Chemopreventive effects of Ku-jin tea against AOM-induced precancerous colorectal lesions in rats and metabolomic analysis.

abstract：:Kohlschutter-Tönz syndrome (KTS) is a rare genetic disorder with neurological dysfunctions including seizure and intellectual impairment. Mutations at the Rogdi locus have been linked to development of KTS, yet the underlying mechanisms remain elusive. Here we demonstrate that a Drosophila homolog of Rogdi acts as a n...

journal_title：Scientific reports

authors： Kim M,Jang D,Yoo E,Oh Y,Sonn JY,Lee J,Ki Y,Son HJ,Hwang O,Lee C,Lim C,Choe J

更新日期：2017-09-12 00:00:00

abstract：:Highly omnidirectional and frequency controllable carbon/polyaniline (C/PANI)-based, two- (2D) and three-dimensional (3D) monopole antennas were fabricated using screen-printing and a one-step, dimensionally confined hydrothermal strategy, respectively. Solvated C/PANI was synthesized by low-temperature interfacial po...

journal_title：Scientific reports

authors： Shin KY,Kim M,Lee JS,Jang J

更新日期：2015-09-04 00:00:00

abstract：:Neurodegenerative diseases show an increase in prevalence and incidence, with the most prominent example being Alzheimer's disease. DNA damage has been suggested to play a role in the pathogenesis, but the exact mechanisms remain elusive. We enrolled 425 participants with and without neurodegenerative diseases and ana...

journal_title：Scientific reports

authors： Reimann H,Stopper H,Polak T,Lauer M,Herrmann MJ,Deckert J,Hintzsche H

更新日期：2020-12-17 00:00:00

abstract：:Plasmodium vivax, a major agent of malaria in both temperate and tropical climates, has been thought to be unable to infect humans lacking the Duffy (Fy) blood group antigen because this receptor is critical for erythrocyte invasion. Recent surveys in various endemic regions, however, have reported P. vivax infections...

journal_title：Scientific reports

authors： Cheng Y,Lu F,Wang B,Li J,Han JH,Ito D,Kong DH,Jiang L,Wu J,Ha KS,Takashima E,Sattabongkot J,Cao J,Nyunt MH,Kyaw MP,Desai SA,Miller LH,Tsuboi T,Han ET

更新日期：2016-10-19 00:00:00

abstract：:The purpose of this work is to make a case for epidemiological models with fractional exponent in the contribution of sub-populations to the incidence rate. More specifically, we question the standard assumption in the literature on epidemiological models, where the incidence rate dictating propagation of infections i...

journal_title：Scientific reports

authors： Taghvaei A,Georgiou TT,Norton L,Tannenbaum A

更新日期：2020-11-30 00:00:00

abstract：:Real-time Precise Point Positioning (PPP) technique is being widely applied for providing precise positioning services with the significant improvement on satellite precise products accuracy. With the rapid development of the multi-constellation Global Navigation Satellite Systems (multi-GNSS), currently, about 80 nav...

journal_title：Scientific reports

authors： Gao Z,Shen W,Zhang H,Niu X,Ge M

更新日期：2016-07-29 00:00:00

abstract：:Transition metal oxides potentially present higher specific capacities than the current anodes based on carbon, providing an increasing energy density as compared to commercial Li-ion batteries. However, many parameters could influence the performance of the batteries, which depend on the processing of the electrode m...

journal_title：Scientific reports

authors： Prado FD,Andersen HF,Taeño M,Mæhlen JP,Ramírez-Castellanos J,Maestre D,Karazhanov S,Cremades A

更新日期：2020-03-26 00:00:00

abstract：:The live attenuated yellow fever (YF) vaccine is a highly effective human vaccine and induces long-term protective neutralizing antibodies directed against the viral envelope protein E. The generation of such antibodies requires the help of CD4 T cells which recognize peptides derived from proteins in virus particles ...

journal_title：Scientific reports

authors： Koblischke M,Mackroth MS,Schwaiger J,Fae I,Fischer G,Stiasny K,Heinz FX,Aberle JH

更新日期：2017-08-21 00:00:00

abstract：:Several microbes, including Staphylococcus epidermidis (S. epidermidis), a Gram-positive bacterium, live inside the human nasal cavity as commensals. The role of these nasal commensals in host innate immunity is largely unknown, although bacterial interference in the nasal microbiome may promote ecological competition...

journal_title：Scientific reports

authors： Chen HW,Liu PF,Liu YT,Kuo S,Zhang XQ,Schooley RT,Rohde H,Gallo RL,Huang CM

更新日期：2016-06-16 00:00:00

abstract：:Insect glutathione S-transferases (GSTs) play important roles in insecticide/drug resistance and stress response. Medically, GSTs of house dust mites (Dermatophagoides pteronyssinus and Blomia tropicalis) and German cockroach (Blattella germanica) are human allergens. In this study, classes, isoforms and B-cell and al...

journal_title：Scientific reports

authors： Sookrung N,Reamtong O,Poolphol R,Indrawattana N,Seesuay W,Saelim N,Tantilipikorn P,Bunnag C,Chaicumpa W,Tungtrongchitr A

更新日期：2018-01-11 00:00:00

abstract：:Histological molecular classification of hepatocellular carcinoma (HCC) is clinically important for predicting the prognosis. However, a reliable serum marker has not been established. The aim of this study was to evaluate the diagnostic value of serum Wisteria Floribunda agglutinin-positive sialylated mucin 1 (WFA-si...

journal_title：Scientific reports

authors： Tamaki N,Kuno A,Matsuda A,Tsujikawa H,Yamazaki K,Yasui Y,Tsuchiya K,Nakanishi H,Itakura J,Korenaga M,Mizokami M,Kurosaki M,Sakamoto M,Narimatsu H,Izumi N

更新日期：2017-03-21 00:00:00

abstract：:There a few reports of rhodamine-based fluorescent sensors for selective detection of only Al3+, due to the challenge of identifying a suitable ligand for binding Al3+ ion. The use of fluorophore moieties appended to a polymer backbone for sensing applications is far from mature. Here, we report a new fluorescent prob...

journal_title：Scientific reports

authors： Gandra UR,Courjaret R,Machaca K,Al-Hashimi M,Bazzi HS

更新日期：2020-11-11 00:00:00

abstract：:This retrospective study was undertaken to identify predictors for the development of hypocalcaemia even with prophylactic administration of calcium and vitamin D, and to help guide future strategies to improve the safety, efficacy, and QOL of patients receiving denosumab. Between January 2016 and February 2020, a tot...

journal_title：Scientific reports

authors： Kanbayashi Y,Sakaguchi K,Hongo F,Ishikawa T,Tabuchi Y,Ukimura O,Takayama K,Taguchi T

更新日期：2021-01-13 00:00:00

abstract：:Adenosine-to-Inosine (A-to-I) RNA editing is the most prevalent post-transcriptional modification of RNA molecules. Researchers have attempted to find reliable RNA editing using next generation sequencing (NGS) data. However, most of these attempts suffered from a high rate of false positives, and they did not conside...

journal_title：Scientific reports

authors： Hwang W,Calza S,Silvestri M,Pawitan Y,Lee Y

更新日期：2019-03-25 00:00:00

abstract：:Persons infected with HIV are particularly vulnerable to a variety of oral microbial diseases. Although various study designs and detection approaches have been used to compare the oral microbiota of HIV-negative and HIV-positive persons, both with and without highly active antiretroviral therapy (HAART), methods have...

journal_title：Scientific reports

authors： Griffen AL,Thompson ZA,Beall CJ,Lilly EA,Granada C,Treas KD,DuBois KR 3rd,Hashmi SB,Mukherjee C,Gilliland AE,Vazquez JA,Hagensee ME,Leys EJ,Fidel PL Jr

更新日期：2019-12-27 00:00:00

abstract：:Although the rapid urease test (RUT) is a simple method for detecting Helicobacter pylori (H. pylori) infection, it requires sufficient biopsy samples and its sensitivity varies depending on the site and condition of H. pylori infection. We compared the diagnostic performance of a "sweeping method" for H. pylori detec...

journal_title：Scientific reports

authors： Noh CK,Lee GH,Park JW,Roh J,Han JH,Lee E,Park B,Lim SG,Shin SJ,Cheong JY,Kim JH,Lee KM

更新日期：2020-10-28 00:00:00

abstract：:MRI of hyperpolarized media, such as (129)Xe and (3)He, shows great potential for clinical applications. The optimal use of the available spin polarization requires accurate flip angle calibrations and T1 measurements. Traditional flip angle calibration methods are time-consuming and suffer from polarization losses du...

journal_title：Scientific reports

authors： Zhong J,Ruan W,Han Y,Sun X,Ye C,Zhou X

更新日期：2016-05-12 00:00:00

abstract：:The study was aimed to evaluate the performance of a newly developed non-invasive and non-contact bilirubin measurement device (AJO-Neo) as an alternative to the conventional invasive biochemical method of total serum bilirubin (TSB) estimation in preterm and term neonates suffering from hyperbilirubinemia associated ...

journal_title：Scientific reports

authors： Halder A,Adhikari A,Ghosh R,Singh S,Banerjee A,Ghosh N,Bhattacharya AM,Mandal S,Chakrabarti P,Bhattacharyya D,Altass HM,Morad M,Ahmed SA,Mallick AK,Pal SK

更新日期：2020-07-07 00:00:00

abstract：:We evaluated the performance of CSF biomarkers for predicting risk of clinical decline and conversion to dementia in non-demented patients with cognitive symptoms. CSF samples from patients in two multicentre longitudinal studies (ADNI, n = 619; BioFINDER, n = 431) were analysed. Aβ(1-42), tTau and pTau CSF concentrat...

journal_title：Scientific reports

authors： Blennow K,Shaw LM,Stomrud E,Mattsson N,Toledo JB,Buck K,Wahl S,Eichenlaub U,Lifke V,Simon M,Trojanowski JQ,Hansson O

更新日期：2019-12-13 00:00:00

abstract：:Crotoxin B (CB) is a catalytically active group IIA sPLA2 from Crotalus durissus terrificus snake venom. In contrast to most GIIA sPLA2s, CB exhibits anti-inflammatory effects, including the ability to inhibit leukocyte functions. Lipid droplets (LDs) are lipid-rich organelles associated with inflammation and recogniz...

journal_title：Scientific reports

authors： Giannotti KC,Leiguez E,Carvalho AEZ,Nascimento NG,Matsubara MH,Fortes-Dias CL,Moreira V,Teixeira C

更新日期：2017-06-22 00:00:00

abstract：:Marek's disease virus (MDV) is a highly cell-associated alphaherpesvirus that causes deadly lymphomas in chickens. While vaccination protects against clinical symptoms, MDV field strains can still circulate in vaccinated flocks and continuously evolve towards greater virulence. MDV vaccines do not provide sterilizing ...

journal_title：Scientific reports

authors： Hagag IT,Wight DJ,Bartsch D,Sid H,Jordan I,Bertzbach LD,Schusser B,Kaufer BB

更新日期：2020-07-02 00:00:00

abstract：:All grain boundaries are not equal in their predisposition for fracture due to the complex coupling between lattice geometry, interfacial structure, and mechanical properties. The ability to understand these relationships is crucial to engineer materials resilient to grain boundary fracture. Here, a methodology is pre...

journal_title：Scientific reports

authors： Dingreville R,Aksoy D,Spearot DE

更新日期：2017-08-21 00:00:00

abstract：:A novel and convenient copper (II) bromide and 1,8-diazabicyclo[5.4.1]undec-7-ene (DBU) or 1,10-phenanthroline catalysis protocol for the construction of α-alkyl-β-keto sulfones via C(sp(3))-H bond functionalization followed by C(sp(3))-S bond formation between aryl ketones and sodium sulfinates at room temperature ha...

journal_title：Scientific reports

authors： Lan XW,Wang NX,Bai CB,Zhang W,Xing Y,Wen JL,Wang YJ,Li YH

更新日期：2015-12-18 00:00:00

abstract：:Topical anesthetics are widely applied in order to relieve the discomfort and anxiety caused by needle insertion and other painful superficial interventions at the oral cavity. So far, there are no commercially available effective topical anesthetic formulations for that purpose, and the most of developments are relat...

journal_title：Scientific reports

authors： Ribeiro LNM,Franz-Montan M,Alcântara ACS,Breitkreitz MC,Castro SR,Guilherme VA,Muniz BV,Rodrigues da Silva GH,de Paula E

更新日期：2020-07-09 00:00:00

abstract：:Resin composites containing reinforcing inert glass fillers combined with bioactive glass (BG) can aid in the prevention of secondary caries, which is a major cause of failure of contemporary composite restorations. A series of previous studies on experimental resin composites filled with BG 45S5 has demonstrated that...

journal_title：Scientific reports

authors： Par M,Spanovic N,Tauböck TT,Attin T,Tarle Z

更新日期：2019-11-21 00:00:00

abstract：:Activating transcription factor 4 (ATF4) is constitutively expressed in a variety of tissues, and regulates several pathological features associated with metabolic diseases such as non-alcoholic fatty liver diseases (NAFLD) and obesity. However, the role of ATF4 in animal model systems is poorly understood. To investi...

journal_title：Scientific reports

authors： Yeh KY,Lai CY,Lin CY,Hsu CC,Lo CP,Her GM

更新日期：2017-11-27 00:00:00

abstract：:The primary objective of this study was to evaluate how schizophrenia (SCH) spectrum disorders and applied antipsychotic (AP) treatment affect serum level of amino acids (AAs) and biogenic amines (BAs) in the early course of the disorder. We measured 21 different AAs and 10 BAs in a sample of antipsychotic (AP)-naïve ...

journal_title：Scientific reports

authors： Parksepp M,Leppik L,Koch K,Uppin K,Kangro R,Haring L,Vasar E,Zilmer M

更新日期：2020-08-19 00:00:00

abstract：:Hormonal changes due to menopause can cause various health problems including weight gain and depressive symptoms. Multiple lines of evidence indicate that oestrogen receptors (ERs) play a major role in postmenopausal obesity and depression. However, little is known regarding the ER subtype-specific effects on obesity...

journal_title：Scientific reports

authors： Sasayama D,Sugiyama N,Yonekubo S,Pawlak A,Murasawa H,Nakamura M,Hayashi M,Ogawa T,Moro M,Washizuka S,Amano N,Hongo K,Ohnota H

更新日期：2017-07-05 00:00:00

abstract：:Aberrant restoration of AR activity is linked with prostate tumor growth, therapeutic failures and development of castrate-resistant prostate cancer. Understanding the processes leading to AR-reactivation should provide the foundation for novel avenues of drug discovery. A differential gene expression study was conduc...

journal_title：Scientific reports

authors： Bhowal A,Majumder S,Ghosh S,Basu S,Sen D,Roychowdhury S,Sengupta S,Chatterji U

更新日期：2017-08-29 00:00:00

abstract：:Multicolor microscopy tools necessary to localize and visualize the complexity of subcellular systems are limited by current fluorophore technology. While commercial fluorophores cover spectral space from the ultraviolet to the near infrared region and are optimized for conventional bandpass based fluorescence microsc...

journal_title：Scientific reports

authors： Bittel AM,Davis AM,Wang L,Nederlof MA,Escobedo JO,Strongin RM,Gibbs SL

更新日期：2018-03-15 00:00:00