to objectives like conductance or density, is that communities are groups of nodes that have extremal properties with respect to the number of internal edges and cut edges. Here we show that identifying community boundaries rather than communities results in a more accurate decomposition of the network into informative components. We derive a network analog of Gauss's law that relates a measure of flux through a subgraph's boundary to the connectivity among the subgraph's nodes. Our Gauss's law for networks naturally characterizes a community as a subgraph with high flux through its boundary. Aggregating flux over these boundaries gives rise to a Laplacian and forms the basis of our "Laplacian modularity" quality function for community detection that is applicable to general network types. This technique allows us to determine communities that are both overlapping and hierarchically organized.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Sinha A,Gleich DF,Ramani K

doi

10.1038/s41598-018-30401-0

subject

Has Abstract

pub_date

2018-08-09 00:00:00

pages

11909

issue

1

issn

2045-2322

pii

10.1038/s41598-018-30401-0

journal_volume

8

pub_type

杂志文章
  • Spatial memory deficiency early in 6xTg Alzheimer's disease mouse model.

    abstract::Alzheimer's disease (AD) is mainly characterized by the deposition of extracellular amyloid plaques and intracellular accumulation of neurofibrillary tangles (NFTs). While the recent 5xFAD AD mouse model exhibits many AD-related phenotypes and a relatively early and aggressive amyloid β production, it does not show NF...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-79344-5

    authors: Kang S,Kim J,Chang KA

    更新日期:2021-01-14 00:00:00

  • Receptor-interacting serine/threonine kinase 1- and 3-dependent inflammation induced in lungs of chicken infected with Pasteurella multocida.

    abstract::Fowl cholera is a serious, highly contagious disease caused by the bacterium Pasteurella multocida (P. multocida) in a range of avian species and is characterized by an acute form of septicaemia. The pathogenic mechanism of chicken lung injury caused by the bacterium is unclear. Therefore, P. multocida Q (a reference ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62042-7

    authors: Li W,Tang Q,Dai N,Feng W,Xie C,Cheng G,Liu X,Zhang W,Hu X,Gu C

    更新日期:2020-04-14 00:00:00

  • Associations of triglyceride levels with longevity and frailty: A Mendelian randomization analysis.

    abstract::Observational studies suggest associations of triglyceride levels with longevity and frailty. This study aimed to test whether the associations are causal. We used data from the Rugao Longevity and Ageing Study, a population-based cohort study performed in Rugao, China. A variant in the APOA5 gene region (rs662799) wa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep41579

    authors: Liu Z,Burgess S,Wang Z,Deng W,Chu X,Cai J,Zhu Y,Shi J,Xie X,Wang Y,Jin L,Wang X

    更新日期:2017-01-30 00:00:00

  • Novel Rbfox2 isoforms associated with alternative exon usage in rat cortex and suprachiasmatic nucleus.

    abstract::Transcriptome diversity in adult neurons is partly mediated by RNA binding proteins (RBPs), including the RBFOX factors. RBFOX3/NeuN, a neuronal maturity marker, is strangely depleted in suprachiasmatic nucleus (SCN) neurons, and may be compensated by a change in Rbfox2 expression. In this study, we found no superfici...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10535-3

    authors: Partridge LMM,Carter DA

    更新日期:2017-08-30 00:00:00

  • Identification of a New Cell Population Constitutively Circulating in Healthy Conditions and Endowed with a Homing Ability Toward Injured Sites.

    abstract::Stem and progenitor cells are the critical units for tissue maintenance, regeneration, and repair. The activation of regenerative events in response to tissue injury has been correlated with mobilization of tissue-resident progenitor cells, which is functional to the wound healing process. However, until now there has...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16574

    authors: Lo Sicco C,Tasso R,Reverberi D,Cilli M,Pfeffer U,Cancedda R

    更新日期:2015-11-12 00:00:00

  • TASI: A software tool for spatial-temporal quantification of tumor spheroid dynamics.

    abstract::Spheroid cultures derived from explanted cancer specimens are an increasingly utilized resource for studying complex biological processes like tumor cell invasion and metastasis, representing an important bridge between the simplicity and practicality of 2-dimensional monolayer cultures and the complexity and realism ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-25337-4

    authors: Hou Y,Konen J,Brat DJ,Marcus AI,Cooper LAD

    更新日期:2018-05-08 00:00:00

  • Serum albumin cysteine trioxidation is a potential oxidative stress biomarker of type 2 diabetes mellitus.

    abstract::Metabolic disorders in T2DM generate multiple sources of free radicals and oxidative stress that accelerate nonenzymatic degenerative protein modifications (DPMs) such as protein oxidation, disrupt redox signaling and physiological function, and remain a major risk factor for clinical diabetic vascular complications. ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62341-z

    authors: Paramasivan S,Adav SS,Ngan SC,Dalan R,Leow MK,Ho HH,Sze SK

    更新日期:2020-04-15 00:00:00

  • A size-dependent constitutive model of bulk metallic glasses in the supercooled liquid region.

    abstract::Size effect is of great importance in micro forming processes. In this paper, micro cylinder compression was conducted to investigate the deformation behavior of bulk metallic glasses (BMGs) in supercooled liquid region with different deformation variables including sample size, temperature and strain rate. It was fou...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08083

    authors: Yao D,Deng L,Zhang M,Wang X,Tang N,Li J

    更新日期:2015-01-28 00:00:00

  • Characterisation and use of a functional Gadd45g bacterial artificial chromosome.

    abstract::Bacterial artificial chromosomes (BACs) offer a means of manipulating gene expression and tagging gene products in the mammalian genome without the need to alter endogenous gene structure and risk deleterious phenotypic consequences. However, for a BAC clone to be useful for such purposes it must be shown to contain a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35458-5

    authors: Warr N,May J,Teboul L,Suzuki T,Asami M,Perry ACF,Wells S,Greenfield A

    更新日期:2018-11-23 00:00:00

  • Risk factors of immune checkpoint inhibitor-related interstitial lung disease in patients with lung cancer: a single-institution retrospective study.

    abstract::Immune checkpoint inhibitors (ICIs) elicit antitumour effects by activating the host immunity and cause immune-related adverse events (irAEs). ICI-related interstitial lung disease (ICI-ILD) is a fatal irAE that is difficult to treat; moreover, its incidence is relatively higher in patients with lung cancer. Therefore...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70743-2

    authors: Okada N,Matsuoka R,Sakurada T,Goda M,Chuma M,Yagi K,Zamami Y,Nishioka Y,Ishizawa K

    更新日期:2020-08-13 00:00:00

  • Analytical model of surface second-harmonic generation.

    abstract::The process of second-harmonic generation (SHG) in a finite one-dimensional nonlinear medium is analyzed in parallel by the Green-function technique and the Fourier-transform method. Considering the fundamental pump field propagating along a given direction and eliminating back-reflections at the boundaries the terms ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39260-9

    authors: Javůrek D,Peřina J Jr

    更新日期:2019-03-20 00:00:00

  • Driving forces of researchers mobility.

    abstract::Starting from the dataset of the publication corpus of the APS during the period 1955-2009, we reconstruct the individual researchers trajectories, namely the list of the consecutive affiliations for each scholar. Crossing this information with different geographic datasets we embed these trajectories in a spatial fra...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04860

    authors: Gargiulo F,Carletti T

    更新日期:2014-05-07 00:00:00

  • Helicobacter pylori colonization and obesity - a Mendelian randomization study.

    abstract::Obesity is associated with substantial morbidity, costs, and decreased life expectancy, and continues to rise worldwide. While etiological understanding is needed for prevention, epidemiological studies indicated that colonization with Helicobacter pylori (H. pylori) may affect body mass index (BMI), but with inconsis...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-14106-4

    authors: den Hollander WJ,Broer L,Schurmann C,Meyre D,den Hoed CM,Mayerle J,Hofman A,Homuth G,Uitterlinden AG,Lerch MM,Kuipers EJ

    更新日期:2017-10-31 00:00:00

  • Ultrathin SmCo5 nanoflakes with high-coercivity prepared by solid particle (NaCl) and surfactant co-assisted ball milling.

    abstract::The ultrathin SmCo5 nanoflakes with average thickness smaller than 50 nm are prepared by a novel method of solid particle (NaCl) and surfactant co-assisted ball milling. The as-prepared nanoflakes exhibit a narrower thickness distribution of 10-50 nm and high coercivity of 23 kOe. The possible formation mechanism of n...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25805

    authors: Zuo WL,Zhao X,Zhao TY,Hu FX,Sun JR,Shen BG

    更新日期:2016-05-13 00:00:00

  • Nutritional status modifies pregnane X receptor regulated transcriptome.

    abstract::Pregnane X receptor (PXR) regulates glucose and lipid metabolism, but little is known of the nutritional regulation of PXR function. We investigated the genome wide effects of the nutritional status on the PXR mediated gene regulation in the liver. Mice were treated with a PXR ligand pregnenolone 16α-carbonitrile (PCN...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-53101-9

    authors: Hassani-Nezhad-Gashti F,Kummu O,Karpale M,Rysä J,Hakkola J

    更新日期:2019-11-13 00:00:00

  • Characterization of the electrical conductivity of bone and its correlation to osseous structure.

    abstract::The interaction of osseous tissue with electric fields is an important subject. The electrical stimulation of bone promotes osteogenesis, while bone impedance has been proposed as a measure of osteoporosis, to follow fracture healing, or as a method to improve safety of surgical procedures. However, a deeper understan...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-26836-0

    authors: Balmer TW,Vesztergom S,Broekmann P,Stahel A,Büchler P

    更新日期:2018-06-05 00:00:00

  • Detection of DNA Amplicons of Polymerase Chain Reaction Using Litmus Test.

    abstract::We report on a new colorimetric DNA detection method that takes advantage of the power of polymerase chain reaction (PCR) and the simplicity of the classic litmus test. The strategy makes use of a modified set of primers for PCR to facilitate ensuing manipulations of resultant DNA amplicons: their tagging with urease ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03009-z

    authors: Chang D,Tram K,Li B,Feng Q,Shen Z,Lee CH,Salena BJ,Li Y

    更新日期:2017-06-08 00:00:00

  • Publisher Correction: Identification of microRNAs as potential cellular monocytic biomarkers in the early phase of myocardial infarction: a pilot study.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-018-23598-7

    authors: Parahuleva MS,Euler G,Mardini A,Parviz B,Schieffer B,Schulz R,Aslam M

    更新日期:2018-04-11 00:00:00

  • Substantial fat mass loss reduces low-grade inflammation and induces positive alteration in cardiometabolic factors in normal-weight individuals.

    abstract::The accumulation of fat, especially in visceral sites, is a significant risk factor for several chronic diseases with altered cardiometabolic homeostasis. We studied how intensive long-term weight loss and subsequent weight regain affect physiological changes, by longitudinally interrogating the lipid metabolism and w...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40107-6

    authors: Sarin HV,Lee JH,Jauhiainen M,Joensuu A,Borodulin K,Männistö S,Jin Z,Terwilliger JD,Isola V,Ahtiainen JP,Häkkinen K,Kristiansson K,Hulmi JJ,Perola M

    更新日期:2019-03-05 00:00:00

  • Homo sapiens exhibit a distinct pattern of CNV genes regulation: an important role of miRNAs and SNPs in expression plasticity.

    abstract::Gene expression regulation is a complex and highly organized process involving a variety of genomic factors. It is widely accepted that differences in gene expression can contribute to the phenotypic variability between species, and that their interpretation can aid in the understanding of the physiologic variability....

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12163

    authors: Dweep H,Kubikova N,Gretz N,Voskarides K,Felekkis K

    更新日期:2015-07-16 00:00:00

  • Reciprocal immune benefit based on complementary production of antibiotics by the leech Hirudo verbana and its gut symbiont Aeromonas veronii.

    abstract::The medicinal leech has established a long-term mutualistic association with Aeromonas veronii, a versatile bacterium which can also display free-living waterborne and fish- or human-pathogenic lifestyles. Here, we investigated the role of antibiotics in the dynamics of interaction between the leech and its gut symbio...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep17498

    authors: Tasiemski A,Massol F,Cuvillier-Hot V,Boidin-Wichlacz C,Roger E,Rodet F,Fournier I,Thomas F,Salzet M

    更新日期:2015-12-04 00:00:00

  • Shape dependent physical mutilation and lethal effects of silver nanoparticles on bacteria.

    abstract::In this report, spherical silver nanoparticle (AgNP-sp) and rod-shaped silver nanoparticle (AgNR) were prepared by chemical reduction method and their antibacterial activity against various Gram-positive and Gram-negative bacteria had been evaluated for their efficiency. Minimal inhibitory concentration (MIC) tests we...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18590-6

    authors: Acharya D,Singha KM,Pandey P,Mohanta B,Rajkumari J,Singha LP

    更新日期:2018-01-09 00:00:00

  • Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface.

    abstract::Drug discovery efforts against the pathogen Mycobacterium tuberculosis (Mtb) have been advanced through phenotypic screens of extensive compound libraries. Such a screen revealed sulfolane 1 and indoline-5-sulfonamides 2 and 3 as potent inhibitors of mycobacterial growth. Optimization in the sulfolane series led to co...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-09642-y

    authors: Abrahams KA,Cox JAG,Fütterer K,Rullas J,Ortega-Muro F,Loman NJ,Moynihan PJ,Pérez-Herrán E,Jiménez E,Esquivias J,Barros D,Ballell L,Alemparte C,Besra GS

    更新日期:2017-08-25 00:00:00

  • Recombinant Adeno-Associated Virus-Mediated Expression of Methamphetamine Antibody Attenuates Methamphetamine-Induced Hyperactivity in Mice.

    abstract::Methamphetamine (Meth) is one of the most frequently abused drugs worldwide. Recent studies have indicated that antibodies with high affinity for Meth reduce its pharmacological effects. The purpose of this study was to develop a technique for virus-based passive immunization against Meth effects. We generated a recom...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep46301

    authors: Chen YH,Wu KJ,Wu KL,Wu KL,Tsai HM,Chen ML,Chen YW,Hsieh W,Lin CM,Wang Y

    更新日期:2017-04-07 00:00:00

  • Nonequilibrium Magnetic Oscillation with Cylindrical Vector Beams.

    abstract::Magnetic oscillation is a generic property of electronic conductors under magnetic fields and widely appreciated as a useful probe of their electronic band structure, i.e. the Fermi surface geometry. However, the usage of the strong static magnetic field makes the measurement insensitive to the magnetic order of the t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-33651-0

    authors: Fujita H,Sato M

    更新日期:2018-10-24 00:00:00

  • Same habitat types but different use: evidence of context-dependent habitat selection in roe deer across populations.

    abstract::With the surge of GPS-technology, many studies uncovered space use of mobile animals and shed light on the underlying behavioral mechanisms of habitat selection. Habitat selection and variation in either occurrence or strength of functional responses (i.e. how selection changes with availability) have given new insigh...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-23111-0

    authors: William G,Jean-Michel G,Sonia S,Christophe B,Atle M,Nicolas M,Maryline P,Clément C

    更新日期:2018-03-23 00:00:00

  • Loss of Gαi proteins impairs thymocyte development, disrupts T-cell trafficking, and leads to an expanded population of splenic CD4+PD-1+CXCR5+/- T-cells.

    abstract::Thymocyte and T cell trafficking relies on signals initiated by G-protein coupled receptors. To address the importance of the G-proteins Gαi2 and Gαi3 in thymocyte and T cell function, we developed several mouse models. Gαi2 deficiency in hematopoietic progenitors led to a small thymus, a double negative (DN)1/DN2 thy...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04537-4

    authors: Hwang IY,Harrison K,Park C,Kehrl JH

    更新日期:2017-06-23 00:00:00

  • High-throughput sequencing analysis revealed the regulation patterns of small RNAs on the development of A. comosus var. bracteatus leaves.

    abstract::Studies of the molecular mechanisms involved in the formation of the albino leaf cells are important for understanding the development of chimera leaves in Ananas comosus var. bracteatus. In this study, we identified a total of 163 novel miRNAs involved in the development of complete white (CWh) and complete green (CG...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-20261-z

    authors: Xiong YY,Ma J,He YH,Lin Z,Li X,Yu SM,Li RX,Jiang FX,Li X,Huang Z,Sun LX

    更新日期:2018-01-31 00:00:00

  • SIK2 regulates fasting-induced PPARα activity and ketogenesis through p300.

    abstract::Fatty acid oxidation and subsequent ketogenesis is one of the major mechanisms to maintain hepatic lipid homeostasis under fasting conditions. Fasting hormone glucagon has been shown to stimulate ketone body production through activation of PPARα; however, the signal pathway linking glucagon to PPARα is largely undisc...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep23317

    authors: Zhang ZN,Gong L,Lv S,Li J,Tai X,Cao W,Peng B,Qu S,Li W,Zhang C,Luan B

    更新日期:2016-03-17 00:00:00

  • Revealing Tumor Habitats from Texture Heterogeneity Analysis for Classification of Lung Cancer Malignancy and Aggressiveness.

    abstract::We propose an approach for characterizing structural heterogeneity of lung cancer nodules using Computed Tomography Texture Analysis (CTTA). Measures of heterogeneity were used to test the hypothesis that heterogeneity can be used as predictor of nodule malignancy and patient survival. To do this, we use the National ...

    journal_title:Scientific reports

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/s41598-019-38831-0

    authors: Cherezov D,Goldgof D,Hall L,Gillies R,Schabath M,Müller H,Depeursinge A

    更新日期:2019-03-14 00:00:00